keyword
https://read.qxmd.com/read/38505596/the-potential-of-circhipk3-as-a-biomarker-in-chronic-myeloid-leukemia
#1
REVIEW
Eduardo Wandame Gomez, Laura Berti De Paula, Rafael Diogo Weimer, Alessandra Helena da Silva Hellwig, Grazielle Motta Rodrigues, Ana Paula Alegretti, Jarbas Rodrigues de Oliveira
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by leukocytosis and left shift. The primary molecular alteration is the BCR::ABL1, chimeric oncoprotein with tyrosine kinase activity, responsible for the initial oncogenesis of the disease. Therapy of CML was revolutionized with the advent of tyrosine kinase inhibitors, but it is still not considered curative and may present resistance and serious adverse effects. Discoveries in CML inaugurated a new era in cancer treatment and despite all the advances, a new biomarker is needed to detect resistance and adverse effects...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38422649/qingjie-huagong-decoction-inhibits-pancreatic-acinar-cell-pyroptosis-by-regulating-circhipk3-mir-193a-5p-nlrp3-pathway
#2
JOURNAL ARTICLE
MinChao Feng, BaiJun Qin, Fang Luo, XiaoDong Zhu, KunRong Liu, Kai Li, DongYang Wu, GuoZhong Chen, XiPing Tang
BACKGROUND: Safer and more effective drugs are needed for the treatment of acute pancreatitis (AP). Qingjie Huagong decoction (QJHGD) has been applied to treat AP for many years and has shown good clinical effects. However, the potential mechanism has not yet been determined. PURPOSE: To investigate the role and underlying mechanism of the effects of QJHGD on AP both in vitro and in vivo. METHODS: QJHGD was characterized by UHPLC-Q-Orbitrap-MS...
December 7, 2023: Phytomedicine
https://read.qxmd.com/read/38342263/whole-transcriptome-analysis-of-longissimus-dorsi-muscle-in-cattle-yaks-reveals-the-regulatory-functions-of-adamts6-gene-in-myoblasts
#3
JOURNAL ARTICLE
Chun Huang, Fen Feng, Rongfeng Dai, Wenwen Ren, Xinyi Li, Ta Zhaxi, Xiaoming Ma, Xiaoyun Wu, Min Chu, Yongfu La, Pengjia Bao, Xian Guo, Jie Pei, Ping Yan, Chunnian Liang
Cattle-yak, which is the hybrid F1 generation of cattle and yak, demonstrates better production performance compared to yak. However, there is limited research on the molecular mechanisms responsible for the muscle development of cattle-yak. To address this knowledge gap, a comprehensive transcriptomic survey of the longissimus dorsi muscle in cattle-yak was conducted. Three transcript types, namely lncRNAs, miRNAs, and circRNAs, along with protein-coding genes were characterized at two developmental stages (6 m, 18 m) of cattle-yak...
February 9, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38205898/molecular-mechanism-of-circhipk3-in-mitochondrial-function-in-septic-acute-kidney-injury
#4
JOURNAL ARTICLE
Lili Tang, Jie Zhang, Jing Han, Danhong Zhang, Hongtao Zhang, Jun Liu, Xiaoyue Li
Cell senescence, glycolysis, and mitochondrial deficit jointly regulate the development of septic acute kidney injury (SAKI). This study aimed to explore the role of circular RNA HIPK3 (circHIPK3) in mitochondrial function in SAKI. The SAKI mouse model was established by Candida albicans infection, followed by Western blot assay, measurements of serum lactate, and adenosine triphosphate (ATP), 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimi-dazolylcarbocyanine iodide (JC-1) staining and flow cytometry. Human renal tubular epithelial cells were treated with lipopolysaccharide to establish the SAKI cell model, followed by cell counting kit-8 assay, tests of hexokinase activity, lactate production, oxygen consumption rate, extracellular acidification rate, ATP, and JC-1 staining, and Western blot assay...
January 11, 2024: Environmental Toxicology
https://read.qxmd.com/read/38116839/a-dna-octahedral-amplifier-for-endogenous-circrna-detection-and-bioimaging-in-living-cells-and-its-biomarker-study
#5
JOURNAL ARTICLE
Rong Feng, Shengrong Yu, Zhiling Qian, Yiming Wang, Gege Xie, Bingqian Li, Jingwen Chen, Yong-Xiang Wu, Keqi Tang
The discovery of reliable biomarkers is essential for early diagnosis, treatment, and prognosis assessment of diseases. Many research studies have shown that circRNA is a potential biomarker for diagnosis and prognosis of diseases. However, in situ monitoring circRNA in live cells is still a challenge at present, which brings a major limitation to the development and verification of circRNA as a disease biomarker. In this study, a catalytic hairpin assembly (CHA) reaction-based DNA octahedral amplifier (DOA) was developed for fluorescence resonance energy transfer (FRET) detection and bioimaging of circRNA in living cells...
