Paulo Rodolfo Moraes Dos Santos, Paulo Ricardo da Silva Gomes, Poliana Romão, Feres Camargo Maluf, Vanessa Ribeiro Guimarães, Patrícia Candido, Guilherme Lopes Gonçalves, Juliana Alves de Camargo, Gabriel Arantes Dos Santos, Iran Silva, Katia Ramos Moreira Leite, William Nahas, Sabrina T Reis, Ruan Pimenta, Nayara Izabel Viana
Bladder carcinoma (BC) is the tenth most frequent malignancy worldwide, with high morbidity and mortality rates. Despite recent treatment advances, high-grade BC and muscle-invasive BC present with significant progression and recurrence rates, urging the need for alternative treatments. The microRNA-21 (miR-21) has superexpression in many malignancies and is associated with cellular invasion and progression. One of its mechanisms of action is the regulation of RECK, a tumor suppressor gene responsible for inhibiting metalloproteinases, including MMP9...
March 24, 2024: Biochemical Genetics