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Exercise and syndrome down

Francesca Losa, Margherita Deidda, Davide Firinu, Maria Luisa Di Martino, Maria Pina Barca, Stefano Del Giacco
BACKGROUND: The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showed a high degree of safety, it can act as cofactor of anaphylaxis, especially in condition at high risk, such as mast cell activation syndrome (MCAS). We reported this case to sensitize practitioners to investigate to the use of complementary and alternative medicine, in case of exercise-induced anaphylaxis (EIAn)...
March 6, 2019: World Journal of Clinical Cases
C-C J J Chen, S D R Ringenbach
BACKGROUND: The high prevalence of cognitive dysfunction is well documented in individuals with Down syndrome. However, only a few studies have focused on the effect of exercise on cognitive performance in this population. In particular, verbal fluency has been shown to be relevant to the early onset of Alzheimer's disease in individuals with Down syndrome. Thus, this study was aimed at investigating the relationship between acute exercise and verbal fluency in this population. METHODS: It was a pre-post design...
February 27, 2019: Journal of Intellectual Disability Research: JIDR
Linda Bühl, Thomas Abel, Florian Wolf, Max Oberste, Wilhelm Bloch, Michael Hallek, Thomas Elter, Philipp Zimmer
In patients with hematological malignancies, exercise is studied as a supportive measure with potential benefits on therapy and disease-related side effects. However, clinical trials have not yet integrated people with Down syndrome (DS), although this disability is associated with an increased risk for hematological malignancies. Therefore, we examined safety and feasibility of a mixed-modality exercise intervention in a male with DS undergoing high-dose chemotherapy for acute lymphoblastic leukemia. Furthermore, physical capacity and fatigue were assessed...
January 2019: Integrative Cancer Therapies
Rakib U Rayhan, Stuart D Washington, Richard Garner, Kristina Zajur, Florencia Martinez Addiego, John W VanMeter, James N Baraniuk
BACKGROUND: Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertional malaise (PEM). This is recognized as an exacerbation of everyday symptoms following a physically stressful or cognitively demanding activity. The underlying mechanism of PEM is unknown. We previously reported a novel paradigm that possibly captured evidence of PEM by utilizing fMRI scans taken before and after sub-maximal exercises...
February 21, 2019: BMC Neuroscience
Ai-Ping Chi, Zi-Nan Wang, Bing Shi, Xiao-Fan Yang, Rui-Xin Min, Jing Song
OBJECTIVE: To study the differential metabolites in urine and the characteristics of metabolic pathway of middle school students with chronic fatigue syndrome (CFS) before and after exercise, and then explain the metabolic mechanism of CFS. METHODS: Eight male middle school students (age:17-19) with CFS were selectedas the CFS group according to CFS screening criteria of the U.S. centers.At the same time, 8 male health students of the same age from the same school were selected as the control group...
April 8, 2018: Chinese Journal of Applied Physiology
Miryam Olivares Jara, Maria Isabel Vázquez Arce, Laura Peña Pachés, Catalina Roser Mas, Sofía Pérez-Alenda, Elena Marques-Sule
We present a non-randomised trial to evaluate a continuous physiotherapy program versus a periodic one in overweight patients suffering from acute coronary syndrome. AIM: To detect differences between a continuous (CONT) physiotherapy program (PF) and a periodic (INT) physiotherapy program in overweight patients with acute coronary syndrome on anthropometric parameters, analytical parameters, heart rate, adherence, drop-outs, safety and tolerance. DESIGN: A multicentre, non-randomised two-armed quasi-experimental study with pre-post design...
February 4, 2019: Atencion Primaria
Nicolás Gómez Álvarez, Alexandra Venegas Mortecinos, Valentina Zapata Rodríguez, Miguel López Fontanilla, Matías Maudier Vásquez, Gustavo Pavez-Adasme, Claudio Hemández-Mosqueira
There are few studies on the effect of a virtual reality-based intervention on motor development and postural control in children with Down Syndrome (DS). OBJECTIVE: To determine the effect of a virtual reality-based intervention on motor development and postural control in children with DS. PATIENTS AND METHOD: Study with a quantitative approach, with a quasi-experimental design, which included 16 children with DS randomly assigned to an experimental group (GWBB, n = 9) and con trol group (GC, n = 7)...
