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E Huynh, S Klouche, C Martinet, F Le Mercier, T Bauer, A Lecoeur
INTRODUCTION: The development of outpatient surgery, cost-reduction pressures and instrumentation storage limitations have led to their use "just-in-time". A recent study showed that stoppage of surgical procedures immediately before the incision (No-Go) was often due to the management of supplies and implantable medical devices. To our knowledge, since the development of outpatient surgery and the shortening of hospital stays, managing the flow of instrumentation has not been optimized...
March 9, 2019: Orthopaedics & Traumatology, Surgery & Research: OTSR
Jean-Charles Aurégan, Shahnaz Klouche, Bruno Levy, Thomas Bauer, Benoit Rousselin, Mathieu Ferrand, Philippe Hardy
INTRODUCTION: Despite improvements in technique and materials for rotator cuff repair, mean re-tear rates remain close to 30%. The aim of the present study was to assess injection of Autologous Conditioned Plasma (ACP™, Arthrex) for tendon healing after arthroscopic repair. The study hypothesis was that ACP™ improves the tendon-healing rate. MATERIAL AND METHOD: A non-randomized comparative prospective study included all patients aged over 18 years operated on in 2010 for arthroscopic repair of full-thickness rotator cuff tear with≤2 fatty degeneration on the Goutallier classification, whatever the severity of retraction, on virgin non-osteoarthritic shoulder without contraindications for magnetic resonance (MR) arthrography...
March 8, 2019: Orthopaedics & Traumatology, Surgery & Research: OTSR
Yoann Bohu, Shahnaz Klouche, Hasan Basri Sezer, Antoine Gerometta, Nicolas Lefevre, Serge Herman
BACKGROUND: Patellofemoral arthroplasty (PFA) is an alternative to a total knee arthroplasty (TKA) in patients with severe isolated patellofemoral osteoarthritis. The main goal of this study was to determine the revision rate of the Hermes™ (Ceraver) anatomical unconstrained PFA. METHODS: A retrospective single surgeon study was performed including all patients operated for PFA between 1997 and 2015. A standardized procedure was used to perform PFA with one type of prosthesis...
February 20, 2019: Knee
Romaric Larcher, Manon Lounnas, Yann Dumont, Anne-Laure Michon, Lucas Bonzon, Raphael Chiron, Christian Carriere, Kada Klouche, Sylvain Godreuil
We report Mycobacterium chimaera pulmonary disease in 4 patients given a diagnosis of cystic fibrosis in a university hospital in Montpellier, France. All patients had M. chimaera-positive expectorated sputum specimens, clinical symptoms of pulmonary exacerbation, or a decrease in spirometry test results that improved after specific treatment.
March 2019: Emerging Infectious Diseases
Guillaume Jeantet, Vincent Pernin, Vincent Brunot, Arnaud Roccabianca, Anouk Macombe, Ilan Szwarc, Kada Klouche, Chantal Loirat, Georges Mourad, Véronique Frémeaux-Bacchi, Moglie Le Quintrec
Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.
February 2019: Clinical Kidney Journal
Mansour Sadeqi, Shahnaz Klouche, Yoann Bohu, Serge Herman, Nicolas Lefevre, Antoine Gerometta
Background: Successful return to sport after anterior cruciate ligament (ACL) reconstruction requires optimal physical and psychological recovery. The main validated tool to quantify a patient's psychological readiness to return to sport after this surgery is the Anterior Cruciate Ligament-Return to Sport after Injury (ACL-RSI) scale. Purpose: The primary aim was to analyze the progression of the ACL-RSI score from preoperatively to 2-year follow-up. A secondary goal was to identify the factors associated with returning to the same preinjury sport...
December 2018: Orthopaedic Journal of Sports Medicine
Julia Sicard, Shahnaz Klouche, Christel Conso, Nicolas Billot, Jean-Charles Auregan, Samuel Poulain, Florent Lespagnol, Nicolas Solignac, Thomas Bauer, Mathieu Ferrand, Philippe Hardy
BACKGROUND: The aim of this study was to compare the efficacy of local infiltration analgesia (LIA) and interscalene nerve block (ISB) for early postoperative pain control after total shoulder arthroplasty (TSA). The hypothesis was that LIA is not inferior to ISB. METHODS: A prospective, randomized controlled study was performed in 2014-2016. All patients who underwent TSA for shoulder osteoarthritis were included. Patients in the ISB group received a continuous infusion of 0...
February 2019: Journal of Shoulder and Elbow Surgery
Yoann Bohu, Shahnaz Klouche, Serge Herman, Olivier de Pamphilis, Antoine Gerometta, Nicolas Lefevre
BACKGROUND: The rate of septic arthritis in the knee after anterior cruciate ligament (ACL) reconstruction varies in the literature but is generally less than 1%. It has been reported to be higher in professional athletes (5.7%). PURPOSE: The primary goal was to evaluate the rate of septic arthritis after ACL reconstruction in professional athletes compared with other patients. The secondary goals were to analyze the risk factors; increased cost of infections; return to sport, satisfaction, and functional results at 1-year follow-up; and resolution rate of infections at final follow-up...
