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L-Arginine Cancer

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https://read.qxmd.com/read/30736843/the-arginine-methyltransferase-prmt5-and-prmt1-distinctly-regulate-the-degradation-of-anti-apoptotic-protein-cflar-l-in-human-lung-cancer-cells
#1
Mingyue Li, Wentao An, Linyan Xu, Yidan Lin, Ling Su, Xiangguo Liu
BACKGROUND: CFLARL , also known as c-FLIPL , is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that arginine 122 of CFLARL can be mono-methylated. However, the precise role of arginine methyltransferase of CFLARL remains unknown. PRMT5 and PRMT1, which are important members of the PRMT family, catalyze the transfer of methyl groups to the arginine of substrate proteins. PRMT5 can monomethylate or symmetrically dimethylate arginine residues, while PRMT1 can monomethylate or asymmetrically dimethylate arginine residues...
February 8, 2019: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/30696923/immune-control-by-amino-acid-catabolism-during-tumorigenesis-and-therapy
#2
REVIEW
Henrique Lemos, Lei Huang, George C Prendergast, Andrew L Mellor
Immune checkpoints arise from physiological changes during tumorigenesis that reprogramme inflammatory, immunological and metabolic processes in malignant lesions and local lymphoid tissues, which constitute the immunological tumour microenvironment (TME). Improving clinical responses to immune checkpoint blockade will require deeper understanding of factors that impact local immune balance in the TME. Elevated catabolism of the amino acids tryptophan (Trp) and arginine (Arg) is a common TME hallmark at clinical presentation of cancer...
January 29, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30652655/perspectives-on-the-therapeutic-benefits-of-arginine-supplementation-in-cancer-treatment
#3
Fabiani L R Beal, Pedro R Beal, Juliana R Beal, Natan Carvalho-Neves, Octávio L Franco, Osmar N Silva
BACKGROUND: Arginine is considered a semi-essential amino acid in healthy adults and the elderly. This amino acid seems to improve the immune system, stimulate cell growth and differentiation, and increase endothelial permeability, among other effects. For those reasons, it has been theorized that arginine supplementation may be used as an adjuvant to conventional cancer therapy treatments. OBJECTIVE: This review aims to evaluate the existing knowledge of the scientific community on arginine supplementation in order to improve the efficacy of current cancer treatment...
January 16, 2019: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/30651352/arg78-of-nprl2-catalyzes-gator1-stimulated-gtp-hydrolysis-by-the-rag-gtpases
#4
Kuang Shen, Max L Valenstein, Xin Gu, David M Sabatini
mTOR complex 1 (mTORC1) is a major regulator of cell growth and proliferation that coordinates nutrient inputs with anabolic and catabolic processes. Amino acid signals are transmitted to mTORC1 through the Rag GTPases, which directly recruit mTORC1 onto the lysosomal surface, its site of activation. The Rag GTPase heterodimer has a unique architecture that consists of two GTPase subunits, RagA or RagB bound to RagC or RagD. Their nucleotide-loading states are strictly controlled by several lysosomal or cytosolic protein complexes that directly detect and transmit the amino acid signals...
January 16, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30611984/small-molecule-inhibition-of-ddah1-significantly-attenuates-triple-negative-breast-cancer-cell-vasculogenic-mimicry-in-vitro
#5
Julie-Ann Hulin, Sara Tommasi, David Elliot, Arduino A Mangoni
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a key enzyme involved in the metabolism of the endogenous nitric oxide synthase (NOS) inhibitors asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA). Increased DDAH1 expression and subsequent increased NO production have been recently linked to cancer. Specifically, DDAH1 is implicated in establishment of a vascular network by tumour cells, vasculogenic mimicry (VM), which is strongly associated with tumour progression and poor patient prognosis...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30605863/metabolic-pathways-of-l-arginine-and-therapeutic-consequences-in-tumors
#6
REVIEW
Jarosław Szefel, Aleksandra Danielak, Wiesław Janusz Kruszewski
Difference in the metabolism of normal and cancer cells inspires to search for new, more specific and less toxic therapies than those currently used. The development of tumors is conditioned by genetic changes in cancer-transformed cells, immunological tolerance and immunosuppression. At the initial stages of carcinogenesis, the immune system shows anti-tumor activity, however later, cancer disrupts the function of Th1/Th17/Th2 lymphocytes by regulatory T (Treg) cells, tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) and finally causes immunosuppression...