December 2018: Revista Chilena de Pediatría
Sara Ahmed, Shereen Khattab, Chris Haddad, Jessica Babineau, Andrea Furlan, Dinesh Kumbhare
Myofascial pain is prevalent chronic pain disorder that is comorbid with many conditions. Strengthening and stretching exercises are capable of inducing hypoalgesic effects in people with myofascial pain syndrome. The goal of this systematic review was to summarize the effects of aerobic exercise on the management of myofascial pain. A comprehensive database search was conducted. A total of 1,331 articles were identified for review. One article was eligible for inclusion after full screening. Risk of bias was assessed using the Downs and Black quality assessment questionnaire (1998)...
December 2018: Journal of Exercise Rehabilitation
Maria À Cebrià I Iranzo, Robin Vos, Geert M Verleden, Rik Gosselink, Daniel Langer
INTRODUCTION: Bronchiolitis Obliterans Syndrome (BOS) is a debilitating disease with limited treatment options that threatens both the quality of life and long-term survival of lung transplant (LTx) recipients. This retrospective longitudinal case-control study was performed to compare the long-term functional evolution of LTx recipients with and without BOS. METHODS: Twenty-four LTx recipients with BOS (BOS=Cases) and 24 without BOS (NON-BOS=Controls) were selected and individually matched according to age, gender, diagnosis and LTx characteristics...
December 27, 2018: Archivos de Bronconeumología
L A Koehler, T C Haddad, D W Hunter, T M Tuttle
Axillary web syndrome (AWS) is a common condition occurring in up to 86% of patients following breast cancer surgery with ipsilateral lymphadenectomy of one or more nodes. AWS presents as a single cord or multiple thin cords in the subcutaneous tissues of the ipsilateral axilla. The cords may extend variable distances "down" the ipsilateral arm and/or chest wall. The cords frequently result in painful shoulder abduction and limited shoulder range of motion. AWS most frequently becomes symptomatic between 2 and 8 weeks postoperatively but can also develop and recur months to years after surgery...
2019: Breast Cancer: Targets and Therapy
Michael A Gatzoulis, Michael Landzberg, Maurice Beghetti, Rolf M Berger, Michela Efficace, Sophie Gesang, Jian'guo He, Kelly Papadakis, Tomás Pulido, Nazzareno Galiè
BACKGROUND: Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome. METHODS: Patients with Eisenmenger syndrome aged ≥12 years and in World Health Organization functional class II-III were randomized 1:1 to placebo or macitentan 10 mg once daily for 16 weeks...
January 2, 2019: Circulation
Kyoko Kanae, Hirotaka Mutsuzaki, Yoshihide Kanai
[Purpose] This case study describes the reacquisition of knee joint function in a patient with Down syndrome after surgery for patellar dislocation using external focus training. [Participant and Methods] The patient was a female aged 24 years with Down syndrome and a low Intelligence Quotient, who suffered from right patellar dislocation. The range of motion in the right knee while walking was 2 to 23 degrees at 3 weeks after surgery. A compensatory gait while walking was confirmed, with her right leg fixed in extension...
December 2018: Journal of Physical Therapy Science
Zhenqi Liu, Baichun Yang
Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. surplus energy intake over expenditure, is at the core for developing metabolic syndrome and T2D. Currently available glycemic control drugs come to the market based on their 1-2 years risk-benefit profiles, but most of them do not correct positive energy balance and lose efficacy in the long-term...
December 16, 2018: Current Drug Targets
Rumit S Kakar, Hilary B Greenberger, Patrick O McKeon
CONTEXT: Anterior knee pain also known as patellofemoral pain syndrome is a frequently encountered musculoskeletal disorder that worsens with activity. The multifactorial etiology of patellofemoral pain syndrome alters lower-extremity mechanics, increasing patellofemoral joint stresses during weight-bearing tasks. Kinesio and McConnell tapings are often incorporated into the treatment, but their efficacy is still unclear. OBJECTIVE: To test the efficacy of Kinesio taping, McConnell taping, and sham taping in improving knee mechanics and reducing pain during activity...
