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https://read.qxmd.com/read/30768819/spontaneous-anecdotal-retrospective-open-label-study-on-the-efficacy-safety-and-tolerability-of-cannabis-galenical-preparation-bedrocan
#1
Beniamino Palmieri, Carmen Laurino, Maria Vadalà
OBJECTIVES: Our main aim was to investigate the short-term therapeutic effects, safety/tolerability and potential side effects of the cannabis galenical preparation (Bedrocan) in patients with a range of chronic conditions unresponsive to other treatments. METHODS: In this retrospective, 'compassionate use', observational, open-label study, 20 patients (age 18-80 years) who had appealed to our 'Second Opinion Medical Consulting Network' (Modena, Italy), were instructed to take sublingually the galenical oil twice a day for 3 months of treatment...
February 15, 2019: International Journal of Pharmacy Practice
https://read.qxmd.com/read/30585986/an-experimental-randomized-study-on-the-analgesic-effects-of-pharmaceutical-grade-cannabis-in-chronic-pain-patients-with-fibromyalgia
#2
Tine van de Donk, Marieke Niesters, Mikael A Kowal, Erik Olofsen, Albert Dahan, Monique van Velzen
In this experimental randomized placebo-controlled 4-way crossover trial, we explored the analgesic effects of inhaled pharmaceutical-grade cannabis in twenty chronic pain patients with fibromyalgia. We tested four different cannabis varieties with exact knowledge on their [INCREMENT]-tetrahydrocannabinol (THC), and cannabidiol (CBD) content: Bedrocan® (22.4 mg THC, < 1 mg CBD), Bediol® (13.4 mg THC, 17.8 mg CBD), Bedrolite® (18.4 mg CBD, < 1 mg THC) and a placebo variety without any THC or CBD. Following a single vapor inhalation, THC and CBD plasma concentrations, pressure and electrical pain thresholds, spontaneous pain scores and drug high were measured for 3 hours...
December 20, 2018: Pain
https://read.qxmd.com/read/30580232/pharmacokinetics-of-bedrocan%C3%A2-a-cannabis-oil-extract-in-fasting-and-fed-dogs-an-explorative-study
#3
Beata Łebkowska-Wieruszewska, Fabio Stefanelli, Silvio Chericoni, Helen Owen, Amnart Poapolathep, Andrzej Lisowski, Mario Giorgi
The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis oil extract Bedrocan® in fasting and fed dogs. Bedrocan® (20% delta-9-tetrahydrocannabinol [THC] and 0.5% cannabidiol [CBD]) was administered at 1.5 and 0.037 mg/kg THC and CBD, respectively in fasted and fed dogs according to a 2 × 2 cross over study design. The quantification of the two active ingredients was performed by LC/MS. No detectable concentrations of CDB were found at any collection time...
December 17, 2018: Research in Veterinary Science
https://read.qxmd.com/read/29247961/comprehensive-quality-evaluation-of-medical-cannabis-sativa-l-inflorescence-and-macerated-oils-based-on-hs-spme-coupled-to-gc-ms-and-lc-hrms-q-exactive-orbitrap%C3%A2-approach
#4
COMPARATIVE STUDY
Lorenzo Calvi, Daniela Pentimalli, Sara Panseri, Luca Giupponi, Fabrizio Gelmini, Giangiacomo Beretta, Davide Vitali, Massimo Bruno, Emanuela Zilio, Radmila Pavlovic, Annamaria Giorgi
There are at least 554 identified compounds in C. sativa L., among them 113 phytocannabinoids and 120 terpenes. Phytocomplex composition differences between the pharmaceutical properties of different medical cannabis chemotype have been attributed to strict interactions, defined as 'entourage effect', between cannabinoids and terpenes as a result of synergic action. The chemical complexity of its bioactive constituents highlight the need for standardised and well-defined analytical approaches able to characterise the plant chemotype, the herbal drug quality as well as to monitor the quality of pharmaceutical cannabis extracts and preparations...
February 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/29072720/cannabis-through-the-looking-glass-chemo-and-enantio-selective-separation-of-phytocannabinoids-by-enantioselective-ultra-high-performance-supercritical-fluid-chromatography
#5
G Mazzoccanti, O H Ismail, I D'Acquarica, C Villani, C Manzo, M Wilcox, A Cavazzini, F Gasparrini
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9 -THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135 %) was not negligible, and it is worth a systematic evaluation of bioactivity.
November 14, 2017: Chemical Communications: Chem Comm
https://read.qxmd.com/read/29057480/cannabinoids-concentration-variability-in-cannabis-olive-oil-galenic-preparations
#6
Chiara Carcieri, Cristina Tomasello, Marco Simiele, Amedeo De Nicolò, Valeria Avataneo, Luca Canzoneri, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
OBJECTIVES: Knowledge of the exact concentration of active compounds in galenic preparations is crucial to be able to ensure their quality and to properly administer the prescribed dose. Currently, the need for titration of extracts is still debated. Considering this, together with the absence of a standard preparation method, the aim of this study was to evaluate cannabinoids concentrations variability in galenic olive oil extracts, to evaluate the interlot and interlaboratory variability in the extraction yield and in the preparation composition...
January 2018: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/20118579/cannabinoid-receptor-1-binding-activity-and-quantitative-analysis-of-cannabis-sativa-l-smoke-and-vapor
#7
Justin Fischedick, Frank Van Der Kooy, Robert Verpoorte
Cannabis sativa L. (cannabis) extracts, vapor produced by the Volcano vaporizer and smoke made from burning cannabis joints were analyzed by GC-flame ionization detecter (FID), GC-MS and HPLC. Three different medicinal cannabis varieties were investigated Bedrocan, Bedrobinol and Bediol. Cannabinoids plus other components such as terpenoids and pyrolytic by-products were identified and quantified in all samples. Cannabis vapor and smoke was tested for cannabinoid receptor 1 (CB1) binding activity and compared to pure Delta(9)-tetrahydrocannabinol (Delta(9)-THC)...
February 2010: Chemical & Pharmaceutical Bulletin
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