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Preeclampsia and adiponectin

Suchitra Chandrasekaran, Hayley Hunt, Susan Melhorn, Hilary S Gammill, Ellen A Schur
OBJECTIVES: Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE), are associated with short- and long-term maternal health complications, and obesity is a leading attributable risk factor for HDP. Yet, most women identified as obese (by body mass index [BMI] ≥ 30 kg/m2 ) do not develop HDP, indicating limited predictability of BMI alone. In nonpregnant populations, increased visceral fat mass (VFM) is an obesity-associated phenotype increasing the risk for developing hypertension...
December 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
Matias C Vieira, Shahina Begum, Paul T Seed, Dania Badran, Annette L Briley, Carolyn Gill, Keith M Godfrey, Deborah A Lawlor, Scott M Nelson, Nashita Patel, Naveed Sattar, Sara L White, Lucilla Poston, Dharmintra Pasupathy
OBJECTIVE: To identify clinical and biomarker risk factors for preeclampsia in women with obesity and to explore interactions with gestational diabetes, a condition associated with preeclampsia. STUDY DESIGN: In women with obesity (body mass index ≥ 30 kg/m2 ) from the UK Pregnancies Better Eating and Activity Trial (UPBEAT), we examined 8 clinical factors (socio-demographic characteristics, BMI, waist circumference and clinical variables) and 7 biomarkers (HDL cholesterol, hemoglobin A1c, adiponectin, interleukin-6, high sensitivity C-reactive protein, and placental growth factor (PlGF)) in the early second trimester for association with later development of preeclampsia using logistic regression...
July 2018: Pregnancy Hypertension
Fatemeh Abdi, Zohreh Aghaie, Fatemeh Sadat Rahnemaie, Zainab Alimoradi
BACKGROUND: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first-trimester screening tests for preeclampsia. METHODS: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases...
2018: Current Hypertension Reviews
Matias C Vieira, Sara L White, Nashita Patel, Paul T Seed, Annette L Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Lucilla Poston, Dharmintra Pasupathy
BACKGROUND: All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification of maternal characteristics associated with normal pregnancy outcomes could assist in the management of these pregnancies. The present study aims to identify the factors associated with uncomplicated pregnancy and birth in obese women, and to assess their predictive performance...
November 3, 2017: BMC Medicine
Aya Mousa, Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Negar Naderpoor, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Helena J Teede, Barbora de Courten
SCOPE: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. METHODS AND RESULTS: In 102 overweight or obese pregnant women at high-risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12-15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB])...
November 2017: Molecular Nutrition & Food Research
Zeynep B Güngör, Hakan Ekmekçi, Abdullah Tüten, Sait Toprak, Gülsel Ayaz, Oktay Çalışkan, Hüseyin Sönmez, Rıza Madazlı, Orkide Donma, Mine Kucur, Turgut Ulutin, Özlem Balcı Ekmekçi
PURPOSE: Preeclampsia is a multisystem disorder and its etiology remains still unclear. Recent hypotheses rely on imbalance between angiogenic and antiangiogenic factors and disruption of endothelial function of spiral arteries. In addition; increased VTE (venous thromboembolism) risk is still unclear in preeclampsia. Our aim was to investigate the relationship between endothelial dysfunction, adipocytokines, platelet function, and vasculogenesis in preeclampsia. METHODS: Plasma angiogenic (PlGF, VEGF), antiangiogenic factors (sflt-1, endoglin) with adipocytokines (leptin, adiponectin, ghrelin), endothelial dysfunction markers (vWF, NO), and platelet function markers (ADP and collagen induced platelet aggregation, P-selectin) were examined in 30 early-onset, 22 late-onset preeclampsia, and 27 healthy pregnants...
September 2017: Archives of Gynecology and Obstetrics
Yingna Song, Jinsong Gao, Yimin Qu, Shu Wang, Xi Wang, Juntao Liu
BACKGROUND: Alterations in serum adipokines in preeclampsia remain vague. We investigated the roles of leptin, adiponectin and resistin and their relationships with clinical characteristics in normotensive and preeclamptic patients. METHODS: A case-control study was carried out in a cohort of 74 preeclampsia(PE) and 79 healthy pregnant women. Serum levels of leptin, adiponectin and resistin were measured by enzyme-linked immunosorbent assay. RESULTS: The mean body mass index(BMI), the serum leptin and resistin levels were significantly higher in the PE group than in the control group (p<0...
