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Intravoxel incoherent motion

C C Wang, H B Dong, F Ding, Y D Li, G Y Wang, H X Ding
Objective: To investigate the value of multiple parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional arterial spin labeling (3D-ASL) in Ki-67 labeling index (Ki-67 LI) and grading of human brain gliomas. Methods: From December 2015 to May 2018, 45 patients of gliomas confirmed by surgical pathology in Li Huili Hospital, Ningbo Medical Center were divided into low-grade group (20 cases of WHO grade Ⅱ) and high-grade group (12 cases of WHO grade Ⅲ, 13 cases of WHO grade Ⅳ), and the Ki-67 LI of glioma was obtained by immunohistochemistry...
January 29, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Cheng-Cheng Liao, Yun-Ying Qin, Qi Tang, Xiao-Hong Tan, Qing Ke, Yan Rong, Jian-Hong Zhong, Le-Qun Li, Hong Cen
The diagnostic efficiency of diffusion-weighted magnetic resonance imaging with different b-values and application of an intravoxel incoherent motion (IVIM) model for differentiating disease states of lymphoma was investigated.Thirty-six patients at initial diagnosis and 69 after chemotherapy underwent diffusion-weighted magnetic resonance imaging (DW-MRI) with multiple b-values. Analysis parameters included the apparent diffusion coefficient (ADC) for each b-value. Standard ADC, D, D*, and f were calculated using an IVIM model...
February 2019: Medicine (Baltimore)
Motoshi Fujimori, Koichi Murakami, Hiroyuki Sugimori, Yutong Lu, Kenneth Sutherland, Nozomi Oki, Takatoshi Aoki, Tamotsu Kamishima
BACKGROUND: Postcontrast-enhanced MRI is currently the reference standard for synovial proliferation in rheumatoid arthritis (RA). However, the technique is somewhat invasive due to the use of gadolinium contrast agents, which may cause severe adverse/side effects. Intravoxel incoherent motion (IVIM) simultaneously permits quantification of perfusion as well as diffusion using a single imaging scan. PURPOSE/HYPOTHESIS: To test the capability of IVIM MRI for noninvasive discrimination of synovial proliferation in hand arthritis...
January 31, 2019: Journal of Magnetic Resonance Imaging: JMRI
Takeshi Fukuda, Kenneth Wengler, Ruben de Carvalho, Pattira Boonsri, Mark E Schweitzer
Although radiography continues to play a critical role in osseous tumor assessment, there have been remarkable advances in cross-sectional imaging. MRI has taken a lead in this assessment due to high tissue contrast and spatial resolution, which are well suited for bone lesion assessment. More recently, although somewhat lagging other organ systems, quantitative parameters have shown promising potential as biomarkers for osseous tumors. Among these sequences are chemical shift imaging (CSI), apparent diffusion coefficient (ADC), and intravoxel incoherent motion (IVIM) from diffusion-weighted imaging (DWI), quantitative dynamic contrast enhanced (DCE)-MRI, and magnetic resonance spectroscopy (MRS)...
January 30, 2019: Journal of Magnetic Resonance Imaging: JMRI
Jianye Liang, Rong Ma, Heru Chen, Dongmei Zhang, Wencai Ye, Changzheng Shi, Liangping Luo
OBJECTIVE: This study aimed to investigate the feasibility of intravoxel incoherent motion (IVIM) DWI and R2* (transverse relaxation rate) mapping to monitor the hyperacute therapeutic efficacy of desacetylvinblastine monohydrazide (DAVLBH) on an experimental hepatocellular carcinoma mouse model within 24 hours. MATERIALS AND METHODS: Forty-four mice were implanted with hepatocellular carcinoma and divided into three random groups. A treatment group and a control group underwent IVIM-DWI and R2* mapping examinations before and after a single injection of DAVLBH or saline at 1, 2, 4, and 24 hours...
January 30, 2019: AJR. American Journal of Roentgenology
Rasha S Hussein, Wahid Tantawy, Yasser A Abbas
Liver cirrhosis and hepatocellular carcinoma (HCC) constitute one of the major causes of morbidity, mortality, and high health care costs worldwide. Multiple treatment options are available for HCC depending on the clinical status of the patient, size and location of the tumor, and available techniques and expertise. Locoregional treatment options are multiple. The most challenging part is how to assess the treatment response by different imaging modalities, but our scope will be assessing the response to locoregional therapy for HCC by MRI...
