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Resonance frequency cancer protocol

Niranjan J Sathianathen, Badrinath R Konety, Fernando Alarid-Escudero, Nathan Lawrentschuk, Damien M Bolton, Karen M Kuntz
BACKGROUND: Active surveillance (AS) has become the recommended management strategy for men with low-risk prostate cancer. However, there is considerable uncertainty about the optimal follow-up schedule in terms of the tests to perform and their frequency. OBJECTIVE: To assess the costs and benefits of different AS follow-up strategies compared to watchful waiting (WW) or immediate treatment. DESIGN, SETTING, AND PARTICIPANTS: A state-transition Markov model was developed to simulate the natural history (ie, no testing or intervention) of prostate cancer for a hypothetical cohort of 50-yr-old men newly diagnosed with low-risk prostate cancer...
November 10, 2018: European Urology
Sh Barzanjeh, V Salari, J A Tuszynski, M Cifra, C Simon
Microtubules provide the mechanical force required for chromosome separation during mitosis. However, little is known about the dynamic (high-frequency) mechanical properties of microtubules. Here, we theoretically propose to control the vibrations of a doubly clamped microtubule by tip electrodes and to detect its motion via the optomechanical coupling between the vibrational modes of the microtubule and an optical cavity. In the presence of a red-detuned strong pump laser, this coupling leads to optomechanical-induced transparency of an optical probe field, which can be detected with state-of-the art technology...
July 2017: Physical Review. E
Demetrios Moris, Christos Damaskos, Eleftherios Spartalis, Alexandros Papalampros, Spyridon Vernadakis, Dimitrios Dimitroulis, John Griniatsos, Evangelos Felekouras, Nikolaos Nikiteas
Intraductal papillary mucinous neoplasms (IPMNs) are presumed to evolve from low-grade dysplasia to high-grade dysplasia to invasive carcinoma. Resection of lesions before the development of pancreatic cancer may prevent the development of an incurable process as, once IPMNs progress to invasive cancer, the prognosis may be as poor as resected conventional pancreatic ductal adenocarcinoma. Resection of IPMNs, particularly in the setting of high-grade dysplasia, is presumed to provide a survival benefit. IPMNs also present many challenges as the identification of high-grade dysplasia and early invasive carcinoma and the timing and frequency of malignant progression are not yet established...
May 2017: Anticancer Research
Nfally Badji, Hamidou Deme, Geraud Akpo, Boucar Ndong, Mouhamadou Hamine Toure, Sokhna Ba Diop, El Hadji Niang
Slow spinal cord compressions are due to the development of an expansive lesion within the medullary canal. This is a very common condition whose diagnosis is primarily clinical. The magnetic resonance imaging occupies a central and currently irreplaceable position in diagnosis and localization as well as in etiological research. Etiology of cancer is predominant in Europe. This study aims to describe the MRI features of slow spinal cord compressions and to determine its etiologic profile. This is a retrospective study of 97 cases whose data were collected at the Department of Radiology, National University Hospital Centre (CHUN) of Fann, over a period of 30 months (from March 8, 2010 to September 29 2012)...
2016: Pan African Medical Journal
Stacy Loeb, Dawn Walter, Caitlin Curnyn, Heather T Gold, Herbert Lepor, Danil V Makarov
PURPOSE: While major prostate cancer active surveillance programs recommend repeat testing such as prostate specific antigen and prostate biopsy, to our knowledge compliance with such testing is unknown. We determined whether men in the community receive the same intensity of active surveillance testing as in prospective active surveillance protocols. MATERIALS AND METHODS: We performed a retrospective cohort study of men 66 years old or older in the SEER (Surveillance, Epidemiology and End Results)-Medicare database...
September 2016: Journal of Urology
Pallavi Tiwari, Shabbar F Danish, Benjamin Jiang, Anant Madabhushi
Laser interstitial thermal therapy (LITT) has recently emerged as a new treatment modality for cancer pain management that targets the cingulum (pain center in the brain) and has shown promise over radio frequency (RF)-based ablation, due to magnetic resonance image (MRI) guidance that allows for precise ablation. Since laser ablation for pain management is currently exploratory and is only performed at a few centers worldwide, its short- and long-term effects on the cingulum are currently unknown. Traditionally, treatment effects for neurological conditions are evaluated by monitoring changes in intensities and/or volume of the ablation zone on post-treatment Gadolinium-contrast T1-w (Gd-T1) MRI...
