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Indeterminate cell tumor

Christopher R Lamb, James Whitlock, Andrew T L Foster-Yeow
In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%)...
February 19, 2019: Veterinary Radiology & Ultrasound
Thomas J Jackson, Richard D Williams, Jesper Brok, Tanzina Chowdhury, Milind Ronghe, Mark Powis, Kathy Pritchard-Jones, Gordan M Vujanić
INTRODUCTION: The International Society of Paediatric Oncology (SIOP) protocols recommend preoperative chemotherapy appropriate for Wilms tumors (WTs) in children with renal tumors aged ≥6 months, reserving biopsy for "atypical" cases. The Children's Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation. METHOD: Retrospective study of concordance between locally reported renal tumor biopsies and central pathology review nephrectomy diagnoses of children enrolled by CCLG centers in the SIOP-WT-2001 study...
February 13, 2019: Pediatric Blood & Cancer
Marcin Sniadecki, Dariusz Grzegorz Wydra, Szymon Wojtylak, Ewa Wycinka, Marcin Liro, Nikola Sniadecka, Agnieszka Mrozinska, Sambor Sawicki
OBJECTIVES: To assess the significance of pathologic ultrastaging (PU) of sentinel (SLN) and non-sentinel (nSLN) lymph nodes (LNs) and the influence on cancer staging in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IB1 cervical cancer. MATERIAL AND METHODS: A retrospective study was conducted with 54 patients divided into two equal-sized groups. In test group (n1), at least one SLN/patient was detected with blue dye. All excised LNs in this group were subjected to PU (4 μm slices/150 μm intervals) with hematoxylin-eosin staining and immunohistochemistry (AE1-AE3 antibodies)...
2019: Ginekologia Polska
Wassim Abida, Michael L Cheng, Joshua Armenia, Sumit Middha, Karen A Autio, Hebert Alberto Vargas, Dana Rathkopf, Michael J Morris, Daniel C Danila, Susan F Slovin, Emily Carbone, Ethan S Barnett, Melanie Hullings, Jaclyn F Hechtman, Ahmet Zehir, Jinru Shia, Philip Jonsson, Zsofia K Stadler, Preethi Srinivasan, Vincent P Laudone, Victor Reuter, Jedd D Wolchok, Nicholas D Socci, Barry S Taylor, Michael F Berger, Philip W Kantoff, Charles L Sawyers, Nikolaus Schultz, David B Solit, Anuradha Gopalan, Howard I Scher
Importance: The anti-programmed cell death protein 1 (PD-1) antibody pembrolizumab is approved by the US Food and Drug Administration for the treatment of microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) solid tumors, but the prevalence of MSI-H/dMMR prostate cancer and the clinical utility of immune checkpoint blockade in this disease subset are unknown. Objective: To define the prevalence of MSI-H/dMMR prostate cancer and the clinical benefit of anti-PD-1/programmed cell death 1 ligand 1 (PD-L1) therapy in this molecularly defined population...
December 27, 2018: JAMA Oncology
Xie Qian, Zhang Wenqi, Gao Shi, Chen Bin, Ma Qingjie, Liu Tianji, Ji Bin
OBJECTIVE: This study aims to evaluate the added value of hybrid SPECT-CT in differential diagnosis of indeterminate solitary vertebral lesion (SVL) on planar scintigraphy in patients with non-small cell lung cancer (NSCLC). METHODS: Sixty-three NSCLC patients with indeterminate "hot spot" SVL on planar scintigraphy were retrospectively included in this study. Pathological confirmation and followup by whole body scintigraphy and SPECT-CT were used as golden standard for the evaluation of diagnostic performance of planar scintigraphy, SPECT, and SPECT-CT...
December 2018: Nuklearmedizin. Nuclear Medicine
Hiromasa Hazama, Masaki Tanaka, Naomi Kakushima, Yohei Yabuuchi, Masao Yoshida, Noboru Kawata, Kohei Takizawa, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Keita Mori, Hiroyuki Ono
BACKGROUND: Endoscopic submucosal dissection (ESD) is the standard treatment for superficial esophageal cancer (SEC); however, it is sometimes technically difficult. Our aim was to identify the predictors of technical difficulty during ESD for SEC. METHODS: We reviewed the records of patients who underwent ESD for superficial esophageal squamous cell carcinomas at a tertiary cancer center between April 2008 and March 2016. Patients undergoing ESD after esophagectomy or for residual/recurrent lesions were excluded...
November 26, 2018: Surgical Endoscopy
Athina C Tsili, Nikolaos Sofikitis, Efrosyni Stiliara, Maria I Argyropoulou
Although testicular carcinoma represents approximately only 1% of solid neoplasms in men, it is the most common malignancy between young men. The two main histologic categories are testicular germ cell tumors (TGCTs), including seminomas and nonseminomas, accounting for 90-95% of testicular neoplasms and sex cord-stromal tumors. Scrotal MRI, including a multiparametric protocol, has been proposed as a valuable supplemental imaging technique in the investigation of testicular pathology. Recently, the Scrotal and Penile Imaging Working Group appointed by the board of the European Society of Urogenital Radiology has produced recommendations on when to perform scrotal MRI...