January 29, 2019: Insights Into Imaging
Chung-Man Moon, Sang-Soo Shin, Suk-Hee Heo, Hyo-Soon Lim, Myeong-Ju Moon, Suchithra Poilil Surendran, Ga-Eon Kim, Il-Woo Park, Yong-Yeon Jeong
PURPOSE: The objective was to assess metabolic changes in different stages of liver fibrosis using hyperpolarized C-13 magnetic resonance spectroscopy (MRS) and metabolic imaging. PROCEDURES: Mild and severe liver fibrosis were induced in C3H/HeN mice (n = 14) by injecting thioacetamide (TAA). Other C3H/HeN mice (n = 7) were injected with phosphate buffer saline (PBS) (7.4 pH) as normal controls. Hyperpolarized C-13 MRS was performed on the livers of the mice, which was accompanied by intravoxel incoherent motion (IVIM) diffusion-weighted imaging with 12 b values...
January 28, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Rossano Girometti, Lorenzo Cereser, Filippo Bonato, Chiara Zuiani
Multiparametric magnetic resonance imaging (mpMRI) has become the standard of care to achieve accurate and reproducible diagnosis of prostate cancer. However, mpMRI is quite demanding in terms of technical rigour, patient's tolerability and safety, expertise in interpretation, and costs. This paper reviews the main technical strategies proposed as less-is-better solutions for clinical practice (non-contrast biparametric MRI, reduction of acquisition time, abbreviated protocols, computer-aided diagnosis systems), discussing them in the light of the available evidence and of the concurrent evolution of Prostate Imaging Reporting and Data System (PI-RADS)...
January 28, 2019: European radiology experimental
Xiao Yuan, Cui Yue, Mei Yu, Ping Chen, Pang Du, Chang-Hua Shao, Si-Chao Cheng, Ren-Jie Bian, Shao-Yu Wang, Wen Wang, Guang-Bin Cui
BACKGROUND: The fetal brain developmental changes of water diffusivity and perfusion has not been extensively explored. PURPOSE/HYPOTHESIS: To evaluate the fetal brain developmental changes of water diffusivity and perfusion using intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). STUDY TYPE: Prospective. POPULATION: Seventy-nine normal singleton fetuses were scanned without sedation of healthy pregnant women...
January 24, 2019: Journal of Magnetic Resonance Imaging: JMRI
Emma Metcalfe-Smith, Emma Meeus, Jan Novak, Hamid Dehghani, Andrew Peet, Niloufar Zarinabad
ObjectivObjective: A new method for fitting Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) data composed of an unknown number of multi-exponential components is presented and evaluated. METHODS: The Auto-regressive Discrete Acquisition Points Transformation (ADAPT) method is an adaption of the auto-regressive moving average system, which allows for the modelling of multi-exponential data and enables the estimation of the number of exponential components without prior assumptions...
January 24, 2019: IEEE Transactions on Bio-medical Engineering
Xin Xu, Xuening Zhang
OBJECTIVE: The aim of this study was to investigate the potential of intravoxel incoherent motion diffusion-weighted imaging in diagnosing hilar obstructive jaundice. METHODS: Fifty-nine patients diagnosed with hilar obstructive jaundice were enrolled in our hospital form January 2017 to January 2018. All the patients received scanning by a 3.0-T nuclear magnetic resonance scanner. The values of apparent diffusion coefficient (ADC)slow, ADCfast, and f were obtained and analyzed by 2 experienced radiologists...
January 17, 2019: Journal of Computer Assisted Tomography
Charlotte Debus, Ralf Floca, Michael Ingrisch, Ina Kompan, Klaus Maier-Hein, Amir Abdollahi, Marco Nolden
BACKGROUND: Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)/computed tomography (CT), apparent diffusion coefficient calculations and intravoxel incoherent motion modeling in diffusion-weighted MRI and Z-spectra analysis in chemical exchange saturation transfer MRI. Most available software tools are limited to a special purpose and do not allow for own developments and extensions...
January 16, 2019: BMC Bioinformatics
Xiangsheng Li, Shandong Wu, Dechang Li, Tao Yu, Hongxian Zhu, Yunlong Song, Limin Meng, Hongxia Fan, Lizhi Xie
BACKGROUND: The identification of hypoxia inducible factor (HIF-1α) expression is helpful for the quantitative assessment of tumor hypoxia. The application of multimodal imaging techniques may play a part in the assessment of HIF-1α expression of cervical carcinoma. PURPOSE: To investigate the correlations between multiple imaging parameters and HIF-1α expression of early cervical carcinoma and to determine whether tumor hypoxia can be predicted using multisequence imaging parameters...