October 2015: Journal of Medical Imaging
J Uzan, A E Nahum, I Syndikus
AIMS: To describe the treatment of 11 patients with radiobiologically guided dose-painting radiotherapy and report on toxicity. MATERIALS AND METHODS: Boost volumes were identified with functional magnetic resonance imaging scans in 11 patients with high-risk prostate cancer. Patients were treated using a dose-painting approach; the boost dose was limited to 86 Gy in 37 fractions, while keeping the rectal normal tissue complication probability to 5-6%. Rotational intensity-modulated radiotherapy was used with daily image guidance and fiducial markers...
March 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Shalini Singh, Chunliu Pan, Ronald Wood, Chiuan-Ren Yeh, Shuyuan Yeh, Kai Sha, John J Krolewski, Kent L Nastiuk
BACKGROUND: Genetically engineered mouse models are essential to the investigation of the molecular mechanisms underlying human prostate pathology and the effects of therapy on the diseased prostate. Serial in vivo volumetric imaging expands the scope and accuracy of experimental investigations of models of normal prostate physiology, benign prostatic hyperplasia and prostate cancer, which are otherwise limited by the anatomy of the mouse prostate. Moreover, accurate imaging of hyperplastic and tumorigenic prostates is now recognized as essential to rigorous pre-clinical trials of new therapies...
September 21, 2015: BMC Urology
Jetse S van Gorp, Peter R Seevinck, Anna Andreychenko, Alexander J E Raaijmakers, Peter R Luijten, Max A Viergever, Miriam Koopman, Vincent O Boer, Dennis W J Klomp
Capecitabine (Cap) is an often prescribed chemotherapeutic agent, successfully used to cure some patients from cancer or reduce tumor burden for palliative care. However, the efficacy of the drug is limited, it is not known in advance who will respond to the drug and it can come with severe toxicity. (19)F Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Spectroscopic Imaging (MRSI) have been used to non-invasively study Cap metabolism in vivo to find a marker for personalized treatment. In vivo detection, however, is hampered by low concentrations and the use of radiofrequency (RF) surface coils limiting spatial coverage...
November 2015: NMR in Biomedicine
Siobhan West, Sarah J Nolan, Jennifer Cotton, Sacha Gandhi, Jennifer Weston, Ajay Sudan, Roberto Ramirez, Richard Newton
BACKGROUND: Focal epilepsies are caused by a malfunction of nerve cells localised in one part of one cerebral hemisphere. In studies, estimates of the number of individuals with focal epilepsy who do not become seizure-free despite optimal drug therapy vary according to the age of the participants and which focal epilepsies are included, but have been reported as at least 20% and in some studies up to 70%. If the epileptogenic zone can be located surgical resection offers the chance of a cure with a corresponding increase in quality of life...
July 1, 2015: Cochrane Database of Systematic Reviews
Mitchell Kamrava, Amar U Kishan, Daniel J Margolis, Jiaoti Huang, Fred Dorey, Patricia Lieu, Patrick A Kupelian, Leonard S Marks
PURPOSE: Magnetic resonance imaging (MRI) guidance may improve the accuracy of Gleason score (GS) determination by directing the biopsy to regions of interest (ROI) that are likely to harbor high-grade prostate cancer (CaP). The aim of this study was to determine the frequency and predictors of GS upgrading when a subsequent MRI-guided biopsy is performed on patients with a diagnosis of GS 6 disease on the basis of conventional, transrectal ultrasound-guided biopsy. METHODS AND MATERIALS: A consecutive series of 245 men with a diagnosis of low-risk CaP (ie, cT1c, GS 6, prostate-specific antigen <10) based on transrectal ultrasound-guided biopsy was enrolled in an active surveillance protocol that used subsequent MRI-guided biopsy for confirmation of GS...
November 2015: Practical Radiation Oncology
Francesco Sclafani, Clare Peckitt, David Cunningham, Diana Tait, Jordi Giralt, Bengt Glimelius, Susana Roselló Keränen, Andrew Bateman, Tamas Hickish, Josep Tabernero, Janet Thomas, Gina Brown, Jacqueline Oates, Ian Chau
OBJECTIVE: Intensified preoperative treatments have been increasingly investigated in locally advanced rectal cancer (LARC), but limited data are available for the impact of these regimens on quality of life (QoL) and bowel function (BF). We assessed these outcome measures in EXPERT-C, a randomized phase 2 trial of neoadjuvant capecitabine combined with oxaliplatin (CAPOX), followed by chemoradiation therapy (CRT), total mesorectal excision, and adjuvant CAPOX with or without cetuximab in magnetic resonance imaging-defined, high-risk LARC...
