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https://read.qxmd.com/read/30763230/are-there-differences-between-de-novo-and-secondary-upper-tract-urothelial-carcinoma-tumours
#1
Hanan Goldberg, Douglas C Cheung, Thenappan Chandrasekar, Zachary Klaassen, Christopher J D Wallis, Girish S Kulkarni, Rashid Sayyid, Andrew Evans, Mehdi Masoomian, Bharati Bapat, Theodorus Van Der Kwast, Robert J Hamilton, Alexandre Zlotta, Neil Fleshner
INTRODUCTION: Upper tract urothelial carcinoma (UTUC) accounts for <5% of all urothelial cancers. We aimed to ascertain the clinical differences between UTUC tumours presenting de novo (DnUTUC) and those presenting secondary (SUTUC) following a bladder cancer diagnosis. METHODS: Our institutional database was queried for all UTUC patients who were surgically treated with radical nephroureterectomy or ureterectomy between 2003 and 2017. Bladder recurrence and cancer-specific mortality were compared...
January 21, 2019: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://read.qxmd.com/read/30762673/upper-urinary-tract-recurrence-following-bladder-cancer-therapy-a-review-of-surveillance-and-management
#2
Aurash Naser-Tavakolian, Saum Ghodoussipour, Hooman Djaladat
PURPOSE OF REVIEW: Our aim is to review recent investigations into the recurrence of urothelial carcinoma in the upper urinary tract following bladder cancer therapy focusing on surveillance and management. RECENT FINDINGS: After radical cystectomy, rates of recurrence in the upper tract are between 0.75 and 6.4%. The poor prognosis of upper tract urothelial carcinoma (UTUC) is in part attributable to delayed diagnosis. Guidelines recommend a gradual de-escalation of surveillance in disease-free patients with the potential for discontinuation beyond 5 years...
February 11, 2019: Current Opinion in Urology
https://read.qxmd.com/read/30761801/-interstitial-laser-coagulation-in-the-management-of-urothelial-papillary-carcinoma-of-the-renal-pelvis
#3
O V Teodorovich, M N Shatokhin, M I Abdullaev, A V Krasnov, M R Khommyatov
This article presents a case of a 59-year-old patient with a primary tumor of the right kidney with bladder and liver metastases. The patient was treated in three-stages. In the first stage, he underwent ureteral stone extraction, laser resection of the tumor with subsequent vaporization. In the second stage, a repeat laser resection and vaporization of the tumor was performed. During the third stage, the patient underwent TUR of the bladder wall with the tumor, followed by laser vaporization of the tumor bed...
October 2018: Urologii︠a︡
https://read.qxmd.com/read/30760315/multiple-cutaneous-metastasis-of-synchronous-urothelial-carcinoma-of-the-bladder-and-the-renal-pelvis-a-case-report
#4
M Ghalleb, M A Ayadi, S Slim, I Zemni, R Doghri, J Ben Hassouna, K Rahal
INTRODUCTION: Cutaneous metastatic disease arising from urinary tract carcinoma is rare and associated with a poor prognosis. We report a case of metastatic disease occurring in a patient treated for synchronous urothelial tumor of the bladder and left renal pelvis. CASE PRESENTATION: A 61-year-old Caucasian man was treated for a synchronous urothelial tumor of the bladder and left renal pelvis. He had an en bloc radical cystectomy and left ureteronehprectomy associated with a cutaneous transileal urinary diversion and lymph node dissection...
February 14, 2019: Journal of Medical Case Reports
https://read.qxmd.com/read/30756531/-progress-in-roles-and-mechanisms-of-deacetylase-sirt7
#5
Lin Li, Zhen Dong, Jie Yang, Qian Li, Qian Lei, Jingxin Mao, Liqun Yang, Hongjuan Cui
As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. In particular, SIRT7 plays important roles in the regulation of initiation and development of various tumors, such as liver cancer, gastric cancer, breast cancer, bladder cancer, colorectal cancer, and head/neck squamous cell carcinoma...
