keyword
https://read.qxmd.com/read/38537149/urinary-bladder-involvement-in-igg4-related-disease-a-case-based-review
#1
JOURNAL ARTICLE
Parag Vijayvergia, Sayan Mukherjee, Lily Singh, Urmila Dhakad
Immunoglobulin G4-related disease (IgG4-RD) is an immune-driven fibroinflammatory disease that presents as tumefactive lesions that not only commonly affects the pancreas, lacrimal and salivary glands, lung, liver and kidney but can also affect any organs. However, involvement of the urinary bladder in IgG4-RD is rarely reported. We describe a case of IgG4-RD involving the urinary bladder mimicking carcinoma and review the published literature-a 39-year-old male presented with complaints of dysuria, urgency and hesitancy...
March 2, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38536193/-complications-of-intravesical-bcg-therapy
#2
JOURNAL ARTICLE
Aresh Farokhnia, Silvana K Rampini, Micha Gundelfinger
BCG instillations are considered to be the standard of care therapy for superficial urothelial bladder carcinoma. Although serious adverse events are uncommon, the presence of high fever for at least two days in conjunction with systemic and/or local organ manifestations (except for urogenital symptoms), with the exclusion of other causes, suffice for the diagnosis of a disseminated BCG infection. Microbiologic detection of the pathogen is not necessary for diagnosis, as the detection of granuloma is more often successful and sufficient...
February 2024: Praxis
https://read.qxmd.com/read/38534771/prognostic-value-of-p63-expression-in-muscle-invasive-bladder-cancer-and-association-with-molecular-subtypes-preliminary-report
#3
JOURNAL ARTICLE
Francesca Sanguedolce, Ugo Giovanni Falagario, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Stefano Ascani, Simona Tortorella, Gian Maria Busetto, Angelo Cormio, Giuseppe Carrieri, Luigi Cormio
There is an ongoing need for biomarkers that could reliably predict the outcome of BC and that could guide the management of this disease. In this setting, we aimed to explore the prognostic value of the transcription factor P63 in patients with muscle-invasive bladder cancer (MIBC) having undergone radical cystectomy. The correlation between P63 expression and clinicopathological features (tumor stage, nodes involvement, patterns of muscularis propria invasion, papillary architecture, anaplasia, concomitant carcinoma in situ, lymphovascular invasion, perineural invasion, necrosis) and molecular subtyping (basal and luminal type tumors) was tested in 65 radical cystectomy specimens and matched with cancer-specific survival (CSS) and overall survival (OS)...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38532369/preliminary-findings-on-the-development-of-a-predictive-model-for-blca-based-on-disulfidptosis-associated-incrnas-signature
#4
JOURNAL ARTICLE
Chao Tang, Yanpeng Fan, Shusheng Zhu
BACKGROUND: Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis. Disulfidptosis is a newly identified cell death method and closely associated with BLCA progression, prognosis, and treatment outcome. Currently, we need to construct a new prognostic model for disulfidptosis-related long noncoding RNAs (drlncRNAs) to improve the treatment strategy of BLCA. METHODS: The data for BLCA samples were obtained from The Cancer Genome Atlas (TCGA), and then 10 unique genes related to disulfidoptosis (DRGs) were identified from research papers...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38532363/quantitative-differentiation-of-non-invasive-bladder-urothelial-carcinoma-and-inverted-papilloma-based-on-ct-urography
#5
JOURNAL ARTICLE
Pengfei Jin, Liqin Yang, Yitao Liu, Jiehui Huang, Xu Wang
PURPOSE: To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB). MATERIAL AND METHODS: The clinical and preoperative CTU imaging data of continuous 103 patients with histologically confirmed BUC or IPB were retrospectively analyzed. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38531795/unlocking-the-therapeutic-potential-of-lncrna-blacat1-in-hypopharynx-squamous-cell-carcinoma
#6
JOURNAL ARTICLE
Fan-Li Liu, Zhan-Cheng Zhang, Sheng-Li Zhou, Xu-Liang Liu, Wei Xu
BACKGROUND: Identifying the key molecular targets in hypopharynx squamous cell carcinoma (HSCC) is crucial for understanding this prevalent and highly fatal type of head and neck tumor. The study aims to enhance comprehension of the HSCC process by accurately identifying these key molecular targets. MATERIALS AND METHODS: In this study, we examined 47 clinical tissue samples from individuals diagnosed with HSCC using RNA-seq high-throughput assay. Quantitative real-time PCR (RT-PCR) was used to compare long non-coding RNA (lncRNA) bladder cancer-associated transcript 1 ( BLACAT1 ) expression in HSCC tissues versus adjacent non-tumor tissues...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531255/on-relevant-features-for-the-recurrence-prediction-of-urothelial-carcinoma-of-the-bladder
#7
JOURNAL ARTICLE
Louisa Schwarz, Dominik Sobania, Franz Rothlauf
BACKGROUND: Urothelial bladder cancer (UBC) is characterized by a high recurrence rate, which is predicted by scoring systems. However, recent studies show the superiority of Machine Learning (ML) models. Nevertheless, these ML approaches are rarely used in medical practice because most of them are black-box models, that cannot adequately explain how a prediction is made. OBJECTIVE: We investigate the global feature importance of different ML models. By providing information on the most relevant features, we can facilitate the use of ML in everyday medical practice...