October 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Lorenzo Marconi, Michael A Gorin, Mohamad E Allaf
To ensure the early detection of recurrent disease, all patients should undergo routine surveillance following partial nephrectomy for renal cell carcinoma. In order to optimize resource allocation and avoid unnecessary radiation exposure, the frequency and duration of surveillance should be tailored to the individual patient's risk of cancer recurrence. The evidence for surveillance after partial nephrectomy is presented reviewing the current literature on prognostic models and proposed surveillance protocols based on the timing and patterns of renal cell carcinoma recurrence...
April 2015: Current Urology Reports
Yanping Sun, Andrew L Kung
The use of magnetic resonance imaging (MRI) in humans and animal models has been rapidly growing. MRI provides high spatial resolution, excellent tissue contrast, and outstanding definition of the anatomical structure of normal organs and tumors. Because MRI does not require genetically encoded reporters, it can be used for tumor surveillance and the assessment of treatment effects in a variety of mouse cancer models. MRI systems for preclinical imaging typically operate at higher magnetic field strength, ranging from 4...
January 2015: Cold Spring Harbor Protocols
Pallavi Tiwari, Shabbar Danish, Anant Madabhushi
Laser interstitial thermal therapy (LITT) has recently emerged as a new treatment modality for cancer pain management that targets the cingulum (pain center in the brain), and has shown promise over radio-frequency (RF) based ablation which is reported to provide temporary relief. One of the major advantages enjoyed by LITT is its compatibility with magnetic resonance imaging (MRI), allowing for high resolution in vivo imaging to be used in LITT procedures. Since laser ablation for pain management is currently exploratory and is only performed at a few centers worldwide, its short-, and long-term effects on the cingulum are currently unknown...
March 12, 2014: Proceedings of SPIE
Panagiotis Trilianos, Florin Selaru, Zhiping Li, Ahmet Gurakar
BACKGROUND: Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging. AIM: To investigate the strategies among liver centers regarding pre-transplant screening for CCA in patients with PSC. METHODS: An online survey was returned from 46 US transplant centers, inquiring on the frequency of screening, the use of specific tests, or tactical approaches to high-grade dysplasia (HGD) or CCA...
2014: Digestion
David S Smith, Xia Li, Richard G Abramson, C Chad Quarles, Thomas E Yankeelov, E Brian Welch
Classic signal processing theory dictates that, in order to faithfully reconstruct a band-limited signal (e.g., an image), the sampling rate must be at least twice the maximum frequency contained within the signal, i.e., the Nyquist frequency. Recent developments in applied mathematics, however, have shown that it is often possible to reconstruct signals sampled below the Nyquist rate. This new method of compressed sensing (CS) requires that the signal have a concise and extremely dense representation in some mathematical basis...
December 30, 2013: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2013: Rapid Communications in Mass Spectrometry: RCM
Marie Louise Mølgaard Binderup, Steen Gimsing, Michael Kosteljanetz, Carsten Thomsen, Marie Luise Bisgaard
OBJECTIVE: Endolymphatic sac tumours (ELSTs) of the inner ear occur in 16% of patients with the hereditary tumor syndrome von Hippel-Lindau disease (vHL). ELSTs of all sizes can cause irreversible hearing loss which can, however, be prevented through early diagnosis and treatment. We aim to emphasize the challenges of prophylactic ELST screening and to explore the role of audiometry in pre-symptomatic ELST screening. DESIGN: For a period of 17 years our patient was screened for ELSTs with inner-ear MRI (magnetic resonance imaging), audiometry, and clinical interviews...
November 2013: International Journal of Audiology
Peter Grimison, Baerin Houghton, Mark Chatfield, Guy C Toner, Ian D Davis, Jarad Martin, Elizabeth Hovey, Martin R Stockler
OBJECTIVE: To determine the patterns of management and surveillance imaging amongst medical oncologists in Australia for stage I testicular cancer during 2010. METHODS: We conducted a survey comprising 14 questions about the management strategy and surveillance imaging for all patients with stage I testicular cancer treated over the previous 12 months. RESULTS: A total of 52 medical oncologists documented the management for an estimated 470 patients...
July 2013: BJU International
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