January 25, 2019: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/30755618/whole-genome-sequencing-identifies-adgrg6-enhancer-mutations-and-frs2-duplications-as-angiogenesis-related-drivers-in-bladder-cancer
#6
Song Wu, Tong Ou, Nianzeng Xing, Jiang Lu, Shengqing Wan, Changxi Wang, Xi Zhang, Feiya Yang, Yi Huang, Zhiming Cai
Bladder cancer is one of the most common and highly vascularized cancers. To better understand its genomic structure and underlying etiology, we conduct whole-genome and targeted sequencing in urothelial bladder carcinomas (UBCs, the most common type of bladder cancer). Recurrent mutations in noncoding regions affecting gene regulatory elements and structural variations (SVs) leading to gene disruptions are prevalent. Notably, we find recurrent ADGRG6 enhancer mutations and FRS2 duplications which are associated with higher protein expression in the tumor and poor prognosis...
February 12, 2019: Nature Communications
https://read.qxmd.com/read/30755598/high-mobility-group-box-1-promotes-radioresistance-in-esophageal-squamous-cell-carcinoma-cell-lines-by-modulating-autophagy
#7
Hongbing Ma, Shuyu Zheng, Xiaozhi Zhang, Tuotuo Gong, Xin Lv, Shenbo Fu, Shuqun Zhang, Xiaoran Yin, Jingcan Hao, Changyou Shan, Shan Huang
Resistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Here, we investigated the role of HMGB1 to radioresistance in ESCC clinical samples and cell lines. We found that HMGB1 expression was associated with tumor recurrence after postoperative radiotherapy in locally advanced ESCC patients...
February 12, 2019: Cell Death & Disease
https://read.qxmd.com/read/30755341/contemporary-use-and-survival-after-perioperative-systemic-chemotherapy-in-patients-with-locally-advanced-non-metastatic-urothelial-carcinoma-of-the-bladder-treated-with-radical-cystectomy
#8
Elio Mazzone, Sebastiano Nazzani, Sophie Knipper, Zhe Tian, Felix Preisser, Andrea Gallina, Denis Soulières, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Juan Wisnivesky, Pierre I Karakiewicz
BACKGROUND: Locally advanced muscle-invasive bladder cancer (MIBC) patients who are candidates for radical cystectomy (RC) should receive perioperative chemotherapy (CHT). However, the adherence to CHT guidelines is low. Thus, we tested contemporary CHT use rates and associated cancer-specific mortality (CSM) and overall mortality (OM) rates. MATERIALS AND METHODS: Within the SEER database (2004-2015), we identified pT3N0/+ MIBC patients, who underwent RC, with or without perioperative CHT...
February 3, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30754663/metabolic-and-molecular-basis-of-sarcopenia-implications-in-the-management-of-urothelial-carcinoma
#9
REVIEW
Hiroshi Fukushima, Yasuhisa Fujii, Fumitaka Koga
Sarcopenia, which represents the degenerative and systemic loss of skeletal muscle mass, is a multifactorial syndrome caused by various clinical conditions. Sarcopenia reflects not only frailty and poor general health status, but also the possible presence of advanced or progressive cancer or cancer cachexia. Therefore, sarcopenia affects the management of cancer-bearing patients, including those with urothelial carcinoma. Recently, growing evidence has shown that sarcopenia is significantly associated with higher rates of treatment-related complications and worse prognosis in patients with urothelial carcinoma, including muscle-invasive bladder cancer, upper tract urothelial carcinoma, and advanced urothelial carcinoma...
February 11, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30753532/histologic-variants-associated-with-biological-aggressiveness-and-poor-prognosis-in-patients-treated-with-radical-cystectomy
#10
Dai Koguchi, Kazumasa Matsumoto, Masaomi Ikeda, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
Background: The prognostic value of histologic variants (HV) after radical cystectomy (RC) remains controversial. We evaluated the clinicopathological features and prognosis in patients with pure urothelial carcinoma (UC) and HV following RC. Methods: From 1990 to 2015, 286 patients with bladder cancer were treated with RC at six Kitasato University-affiliated hospitals. All patients were divided into two groups: pure UC and HV, which contained pure variants and mixed-type UC with variant pattern...