March 18, 2024: International Journal of Medical Informatics
https://read.qxmd.com/read/38530111/a-low-risk-hpv-associated-well-differentiated-squamous-cell-carcinoma-of-the-cervix-with-low-grade-squamous-intraepithelial-lesion-morphology-clinical-and-pathologic-diagnostic-difficulties-and-review-of-the-literature
#8
JOURNAL ARTICLE
Deniz Ates, Esra Nur Sahin, Kübra Katipoglu, Alp Usubutun
Approximately 95% of cervical squamous cell carcinomas are associated with high-risk HPV, with a small number of HPV-independent tumors. However, low-risk HPV types have also been detected in rare cervical squamous cell carcinomas. Low-grade squamous intraepithelial lesion-related changes are a rare morphologic finding in cervical squamous cell carcinoma. We present the case of a 30-yr-old woman who presented with pelvic pain and foul-smelling vaginal discharge showing an exophytic lesion protruding from the cervix...
March 26, 2024: Türk Patoloji Dergisi
https://read.qxmd.com/read/38529382/primary-pure-large-cell-neuroendocrine-carcinoma-of-the-urinary-bladder-a-case-report-and-literature-review
#9
Zhenpeng Sun, Xin Liang, Changcun Zhang, Shizhang Song, Jiangang Gao
BACKGROUND: The large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is a rare malignancy. With its high aggressiveness and poor prognosis, the disease is often accompanied by metastasis or recurrence. The lack of specific clinical manifestations and imaging features causes considerable challenges for clinical diagnosis and treatment. CASE PRESENTATION: We report a case of LCNEC of the urinary bladder. The patient was a 79-year-old male admitted to our hospital with recurrent episodes of asymptomatic gross hematuria...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38527985/endothelial-cell-proliferation-and-vascular-patterns-in-urothelial-carcinoma
#10
JOURNAL ARTICLE
Tiberiu Gabriel Adelmann, Amalia Raluca Ceauşu, Nela Puşa Gaje, Marius Raica
INTRODUCTION: The bladder cancer has some characteristics: the sixth most incident neoplasm in the United States, the majority of diagnosed cases in those 55 years of age and older, four times more common in man than women, a reduced five-year survival rate in case of metastatic disease. Despite the beneficial effects of the combination therapy and immunotherapy, the low response rate and drug resistance were reported. The main goal of this work was evaluation of the endothelial cell proliferation from urothelial carcinomas...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38526374/objective-evaluation-of-gaze-location-patterns-using-eye-tracking-during-cystoscopy-and-artificial-intelligence-assisted-lesion-detection
#11
JOURNAL ARTICLE
Atsushi Ikeda, Kazuya Izumi, Kensuke Katori, Hirokazu Nosato, Keita Kobayashi, Shuhei Suzuki, Shuya Kandori, Masaru Sanuki, Yoichi Ochiai, Hiroyuki Nishiyama
BACKGROUND: The diagnostic accuracy of cystoscopy varies according to the knowledge and experience of the performing physician. Here, we evaluated the difference in cystoscopic gaze location patterns between medical students and urologists and assessed the differences in their eye movements when simultaneously observing conventional cystoscopic images and images with lesions detected by artificial intelligence (AI). METHODOLOGY: Eye-tracking measurements were performed, and observation patterns of participants (24 medical students and 10 urologists) viewing images from routine cystoscopic videos were analyzed...
