Shinsuke Sakai, Youichi Tanaka, Yusuke Tsukamoto, Shihoko Kimura-Ohba, Atsushi Hesaka, Kenji Hamase, Chin-Ling Hsieh, Eiryo Kawakami, Hiraku Ono, Kotaro Yokote, Mitsuaki Yoshino, Daisuke Okuzaki, Hiroyo Matsumura, Atsuko Fukushima, Masashi Mita, Maiko Nakane, Masao Doi, Yoshitaka Isaka, Tomonori Kimura
BACKGROUND: The aberrant glucose circadian rhythm is associated with the pathogenesis of diabetes. Similar to glucose metabolism in kidney and liver, d-alanine, a rare enantiomer of alanine, shows circadian alteration, although the effect of d-alanine on glucose metabolism has not been explored. Here we show that d-alanine acts on the circadian clock and affects glucose metabolism in the kidney. METHODS: The blood and urinary levels of d-alanine in mice were measured using two-dimensional high performance liquid chromatography system...
December 15, 2023: Kidney360