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https://read.qxmd.com/read/37781558/wilson-s-disease-presents-as-recurrent-hypokalemic-muscle-paralysis
#1
Mythri Shankar, Monica Nayaka, Kishan Aralapuram, Sreedhara C Gurusiddaiah
A 21-year-old euthyroid gentleman born to nonconsanguineous parents was diagnosed with bipolar affective disorder. He presented 4 years later with hypokalemic quadriparesis. On evaluation, he was found to have features of both proximal and distal renal tubular acidosis. Ophthalmologic examination by slit lamp confirmed the presence of the Kayser-Fleischer ring. The diagnosis of Wilson's disease was established with serum ceruloplasmin levels and 24-h urinary copper levels.Here is a rare clinical presentation of Wilson's disease in the form of hypokalemic muscle paralysis due to proximal renal tubular acidosis with distal tubule involvement...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/33786213/undiagnosed-wilson-s-disease-and-fibromyalgia-masking-bowel-perforation
#2
Tyler Culpepper, Amar H Kelkar
Wilson's disease is a complex multi-organ disease characterized by impaired biliary excretion of copper and resulting deposition of excess copper in the liver and other organs. It has a wide range of clinical presentations, and diagnosis often requires a high degree of clinical suspicion, especially in patients with multiple other comorbidities. We present the case of a 37-year-old woman with a complex medical and psychiatric history who was admitted for chronic diarrhea, hepatic enzyme elevation, electrolyte abnormalities, hyperammonemia, and methicillin-sensitive Staphylococcus aureus bacteremia...
February 23, 2021: Curēus
https://read.qxmd.com/read/33275389/commentary-on-a-new-onset-of-mania-in-a-49-year-old-man-an-interesting-case-of-wilson-disease
#3
JOURNAL ARTICLE
Amir Garakani
Wilson disease is a rare copper metabolism disorder that generally occurs in individuals between 5 and 35 years of age. Common clinical manifestations are hepatic, neurological, and psychiatric symptoms. Roughly, 4% of all cases occur in patients over 40 years of age and, among these patients, the presenting symptoms are generally neuropsychiatric, which often leads to misdiagnosis as a primary psychiatric disorder and a delay in correct diagnosis. This report presents the case of a 49-year-old man with no formal psychiatric history who presented with a new onset of mania...
November 2020: Journal of Psychiatric Practice
https://read.qxmd.com/read/33275388/a-new-onset-of-mania-in-a-49-year-old-man-an-interesting-case-of-wilson-disease
#4
JOURNAL ARTICLE
Silvia Sloan, Ryan T Dosumu-Johnson
Wilson disease is a rare copper metabolism disorder that generally occurs in individuals between 5 and 35 years of age. Common clinical manifestations are hepatic, neurological, and psychiatric symptoms. Roughly, 4% of all cases occur in patients over 40 years of age and, among these patients, the presenting symptoms are generally neuropsychiatric, which often leads to misdiagnosis as a primary psychiatric disorder and a delay in correct diagnosis. This report presents the case of a 49-year-old man with no formal psychiatric history who presented with a new onset of mania...
November 2020: Journal of Psychiatric Practice
https://read.qxmd.com/read/32445306/a-case-of-copper-deficiency-myeloneuropathy-precipitated-by-zinc-ingestion-and-bariatric-surgery
#5
JOURNAL ARTICLE
Jillian Draine, Matthew Simmons
In this report, we present a case of acquired copper deficiency which initially presented as progressive pain and numbness in the patient's lower extremities. The acquired copper deficiency is attributed to a previous bariatric surgery exacerbated by zinc toxicity. A 42-year-old female with a past medical history of type 2 diabetes mellitus, anemia, hypertension, bipolar disorder, attention deficit disorder, pulmonary embolus, fibromyalgia, migraine headaches, and chronic pain as well as a remote past surgical history of gastric bypass procedure presented with progressive pain and numbness in her lower extremities...
April 2020: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://read.qxmd.com/read/30513246/changes-in-cortical-protein-markers-of-iron-transport-with-gender-major-depressive-disorder-and-suicide
#6
JOURNAL ARTICLE
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
Objectives : The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. Methods : Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder ( n  = 13), bipolar disorder ( n  = 12) and age/sex matched controls ( n  = 13). Results : We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females...
February 2020: World Journal of Biological Psychiatry
https://read.qxmd.com/read/29611101/the-compensatory-immune-regulatory-reflex-system-cirs-in-depression-and-bipolar-disorder
#7
REVIEW
Michael Maes, Andre F Carvalho
Here, we review a novel concept namely the compensatory immune-regulatory reflex system (CIRS) as applied to the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). There is evidence that a substantial subset of individuals with MDD and BD exhibit an activation of the immune-inflammatory response system (IRS), as indicated by an increased production of macrophagic M1 and T helper (Th)-1 pro-inflammatory cytokines, interleukin (IL)-6 trans-signaling, positive acute phase proteins (APPs), and complement factors...
December 2018: Molecular Neurobiology
https://read.qxmd.com/read/23049615/quality-of-life-and-psychiatric-symptoms-in-wilson-s-disease-the-relevance-of-bipolar-disorders
#8
JOURNAL ARTICLE
Mg Carta, G Mura, O Sorbello, G Farina, L Demelia
INTRODUCTION: Wilson's disease is an inherited disorder caused by a gene located on chromosome 13, which involved copper transportation across cell membranes. The disease can cause a reduced incorporation of copper into ceruloplasmin resulting in accumulation of this metal in the liver, central nervous system, kidneys and other organs. The objective is to define the frequencies of psychiatric disorders in WD, the amount of impairment of Quality of Life [QoL] in patients with WD and the relevance of the psychiatric disorders in the QoL of people suffering by WD...
