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Héla Toumi, Sami Abidli, Mustapha Bejaoui
Microplastic (MP) concentrations were determined, for the first time, in surface sediment of seven streams around the lagoon of Bizerte (Northern Tunisia), using a saturated NaCl flotation technique. Microplastics were categorised according to type, colour and size using a stereoscopic microscope. Results showed that all sediment samples contained MPs. The greatest MP abundance was observed at Jedara stream (6920 ± 395.98 items kg-1 dry weight), while the lowest mean value was 2340 ± 227.15 items kg-1 dry weight at Khima stream...
March 15, 2019: Environmental Science and Pollution Research International
Yusheng Wang, Xiaoqi Wang, Wei Lu, Qingpan Yuan, Yourong Zheng, Bo Yao
In this work, a thin film PET based gold electrode (PGE) glucose sensor was fabricated through ultraviolet mediated chemical plating technique. Compared with the most existing wearable thin film gold electrode sensors, the PGE-glucose sensor is simple, low cost and minimum instrumentation was required. The proposed glucose sensor revealed a sensitivity of 22.05 μA mM-1 cm-2 in a linear range from 0.02 to 1.11 mM with a low detection limit of 2.7 μM (S/N = 3). The PGE-glucose sensor had a good selectivity and was not interfered by lactic acid, urea, acetaminophen, uric acid, dopamine and ascorbic acid...
June 1, 2019: Talanta
M Negahdary, H Heli
An extremely sensitive and highly simple aptasensor was fabricated for quantitation of amyloid beta (Aβ) by electrochemical transduction of a fern leaves-like gold nanostructure. The gold nanostructure was synthesized by electrodeposition using polyethylene glycol 6000 as a shape-directing agent, and characterized electrochemically and by field emission scanning electron microscopy. A specific RNA aptamer was immobilized on the fern leaves-like gold nanostructure, and binding with Aβ was detected by the ferro/ferricyanide redox marker...
June 1, 2019: Talanta
J Guo, H Sun, W Lei, Y Tang, S Hong, H Yang, F R Tay, C Huang
Currently available drug delivery systems for oral diseases suffer from short retention time and poor local concentrations at the target site. A biodegradable stimulus-responsive hydrogel was synthesized in the present study to evaluate its application as an environmentally sensitive carrier for on-demand intraoral drug delivery. The hydrogel was synthesized from diacrylate-containing polyethylene glycol-based scaffolds and a cysteine-terminated peptide crosslinker (CGPQG↓IWGQC) via a Michael-type addition reaction...
March 15, 2019: Journal of Dental Research
Praveena Velpurisiva, Prakash Rai
Glioblastoma Multiforme is a deadly cancer of glial cells with very low survival rates. Current treatment options are invasive and have serious side effects. Single drug treatments make the tumor refractory after a certain period. Combination therapies have shown improvements in treatment responses against aggressive forms of cancer and are becoming a mainstay in the management of cancer. The purpose of this study is to design a combinatorial treatment regimen by engineering desired ratios of two different small molecule drugs (gefitinib and GSK461364A) in a single carrier that can reduce off-target effects and increase their bioavailability...
March 15, 2019: Journal of Clinical Medicine
Deyang Zhao, Frederic Delbecq, Christophe Len
A one pot-two step procedure for the synthesis of diethyl furan-2,5-dicarboxylate (DEFDC) starting from mucic acid without isolation of the intermediate furan dicarboxylic acid (FDCA) was studied. Then, the production of three different kinds of furan-based polyesters- polyethylene-2,5-furan dicarboxylate (PEF), polyhydropropyl-2,5-furan dicarboxylate(PHPF) and polydiglycerol-2,5-furandicarboxylate (PDGF)-was realized through a Co(Ac)₂·4H₂O catalyzed polytransesterification performed at 160 °C between DEFDC and a defined diol furan-based prepolymer or pure diglycerol...
March 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Anouchka Plan Sangnier, Romain Aufaure, Soshan Cheong, Laurence Motte, Bruno Palpant, Richard D Tilley, Erwann Guenin, Claire Wilhelm, Yoann Lalatonne
Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene glycol-functionalized bisphosphonates. The original structure shifted the optical absorption to infrared, revealing very efficient photothermal properties within the 2nd biological transparency window and leading to cancer cell necrosis at moderate intracellular doses and low (safe) laser power.
March 15, 2019: Chemical Communications: Chem Comm
Lin Zhu, Yuan-Yuan Gao, Bing Han, Yong-Lai Zhang, Hong-Bo Sun
Electrothermal actuators (ETAs) that can convert electric energy into mechanical works have been extensively studied for their great potential in artificial muscles and robotics. However, the production of ETAs that enable complex and predictable deformation is still challenging. In this Letter, an ETA based on reduced graphene oxide (RGO) and polyethylene (PE) bimorph is developed through a facile laser-scribing method. Since the laser-scribing technology permits flexible patterning, conductive RGO electrodes with complex circuit patterns can be readily produced on a thermally active PE film, forming an ETA capable of fast and reversible deformation...