November 1, 2018: Abdominal Radiology
Alicia Latham, Preethi Srinivasan, Yelena Kemel, Jinru Shia, Chaitanya Bandlamudi, Diana Mandelker, Sumit Middha, Jaclyn Hechtman, Ahmet Zehir, Marianne Dubard-Gault, Christina Tran, Carolyn Stewart, Margaret Sheehan, Alexander Penson, Deborah DeLair, Rona Yaeger, Joseph Vijai, Semanti Mukherjee, Jesse Galle, Mark A Dickson, Yelena Janjigian, Eileen M O'Reilly, Neil Segal, Leonard B Saltz, Diane Reidy-Lagunes, Anna M Varghese, Dean Bajorin, Maria I Carlo, Karen Cadoo, Michael F Walsh, Martin Weiser, Julio Garcia Aguilar, David S Klimstra, Luis A Diaz, Jose Baselga, Liying Zhang, Marc Ladanyi, David M Hyman, David B Solit, Mark E Robson, Barry S Taylor, Kenneth Offit, Michael F Berger, Zsofia K Stadler
PURPOSE: Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and endometrial cancer (EC) to screen for Lynch syndrome (LS)-associated cancer predisposition. The recent success of immunotherapy in high-frequency MSI (MSI-H) and/or MMR-D tumors now supports testing for MSI in all advanced solid tumors. The extent to which LS accounts for MSI-H across heterogeneous tumor types is unknown. Here, we establish the prevalence of LS across solid tumors according to MSI status...
February 1, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Friedrich Prall, Maja Hühns
This study addressed if TP53 immunohistochemistry as a surrogate method for gene sequencing could be applied to colorectal carcinomas as successfully as recently reported for ovarian cancers. Sanger sequencing of the coding exons 2-11 of 87 tumors yielded a total of 65 mutations in 61 of the tumors. Immunohistochemistry was done with the Do-7 antibody. By a pattern-recognition evaluation of immunohistochemistry, 44 cases were classified as "overexpressors", and 20 as having "wild-type" immunostaining; complete absence of or cytoplasmic immunostaining was seen in 9 and 4 cases, respectively...
October 22, 2018: Human Pathology
Jen-Fan Hang, Fatimah Alruwaii, Bao-Rung Zeng, Chiung-Ru Lai, Howard H Wu
BACKGROUND: The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types...
November 2018: Cancer Cytopathology
Mi Ra Ryu, Min-Seung Park, Eun Hye Cho, Chul Won Jung, Kihyun Kim, Seok Jin Kim, Ha Young Oh, Wooseong Huh, Hye Ryoun Jang, Won-Jung Koh, Hye Yun Park, Young-Ho Kim, Dong Hyun Sinn, Jin-Oh Choi, Jae-Won Joh, Jong Man Kim, Sung Joo Kim, Jae Berm Park, Eun-Suk Kang
QuantiFERON-TB Gold Plus (QFT-Plus) is a new-generation QuantiFERON-TB Gold In-Tube (QFT-GIT) assay which has two antigen-coated tubes called TB1, which contains long peptides derived from ESAT-6 and CFP-10, and TB2, which contains the same components as TB1 and additional short peptides which potentially stimulate CD8+ T cells through the presentation of major histocompatibility complex class I. This is the first study to compare QFT-Plus and QFT-GIT for use in the diagnosis of latent tuberculosis infection (LTBI) among immunocompromised patients in the Republic of Korea...
November 2018: Journal of Clinical Microbiology
David P Steensma
Clonal hematopoiesis (CH)-an expansion of blood cells derived from a single hematopoietic stem cell-is a defining feature of hematologic cancers, but recently CH was also found to be a frequent consequence of aging. When aging-associated CH results from acquisition of a somatic mutation in a driver gene associated with leukemia, and this mutation is present at a variant allele frequency of at least 0.02 (2%) yet the patient does not meet World Health Organization diagnostic criteria for a hematologic neoplasm, this state is termed clonal hematopoiesis of indeterminate potential (CHIP)...
August 2018: Mayo Clinic Proceedings
Jonathan J Davick, Jinah Kim, Mark R Wick, Alejandro A Gru
Indeterminate dendritic cell tumor (IDCT) is a cutaneous proliferation of histiocytes that share morphologic and immunophenotypic properties with Langerhans cells. IDCT was recently included in the updated WHO classification of tumors of hematopoietic and lymphoid tissues. Recent studies have shown that some cases of IDCT demonstrate an ETV3-NCOA2 translocation, supporting the idea that IDCT is a clonal neoplasm. We report 2 new cases of IDCT at our institution lacking the ETV3-NCOA2 translocation. We also present a comprehensive review of reported cases of IDCT in the medical literature...