July 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ulrik Lausten-Thomsen, Michael Christiansen, Paula Louise Hedley, Jens-Christian Holm, Kjeld Schmiegelow
BACKGROUND: The etiology of childhood obesity and the associated morbidity is multifactorial. Recently, data suggesting a prenatal programming towards later childhood obesity and metabolic deregulation through the intrauterine environment has emerged. This study explored the concentrations of adipokines and their mutual relationship at birth in children born to non-diabetic mothers. METHODS: Adiponectin, leptin and sOB-R were measured using ELISA-based commercial kits in umbilical cord blood from 60 neonates (30 born large for gestational age [LGA] and 30 born appropriate for gestational age [AGA])...
January 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
S Daher, P A Akita, C M Tobinaga, K P T Pendeloski, B Y Gueuvoghlanian-Silva, M R Torloni, N Sass
INTRODUCTION: The pathogenesis of preeclampsia (PE) is complex and involves many mechanisms, including impaired placental angiogenesis. Endoglin (Eng) promotes angiogenesis, but in its soluble form (sEng) it is antiangiogenic and adiponectin has pro-angiogenic and anti-inflammatory effects on the endothelium. The combined analysis of these factors seems to better reflect maternal vascular damage. OBJECTIVES: We aimed to evaluate adiponectin and soluble endoglin levels, to analyze adiponectin (+45) gene polymorphism and its relation with adiponectin serum levels in patients with PE...
July 2012: Pregnancy Hypertension
J S R Machado, R C Cavalli, V C Sandrim, A C T Palei, L M Amaral, A C Bueno, S R R Antonini, J E Tanus Santos, G Duarte
INTRODUCTION: Adiponectin is involved in energy homeostasis by regulating glucose and lipid metabolism. Additionally, it presents anti-inflammatory and anti-atherosclerotic functions. Polymorphisms in adiponectin gene (ADIPOQ) can modulate the concentrations of adiponectin. The influence of these polymorphisms on the development of gestational hypertension (GH) and preeclampsia (PE) is unknown. OBJECTIVES: The aim of this work was to examine the influence of polymorphisms in the gene ADIPOQ on the development of gestational hypertension and preeclampsia...
July 2012: Pregnancy Hypertension
Satu Seppä, Raimo Voutilainen, Sirpa Tenhola
OBJECTIVE: To determine whether maternal preeclampsia influences insulin sensitivity (IS) or its biochemical markers in offspring. STUDY DESIGN: Sixty children born from a preeclamptic pregnancy (PRE) and 60 matched control subjects born from a normotensive pregnancy (non-PRE) were studied at age 12 years. IS was estimated using the Quantitative Insulin Sensitivity Check Index (QUICKI), and serum concentrations of adiponectin, leptin, insulin-like growth factor (IGF)-1, IGF-2, IGF-binding protein-1 (IGFBP-1), sex hormone-binding globulin, lipids, and casual blood pressure (BP) were measured...
July 2015: Journal of Pediatrics
Nibia Mariana Eleuterio, Ana C T Palei, Jackeline S Rangel Machado, Jose E Tanus-Santos, Ricardo C Cavalli, Valeria C Sandrim
OBJECTIVE: The aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them. METHODS: A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs. RESULTS: Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0...
April 2015: Pregnancy Hypertension
Ali Khosrowbeygi, Nahid Lorzadeh, Hassan Ahmadvand
BACKGROUND: The association between lipid peroxidation biomarkers and adipocytokines is hypothesized in preeclampsia but little is known about it. OBJECTIVE: he present study was undertaken to determine the association of lipid peroxidation biomarkers measured by the levels of 8-isoprostane and malondialdehyde with adipocytokines leptin and adiponectin in maternal serum of preeclamptic women. MATERIALS AND METHODS: A cross-sectional study was designed...