2012: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://read.qxmd.com/read/17659342/art-alpha-1-antitrypsin-polymorphisms-and-intense-creative-energy-blessing-or-curse
#9
JOURNAL ARTICLE
Donald Everett Schmechel
Persons heterozygous for Z, S and rare alpha-1-antitrypsin (AAT, SERPIN1A) polymorphisms (ca. 9% of population) are often considered 'silent' carriers with increased vulnerability to environmentally modulated liver and lung disease. They may have significantly more anxiety and bipolar spectrum disorders, nutritional compromise, and white matter disease [Schmechel DE, Browndyke J, Ghio A. Strategies for the dissection of genetic-environmental interactions in neurodegenerative disorders. Neurotoxicology 2006;27:637-57]...
September 2007: Neurotoxicology
https://read.qxmd.com/read/15354085/immunolocalization-and-regulation-of-iron-handling-proteins-ferritin-and-ferroportin-in-the-retina
#10
JOURNAL ARTICLE
Paul Hahn, Tzvete Dentchev, Ying Qian, Tracey Rouault, Z Leah Harris, Joshua L Dunaief
PURPOSE: CNS iron accumulation is associated with several neurodegenerative diseases, including age-related macular degeneration. Intracellular overload of free iron is prevented, in part, by the iron export protein, ferroportin, and the iron storage protein, ferritin. The purpose of this study was to assess retinal localization and regulation of ferroportin and ferritin. METHODS: Normal murine retinas were analyzed by immunohistochemistry to localize ferroportin, cytosolic ferritin, and mitochondrial ferritin, with double-labeling using cell-specific markers to identify cell types...
August 26, 2004: Molecular Vision
https://read.qxmd.com/read/11711858/altered-levels-of-reelin-and-its-isoforms-in-schizophrenia-and-mood-disorders
#11
JOURNAL ARTICLE
S H Fatemi, J L Kroll, J M Stary
Reelin is a secreted extracellular matrix protein approximately 410 kDa mol. wt that is reduced in brains of patients with schizophrenia, autism, bipolar disorder and major depression. Recent reports also indicate its near absence in sera of some patients with an autosomal recessive form of lissencephaly. Moreover, Reelin is involved not only in normal cortical lamination of the brain during mammalian embryogenesis but is also implicated in cell signaling systems subserving cognition in adult brain. Here, we show that blood levels of Reelin and its isoforms are altered in three psychiatric disorders, namely, schizophrenia, bipolar disorder and major depression...
October 29, 2001: Neuroreport
https://read.qxmd.com/read/10933485/psychiatric-symptoms-as-late-onset-of-wilson-s-disease-neuroradiological-findings-clinical-features-and-treatment
#12
JOURNAL ARTICLE
R Keller, R Torta, M Lagget, S Crasto, B Bergamasco
We describe a case of Wilson's disease with late psychiatric onset. Major depressive disorder was the first clinical manifestation at the age of 38 years. After pharmacotherapy with antidepressive agents, a manic episode was observed. Extrapyramidal hand tremor and micrography were the first neurological signs. Emotional lability occurred during worsening of extrapyramidal signs. Diagnosis was based on urinary and serum copper levels, ceruloplasmin serum level, Kayser-Fleischer ring, and liver biopsy that detected cirrhosis...
February 1999: Italian Journal of Neurological Sciences
https://read.qxmd.com/read/6943602/-genetic-markers-in-delusional-diseases-in-middle-age
#13
JOURNAL ARTICLE
V Lange
In the distribution of their serum groups the totality of 48 patients with paranoid psychoses of late onset is characterized by failure of the well-known markers of manic-depressive or schizophrenic illness. However, when differentiated psychopathologically, the haptoglobin (Hp) type 2-2 as a risk factor of cyclothymic psychoses is found to be significantly overrepresented in the patient group with a cyclic axis syndrome. On the other hand, an excess of Hp 1-1 can be observed and statistically confirmed in comparison with the population level among the patients offering a schizophrenic axis syndrome or resting unclassified...
1981: Psychiatria Clinica
https://read.qxmd.com/read/5143852/serum-proteins-in-acutely-psychotic-patients
#14
JOURNAL ARTICLE
E Bock, B Weeke, O J Rafaelsen
No abstract text is available yet for this article.
December 1971: Journal of Psychiatric Research
https://read.qxmd.com/read/2338328/-distribution-of-serum-haptoglobin-groups-in-affective-psychoses-more-than-a-genetic-marker-indication
#15
JOURNAL ARTICLE
V Lange
The haptoglobin serum group 2-2 has a preponderance in affective psychoses (p less than 0.0005). This genetic marker trait is extended on unipolar depressions (p less than 0.005) and cycloid psychoses (p less than 0.0005). In addition, it must be assumed that the serum levels of albumin (p less than 0.0001), ceruloplasmin (p less than 0.0001) and haptoglobin (p less than 0.0001) are increased in affective disorders. Besides, the transferrin serum values are decreased in cycloid psychoses (p less than 0.001)...
March 1990: Fortschritte der Neurologie-Psychiatrie
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