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citrullinated protein antibody

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https://read.qxmd.com/read/30746589/production-of-functional-recombinant-cyclic-citrullinated-peptide-monoclonal-antibody-in-transgenic-rice-cell-suspension-culture
#1
Do Van Giap, Jae-Wan Jung, Nan-Sun Kim
Cyclic citrullinated peptide (CCP) antibody has been shown recently to be a promising marker for early detection and diagnosis of rheumatoid arthritis (RA). In order to exploit newly developed therapies for RA, early intervention is crucial in preventing irreversible joint damage. Here, we describe use of a plant expression system to produce a CCP antibody that could be used in the early diagnosis of RA. Heavy and light chain gene sequences of a CCP monoclonal antibody (CCP mAb) were cloned from the hybridoma cell (12G1) and introduced into two separate plant expression vectors under the control of the rice α-amylase 3D (RAmy3D) promoter system...
February 11, 2019: Transgenic Research
https://read.qxmd.com/read/30742363/smoking-hla-genes-and-serology-in-rheumatoid-arthritis-complex-relationships-investigated-in-the-swedish-eira-case-control-study
#2
Anna Karin Hedström, Johan Rönnelid, Lars Klareskog, Lars Alfredsson
OBJECTIVES: Smoking is associated with increased risk for subsets of RA defined by the presence of anti-citrulline protein antibodies (ACPA) and rheumatoid factors (RF) and an interaction between smoking and HLA-DRB1 SE has been confined to risk of seropositive RA. We aimed to investigate the interplay between smoking and HLA-DRB1 SE with regard to risk of different RA subsets, based on RF and ACPA status. METHODS: Incident cases of RA (3645 cases, 5883 matched controls) were divided into four subgroups based on the presence or absence of RF and anti-CCP2 antibodies...
February 11, 2019: Arthritis & Rheumatology
https://read.qxmd.com/read/30717793/anti-citrullinated-protein-antibodies-are-associated-with-osteopenia-but-not-with-pain-at-diagnosis-of-rheumatoid-arthritis-data-from-the-barfot-cohort
#3
Ingiäld Hafström, Sofia Ajeganova, Kristina Forslind, Björn Svensson
BACKGROUND: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis. METHODS: Baseline data from the BARFOT (Better Anti-Rheumatic PharmacOTherapy) cohort, which consists of patients with RA with a disease duration of 1 year or less, were analyzed...
February 4, 2019: Arthritis Research & Therapy
https://read.qxmd.com/read/30714481/clinical-and-etiological-meaning-of-anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis
#4
Shuichiro Nakabo
Several autoantibodies against proteins with post-translational modifications have been detected in patients with rheumatoid arthritis (RA) and are called anti-modified protein antibodies (AMPAs). Anti-carbamylated protein antibodies (Anti-CarP Ab) are the second most vigorously researched AMPAs following anti-citrullinated protein/peptide antibodies (ACPA). Anti-CarP Ab and ACPA show cross-reactivity to some extent and frequently co-exist with each other in RA, but are two distinct antibodies. Although the diagnostic efficacy of anti-CarP Ab is inferior to that of ACPA, the diagnostic specificity of RA may improve when used in combination with ACPA and rheumatoid factor...
February 3, 2019: Immunological medicine
https://read.qxmd.com/read/30709614/neutrophils-in-rheumatoid-arthritis-breaking-immune-tolerance-and-fueling-disease
#5
REVIEW
Liam J O'Neil, Mariana J Kaplan
Rheumatoid arthritis (RA), a common autoimmune disease, is characterized by a highly coordinated inflammatory response that involves innate and adaptive immunity. One of the hallmarks of RA is an immune response directed at citrullinated peptides that are specifically targeted by anticitrullinated protein antibodies (ACPAs). Among the various mechanisms by which neutrophils may promote immune dysregulation in RA, their ability to extrude neutrophil extracellular traps has recently been implicated in the development of ACPAs...
