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Near Infrared Therapy

Qing Cao, Xin Guo, Wenlong Zhang, Guoqiang Guan, Xiaojuan Huang, Shu-Ang He, Mingdong Xu, Rujia Zou, Xinwu Lu, Junqing Hu
Although various photothermal therapy (PTT) nanoagents have been developed in recent years, the rational design and easy synthesis of a PTT nanoplatform with improved near-infrared (NIR) absorption have remained challenging. Herein, via a facile one-pot solvothermal strategy, hydrophilic nanosheet-assembled flower-like Fe7S8/Bi2S3 superstructures were fabricated successfully. Such nanoflowers exhibit improved NIR absorption, which is 1.54 times higher than that of pure Bi2S3 nanosheets at a wavelength of 808 nm...
February 20, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Hala S Abuelmakarem, Mahmoud A Sliem, Jala El-Azab, Moustafa M A Farghaly, Wafaa A Ahmed
Chitosan-tripolyphosphate nanoparticles (C-TPP NPs) were synthesized to investigate their cytotoxicity against colon cancer cells (Caco2 cells) in the absence and the presence of a near-infrared (NIR) laser to evaluate their influence in cancer detection using the NIR laser and to evaluate the NIR laser on cancer treatment. The synthesized NPs were characterized by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), zeta potential (ZP), and transmission electronic microscope (TEM)...
February 18, 2019: Biosensors
Huili Li, Huanjie Li, Wei Yu, Shengnan Huang, Ying Liu, Ningxia Zhang, Jinxiu Yuan, Xin Xu, Shaofeng Duan, Yurong Hu
In recent years, cancer treatment has been facing the challenge of increasing antitumor efficiency and avoiding severe adverse effects simultaneously. In this study, we designed a controlled release drug delivery system, doxorubicin (Dox)-loaded and hyaluronic acid (HA)-modified PEGylated gold nanocages (AuNCs), which was designated as PEG-HAn-AuNCs/Dox (n represented 10n HA repeating units were modified on each AuNC). In this system, AuNCs were applied as the photothermal cores, Dox was employed as the model drug, HA was applied as the tumor-microenvironment responsive switch to achieve controlled release, and poly (ethylene glycol) (PEG) was used as the stealth polymer to prolong systemic circulation time...
February 16, 2019: European Journal of Pharmaceutical Sciences
Xue Shen, Tingting Li, Zhongyuan Chen, Xiaoxue Xie, Hanxi Zhang, Yi Feng, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
A promising approach towards cancer therapy is expected to integrate imaging and therapeutic agents into a versatile nanocarrier for achieving improved antitumor efficacy and reducing the side effects of conventional chemotherapy. Herein, we designed a poly(D,L-lactic-co-glycolic acid) (PLGA)-based theranostic nanoplatform using the double emulsion solvent evaporation method (W/O/W), which is associated with bovine serum albumin (BSA) modifications, to co-deliver indocyanine green (ICG), a widely used near-infrared (NIR) dye, and doxorubicin (Dox), a chemotherapeutic drug, for dual-modality imaging-guided chemo-photothermal combination cancer therapy...
February 18, 2019: Molecular Pharmaceutics
Xiao Zhang, Jiangfeng Du, Zhao Guo, Jie Yu, Qin Gao, Wenyan Yin, Shuang Zhu, Zhanjun Gu, Yuliang Zhao
Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2 S3 ) nanoparticles and bis- N -nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Chenyang Gao, Meng Wang, Ling He, Yanni He, Ting Li
Cupping therapy is a promising method to cure or reduce the symptoms of some diseases including muscle pain/tendency/fatigue. Although the applications of cupping therapy have a thousand-year history in traditional Chinese medicine, the therapeutic effect of cupping is still questionable due to a lack of scientific evidence and the absence of physiological observations. In our previous study, we utilized near-infrared spectroscopy (NIRS) to assess the concentration change surrounding the cupping site and found a significant elevation in oxy-hemoglobin (HbO2 )...
January 1, 2019: Biomedical Optics Express
Bingqian Guo, Jiulong Zhao, Chenyao Wu, Yuting Zheng, Changqing Ye, Mingxian Huang, Shige Wang
With an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied...