2011: Iranian Journal of Reproductive Medicine
José T Drost, Angela H E M Maas, Suzanne Holewijn, Leo A B Joosten, Jim van Eyck, Yvonne T van der Schouw, Jacqueline de Graaf
OBJECTIVE: Women with a history of preeclampsia are at increased risk for future cardiovascular disease. Determination of cardiovascular biomarkers may be useful to understand the pathophysiological mechanism of cardiovascular disease development in these women. METHODS: We performed an analysis in the Preeclampsia Risk EValuation in FEMales study, a retrospective cohort consisting of 339 women with a history of early preeclampsia and 332 women after normotensive pregnancy...
November 2014: Atherosclerosis
M S Weedon-Fekjær, Y Sheng, M Sugulle, G M Johnsen, F Herse, C W Redman, R Lyle, R Dechend, A C Staff
INTRODUCTION: miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS: We performed high-throughput sequencing of small RNAs in placenta from 72 well-defined patients: 23 early-onset preeclampsia (PE), 26 late-onset PE and 23 controls. The regulation of some miRNAs was confirmed on qRT-PCR...
September 2014: Placenta
Madhu Gupta, Malvika H Solanki, Prodyot K Chatterjee, Xiangying Xue, Amanda Roman, Neeraj Desai, Burton Rochelson, Christine N Metz
Inadequate magnesium (Mg) intake is a widespread problem, with over 50% of women of reproductive age consuming less than the Recommended Dietary Allowance (RDA). Because pregnancy increases the requirement for Mg and the beneficial effects of magnesium sulfate for preeclampsia/eclampsia and fetal neuroprotection are well described, we examined the outcomes of Mg deficiency during pregnancy. Briefly, pregnant Swiss Webster mice were fed either control or Mg-deficient diets starting on gestational day (GD) 6 through euthanasia on GD17...
August 14, 2014: Molecular Medicine
Tao Wang, Rong Zhou, Linbo Gao, Yanyun Wang, Changping Song, Yunhui Gong, Jin Jia, Wei Xiong, Li Dai, Lin Zhang, Huaizhong Hu
Early diagnosis and treatment of preeclampsia are essential for prevention of seizure development and fetus maturation. Although various methods have been developed for predicting or monitoring the onset of preeclampsia, a simple assay that can be used as a home or point of care test remains unavailable. We attempted to find a urinary protein that could be used as a biomarker for developing such a test. Urinary samples were collected from 124 preeclampsia and 135 healthy pregnant women for screening using a protein array technology and quantification by ELISA...
October 2014: Hypertension
Saeedeh Salimi, Farzaneh Farajian-Mashhadi, Anoosh Naghavi, Mojgan Mokhtari, Mahnaz Shahrakipour, Mohsen Saravani, Minoo Yaghmaei
AIM: This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia. METHOD: This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA). RESULTS: Maternal serum leptin and adiponectin were significantly higher in PE women than controls...
2014: Disease Markers
Clarissa M Tobinaga, Maria R Torloni, Bárbara Y Gueuvoghlanian-Silva, Karen P T Pendeloski, Patrícia A Akita, Nelson Sass, Silvia Daher
OBJECTIVE: To assess correlations between maternal serum levels of pro- and anti-angiogenic factors with uterine perfusion in women with early- compared with late-onset preeclampsia, and in healthy pregnant women. DESIGN: Case-control study. SETTING: Antenatal care clinic located within a hospital (São Bernardo do Campo, Brazil). POPULATION: We enrolled 54 preeclamptic and 54 healthy control women who were coming for routine ultrasound at 28-36 weeks' gestation...
May 2014: Acta Obstetricia et Gynecologica Scandinavica
Nibia Mariana Eleuterio, Ana C T Palei, Jackeline S Rangel Machado, Jose E Tanus-Santos, Ricardo C Cavalli, Valeria C Sandrim
Preeclampsia (PE) is a pregnancy-specific disease, directly related to high rates of maternal-fetal morbidity and mortality worldwide. Upregulation of anti-angiogenic factors (soluble fms-like tyrosine kinase-1; sFLT-1 and soluble endoglin; sENG) have been suggested to trigger the maternal endothelial dysfunction observed in PE. Studies focusing on the role of adiponectin and leptin, in normal pregnancy as well as in complicated pregnancies, have revelated interesting findings due to the vascular actions of such adipokines...
February 2014: Hypertension in Pregnancy
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