Read by QxMD icon Read

Antiaging medicine

Sandro Argüelles, Angélica Guerrero-Castilla, Mercedes Cano, Mario F Muñoz, Antonio Ayala
Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the last century, but perhaps not always the quality of life in parallel with it. Future generations will be faced with the problems of an increased life expectancy along with the emergence of new age-related diseases. A deeper understanding of the aging process is crucial to ameliorate, if not to prevent, these projected new old-age diseases. One of the mechanisms responsible for healthy aging is through the effective maintenance of physiological, biochemical, and immunological functions...
March 6, 2019: Annals of the New York Academy of Sciences
So Wun Kim, Ravi Gupta, Cheol Woo Min, Seo Hyun Lee, Ye Eun Cheon, Qing Feng Meng, Jeong Woo Jang, Chi Eun Hong, Ji Yoon Lee, Ick Hyun Jo, Sun Tae Kim
Background: Ginseng is one of the well-known medicinal plants, exhibiting diverse medicinal effects. Its roots possess anticancer and antiaging properties and are being used in the medical systems of East Asian countries. It is grown in low-light and low-temperature conditions, and its growth is strongly inhibited at temperatures above 25°C. However, the molecular responses of ginseng to heat stress are currently poorly understood, especially at the protein level. Methods: We used a shotgun proteomics approach to investigate the effect of heat stress on ginseng leaves...
January 2019: Journal of Ginseng Research
Yan-Yan Hor, Cheong-Hwa Ooi, Boon-Yin Khoo, Sy-Bing Choi, Azman Seeni, Shaharum Shamsuddin, Chern-Ein Oon, Kee-Leong Ong, Woo-Sik Jeong, Min-Tze Liong
Aging is an inevitable and ubiquitous progress that affects all living organisms. A total of 18 strains of lactic acid bacteria (LAB) were evaluated on the activation of adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor mediating lifespan extension. The cell-free supernatant (CFS) of Lactobacillus fermentum DR9 (LF-DR9), Lactobacillus paracasei OFS 0291 (LP-0291), and Lactobacillus helveticus OFS 1515 (LH-1515) showed the highest activation of AMPK and was further evaluated...
January 2019: Journal of Medicinal Food
Lingling Zhang, Jianzong Chen
Polygonum multiflorum Thunb. (PM), a traditional Chinese medicinal herb, has been widely used in the Orient as a tonic and antiaging agent. 2,3,5,4'-Tetrahydroxystilbene-2- O - β -D-glucoside (TSG, C20 H22 O9 , FW = 406.38928) is one of the active components extracted from PM. TSG is an antioxidant agent, which exhibits remarkable antioxidative activities in vivo and in vitro. The antioxidant effect of TSG is achieved by its radical-scavenging effects. TSG can inhibit apoptosis and protect neuronal cells against injury through multifunctional cytoprotective pathways...
2018: Oxidative Medicine and Cellular Longevity
Yung-Ming Chang, Marthandam Asokan Shibu, Chuan-Te Tsai, Chin-Chuan Tsai, Shu-Luan Lin, Chia-Cheng Chang, Vijaya Padma Viswanadha, Ray-Jade Chen, Julia Huei-Mei Chang, Chih-Yang Huang
Adipose-derived mesenchymal stem cells (ADMSCs) are easily accessible and are attractive mesenchymal stem cells for use in regenerative medicine; however their application is frequently restricted due to various challenges present in the environment they are administered. Therefore ADMSCs are preferably preconditioned with various stimulating factors to overcome the barriers developed in any pathological conditions. Here we used ADMSCs from rat adipose based on the abundance of positive markers and preconditioned the cells with extracts from Alpinate Oxyphyllae Fructus (AOF), a traditional Chinese herb used for antiaging, associated various health benefits...
December 4, 2018: Journal of Cellular Physiology
Pan Zhao, Jing Wang, Wei Zhao, Xiaoli Ma, Haiji Sun
Chinese rice wine (CRW) is widely known for keeping good health and commonly used in the traditional Chinese medicine prescription guiding drug. This study assesses the effects of CRW on antifatigue and antiaging activities in mice models. Mice were randomly divided into four groups performing with 0.25 ml of distilled water, 0.15, 0.25, and 0.4 ml of CRW for 15 consecutive days. The CRW could obviously increase the content of liver glycogen (LG) and decrease the levels of blood lactic acid (BLA)and blood urea nitrogen (BUN) to improve antifatigue ability...
November 2018: Food Science & Nutrition
Rodrigo Castañeda, Sathishkumar Natarajan, Seo Yule Jeong, Bin Na Hong, Tong Ho Kang
ETHNOPHARMACOLOGICAL RELEVANCE: In Traditional Oriental Medicine (TOM), the development of hearing pathologies is related to an inadequate nourishment of the ears by the kidney and other organs involved in regulation of bodily fluids and nutrients. Several herbal species have historically been prescribed for promoting the production of bodily fluids or as antiaging agents to treat deficiencies in hearing. AIM OF REVIEW: The prevalence of hearing loss has been increasing in the last decade and is projected to grow considerably in the coming years...
November 12, 2018: Journal of Ethnopharmacology
Chun-Ming Yen, Chia-Wen Tsai, Wen-Shin Chang, Yi-Chin Yang, Yi-Wen Hung, Hsu-Tung Lee, Chiung-Chyi Shen, Meei-Ling Sheu, Ju-Yu Wang, Chi-Li Gong, Wen-Yu Cheng, DA-Tian Bau
AIM: Arsenic trioxide (As2 O3 ), known as pi-shuang and the most toxic compound in traditional Chinese medicine, has been used as an antitumor agent for thousands of years. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol that has significant anti-bacterial, anti-fungaI and antiaging activities. Our study aimed to examine the combined anticancer effects of As2 O3 and resveratrol against human neuroblastoma SK-N-SH cells, and elucidate the underlying intracellular signaling...