February 8, 2019: Colloids and Surfaces. B, Biointerfaces
Baozhong Lü, Yifa Chen, Pengyu Li, Bo Wang, Klaus Müllen, Meizhen Yin
Radical anions of electron-deficient systems are widely used, but are easily reoxidized upon exposure to air. Therefore, the stabilization of radical anions under ambient conditions is of great significance, but still remains a scientific challenge. Herein, perylenediimide is employed to prepare a crystalline metal-organic framework for stabilizing radical anions without extensive chemical modification. The porous, three-dimensional framework of perylenediimide can trap electron donors such as amine vapors and produce radical anions in-situ through photo-induced electron transfer...
February 15, 2019: Nature Communications
Jia Wen, Kui Yang, Xingcheng Ding, Hongjuan Li, Yongqian Xu, Fengyu Liu, Shiguo Sun
A folic acid (FA) functional drug delivery system (MT@L-PTX@FA) based on in situ formation of tellurium nanodots (Te NDs) in paclitaxel (PTX)-loaded MgAl layered double hydroxide (LDHs) gated mesoporous silica nanoparticles (MSNs) has been designed and fabricated for targeted chemo/PDT/PTT trimode combinatorial therapy. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), N2 adsorption-desorption, Fourier transform infrared (FT-IR) spectra, and UV-vis spectra were used to demonstrate the successful fabrication of MT@L-PTX@FA...
February 15, 2019: Inorganic Chemistry
Jing Liu, Fenfen Zhai, Hong Zhou, Wenrong Yang, Shusheng Zhang
Chemo-photothermal therapy has become a promising tool for clinical noninvasive tumor therapy, which is able to efficiently avoid drug resistance and other side effects from chemical anticarcinogenic drugs. The ability to selectively fast-heat tumor tissues over surrounding compartments is of fundamental importance and makes effective treatment of tumor margins and complex tumor geometries. Currently existing chemo-photothermal methods mainly show slow light-to-heat conversion with increased temperature up to around 45-57 °C for 5-20 min or a longer time in vitro under regular near-infrared laser irradiation, and during tumor therapy, worse performance in temperature changes are obtained due to the much longer penetration distance in vivo...
February 15, 2019: Advanced Healthcare Materials
Ying Wang, Jun Liu, Xiaowei Ma, Chao Cui, Philip R Deenik, Paul K P Henderson, Ashton L Sigler, Lina Cui
Detection of cellular senescence is important not only in the study of senescence in various biological systems, but also in various practical applications such as image-guided surgical removal of senescent cells, as well as the monitoring of drug-responsiveness during cancer therapies. Due to the lack of suitable imaging probes for senescence detection, particularly in living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated β-galactosidase (SABG) activation...
February 14, 2019: Scientific Reports
Hisataka Kobayashi
Near infrared photoimmunotherapy(NIR-PIT)is a new molecularly-targeted cancer photo-therapy based on conjugating a near infrared silica-phthalocyanine dye, IRDye700DX(IR700), to a monoclonal antibody(mAb)targeting cell-surface molecules. NIR-PIT targetingEGFR usingthe cetuximab-IR700 conjugate is now in transition to fast-track global Phase Ⅲ clinical trial in late-stage head and neck squamous cell cancer patients. When exposed to NIR light, the conjugate induces a highlyselective necrotic/immunogenic cell death(ICD)only in target-positive, mAb-IR700-bound cancer cells...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Dickson Joseph, Rengarajan Baskaran, Su Geun Yang, Yun Suk Huh, Young-Kyu Han
We report a one-pot seedless green method for the synthesis of gold-silver (AuAg) spiky branched nanostars, with gold (90%) being the major component. Here, the zwitterionic surfactant lauryl sulfobetaine (LSB) is employed in the synthesis of bimetallic nanostars. The concentration of LSB plays an important role in determining the shape of nano-objects. A minimum LSB concentration of 50 mM is required for the formation of spiky branched nanostars, the size of which is controlled by increasing the LSB concentration...
February 7, 2019: Journal of Colloid and Interface Science
Di Jiang, Minjun Xu, Yuanyuan Pei, Yukun Huang, Yu Chen, Fenfen Ma, Huiping Lu, Jun Chen
Emergence of drug resistance in tumors causes therapeutic failure or tumor relapse. Combination of chemotherapy and photodynamic therapy holds significant promise to treat drug-resistant tumors. However, stubborn hydrophobicity of photosensitizer (PS), low encapsulation efficiency and leaking problem of PS in organic carrier, and disparate physicochemical properties of PS and chemotherapeutics make the combination unachievable. Thus how to efficiently co-deliver the two functional agents to enable photo-chemotherapy seems to be one of the key challenges...