March 15, 2019: Optics Letters
Chih-Kai Liao, Jasmine Phan, Maura Herrera, Mahmoud A Mahmoud
Polyethylene glycol (PEG) assembled on the surface of two-dimensional tungsten disulfide (WS2) into a limited number of nanoislands (NIs), nanoshell (NS), and granular nanoparticulates (GNPs) depending on its chain length. NIs assemblies showed a non-measurable shift of photoluminescence (PL) and the A and B absorption peaks of WS2. This confirmed that the electronic doping by thiol is not effective. PEG NS assembly displayed a smaller red-shift of the PL and a slight decrease of the energy difference between the A and B absorption peaks of WS2...
March 15, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Karthik Yadav Janga, Akshaya Tatke, Narendar Dudhipala, Sai Prachetan Balguri, Mohamed Moustafa Ibrahim, Doaa Nabih Maria, Monica M Jablonski, Soumyajit Majumdar
Short precorneal residence time and poor transocular membrane permeability are the major challenges associated with topical ocular drug delivery. In the present research, the efficiency of electrolyte triggered sol-to-gel forming system of natamycin (NT) transfersomes were investigated for enhanced and prolonged ophthalmic delivery. Transfersomes were optimized by varying the molar ratios of phospholipid, Span and tocopheryl polyethylene glycol succinate (TPGS). NT transfersome formulations (FN) prepared with a 1:1 molar ratio of phospholipid-to-Span and low levels of TPGS showed optimal morphometric properties and were, thus, selected to fabricate the in situ gelling system...
March 14, 2019: Journal of Pharmacology and Experimental Therapeutics
Pauline Pannetier, Jérôme Cachot, Christelle Clérandeau, Florian Faure, Kim Van Arkel, Luiz F de Alencastro, Clément Levasseur, Frédéric Sciacca, Jean-Pascal Bourgeois, Bénédicte Morin
Microplastics (MPs), are tiny plastic fragments from 1 μm to 5 mm generally found in the aquatic environment which can be easily ingested by organisms and may cause chronic physical but also toxicological effects. Toxicological assays on fish cell lines are commonly used as an alternative tool to provide fast and reliable assessment of the toxic and ecotoxic properties of chemicals or mixtures. Rainbow trout liver cell line (RTLW-1) was used to evaluate the toxicity of pollutants sorbed to MPs sampled in sandy beaches from different islands around the world during the first Race for Water Odyssey in 2015...
February 20, 2019: Environmental Pollution
N García-Romero, R Madurga, G Rackov, I Palacín-Aliana, R Núñez-Torres, A Asensi-Puig, J Carrión-Navarro, S Esteban-Rubio, H Peinado, A González-Neira, V González-Rumayor, C Belda-Iniesta, A Ayuso-Sacido
BACKGROUND: Extracellular vesicles (EVs) are small membrane-bound vesicles which play an important role in cell-to-cell communication. Their molecular cargo analysis is presented as a new source for biomarker detection, and it might provide an alternative to traditional solid biopsies. However, the most effective approach for EV isolation is not yet well established. RESULTS: Here, we study the efficiency of the most common EV isolation methods-ultracentrifugation, Polyethlyene glycol and two commercial kits, Exoquick® and PureExo® ...
March 11, 2019: Journal of Translational Medicine
Reem Khan, Sondes Ben Aissa, Tauqir A Sherazi, Gaelle Catanante, Akhtar Hayat, Jean Louis Marty
In the present work, an aptasensing platform was developed for the detection of a carcinogenic mycotoxin termed patulin (PAT) using a label-free approach. The detection was mainly based on a specific interaction of an aptamer immobilized on carbon-based electrode. A long linear spacer of carboxy-amine polyethylene glycol chain (PEG) was chemically grafted on screen-printed carbon electrodes (SPCEs) via diazonium salt in the aptasensor design. The NH₂-modified aptamer was then attached covalently to carboxylic acid groups of previously immobilized bifunctional PEG to build a diblock macromolecule...
March 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lukas Mai, Nils Boysen, David Zanders, Teresa de Los Arcos, Felix Mitschker, Bert Mallick, Guido Grundmeier, Peter Awakowicz, Anjana Devi
New precursor chemistries for the ALD of Al₂O₃ are reported as potential alternatives to the pyrophoric trimethylaluminum which is till date a widely used Al precursor. Combining the high reactivity of aluminum alkyls employing the 3- (dimethylamino)propyl (DMP) ligand with thermally stable amide ligands yielded three non-pyrophoric compounds [Al(NMe₂)₂(DMP)] , [Al(NEt₂)₂(DMP)] (BDEADA) and [Al(NiPr₂)₂(DMP)] that unify the properties of both ligand systems. The compounds are intramolecular stabilized and show only reactive Al-C and Al-N bonds, which are the key factors for the thermal stability accompanied by a sufficient reactivity...