November 27, 2018: American Journal of Sports Medicine
Tiana Raoul, Shahnaz Klouche, Baptiste Guerrier, Badr El-Hariri, Serge Herman, Antoine Gerometta, Nicolas Lefevre, Yoann Bohu
BACKGROUND: The decision to return to sport following anterior cruciate ligament (ACL) reconstruction should not only be based on time since surgery. This study aimed to assess, using isokinetic and neuromuscular (hops) testing in a large group, postoperative objective functional recovery of the knee. The secondary objective was to determine the relationship between psychological, functional scores, and these postoperative tests. METHODS: This prospective study included athletes who underwent surgery between 2013 and 2016 for an isolated full-thickness ACL tear...
November 22, 2018: Knee
Anne Sophie Bargnoux, Vincent Azoury, Stephanie Badiou, Kada Klouche, Maëlle Plawecki, Nils Kuster, Anne Marie Dupuy, Jean-Paul Cristol
BACKGROUND: The study was designed to evaluate the analytical performances of two ERM-DA471/IFCC traceable cystatin C (CysC) reagents available on the market for urinary CysC (u-CysC) quantification. In addition, clinical relevance was assessed by measuring u-CysC in healthy controls and in patients with tubular dysfunction. METHODS: CysC in urine was measured by a particle enhanced nephelometric immunoassay (PENIA) using Siemens reagents and by a particle enhanced turbidimetric immunoassay (PENIA) using DiaSys reagents...
November 14, 2018: Annals of Clinical Biochemistry
Pierre-Marie Bertrand, Bruno Pereira, Mireille Adda, Jean-François Timsit, Michel Wolff, Gilles Hilbert, Didier Gruson, Maïté Garrouste-Orgeas, Laurent Argaud, Jean-Michel Constantin, Russel Chabanne, Jean-Pierre Quenot, Julien Bohe, Claude Guerin, Laurent Papazian, Olivier Jonquet, Kada Klouche, Arnaud Delahaye, Beatrice Riu, Laurent Zieleskiewicz, Michaël Darmon, Elie Azoulay, Bertrand Souweine, Alexandre Lautrette
OBJECTIVES: To compare the assessment of decision-making capacity of ICU patients by attending clinicians (physicians, nurses, and residents) with a capacity score measured by the Mini-Mental Status Examination, completed by Aid to Capacity Evaluation if necessary. The primary outcome was agreement between physicians' assessments and the score. Secondary outcomes were agreement between nurses' or residents' assessments and the score and identification of factors associated with disagreement...
March 2019: Critical Care Medicine
Maëlle Plawecki, Marion Morena, Nils Kuster, Leila Chenine, Hélène Leray-Moragues, Bernard Jover, Pierre Fesler, Manuela Lotierzo, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol
Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression of tumorigenicity 2 (sST2) biomarker is well identified in risk stratification of cardiovascular (CV) events in heart failure. Furthermore, sST2 is included in a bioclinical score to stratify mortality risk...
2018: Mediators of Inflammation
Elie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Lilia Berrahil-Meksen, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Achille Kouatchet, Vincent Peigne, Igor Théodose, Pierre Perez, Christophe Girault, Samir Jaber, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Christine Lebert, Alexandre Lautrette, Naike Bigé, Jean-Herlé Raphalen, Laurent Papazian, Michael Darmon, Sylvie Chevret, Alexandre Demoule
Importance: High-flow nasal oxygen therapy is increasingly used for acute hypoxemic respiratory failure (AHRF). Objective: To determine whether high-flow oxygen therapy decreases mortality among immunocompromised patients with AHRF compared with standard oxygen therapy. Design, Setting, and Participants: The HIGH randomized clinical trial enrolled 776 adult immunocompromised patients with AHRF (Pao2 <60 mm Hg or Spo2 <90% on room air, or tachypnea >30/min or labored breathing or respiratory distress, and need for oxygen ≥6 L/min) at 32 intensive care units (ICUs) in France between May 19, 2016, and December 31, 2017...
November 27, 2018: JAMA: the Journal of the American Medical Association
Saber D Barbar, Raphaël Clere-Jehl, Abderrahmane Bourredjem, Romain Hernu, Florent Montini, Rémi Bruyère, Christine Lebert, Julien Bohé, Julio Badie, Jean-Pierre Eraldi, Jean-Philippe Rigaud, Bruno Levy, Shidasp Siami, Guillaume Louis, Lila Bouadma, Jean-Michel Constantin, Emmanuelle Mercier, Kada Klouche, Damien du Cheyron, Gaël Piton, Djillali Annane, Samir Jaber, Thierry van der Linden, Gilles Blasco, Jean-Paul Mira, Carole Schwebel, Loïc Chimot, Philippe Guiot, Mai-Anh Nay, Ferhat Meziani, Julie Helms, Claire Roger, Benjamin Louart, Remi Trusson, Auguste Dargent, Christine Binquet, Jean-Pierre Quenot
BACKGROUND: Acute kidney injury is the most frequent complication in patients with septic shock and is an independent risk factor for death. Although renal-replacement therapy is the standard of care for severe acute kidney injury, the ideal time for initiation remains controversial. METHODS: In a multicenter, randomized, controlled trial, we assigned patients with early-stage septic shock who had severe acute kidney injury at the failure stage of the risk, injury, failure, loss, and end-stage kidney disease (RIFLE) classification system but without life-threatening complications related to acute kidney injury to receive renal-replacement therapy either within 12 hours after documentation of failure-stage acute kidney injury (early strategy) or after a delay of 48 hours if renal recovery had not occurred (delayed strategy)...