January 29, 2019: Trends in Molecular Medicine
https://read.qxmd.com/read/30704942/neutrophil-extracellular-traps-exert-both-pro-and-anti-inflammatory-actions-in-rheumatoid-arthritis-that-are-modulated-by-c1q-and-ll-37
#6
Matthieu Ribon, Sarra Seninet, Julie Mussard, Mireille Sebbag, Cyril Clavel, Guy Serre, Marie-Christophe Boissier, Luca Semerano, Patrice Decker
OBJECTIVE: Neutrophil extracellular traps (NET), produced by activated polymorphonuclear neutrophils (PMN), are supposed to play a role in the pathogenesis of rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease characterized by anti-citrullinated protein antibodies (ACPA). Indeed, NET contain citrullinated autoantigens and some RA autoantibodies recognize NET. However, the mechanisms by which NET trigger or perpetuate the inflammatory process in RA are hitherto not elucidated...
January 28, 2019: Journal of Autoimmunity
https://read.qxmd.com/read/30700425/-porphyromonas-gingivalis-experimentally-induces-periodontis-and-an-anti-ccp2-associated-arthritis-in-the-rat
#7
Guillaume Courbon, Mélanie Rinaudo-Gaujous, Vincent Blasco-Baque, Isabelle Auger, Robin Caire, Lambert Mijola, Laurence Vico, Stéphane Paul, Hubert Marotte
Association between periodontal disease (PD) and rheumatoid arthritis (RA) has been extensively described, but direct evidence of causal involvement of PD in RA is missing. We investigated the priming role of oral Porphyromonas gingivalis ( P. gingivalis ) in PD and subsequent RA and we assessed biomarkers of bone resorption and arthritis development in rats. METHODS : Lewis rats were orally exposed to either P. gingivalis , Prevotella intermedia or control gel for 1 month and then followed for 8 months...
January 30, 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30692825/the-roles-of-anti-citrullinated-protein-antibodies-in-the-immunopathogenesis-of-rheumatoid-arthritis
#8
REVIEW
Hui-Chun Yu, Ming-Chi Lu
Rheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Recently, the discovery of anti-citrullinated protein antibodies (ACPAs) has revolutionized the diagnosis and our understanding of the immunopathogenesis of RA. The presence of ACPAs is also closely linked to the disease activity of RA...
January 2019: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://read.qxmd.com/read/30685746/a-powerful-test-for-ordinal-trait-genetic-association-analysis
#9
Yuan Xue, Jinjuan Wang, Juan Ding, Sanguo Zhang, Qizhai Li
Response selective sampling design is commonly adopted in genetic epidemiologic study because it can substantially reduce time cost and increase power of identifying deleterious genetic variants predispose to human complex disease comparing with prospective design. The proportional odds model (POM) can be used to fit data obtained by this design. Unlike the logistic regression model, the estimated genetic effect based on POM by taking data as being enrolled prospectively is inconsistent. So the power of resulted Wald test is not satisfactory...
January 26, 2019: Statistical Applications in Genetics and Molecular Biology
https://read.qxmd.com/read/30659089/elevated-serum-il-35-levels-in-rheumatoid-arthritis-are-associated-with-disease-activity
#10
Yuxuan Li, Lutian Yao, Siyan Liu, Jisheng Wu, Liping Xia, Hui Shen, Jing Lu
To investigate serum interleukin (IL)- 35 levels in patients with rheumatoid arthritis (RA) and to describe the association between serum IL-35 levels and clinical parameters: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), global health on Visual Analog Scale, Disease Activity Score in 28 joints based on ESR (DAS28-ESR), rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (ACPAs). The study included 129 patients with RA and 83 healthy controls. Serum IL-35 levels were detected by ELISA...
January 18, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30658699/in-rheumatoid-arthritis-changes-in-autoantibody-levels-reflect-intensity-of-immunosuppression-not-subsequent-treatment-response
#11
Emma C de Moel, Veerle F A M Derksen, Leendert A Trouw, Holger Bang, Gerard Collée, Leroy R Lard, Sofia Ramiro, Tom W J Huizinga, Cornelia F Allaart, René E M Toes, Diane van der Woude
BACKGROUND: Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. It is currently unclear whether changes in autoantibody levels are associated with disease activity/treatment outcomes and whether they are modified by treatment intensity. Therefore, we determined longitudinal changes in RA-autoantibody levels, the association between these changes and activity score (DAS) and treatment outcomes, and the effect of intensity of immunosuppressive treatment on levels...
