Ben Nichols, Anny Briola, Michael Logan, Jaroslav Havlik, Anna Mascellani, Konstantinos Gkikas, Simon Milling, Umer Zeeshan Ijaz, Christopher Quince, Vaios Svolos, Richard K Russell, Richard Hansen, Konstantinos Gerasimidis
BACKGROUND: Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead to therapy personalization and pretreatment optimization. OBJECTIVES: This study aimed to explore the ability of pretreatment parameters to predict fecal calprotectin (FCal) levels at EEN completion in a prospective study in children with CD. METHODS: In children with active CD, clinical parameters, dietary intake, cytokines, inflammation-related blood proteomics, and diet-related metabolites, metabolomics and microbiota in feces, were measured before initiation of 8 wk of EEN...
April 2024: American Journal of Clinical Nutrition