December 31, 2018: Advances in Medical Sciences
https://read.qxmd.com/read/30578842/the-role-of-arginase-in-aging-a-systematic-review
#7
REVIEW
Johnny Moretto, Corine Girard, Céline Demougeot
Aging is a normal, progressive and multi-step degeneration in the physiological functions and metabolic processes of living organisms until death. It represents the main risk factor for many diseases (e.g. cancer, cardiovascular and neurodegenerative diseases) and contributes to increase in mortality. Aging results, at least partially, from an accumulation of cell and tissue damage related to inherited and environmental factors, leading to biological and biochemical dysregulations. Arginase is a ubiquitous L-arginine-metabolizing enzyme involved in some fundamental mechanisms such as the urea cycle or polyamines synthesis...
December 19, 2018: Experimental Gerontology
https://read.qxmd.com/read/30563898/trypanosoma-brucei-prmt1-is-a-nucleic-acid-binding-protein-with-a-role-in-energy-metabolism-and-the-starvation-stress-response
#8
Lucie Kafková, Chengjian Tu, Kyle L Pazzo, Kyle P Smith, Erik W Debler, Kimberly S Paul, Jun Qu, Laurie K Read
In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant regulators of gene expression. Arginine methylation is a posttranslational modification that preferentially targets RNA binding proteins and is, therefore, likely to have a substantial impact on T. brucei biology. The data presented here demonstrate that cells depleted of T...
December 18, 2018: MBio
https://read.qxmd.com/read/30551306/the-bio-interface-between-functionalized-au-nr-go-nanoplatforms-with-protein-corona-and-their-impact-on-delivery-and-release-system
#9
Akram Assali, Shayan Razzazan, Omid Akhavan, Fatemeh Mottaghitalab, Mohsen Adeli, Fatemeh Atyabi
Interaction of nanoplatforms with biomolecules in biological fluids alters nanoplatforms approach to target tissue and deliver their cargo. Here in, three nanoplatforms were utilized as a carrier to detect the effects of subsequent biomolecules on gene delivery using NIR thermal therapy. Nanoplatforms included; graphene oxide coated gold nanorods (NR@GO), PEGylated NR@GO (NR@GO-PEG) and poly L arginine functionalized NR@GO-PEG (NR@GO-PEG-PLArg). Results indicated that incubation of nanoplatforms in different concentrations of human plasma induced the evolution of layer of proteins (corona) with different thickness on the surface of nanoplatforms...
January 1, 2019: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/30514398/alterations-in-arginine-and-energy-metabolism-structural-and-signalling-lipids-in-metastatic-breast-cancer-in-mice-detected-in-plasma-by-targeted-metabolomics-and-lipidomics
#10
Kamil Kus, Agnieszka Kij, Agnieszka Zakrzewska, Agnieszka Jasztal, Marta Stojak, Maria Walczak, Stefan Chlopicki
BACKGROUND: The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, energy metabolism, and structural and signalling lipids in plasma in the early and late stages of murine breast cancer metastasis. METHODS: Mice were orthotopically inoculated with 4T1 metastatic breast cancer cells, and plasma was analysed along the pulmonary metastasis progression using LC-MS/MS-based targeted metabolomics and lipidomics...
December 4, 2018: Breast Cancer Research: BCR
https://read.qxmd.com/read/30449003/correction-to-metabolic-relevance-for-n-hydroxy-l-arginine-reduction-in-estrogen-negative-breast-cancer-cells
#11
Srinidi Mohan, Seema Patel, Ian Greenstein, Cathy Ng, Kelly Frazier, Giang Nguyen, Lisa Harding, David Barlow
We found a unit error with our LC-MS lower limit of quantitation (LLOQ) measurement in the Amino Acids Journal.