October 11, 2018: New England Journal of Medicine
Guillaume Dumas, Sylvie Chevret, Virginie Lemiale, Frédéric Pène, Alexandre Demoule, Julien Mayaux, Achille Kouatchet, Martine Nyunga, Pierre Perez, Laurent Argaud, François Barbier, François Vincent, Fabrice Bruneel, Kada Klouche, Loay Kontar, Anne-Sophie Moreau, Jean Reignier, Laurent Papazian, Yves Cohen, Djamel Mokart, Elie Azoulay
We investigated how the initial ventilation/oxygenation management may influence the need for intubation on the coming day in a cohort of immunocompromised patients with acute hypoxemic respiratory failure (ARF). Data from 847 immunocompromised patients with ARF were used to estimate the probability of intubation at day+1 within the first 3 days of ICU admission, according to oxygenation management. First, noninvasive ventilation (NIV) was compared to oxygen therapy whatever the administration device; then standard oxygen was compared to High Flow Nasal Cannula therapy alone (HFNC), NIV alone or NIV+HFNC...
September 14, 2018: Oncotarget
Alexandre Hardy, Shahnaz Klouche, Pierre Szarzynski, Etienne Charpentier, Jean Sebastien Beranger, Thomas Bauer, Benoit Rousselin, Olivia Judet, Philippe Hardy
PURPOSE: To identify and quantify passive anterior tibial subluxation on MRI using a standardized measurement protocol and determine the diagnostic threshold of subluxation for complete anterior cruciate ligament tears. METHODS: A retrospective case-control study was performed. Patients who underwent surgery for a complete isolated ACL tear between 2009 and 2015 were matched for age and gender to controls with an intact ligament on knee MRI. All subjects underwent 1...
September 22, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Elie Azoulay, Antoine Roux, François Vincent, Achille Kouatchet, Laurent Argaud, Antoine Rabbat, Julien Mayaux, Pierre Perez, Frédéric Pène, Martine Nyunga, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Michael Darmon, Sylvie Chevret, Virginie Lemiale
RATIONALE: The incidence of Pneumocystis jirovecii pneumonia (PjP) is rising. Longer time to treatment is associated with higher mortality. OBJECTIVES: To develop a multivariable risk prediction model for PjP diagnosis. METHODS: In a prospective multicenter cohort of ICU patients with hematological malignancies and acute respiratory failure, factors associated with documented PjP were identified. The risk prediction model was tested in an independent prospective multicenter cohort...
December 15, 2018: American Journal of Respiratory and Critical Care Medicine
Sanjeet Balgobin, Marion Morena, Vincent Brunot, Noemie Besnard, Delphine Daubin, Laura Platon, Romaric Larcher, Laurent Amigues, Liliane Landreau, Anne-Sophie Bargnoux, Anne-Marie Dupuy, Jean-Paul Cristol, Kada Klouche
AIMS: High cut-off (HCO) continuous veno-venous hemodialysis (CVVHD) was compared to high-flux membrane (HFM) continuous veno-venous hemodiafiltration (CVVHDF) in intensive care unit (ICU) acute kidney injury (AKI) in terms of efficiency, hemodynamic tolerance, medium-sized molecules removal, albumin loss, and inflammatory system activation. METHODS: In a prospective cross-over randomized study, 10 AKI patients underwent successively HCO (Ultraflux EmiC2: β2-microglobulin [β2M] sieving coefficient [SC]: 0...
2018: Blood Purification
Romain Chevallier, Shahnaz Klouche, Antoine Gerometta, Yoann Bohu, Serge Herman, Nicolas Lefevre
PURPOSE: To describe the clinical results of patients who underwent surgical treatment for a intra-osseous tibial tunnel cyst on a bioabsorbable interference screw following anterior cruciate ligament reconstruction (ACL). METHODS: This retrospective study included all patients who underwent surgery between 2004 and 2016 for an intra-osseous tibial tunnel cyst on bioabsorbable interference screw following ACL reconstruction. The diagnosis was suggested clinically by pretibial pain at the incision site, sometimes associated with a palpable subcutaneous nodule and then confirmed on MRI...
June 30, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
July 7, 2018: Lancet
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