Xuan He, Dan Liang, Jun Zhou, Kangjing Li, Beibei Xie, Chunyun Liang, Cong Liu, Zhiyong Chen, Xinxin Chen, Ao Long, Shufang Zhuo, Xiaoping Su, Ying Luo, Wenxia Chen, Fengfeng Zhao, Xinglu Jiang
The cell nucleus serves as the pivotal command center of living cells, and delivering therapeutic agents directly into the nucleus can result in highly efficient anti-tumor eradication of cancer cells. However, nucleus-targeting drug delivery is very difficult due to the presence of numerous biological barriers. Here, three antitumor drugs (DNase I, ICG: indocyanine green, and THP: pirarubicin) were sequentially triggered protein self-assembly to produce a nucleus-targeting and programmed responsive multi-drugs delivery system (DIT)...
April 10, 2024: International Journal of Biological Macromolecules