November 17, 2018: Amino Acids
https://read.qxmd.com/read/30429478/colorectal-cancer-liver-metastatic-growth-depends-on-pad4-driven-citrullination-of-the-extracellular-matrix
#12
A E Yuzhalin, A N Gordon-Weeks, M L Tognoli, K Jones, B Markelc, R Konietzny, R Fischer, A Muth, E O'Neill, P R Thompson, P J Venables, B M Kessler, S Y Lim, R J Muschel
Citrullination of proteins, a post-translational conversion of arginine residues to citrulline, is recognized in rheumatoid arthritis, but largely undocumented in cancer. Here we show that citrullination of the extracellular matrix by cancer cell derived peptidylarginine deiminase 4 (PAD4) is essential for the growth of liver metastases from colorectal cancer (CRC). Using proteomics, we demonstrate that liver metastases exhibit higher levels of citrullination and PAD4 than unaffected liver, primary CRC or adjacent colonic mucosa...
November 14, 2018: Nature Communications
https://read.qxmd.com/read/30423404/l-arginine-5-fluorouracil-combination-treatment-approaches-cells-selectively-rescuing-endothelial-cells-while-killing-mda-mb-468-breast-cancer-cells
#13
Mozhgan Jahani, Mehri Azadbakht, Hassan Rasouli, Reza Yarani, Davood Rezazadeh, Nader Salari, Kamran Mansouri
Reducing the adverse effects of chemotherapy on normal cells such as endothelial cells is a determinant factor of treatment success especially in pregnant women. In this regard, modulatory effect of L-arginine on various cancers is still a controversial topic in cancer therapy. So, this study aimed to compare the effect of L-arginine treatment alone and in combination with 5-fluorouracil (5-FU) on the survival and angiogenesis of primary human umbilical vein endothelial cells (HUVECs) and the breast cancer cell line of MDA-MB-468...
November 10, 2018: Food and Chemical Toxicology
https://read.qxmd.com/read/30398232/conductometric-immunoassay-of-alpha-fetoprotein-in-sera-of-liver-cancer-patients-using-bienzyme-functionalized-nanometer-sized-silica-beads
#14
Jiaming Liang, Jing Wang, Luwei Zhang, Sijia Wang, Cuiping Yao, Zhenxi Zhang
A conductometric immunoassay protocol was designed for the sensitive detection of a liver cancer biomarker, alpha-fetoprotein (AFP), in biological fluids by using enzyme-conjugated nanometer-sized enzyme-doped silica beads. Initially, urease molecules were doped into nanosilica particles by using the reverse micelle method. Thereafter, arginase-labeled anti-AFP antibodies were covalently conjugated onto the surface of the synthesized nanoparticles. The immunoreaction was carried out in a monoclonal anti-AFP capture antibody-coated microplate with a sandwich-type assay format by using bienzyme-functionalized silica nanobeads as the recognition elements...
November 6, 2018: Analyst
https://read.qxmd.com/read/30358169/14-3-3%C3%AE-binds-to-hepatitis-b-virus-protein-x-and-maintains-its-protein-stability-in-hepatocellular-carcinoma-cells
#15
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Jiahong Dong, Wenping Zhou
14-3-3ζ, a phosphopeptide-binding molecule, is reportedly overexpressed in the cancerous tissues of patients with hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) protein X (HBx) draws intensive attention in HBV-related HCC because it not only regulates HBV replication, but also promotes carcinogenesis by interacting with various tumor or antitumor molecules. This study is performed to investigate whether and how 14-3-3ζ interacts with HBx. The coimmunoprecipitation (Co-IP) results showed that 14-3-3ζ bond to HBx in HBV-infected Hep3B HCC cells and CSQT-2 portal vein tumor thrombosis (PVTT) cells...