January 29, 2019: Journal of Sport Rehabilitation
Marianna Alesi, Giusppe Battaglia, Annamaria Pepi, Antonino Bianco, Antonio Palma
This cross-sectional study examines differences in gross motor proficiency as a function of different intellectual functioning profiles. Two motor areas have been investigated as being equally essential to gross motor functions in every-day life: locomotion and object control.It aims to compare gross motor skills endorsed by children with Down syndrome (DS), children with borderline intellectual functioning (BIF), and typically developing children (TDC).Group 1 was composed of 18 children with DS (chronological age = 8...
October 2018: Medicine (Baltimore)
Franco Molteni, Giulio Gasperini, Giovanni Cannaviello, Eleonora Guanziroli
Recovery of upper and lower limbs function is essential to reach independence in daily activities in patients with upper motor neuron syndrome (UMNS). Rehabilitation can provide a guide for motor recovery influencing the neurobiology of neuronal plasticity providing controlled, repetitive, and variable patterns. Increasing therapy dosage, intensity, number of repetition, execution of task-oriented exercises, and combining top-down and bottom-up approaches can promote plasticity and functional recovery. Robotic exoskeletons for upper and lower limbs, based on the principle of motor learning, have been introduced in neurorehabilitation...
September 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Ryne Simpson, Anthony A Oyekan, Zarmina Ehsan, David G Ingram
For individuals with Down syndrome (DS), obstructive sleep apnea (OSA) is a complex disorder with significant clinical consequences. OSA is seen frequently in DS, and when present, it tends to be more severe. This increased prevalence is likely related to common anatomic abnormalities and a greater risk of additional comorbidities such as hypotonia and obesity. Because signs and symptoms do not often correlate with disease, all children and adults with DS should receive routine screening for OSA. Similar to the general population, polysomnography remains the gold standard for diagnosis...
2018: Nature and Science of Sleep
Qi-Yu Yang, Xiao-Dan Lai, Jing Ouyang, Jia-Dan Yang
BACKGROUND: Ginsenoside Rg3 (Rg3) is one of the key components of a frequently used herbal tonic panax ginseng for fatigue treatment. However, the molecular mechanisms of Rg3 on anti-fatigue effects have not been completely understood yet. METHODS AND MATERIALS: We built a postoperative fatigue syndrome (POFS) model and tried to elucidate the molecular mechanisms responsible for anti-fatigue effects of Rg3. 160 aged male rats were randomly divided into four groups (n = 40/group): normal group, Rg3-treated normal group (Rg3 group), postoperative fatigue syndrome model group (POFS group) and Rg3-treated postoperative fatigue syndrome model group (POFS + Rg3 group)...
November 1, 2018: Toxicology
Christopher Tomlinson, Alastair Campbell, Alison Hurley, Eoin Fenton, Neil Heron
Down syndrome (DS) is a clinical syndrome comprising typical facial features and various physical and intellectual disabilities due to extra genetic material on chromosome 21, with one in every 1000 babies born in the United Kingdom affected. Patients with Down syndrome are at risk of atlantoaxial instability (AAI). Although AAI can occur in other conditions, such as rheumatoid arthritis, this position statement deals specifically with patients with DS and asymptomatic AAI. Atlantoaxial instability, also referred to as atlantoaxial subluxation, is defined as increased movement between the first (atlas) and second (axial) cervical vertebra joint articulation, the atlantoaxial joint...
August 15, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Magnus von Lukowicz, Nina Herzog, Sebastian Ruthardt, Mirja Quante, Gabriele Iven, Christian F Poets
BACKGROUND: Obstructive sleep apnoea (OSA) is common in children with Down syndrome (DS), yet difficult to treat. As muscular hypotonia of the upper airway may cause OSA and is also common in DS, we tested whether intense myofunctional therapy improves OSA in children with DS. PATIENTS AND METHODS: Forty-two children underwent cardiorespiratory sleep studies immediately before and after a 1-week intensive training camp consisting of three daily 45 min sessions of myofunctional exercises according to Padovan...
August 2, 2018: Archives of Disease in Childhood
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