January 18, 2019: Arthritis Research & Therapy
https://read.qxmd.com/read/30658685/association-between-severity-of-periodontitis-and-clinical-activity-in-rheumatoid-arthritis-patients-a-case-control-study
#12
Beatriz Rodríguez-Lozano, Jerián González-Febles, Jorge Luis Garnier-Rodríguez, Shashi Dadlani, Sagrario Bustabad-Reyes, Mariano Sanz, Fernando Sánchez-Alonso, Carlos Sánchez-Piedra, Enrique González-Dávila, Federico Díaz-González
BACKGROUND: A high prevalence of periodontitis has been reported in rheumatoid arthritis (RA) patients, although the strength of this association, its temporal link and the possible relationship between the severity of periodontitis and RA disease activity remain unclear. The objective of this work was to investigate whether periodontitis is associated with RA and whether periodontitis severity is linked to RA disease activity. METHODS: This case-control study included 187 patients diagnosed with RA and 157 control patients without inflammatory joint disease...
January 18, 2019: Arthritis Research & Therapy
https://read.qxmd.com/read/30657101/clinical-and-pathophysiologic-relevance-of-autoantibodies-in-rheumatoid-arthritis
#13
REVIEW
Sara de Brito Rocha, Danielle Cristiane Baldo, Luis Eduardo Coelho Andrade
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disease affecting 0.5 to 1% of adults worldwide and frequently leads to joint destruction and disability. Early diagnosis and early and effective therapy may prevent joint damage and lead to better long-term results. Therefore, reliable biomarkers and outcome measures are needed. Refinement of the understanding of molecular pathways involved in disease pathogenesis have been achieved by combining knowledge on RA-associated genes, environmental factors and the presence of serological elements...
January 17, 2019: Advances in rheumatology
https://read.qxmd.com/read/30638826/systemic-levels-of-anti-pad4-autoantibodies-correlate-with-airway-obstruction-in-cystic-fibrosis
#14
Ruchi Yadav, Dae-Goon Yoo, J Michelle Kahlenberg, S Louis Bridges, Oluwadamilola Oni, Hanwen Huang, Arlene Stecenko, Balázs Rada
Cystic fibrosis (CF) airway disease is characterized by the long-term presence of neutrophil granulocytes. Formation of neutrophil extracellular traps (NETs) and/or autoantibodies directed against extracellular components of NETs are possible contributors to neutrophil-mediated lung damage in CF. The goal of this study was to measure their levels in CF adults compared to healthy controls and subjects with rheumatologic diseases known to develop NET-related autoantibodies and pathologies, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
January 10, 2019: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/30621158/optimization-of-sequence-display-and-mode-of-operation-of-igg-binding-peptide-ligands-to-develop-robust-high-capacity-affinity-adsorbents-that-afford-high-igg-product-quality
#15
Tuhidul Islam, Amith D Naik, Yasuhiro Hashimoto, Stefano Menegatti, Ruben G Carbonell
This work presents the use of peptide ligand HWRGWV and its cognate sequences to develop affinity adsorbents that compete with Protein A in terms of binding capacity and quality of the eluted product. First, the peptide ligand was conjugated to crosslinked agarose resins (WorkBeads) at different densities and using different spacer arms. The optimization of ligand density and display resulted in values of static and dynamic binding capacity of 85 mg/mL and 65 mg/mL, respectively. A selected peptide-WorkBeads adsorbent was utilized for purifying Mabs from Chinese Hamster Ovary (CHO) cell culture supernatants...