December 20, 2023: Analyst
https://read.qxmd.com/read/38031987/association-between-circhipk3-mir-378a-3p-hdac4-axis-and-osteoporotic-fractures-a-comprehensive-investigation
#6
JOURNAL ARTICLE
Lei Wang, Zhen Sheng, Tao Yao
BACKGROUND: Osteoporotic fractures (OFs) are a significant public health issue, which can lead to pain and impaired mobility. The underlying mechanisms of OFs remain unclear, but recent studies have suggested that the circRNA-miRNA-mRNA pathway may play a crucial role. PURPOSE: This study aimed to investigate the potential involvement of the circHIPK3/miR-378a-3p/HDAC4 pathway in the pathogenesis of OFs. METHODS: We collected tissue and serum samples from 10 patients with OFs and 10 healthy controls...
2023: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/38029383/functional-relevance-of-circrna-aberrant-expression-in-pediatric-acute-leukemia-with-kmt2a-aff1-fusion
#7
JOURNAL ARTICLE
Caterina Tretti Parenzan, Anna Dal Molin, Giorgia Longo, Enrico Gaffo, Alessia Buratin, Alice Cani, Elena Boldrin, Valentina Serafin, Paola Guglielmelli, Alessandro M Vannucchi, Giovanni Cazzaniga, Andrea Biondi, Franco Locatelli, Lueder Hinrich Meyer, Barbara Buldini, Geertruij Te Kronnie, Silvia Bresolin, Stefania Bortoluzzi
Circular RNAs (circRNAs) are emerging molecular players in leukemogenesis and promising therapeutic targets. In KMT2A::AFF1 (MLL::AF4) rearranged leukemia, an aggressive disease compared to other pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), data about circRNAs are limited. Here we disclose the circRNA landscape of KMT2A::AFF1 translocated BCP-ALL infant patients, showing dysregulated, mostly ectopically expressed, circRNAs in leukemia cells. Most of these circRNAs, apart from circHIPK3 and circZNF609 previously associated with oncogenic behavior in ALL, are still uncharacterized...
November 29, 2023: Blood Advances
https://read.qxmd.com/read/38012555/circhipk3-relieves-vascular-calcification-via-mediating-sirt1-pgc-1%C3%AE-mfn2-pathway-by-interacting-with-fus
#8
JOURNAL ARTICLE
Siyi Feng, Youfei Qi, Zhanxiang Xiao, Hao Chen, Sahua Liu, Haimei Luo, Hongfei Wu, Wenbo Zhang
BACKGROUND: Circular RNAs (circRNAs) have been reported to regulate the biological processes of human diseases. CircHIPK3 has been implicated in vascular calcification, but the downstream regulatory mechanisms remain unclear. Our study aimed to understand the regulatory function of circHIPK3 in vascular calcification. METHODS: CircHIPK3 expression in atherosclerosis (AS) serum samples and vascular smooth muscle cells (VSMCs) calcification model was assessed by quantitative real-time polymerase chain reaction (qRT-PCR)...
November 27, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/37866205/extracellular-vesicle-derived-circhipk3-novel-diagnostic-biomarker-for-lung-cancer
#9
JOURNAL ARTICLE
Yingying Zhu, Li Shen, Qiuyan Xia, Heyun Tao, Zhanguo Liu, Mengdie Wang, Xiaomin Zhang, Jun Zhang, Jian Lv
PURPOSE: Lung cancer (LC) is a common malignancy worldwide. A great number of circular RNAs (circRNAs) have been identified that serve crucial roles in cancer development. Extracellular vesicles (EVs) and their contents have been shown to be biomarkers for the diagnosis and prognosis of LC. Thus, we intended to clarify the functional role of EVs-derived circRNA homology domain interacting protein kinase 3 (EVs-circHIPK3) and its underlying mechanism of action. MATERIAL AND METHODS: Bioinformatics analysis was performed to validate the potential of partially circulating HIPK3 in LC diagnosis...
October 20, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37745562/circhipk3-nucleates-igf2bp2-and-functions-as-a-competing-endogenous-rna
#10
Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup, Morten Muhlig Nielsen, Anne Kruse Hollensen, Mette Laugesen Graversgaard, Lasse Sommer Kristensen, Søren Vang, Samuel S Park, Gene W Yeo, Lars Dyrskjøt, Jørgen Kjems, Jakob Skou Pedersen, Christian Kroun Damgaard
Circular RNAs (circRNAs) represent a class of widespread endogenous RNAs that regulate gene expression and thereby influence cell biological decisions with implications for the pathogenesis of several diseases. Here, we disclose a novel gene-regulatory role of circHIPK3 by combining analyses of large genomics datasets and mechanistic cell biological follow-up experiments. Specifically, we use temporal depletion of circHIPK3 or specific RNA binding proteins (RBPs) and identify several perturbed genes by RNA sequencing analyses...