March 14, 2019: Chemistry: a European Journal
Salma A Soudi, Mohamed I Nounou, Salah A Sheweita, Doaa A Ghareeb, Layla K Younis, Labiba K El-Khordagui
Berberine (BBR) exerts documented protection against neurodegenerative disorders. However, data on the effect of nano-encapsulation on the neuroprotective effect of BBR are lacking. We investigated the effect of BBR loading into chitosan (CS) nanoparticles (NPs) and their surface modification with Tween 80 (T80), polyethylene glycol 4000 (PEG), and miltefosine (MFS) against lipopolysaccharide (LPS)-induced neurodegenerative changes in addition to hepatotoxicity in rats. BBR-NPs were prepared by ionic gelation and characterized for morphology by transmission electron microscopy (TEM), colloidal properties, and entrapment efficiency (EE%)...
March 13, 2019: Drug Delivery and Translational Research
Lee B Sims, Keegan C Curry, Sindhu Parupalli, Gwynneth Horner, Hermann B Frieboes, Jill M Steinbach-Rankins
PURPOSE: Hypovascularization of cervical tumors, coupled with intrinsic and acquired drug resistance, has contributed to marginal therapeutic outcomes by hindering chemotherapeutic transport and efficacy. Recently, the heterogeneous penetration and distribution of cell penetrating peptide (CPP, here MPG) and polyethylene glycol (PEG) modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were evaluated as a function of tumor type and morphology in cervical cancer spheroids modeling hypovascularized tumor nodules...
March 13, 2019: Pharmaceutical Research
Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan, Ying Sun
Background : Platinum (II) (Pt(II))-based anticancer drugs dominate the chemotherapy field of ovarian cancer. However, the patient's quality of life has severely limited owing to dose-limiting toxicities and the advanced disease at the time of diagnosis. Multifunctional tumor-targeted nanosized ultrasound contrast agents (glutathione (GSH)-sensitive platinum (IV) (Pt(IV)) prodrug-loaded phase-transitional nanoparticles, Pt(IV) NP-cRGD) were developed for precise theranostics against ovarian cancer. Methods : Pt(IV) NP-cRGD were composed of a perfluorohexane (PFH) liquid core, a hybrid lipid-polymer shell with PLGA12k -PEG2k and DSPE-PEG1k -Pt(IV), and an active targeting ligand, the cRGD peptide (PLGA: poly(lactic-co-glycolic acid), PEG: polyethylene glycol, DSPE: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, cRGD: cyclic Arg-Gly-Asp)...
2019: Theranostics
Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Shitsuko Shimano, Michio Hagihara, Shuji Tohda, Takahiro Kameda, Minoru Tozuka
Cholesterol efflux capacity (CEC) in atherosclerotic lesions is the main anti-atherosclerotic function of high-density lipoprotein (HDL). In recent studies, apolipoprotein (apo) B-depleted serum (BDS) obtained with the polyethylene glycol precipitation method is used as a cholesterol acceptor (CA) substitution for HDL isolated by ultracentrifugation. However, the suitability of BDS as a CA is controversial. In the present study, CEC obtained from BDS was evaluated based on a parameter, defined as whole-CEC, which was calculated by multiplying CEC obtained using fixed amounts of HDL by cholesterol concentration to HDL-cholesterol (HDL-C) levels in the serum...
March 13, 2019: Bioscience Reports
Ibrahim A Ahmad, Hyun-Kyung Kim, Suleyman Deveci, R Vasant Kumar
In the published paper [¹], there was a typo error mistake in Equation (5), which was supposed to be expressed as " log Z t + n log t = log K T - m log Φ " instead of "log Zt + n log t = log K T - m l" [...].
March 7, 2019: Nanomaterials
Luan Zi Sun, Lu Liu, Mengyu Zhang, Liang Yang, Tongtian Guo
RATIONALE: The plant carbon stable isotope composition (δ13 C value) can reflect prolonged drought and salinity, as different isotopic signal resulting from drought and salinity can be retained in plant tissue. Commonly, drought and salinity are interrupted by intermittent precipitation or irrigation. It remains unclear whether the δ13 C values reflect the cumulative duration of intermittent drought or salinity stress. METHODS: Drought (5% and 10% polyethylene glycol) and salinity (35 mM and 85 mM NaCl) were imposed on annual ryegrass consistently or cyclically; throughout the treatments, the stress duration for cyclic drought/salinity was half that of the corresponding prolonged stress treatment...
March 13, 2019: Rapid Communications in Mass Spectrometry: RCM
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