January 4, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30594439/diagnostic-value-of-anti-fibrinogen-citrullinated-peptide-in-rheumatoid-arthritis
#16
Goitybell Martínez Téllez, Bárbara Torres Rives, Jorge Alexis Gómez Morejón, Hilda Pérez Garay, Antonio Melchor Rodríguez, Jose Ángel Portal Miranda
OBJECTIVE: To determinate the diagnostic value of an antibody against a citrullinated fibrinogen peptide in Cuban patients with rheumatoid arthritis, using an enzyme immunasay. MATERIALS AND METHODS: A citrullinated peptide of fibrinogen designed by informatics prediction was synthesized and used in an enzyme immunoassay. The participants were 81 patients with early disease, 81 patients with established disease, 58 patients with other rheumatic and inflammatory diseases, and 43 healthy individuals...
December 26, 2018: Reumatología Clinica
https://read.qxmd.com/read/30593421/nodular-rheumatoid-arthritis-ra-a-distinct-disease-subtype-initiated-by-cadmium-inhalation-inducing-pulmonary-nodule-formation-and-subsequent-ra-associated-autoantibody-generation
#17
D Murphy, E Sinha-Royle, K Bellis, C Harrington, D Hutchinson
Nodular rheumatoid arthritis (RA) patients have raised rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) levels, and are more likely to smoke than RA patients without nodules. Subcutaneous and pulmonary rheumatoid nodules (granulomas) frequently co-exist. Pulmonary rheumatoid nodules develop prior to RA development and have the immunological machinery to generate RF and ACPAs. Pulmonary granulomas have been observed in animal models exposed to cadmium (Cd) inhalation. Cigarette smoke increases pulmonary Cd exposure...
January 2019: Medical Hypotheses
https://read.qxmd.com/read/30567606/the-value-of-joint-ultrasonography-in-predicting-arthritis-in-seropositive-patients-with-arthralgia-a-prospective-cohort-study
#18
Marian H van Beers-Tas, Annelies B Blanken, Mark M J Nielen, Franktien Turkstra, Conny J van der Laken, Marlies Meursinge Reynders, Dirkjan van Schaardenburg
BACKGROUND: The value of joint ultrasonography (US) in the prediction of clinical arthritis in individuals at risk of developing rheumatoid arthritis (RA) is still a point of debate, due to varying scanning protocols and different populations. We investigated whether US abnormalities assessed with a standard joint protocol can predict development of arthritis in seropositive patients with arthralgia. METHODS: Anti-citrullinated protein antibodies and/or rheumatoid factor positive patients with arthralgia, but without clinical arthritis were included...
December 19, 2018: Arthritis Research & Therapy
https://read.qxmd.com/read/30562792/-progressive-pseudorheumatoid-dysplasia-misdiagnosed-as-ankylosing-spondylitis-a-case-report
#19
R Liu, J Y Zhai, X Y Liu, Z Q Yao
In this study, we reported a case of progressive pseudorheumatoid dysplasia in Peking University Third Hospital. A 56-year-old male patient presented with hip joint pain for more than 40 years and multiple joints pain with limitation of movements of these joints for 28 years. This patient suffered from joint pain and impaired range of motion of the hip, knee, elbow and shoulder gradually, associated with difficulty in walking and inability to take care of himself. He was diagnosed with "femoral head necrosis" or "ankylosing spondylitis" in local hospitals, but the treatment of nonsteroidal antiinflammatory drugs (NSAIDs) and sulfasalazine was not effective...
December 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/30562766/-increased-receptor-activator-of-nuclear-factor-kappa-b-ligand-expressed-on-b10-cells-in-rheumatoid-arthritis
#20
H J Liu, X F Guo, F L Hu, C P Yan, X J Cui, X L Yan, Z G Li, Y Jia, S L Song
OBJECTIVE: To detect receptor activator of nuclear factor kappa B ligand (RANKL) expressed on B10 cells in rheumatoid arthritis (RA) and to evaluate the correlation between RANKL-producing B10 cells in RA and clinical features and laboratory parameters, trying to reveal the possible role of B10 cells in the pathogenesis of RA and the potential mechanism of impaired immunosuppressive capacities. METHODS: 25 RA patients and 20 healthy volunteers were enrolled. These RA patients did not received treatment with glucocorticoids, disease-modifying anti-rheumatic drug and biologics during the recent half of a year...
December 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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