November 2018: Cancer Medicine
https://read.qxmd.com/read/30356964/delivery-of-phosphorescent-anticancer-iridium-iii-complexes-by-polydopamine-nanoparticles-for-targeted-combined-photothermal-chemotherapy-and-thermal-photoacoustic-lifetime-imaging
#16
Dong-Yang Zhang, Yue Zheng, Hang Zhang, Jing-Hua Sun, Cai-Ping Tan, Liang He, Wei Zhang, Liang-Nian Ji, Zong-Wan Mao
Recently, phosphorescent iridium complexes have demonstrated great potential as anticancer and imaging agents. Dopamine is a melanin-like mimic of mussel adhesive protein that can self-polymerize to form polydopamine (PDA) nanoparticles that demonstrate favorable biocompatibility, near-infrared absorption, and photothermal effects. Herein, PDA nanoparticles are functionalized with β-cyclodextrin (CD) substitutions, which are further assembled with adamantane-modified arginine-glycine-aspartic acid (Ad-RGD) tripeptides to target integrin-rich tumor cells...
October 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/30319254/cationic-graphene-oxide-nanoplatform-mediates-mir-101-delivery-to-promote-apoptosis-by-regulating-autophagy-and-stress
#17
Akram Assali, Omid Akhavan, Fatemeh Mottaghitalab, Mohsen Adeli, Rassoul Dinarvand, Shayan Razzazan, Ehsan Arefian, Masoud Soleimani, Fatemeh Atyabi
Introduction: MicroRNA-101 (miR-101) is an intense cancer suppressor with special algorithm to target a wide range of pathways and genes which indicates the ability to regulate apoptosis, cellular stress, metastasis, autophagy, and tumor growth. Silencing of some genes such as Stathmin1 with miR-101 can be interpreted as apoptotic accelerator and autophagy suppressor. It is hypothesized that hybrid microRNA (miRNA) delivery structures based on cationized graphene oxide (GO) could take superiority of targeting and photothermal therapy to suppress the cancer cells...
2018: International Journal of Nanomedicine
https://read.qxmd.com/read/30296444/plasma-metabolomic-profiling-distinguishes-right-sided-from-left-sided-colon-cancer
#18
Kui Deng, Peng Han, Wei Song, Zhuozhong Wang, Fan Zhang, Hongyu Xie, Weiwei Zhao, Huan Xu, Yuqing Cai, Zhiwei Rong, Xiwen Yu, Bin-Bin Cui, Kang Li
BACKGROUND: Many studies have demonstrated that right-sided colon cancer (RCC) has a higher mortality rate and worse prognosis than left-sided colon cancer (LCC). However, the underlying biological mechanism that can account for these differences is unclear. METHODS: In this study, plasma metabolic profiles in 147 LCC patients and 105 RCC patients were systematically analyzed by the ultra high performance liquid chromatography quadruple time-of-flight mass spectrometry (UHPLC-QTOF/MS) platform in conjunction with univariate and multivariate statistical analysis...
October 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/30282613/metal-ions-induced-stability-and-function-of-bimetallic-human-arginase-i-a-therapeutically-important-enzyme
#19
Vineet Sadarangani, Safikur Rahman, Apurba Kumar Sau
Recent studies have highlighted the therapeutic importance of bimetallic human arginase-I against hyperargininemia and L-arginine auxotrophic cancers. The longer retention of catalytic activity of the Co2+ -enzyme than that of the Mn2+ in human serum is associated with its enhanced therapeutic potential. To understand the basis of this and also to explore the role of a bimetallic center as well as the role of individual metal ions in the stability, we performed a detailed biochemical and biophysical investigation...
November 2018: Biochimica et biophysica acta. Proteins and proteomics
https://read.qxmd.com/read/30232300/a-case-of-ectopic-acth-syndrome-due-to-ddavp-sensitive-but-v1b-receptor-negative-bronchial-typical-carcinoid-with-lymphatic-metastasis-and-plasma-progrp-elevation
#20
Tadashi Yamamuro, Kana Inoue, Yasuki Nagai, Daisuke Azuma, Aya Yamamoto, Kantaro Hara, Masaharu Kohara, Takashi Iwata, Shinichi Nakatsuka, Eiichi Morii, Tsunehiko Yamamoto
Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical examination. In addition, laboratory examination showed elevated plasma ACTH and serum cortisol levels...
December 28, 2018: Endocrine Journal
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