February 8, 2019: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/30753336/kras-driven-heterotopic-tumor-development-from-hepatobiliary-organoids
#11
Masako Ochiai, Yasunori Yoshihara, Yoshiaki Maru, Matsuura Tetsuya, Masashi Izumiya, Toshio Imai, Yoshitaka Hippo
Cancers arising from the biliary tract are refractory to conventional therapies, requiring the development of novel therapeutics. However, only a limited number of genetically engineered mouse models have been created, partly due to time-consuming work required. Besides, liver-specific gene manipulation mostly resulted in concurrent development of hepatocellular carcinoma, another type of liver cancer, and gall bladder-restricted gene targeting is still not feasible. Consequently, establishment of cancer type-specific disease modeling remains a technical challenge...
February 7, 2019: Carcinogenesis
https://read.qxmd.com/read/30745610/cancer-relapse-in-surgical-patients-who-received-perioperative-transfusion-of-blood-and-blood-products-a-case-control-study
#12
R Subha, Kurian Cherian, Archana Nair, Rachel Cherian Koshy, Jagathnath Krishna
Background and Aims: Immunomodulatory consequences of allogeneic blood transfusion may outweigh the advantages of improved oxygen delivery and tissue perfusion, especially in patients with cancer. In colorectal cancer, there is evidence of cancer relapse in patients who received transfusion. This retrospective analysis was undertaken to evaluate the relationship between perioperative blood transfusion and cancer recurrence in patients undergoing oncosurgery. Methods: In this case-control study, we retrospectively analysed the case sheets of 194 patients who had perioperative transfusion and underwent cancer surgery from March to December 2013(Study group, Cases)...
January 2019: Indian Journal of Anaesthesia
https://read.qxmd.com/read/30745090/tisotumab-vedotin-in-patients-with-advanced-or-metastatic-solid-tumours-innovatv-201-a-first-in-human-multicentre-phase-1-2-trial
#13
Johann S de Bono, Nicole Concin, David S Hong, Fiona C Thistlethwaite, Jean-Pascal Machiels, Hendrik-Tobias Arkenau, Ruth Plummer, Robert Hugh Jones, Dorte Nielsen, Kristian Windfeld, Srinivas Ghatta, Brian M Slomovitz, James F Spicer, Jeffrey Yachnin, Joo Ern Ang, Paul Morten Mau-Sørensen, Martin David Forster, Dearbhaile Collins, Emma Dean, Reshma A Rangwala, Ulrik Lassen
BACKGROUND: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor. METHODS: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe...
February 7, 2019: Lancet Oncology
https://read.qxmd.com/read/30741647/-usefulness-of-photodynamic-diagnosis-in-high-grade-bladder-cancer-and-subsequent-bcg-failure-bibliographic-review
#14
Juan Gómez Rivas, Aritz Eguibar Gonzalez, Leonardo Tortolero Blanco, Alfredo Aguilera Bazán, Luis Martínez-Piñeiro, Rafael Sánchez-Salas
OBJECTIVES: Bladder tumors are thesecond highest incidence urological tumor in the adultpopulation. In recent years, new techniques such as photodynamicdiagnosis have arisen in order to improvethe sensitivity for the detection of non muscle invasivebladder cancer (NMIBC). We intend to update the roleof photodynamic diagnosis in the diagnosis of NMIBC,in cases refractory to BCG and as a treatment in therecurrent bladder cancer. MATERIAL AND METHOD: We performed a descriptivestudy and bibliographic review on the usefulness of photratatodynamicdiagnosis in NMIBC, early recurrence andrefractoriness to BCG published in the universal medicalliterature...
January 2019: Archivos Españoles de Urología
https://read.qxmd.com/read/30741358/treatment-approaches-for-cisplatin-ineligible-patients-with-invasive-bladder-cancer
#15
REVIEW
David J Einstein, Guru Sonpavde
Cisplatin has been established as an important agent in the neoadjuvant setting prior to radical cystectomy (RC) surgery for muscle-invasive urothelial cancer (MIUC) as well as in the unresectable or metastatic urothelial carcinoma (mUC) setting. Unfortunately, many patients in practice are felt to be "cisplatin-ineligible." Thus, it is vital that we develop treatment approaches and novel therapeutics for this population. We evaluate therapeutic alternatives to cisplatin-based treatment. For patients undergoing RC, there is no recommended alternative to neoadjuvant cisplatin-based combination therapy, and upfront RC or clinical trials are preferable...