February 11, 2019: Acta Biomaterialia
Soomin Han, Yoo-Jin Park, Eun-Jung Park, Younghun Kim
As an alternative to traditional cancer treatment, photothermal therapy is a promising method with advantages such as non-invasiveness and high efficiency. Herein, we synthesized armored golden Escherichia coli (AGE) microrods as photothermal agents to evaluate the viability of cancer cell. The hollow gold nanoshell (HAuNS) was synthesized for photothermal effects under near infrared (NIR) region using unicellular E. coli as framework. Coupling HAuNS onto the surface of E. coli@SiO2 enhanced temperature elevation and resulted in high conversion efficiency...
February 14, 2019: ACS Applied Materials & Interfaces
Chanjuan Liu, Changping Ruan, Rui Shi, Bang-Ping Jiang, Shichen Ji, Xing-Can Shen
Indocyanine green (ICG), a multifunctional near-infrared (NIR) imaging agent approved by the FDA, has been extensively used in clinical cancer theranosis, but limited by its inherent instability, short plasma half-life and lack of targeting ability. Herein, an in situ formed photothermal network based thermosensitive hydrogel (PNT-gel) constructed by using supramolecular cross-linking conjugated polymers was developed for the stabilization of ICG and efficient combinatorial photothermal/photodynamic antitumor therapy...
February 13, 2019: Biomaterials Science
Xinqi Zhou, Yuan Fang, Lauren Lesiak, Cliff Stains
Chemotherapeutic agents generally suffer from off-target cytotoxicity in noncancerous cell types, leading to undesired side effects. As a result, significant effort has been put into identifying compounds that are selective for cancerous versus noncancerous cell types. Our lab has recently developed a series of near-infrared (NIR) fluorophores containing a phosphinate functionality at the bridging position of the xanthene scaffold, termed Nebraska Red (NR) fluorophores. Herein, we report the selective cytotoxicity of one NR derivative, NR744, against HeLa (cervical cancer) cells versus NIH-3T3 (noncancerous fibroblast) cells...
February 12, 2019: Chembiochem: a European Journal of Chemical Biology
Haipeng Zhang, Qin Zhang, Chunshui Liu, Bing Han
Janus nanoparticles (JNPs) have emerged in recent years as new compartmentalized colloids with two sides of different components, chemical properties or morphologies that have opened up a wide range of unique applications in biomedicine. Here, we explored a unique lactobionic acid (LA) modified metallic one-dimensional nanorod/metal organic framework (1D NR/MOF) JNP, the LA-gold NR/zeolitic imidazolate framework-8 (LA-AuNR/ZIF-8) JNP, for computed X-ray tomography (CT) image-guided liver cancer targeted synergistic chemo-photothermal theranostics...
February 12, 2019: Biomaterials Science
Jingchao Li, Jiaguo Huang, Yan Lyu, Jingsheng Huang, Yuyan Jiang, Chen Xie, Kanyi Pu
Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic ac-tivity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited can-cer therapy. Upon near-infrared (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic sin-glet oxygen (1O2) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of ribonucleic acid (RNA) specifically in tumor microenvironment...
February 11, 2019: Journal of the American Chemical Society
Shashank Shankar Chetty, Selvarasu Praneetha, Kavitha Govarthanan, Rama Shanker Verma, Arumugam Vadivel Murugan
Acute liver injury is a critical syndrome ascribed to prevalent death of hepatocyte and imperatively requires a liver transplantation. Such methodology is certainly hampered due to deficit of healthy donors. In this regard, stem cells-based regenerative therapies are attractive in repairing injured tissues and organs for medical applications. However, it is crucial to understand the migration, engraftment and regeneration capabilities of transplanted stem cells in the living animal models. For the first time, we demonstrate rapid labeling of umbilical cord-derived mesenchymal stem cells (MSCs) with near-infrared (NIR) fluorescent CuInS2-ZnS nanocrystals (CIZS-NCs) to develop an innovative nano-bioconjugates (MSCs-CIZS-NBCs) that exhibit 98% labeling efficiency...
February 11, 2019: ACS Applied Materials & Interfaces
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