May 31, 2018: American Journal of Dermatopathology
Leomar Y Ballester, Isabella C Glitza Oliva, Dzifa Y Douse, Melissa M Chen, Chieh Lan, Lauren E Haydu, Jason T Huse, Sinchita Roy-Chowdhuri, Rajyalakshmi Luthra, Ignacio I Wistuba, Michael A Davies
Circulating tumor DNA (ctDNA) refers to tumor-derived cell-free DNA that circulates in body fluids. Fluid samples are easier to collect than tumor tissue, and are amenable to serial collection at multiple time points during the course of a patient's illness. Studies have demonstrated the feasibility of performing mutation profiling from blood samples in cancer patients. However, detection of ctDNA in the blood of patients with brain tumors is suboptimal. Cerebrospinal fluid (CSF) can be obtained via lumbar puncture or intraventricular catheter, and may be a suitable fluid to assess ctDNA in patients with brain tumors...
July 1, 2018: Journal of Neuropathology and Experimental Neurology
Hian Liang Huang, Tracy Jie Zhen Loh, Pierce Kah Hoe Chow
Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. To the best of our knowledge, this is the first case reported of an isolated well-differentiated hepatocellular carcinoma (HCC) strongly suspected on gallium-68 (68 Ga)-PSMA positron emission tomography/computed tomography (PET/CT), which was not well characterized both on magnetic resonance imaging (MRI) liver with Primovist as well as fluorine-18 (18 F)-choline PET/CT. Our patient had previous prostate cancer and previously was imaged using 18 F-choline PET/CT...
April 2018: World Journal of Nuclear Medicine
Zhen J Wang, Antonio C Westphalen, Ronald J Zagoria
Small renal masses are increasingly detected incidentally at imaging. They vary widely in histology and aggressiveness, and include benign renal tumors and renal cell carcinomas that can be either indolent or aggressive. Imaging plays a key role in the characterization of these small renal masses. While a confident diagnosis can be made in many cases, some renal masses are indeterminate at imaging and can present as diagnostic dilemmas for both the radiologists and the referring clinicians. This article will summarize the current evidence of imaging features that correlate with the biology of small solid renal masses, and discuss key approaches in imaging characterization of these masses using CT and MRI...
July 2018: British Journal of Radiology
Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim
Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred three months after surgical excision...
July 2018: Journal of Pathology and Translational Medicine
Kristina M Mori, Lisa N Abaid, Alberto A Mendivil, John V Brown, Tiffany L Beck, John P Micha, Howard D Epstein, Bram H Goldstein
INTRODUCTION: When the Food and Drug Administration (FDA) initially reported on the parlous incidence (0.28%) of occult malignancy identified following uterine power morcellation, investigations thereafter documented their particular experience with this surgical procedure. Nevertheless, the precise risk of identifying a sarcoma following uterine morcellation remains indeterminate, primarily due to varying study patient risk factors, diagnostic criteria and operative approach. METHOD: We retrospectively evaluated subjects who underwent an endoscopic hysterectomy and uterine power morcellation for the treatment of a presumptive, benign indication from January 2006 until December 2015...
May 2018: International Journal of Surgery
Ningfei An, Saira Khan, Molly K Imgruet, Sandeep K Gurbuxani, Stephanie N Konecki, Michael R Burgess, Megan E McNerney
Monosomy 7 (-7) and del(7q) are high-risk cytogenetic abnormalities common in myeloid malignancies. We previously reported that CUX1 , a homeodomain-containing transcription factor encoded on 7q22, is frequently inactivated in myeloid neoplasms, and CUX1 myeloid tumor suppressor activity is conserved from humans to Drosophila. CUX1 -inactivating mutations are recurrent in clonal hematopoiesis of indeterminate potential as well as myeloid malignancies, in which they independently carry a poor prognosis. To determine the role for CUX1 in hematopoiesis, we generated 2 short hairpin RNA-based mouse models with ∼54% (Cux1mid ) or ∼12% (Cux1low ) residual CUX1 protein...
June 14, 2018: Blood
Qinghu Ren, Lu Wang, Hikmat A Al-Ahmadie, Samson W Fine, Anuradha Gopalan, Sahussapont J Sirintrapun, Satish K Tickoo, Victor E Reuter, Ying-Bei Chen
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare type of renal cell carcinoma that frequently exhibits histologic and immunophenotypic features overlapping with type 1 papillary renal cell carcinoma (PRCC). To clarify molecular attributes that can be used for this difficult differential diagnosis, we sought to delineate the genome-wide copy number alterations in tumors displaying classic histologic features of MTSCC in comparison to the solid variant of type 1 PRCC and indeterminate cases with overlapping histologic features...
June 2018: American Journal of Surgical Pathology
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