March 25, 2024: Journal of Endourology
https://read.qxmd.com/read/38524652/primary-signet-ring-cell-carcinoma-of-the-bladder-treated-with-laparoscopic-radical-cystectomy-a-case-report
#12
JOURNAL ARTICLE
Yuta Mukae, Kojiro Ohba, Kyohei Araki, Yuichiro Nakamura, Hiromi Nakanishi, Takuji Yasuda, Kensuke Mitsunari, Tomohiro Matsuo, Yasushi Mochizuki, Junji Irie, Ryoichi Imamura
Primary bladder adenocarcinomas comprise 0.5-2% of all epithelial bladder neoplasms. Of these, primary signet-ring cell carcinoma of the bladder is particularly rare, accounting for 0.24% of all bladder malignancies. This tumor is frequently diagnosed at an advanced stage and has a poor prognosis. No standard treatment has yet been established. We here report a patient in whom laparoscopic cystectomy following neoadjuvant chemotherapy was effective. Our patient was a 69-year-old man who had had microscopic hematuria, undergone transurethral resection of a mass in the bladder, and been diagnosed pathologically with a primary signet-ring cell carcinoma of the bladder...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524643/multidisciplinary-treatment-for-small-cell-carcinoma-of-the-bladder-a-case-report
#13
JOURNAL ARTICLE
Yoshie Mita, Jun Teishima, Akihisa Yao, Riku Uematsu, Takahiko Yoshii, Takuto Hara, Masato Fujisawa, Ichiro Nakamura
Small cell carcinoma (SCC) of the urinary bladder is a rare and highly aggressive subtype of bladder cancer. Most cases are diagnosed at advanced stages, and its therapeutic strategy remains unestablished. Here, we report a case of bladder SCC in which multidisciplinary treatment has resulted in relatively long-term survival. A 68-year-old man presented with gross hematuria. A cystoscopy revealed an invasive bladder tumor. A transurethral resection of bladder tumor (TURBT) was performed, and the pathological diagnosis was SCC...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38523920/carcinomatous-meningitis-and-hydrocephalus-in-plasmacytoid-urothelial-carcinoma-of-the-urinary-bladder-with-extremely-elevated-ca19-9-levels
#14
Fumiaki Henmi, Kayako Ukai, Atsuhito Nakayama, Yutaka Takazawa, Yoshikazu Uesaka
This case report describes a rare and aggressive presentation of plasmacytoid urothelial carcinoma (PUC) with carcinomatous meningitis, hydrocephalus, extensive organ involvement, and extremely elevated serum CA19-9 levels. Autopsy findings revealed that PUC of the urinary bladder origin caused carcinomatous meningitis and hydrocephalus, with exacerbation of hydrocephalus as the direct cause of death. Immunohistochemical studies confirmed the bladder origin of PUC, and PUC cells were positive for CA19-9, a tumor marker commonly associated with gastrointestinal malignancies, suggesting that the markedly high serum CA19-9 level was related to the tumor-producing mechanism...
February 2024: Curēus
https://read.qxmd.com/read/38523484/updates-on-urinary-bladder-tumors-with-neuroendocrine-features
#15
JOURNAL ARTICLE
Dilara Akbulut, Hikmat Al-Ahmadie
The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and remains ill-defined but is increasingly recognized. Well-differentiated neuroendocrine tumor and paraganglioma can arise in the bladder but are very rare in this location. Recent advances in molecular characterization allowed for better classification and may offer improved stratification of these tumors...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38523233/immunochemistry-based-quantification-of-tumor-infiltrating-lymphocytes-and-immunoscore-as-prognostic-biomarkers-in-bladder-cancer
#16
JOURNAL ARTICLE
Sarra Ben Rejeb, Sirine Elfekih, Nadia Kouki, Rami Boulma, Hassen Khouni
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) and the derived immunoscore (IS) have gained considerable attention over the last decade as prognostic markers in many solid cancers. However, in bladder cancer (BC), their prognostic value is not clearly established. METHODS: The present study aimed to quantify the TILs rates in BC, assess the derived immunoscore, and investigate their prognostic value. An immunochemistry-based quantification of the different subtypes of TILS was performed on paraffin-embedded blocks from patients with invasive urothelial carcinoma of the bladder...