February 11, 2019: Current Treatment Options in Oncology
https://read.qxmd.com/read/30740862/the-impact-of-non-urothelial-variant-histology-on-oncological-outcomes-following-radical-cystectomy
#16
Luke Stroman, Rajesh Nair, Beth Russell, Nabiah Malik, Arjun Desai, Ashish Chandra, Ramesh Thurairaja, Prokar Dasgupta, Muhammad Shamim Khan, Sachin Malde
OBJECTIVES: To determine if the presence of non-urothelial variant histology (NUVH) is associated with a poorer prognosis following radical cystectomy compared to pure urothelial carcinoma. PATIENTS AND METHODS: A prospectively maintained database of all patients undergoing radical cystectomy (RC) at a high-volume regional tertiary bladder cancer service between January 2010 and January 2017 was retrospectively analysed looking for patients displaying NUVH. Multivariate Cox proportional hazards regression analysis was used to determine disease recurrence, overall and bladder cancer specific survival as well as lymph node positivity...
February 11, 2019: BJU International
https://read.qxmd.com/read/30736840/spag5-upregulation-contributes-to-enhanced-c-myc-transcriptional-activity-via-interaction-with-c-myc-binding-protein-in-triple-negative-breast-cancer
#17
Ming Li, Anqi Li, Shuling Zhou, Hong Lv, Wentao Yang
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks effective therapeutic targets. Sperm-associated antigen 5 (SPAG5) is a mitotic spindle-associated protein that is involved in various biological processes in cervical cancer and bladder urothelial carcinoma. However, the role of SPAG5 in TNBC remains undefined. METHODS: The expression of SPAG5 was examined in TNBC patients via quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry (IHC)...
February 8, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30720471/iatrogenic-disease-of-the-genitourinary-tract
#18
Helen P Cathro
Iatrogenic disease is defined as illness caused by diagnostic procedures or treatment given by health care professionals. More recently described treatment complications involving the genitourinary tract include newly recognized variants of renal carcinoma in the setting of dialysis/end-stage renal disease, treatment effect in genitourinary carcinomas, and medical renal disease caused by drug therapies, including immunotherapy. The objective of this review is to cover iatrogenic inflammatory diseases, pseudotumors and tumors of the kidney, bladder, prostate, testis and paratestis of most interest to surgical pathologists...
February 1, 2019: Advances in Anatomic Pathology
https://read.qxmd.com/read/30719704/multiregion-human-bladder-cancer-sequencing-reveals-tumour-evolution-bladder-cancer-phenotypes-and-implications-for-targeted-therapy
#19
Timon Heide, Angela Maurer, Monika Eipel, Katrin Knoll, Mirja Geelvink, Juergen Veeck, Ruth Knuechel, Julius van Essen, Robert Stoehr, Arndt Hartmann, Janine Altmueller, Trevor A Graham, Nadine T Gaisa
We present an evolutionary analysis of the relative time of genetic events underlying tumorigenesis in human bladder cancers from ten whole cystectomy specimens using multiregional whole exome sequencing. We timed bladder cancer drivers, mutational signatures, ploidy and copy number alterations, provided evidence for kataegis and correlated alterations with tumour areas and histological phenotypes. We found that: i) heterogeneous tumour areas/phenotypes had distinct driver mutations, ii) papillary-invasive tumours divided early into two parallel evolving branches, and iii) parallel evolution of subclonal driver mutations occurred...
February 4, 2019: Journal of Pathology
https://read.qxmd.com/read/30719635/probe-based-confocal-laser-endomicroscopy-during-transurethral-resection-of-bladder-tumors-improves-the-diagnostic-accuracy-and-therapeutic-efficacy
#20
Jongsoo Lee, Seong Uk Jeh, Dong Hoon Koh, Doo Yong Chung, Min Seok Kim, Hyeok Jun Goh, Joo Yong Lee, Young Deuk Choi
PURPOSE: This study was designed to assess the diagnostic accuracy and therapeutic efficacy of probe-based confocal laser endomicroscopy (pCLE), which provides real-time, in vivo histological information during transurethral resection of bladder tumors. METHODS: We performed a prospective study between August 2013 and August 2014. pCLE was performed on a total of 119 lesions in 75 patients. We analyzed the diagnostic accuracy of pCLE by comparing the confocal image reports with the pathology reports of surgical specimen...
February 4, 2019: Annals of Surgical Oncology
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