November 2018: Cancer Genomics & Proteomics
Zahra Ayati, Mohammad Sadegh Amiri, Mahin Ramezani, Elahe Delshad, Amirhossein Sahebkar, Seyed Ahmad Emami
BACKGROUND: The fruit of genus Rosa, known as "rose hip", is frequently used in different traditional medicines. Rose hips have long been used to treat kidney stones, gastroenteric ailments, hypertension and respiratory problems such as bronchitis, cough and cold. AIM: This review focused on the ethnopharmacological uses of rose hip as well as phytochemical and pharmacological aspects. RESULTS: Ethno-medical uses of rose hip have been recorded in many countries since a long time...
October 10, 2018: Current Pharmaceutical Design
Chi-Rei Wu, Hung-Chi Chang, Yih-Dih Cheng, Wan-Cheng Lan, Shu-Er Yang, Hui Ching
The medicinal ferns of Polydiaceae and Davalliaceae species are called "Gusuibu" by Chinese physicians and used as antiaging dietary medicines. Our previous report revealed that Drynaria fortunei (Polydiaceae) protected against 6-hydroxydopamine (6-OHDA)-induced oxidative damage via the PI3K/AKT pathway in B35 neuroblastoma cells. The present study compares the antioxidant phytoconstituent contents and radical scavenging capacities of five Davalliaceae species. The further aim was to clarify the protective mechanism of Davallia mariesii (DM) against 6-OHDA-induced oxidative damage and apoptosis in B35 cells...
October 6, 2018: Nutrients
Haroon Khan, Marya, Tarun Belwal, Mohd Tariq, Atanas G Atanasov, Hari Prasad Devkota
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Vanda (Family: Orchidaceae) comprises about 73 species mainly distributed in Southeast Asia. Plants belonging to this genus are being used in the traditional medicine systems in Asian countries specially in India, Nepal, China and Bangladesh. AIM OF THE REVIEW: The aim of this work was to review the scientific work about medicinal orchids of the genus Vanda regarding their traditional uses, reported bioactive components, and pharmacological activities...
September 27, 2018: Journal of Ethnopharmacology
Maoyang Lu, Zhao Wang
The human gut microbiota is a huge ecosystem that provides lots of functions for host development, immune system, and metabolism. Gut microbiota is linked to lots of diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), irritable bowel syndrome, and cardiovascular disease (CVD). Few studies, however, have noted the relationship between aging and microbiota; the connection between aging and microbiota remains largely to be researched. In this review, recent research findings are summarized on the role of gut microbiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in antiaging medicine...
2018: Advances in Experimental Medicine and Biology
Han Xie, Shouliang Zhao, Shangfeng Liu
With the continuous development of stem cell research in recent years, it is realized that stem cell aging may be the core issue of organ aging. As an important approach and main content of regenerative medicine, the stem cell research brings great hope to overcome difficult diseases and improve the quality of life for human beings and become the key to solve this issue. Based on this research, the varying characteristics of stem cells in aging could be recognized; the role of stem cells in the organ aging and regeneration will be revealed; the function of stem cells will be controllable and regulatable in tissues and organs; the stem cells from tissues and organs with rapid or slow cell renewal (e...
2018: Advances in Experimental Medicine and Biology
Md Faruque Ahmad
Ganoderma lucidum comprises probably 400 different biologically active constituents principally polysaccharides, triterpenoids, proteins, enzymes, steroids, sterols, nucleotides, fatty acids, vitamins and minerals which have been proved to have several therapeutical properties to control various diseases. Broad spectrum of its pharmacological actions have been established which include immunomodulation, anticancer, antidiabetic, antioxidant, antiatherosclerotic, antifibrotic, chemopreventive, antitumor, anticancer drug toxicity prevention, analgesic, anti inflammatory, antinociceptive, antimicrobial, hypolipidemic, hepatoprotective, antiandrogenic, antiangiogenic, antiherpetic, antiarthritic, antiosteoporotic, antiaging, antiulcer properties and estrogenic activity...
November 2018: Biomedicine & Pharmacotherapy
Qing-Xiu Liu, Wei Zhang, Jia Wang, Wei Hou, Ying-Ping Wang
Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster . Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D...
July 2018: Journal of Ginseng Research
Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee, Feng-Lin Yen
Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity...
2018: International Journal of Nanomedicine
Xiao-Bing Huang, Gui-Sheng Wu, Lei-Yu Ke, Xiao-Gang Zhou, Yue-Hu Wang, Huai-Rong Luo
Aging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in Caenorhabditis elegans ( C. elegans ) and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in C...
June 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against A β -induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance...
2018: Oxidative Medicine and Cellular Longevity
Carmela Rita Balistreri
The " long-life elixir " has long represented for humans a dream, a vanity's sin for remaining young and to long survive. Today, because of ageing population phenomenon , the research of antiageing interventions appears to be more important than ever, for preserving health in old age and retarding/or delaying the onset of age-related diseases. A hope is given by experimental data, which evidence the possibility of retarding ageing in animal models. In addition, it has been also demonstrated in animal life-extending studies not only the possibility of increasing longevity but also the ability to retard the onset of age-related diseases...
2018: Mediators of Inflammation
Dexter S L Ma, Loh Teng-Hern Tan, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Lay-Hong Chuah, Long Chiau Ming, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for alternative antimicrobials with natural plant antimicrobials being among the more promising candidates as these substances have good acceptability and likely low toxicity levels as they have long been used in traditional medicines...
2018: Frontiers in Pharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"