January 16, 2019: Journal of Magnetic Resonance Imaging: JMRI
Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Ji Eun Park, Choong Gon Choi, Sang Joon Kim
BACKGROUND: Accurate preoperative differentiation of primary central nervous system lymphoma (PCNSL) and glioblastoma is clinically crucial because the treatment strategies differ substantially. PURPOSE: To evaluate the diagnostic performance of MRI for differentiating PCNSL from glioblastoma. STUDY TYPE: Systematic review and meta-analysis. SUBJECTS: Ovid-MEDLINE and EMBASE databases were searched to find relevant original articles up to November 25, 2018...
January 14, 2019: Journal of Magnetic Resonance Imaging: JMRI
Song Zeng, Lu Liang, Qiang Zhang, Yue Xu, Hao Tang, Zijian Zhang, Xiaodong Zhang, Tao Jiang, Xiaopeng Hu
PURPOSE: To assess the longitudinal changes of allograft pathophysiology by intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) MRI in a rat model of acute renal allograft rejection. MATERIALS AND METHODS: Acute rejection (AR) was induced by transplantation of Dark Agouti donor kidneys into Lewis recipients (n = 18). A Lewis-Lewis rat syngeneically transplanted (sTX) model served as the control (n = 6). Acute tubular necrosis (n = 6) and acute calcineurin inhibitor toxicity (n = 6) groups were established using Lewis rats...
January 7, 2019: Magnetic Resonance Imaging
Akio Ogura, Fumie Maeda, Seiji Yahata, Daisuke Koyama, Fumiya Tsunoda, Norio Hayashi, Shunichi Motegi, Kenichiro Yamamura
PURPOSE: Dynamic contrast enhancement (DCE)-MRI has high diagnostic performance of prostate cancer. However, it is preferable to avoid the use of MRI contrast media. A study reported that the diagnosability of the wash-in index of DCE-MRI was equivalent to the intravoxel incoherent motion of the diffusion weighted image. The purpose of this study was to examine the correlation between the slow component apparent diffusion coefficient (ADC) and the wash-out index of the DCE. MATERIALS AND METHODS: Thirty-eight patients diagnosed with prostate cancer by biopsy were enrolled in this study...
January 7, 2019: Magnetic Resonance Imaging
Pelin Aksit Ciris, Jr-Yuan George Chiou, Daniel I Glazer, Tzu-Cheng Chao, Clare M Tempany-Afdhal, Bruno Madore, Stephan E Maier
PURPOSE: The aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate. MATERIALS AND METHODS: An accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. The number of sampled diffusion weightings, or b-factors, was increased to allow estimation of tissue perfusion based on the intravoxel incoherent motion (IVIM) model...
December 19, 2018: Investigative Radiology
Chun-Yi Liang, Mao-Dong Chen, Xi-Xi Zhao, Cheng-Gong Yan, Ying-Jie Mei, Yi-Kai Xu
PURPOSE: To investigate whether the apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM), and stretched exponential model (SEM) based on histogram analyses derived from the whole-tumor volume combined with prognostic factors can be used to assess the response to chemotherapy and radiation therapy (CRT) in locally advanced rectal cancer (LARC). MATERIALS AND METHODS: This study included 60 patients with LARC who underwent diffusion-weighted imaging with 9b values (0-1000s/mm2 ) before CRT...
January 2019: European Journal of Radiology
Takuya Hino, Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Hiroshi Honda
In this study, we evaluated the efficacy of intravoxel incoherent motion (IVIM)-derived parameters calculated with three b-values in differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs) by comparing those calculated with multiple b-values. Ten patients with LGG (ages 35.1±12.1 yrs; 4 males, 6 females) and 21 patients with HGG (ages 60.6±19.1 yrs; 10 males, 11 females) who underwent subsequent surgical resections were examined with both IVIM imaging and histopathological analysis. The IVIM diffusion-weighted imaging was conducted using a single-shot echo planar sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, and 1000 sec/mm2) at 3T...
2018: PloS One
Harriet J Rogers, Martijn V Verhagen, Susan C Shelmerdine, Christopher A Clark, Patrick W Hales
OBJECTIVES: Volume of necrosis in Wilms tumour is informative of chemotherapy response. Contrast-enhanced T1 -weighted MRI (T1 w) provides a measure of necrosis using gadolinium. This study aimed to develop a non-invasive method of identifying non-enhancing (necrotic) tissue in Wilms tumour. METHODS: In this single centre, retrospective study, post-chemotherapy MRI data from 34 Wilms tumour patients were reviewed (March 2012-March 2017). Cases with multiple b value diffusion-weighted imaging (DWI) and T1 w imaging pre- and post-gadolinium were included...
December 17, 2018: European Radiology
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