March 25, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38522065/enhancing-reck-expression-through-mir-21-inhibition-a-promising-strategy-for-bladder-carcinoma-control
#17
JOURNAL ARTICLE
Paulo Rodolfo Moraes Dos Santos, Paulo Ricardo da Silva Gomes, Poliana Romão, Feres Camargo Maluf, Vanessa Ribeiro Guimarães, Patrícia Candido, Guilherme Lopes Gonçalves, Juliana Alves de Camargo, Gabriel Arantes Dos Santos, Iran Silva, Katia Ramos Moreira Leite, William Nahas, Sabrina T Reis, Ruan Pimenta, Nayara Izabel Viana
Bladder carcinoma (BC) is the tenth most frequent malignancy worldwide, with high morbidity and mortality rates. Despite recent treatment advances, high-grade BC and muscle-invasive BC present with significant progression and recurrence rates, urging the need for alternative treatments. The microRNA-21 (miR-21) has superexpression in many malignancies and is associated with cellular invasion and progression. One of its mechanisms of action is the regulation of RECK, a tumor suppressor gene responsible for inhibiting metalloproteinases, including MMP9...
March 24, 2024: Biochemical Genetics
https://read.qxmd.com/read/38521648/association-of-cabozantinib-dose-reductions-for-toxicity-with-clinical-effectiveness-in-metastatic-renal-cell-carcinoma-mrcc-results-from-the-canadian-kidney-cancer-information-system-ckcis
#18
JOURNAL ARTICLE
Jeffrey Graham, Sunita Ghosh, Rodney H Breau, Lori Wood, Simon Tanguay, Dominick Bosse, Aly-Khan Lalani, Bimal Bhindi, Daniel Heng, Antonio Finelli, Nazanin Fallah-Rad, Vincent Castonguay, Naveen S Basappa, Denis Soulières, Frédéric Pouliot, Christian Kollmannsberger, Georg A Bjarnason
BACKGROUND: Cabozantinib, an oral multi-targeted tyrosine kinase inhibitor (TKI), has demonstrated efficacy in metastatic renal cell carcinoma (mRCC). The association between toxicity and therapeutic effectiveness has been established with other TKIs. We investigated whether cabozantinib dose reductions, a surrogate for toxicity and adequate drug exposure, were associated with improved clinical outcomes in mRCC. METHODS: Employing the CKCis database, we analyzed patients treated with cabozantinib in the second line or later between 2011 to 2021...
February 23, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38518049/arab-world-s-impact-on-bladder-cancer-research-and-opportunities-for-growth-a-bibliometric-review-study
#19
JOURNAL ARTICLE
Mustafa Saleh, Peter Raffoul, Alvar Akil, Paul Bassil, Pascale Salameh
BACKGROUND: Bladder Cancer (BC) is a widespread form of cancer that affects over 1.6 million people globally. The majority of cases are diagnosed as urothelial carcinoma, with a higher likelihood of diagnosis in men and with increasing age. The Arab world (AW) is one of the regions with the highest incidence and mortality rates of BC, and the average age of diagnosis is between 40 and 49 years in North Africa and the Middle East. This study aims to assess the activity and distribution of BC publications in the AW...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38516176/necrotizing-granulomatous-epididymo-orchitis-post-intravesical-bcg-administration-after-brachytherapy-for-prostate-cancer
#20
Jay K Jhaveri, Aaron Dahmen, Alon Lazarovich, David Nusbaum, Quoc-Dien Trinh, Nilesh Gupta, Piyush K Agarwal
Urothelial carcinoma of the bladder remains a challenging disease to treat. Intravesical instillation of BCG has demonstrated tremendous efficacy in preventing recurrence. BCG related necrotizing granulomatous epididymo-orchitis is rare and has not been previously linked to brachytherapy for adenocarcinoma of the prostate. We hypothesize that prior brachytherapy has a deleterious effect on the verumontanum that can result in retrograde transmission of BCG particles leading to granulomatous epididymo-orchitis...
May 2024: Urology Case Reports
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