September 14, 2023: bioRxiv
https://read.qxmd.com/read/37688345/exosomal-circhipk3-derived-from-umbilical-cord-derived-mesenchymal-stem-cells-enhances-skin-fibroblast-autophagy-by-blocking-mir-20b-5p-ulk1-atg13-axis
#11
JOURNAL ARTICLE
Zhi-Yang Qiu, Shi-Shuai Lin, Nan-Fang Pan, Zhi-Hu Lin, Yun-Chuan Pan, Zun-Hong Liang
BACKGROUND: Umbilical cord-derived mesenchymal stem cells (UCMSCs) could alleviate diabetes-induced injury. Hence, this investigation aimed to explore the role and mechanism of UCMSCs-derived exosomal circHIPK3 (exo-circHIPK3) in diabetes mellitus (DM). METHODS: HFF-1 cells were cultured in high glucose (HG) medium or normal medium, and treated with UCMSCs-derived exo-circHIPK3 or miR-20b-5p mimics or Unc-51-like autophagy activating kinase 1 (ULK1) overexpression vector...
September 8, 2023: Journal of Diabetes Investigation
https://read.qxmd.com/read/37681455/perspectives-of-circular-rnas-in-diabetic-complications-from-biological-markers-to-potential-therapeutic-targets-review
#12
JOURNAL ARTICLE
Lingling Yuan, Jinsheng Duan, Hong Zhou
Chronic complications of diabetes increase mortality and disability of patients. It is crucial to find potential early biomarkers and provide novel therapeutic strategies for diabetic complications. Circular RNAs (circRNAs), covalently closed RNA molecules in eukaryotes, have high stability. Recent studies have confirmed that differentially expressed circRNAs have a vital role in diabetic complications. Certain circRNAs, such as circRNA ankyrin repeat domain 36, circRNA homeodomain‑interacting protein kinase 3 (circHIPK3) and circRNA WD repeat domain 77, are associated with inflammation, endothelial cell apoptosis and smooth muscle cell proliferation, leading to vascular endothelial dysfunction and atherosclerosis...
October 2023: Molecular Medicine Reports
https://read.qxmd.com/read/37631249/progress-in-circrna-targeted-therapy-in-experimental-parkinson-s-disease
#13
REVIEW
Simoneide Souza Titze-de-Almeida, Ricardo Titze-de-Almeida
Circular RNAs (circRNAs) are single-stranded RNA molecules often circularized by backsplicing. Growing evidence implicates circRNAs in the underlying mechanisms of various diseases, such as Alzheimer's and Parkinson's disease (PD)-the first and second most prevalent neurodegenerative disorders. In this sense, circSNCA, circHIPK2, circHIPK3, and circSLC8A1 are circRNAs that have been related to the neurodegenerative process of PD. Gain-of-function and loss-of-function studies on circRNAs have shed light on their roles in the pathobiology of various diseases...
July 28, 2023: Pharmaceutics
https://read.qxmd.com/read/37587318/bibliometric-analysis-of-global-research-on-circular-rna-current-status-and-future-directions
#14
JOURNAL ARTICLE
Lv Yehui, Li Zhihong, Tong Fang, Zeng Zixuan, Zhang Mengyuan, Yang Zhifang, Zhao Jiuhong
Circular RNAs (circRNAs) have gained significant attention in recent years. This bibliometric analysis aimed to provide insights into the current state and future trends of global circRNA research. The scientific output on circRNAs from 2010 to 2022 was retrieved from the Web of Science Core Collection with circRNA-related terms as the subjects. Key bibliometric indicators were calculated and evaluated using CiteSpace. A total of 7385 studies on circRNAs were identified. The output and citation number have increased rapidly after 2015...
August 16, 2023: Molecular Biotechnology
https://read.qxmd.com/read/37566605/circhipk3-contributes-to-cisplatin-resistance-in-gastric-cancer-by-blocking-autophagy-dependent-ferroptosis
#15
JOURNAL ARTICLE
Ziqi Shang, Zhengdong Luo, Yifeng Wang, Qi Liu, Yiwei Xin, Mengjiao Zhang, Xinyang Li, Shunjie Zeng, Longchen Yu, Xin Zhang, Yi Zhang
Cisplatin is the first-line chemotherapy for gastric cancer (GC). However, its efficacy is dampened by the development of chemoresistance, which leads to poor prognosis in GC patients. Recently, evidence has revealed that circular RNAs (circRNAs) and dysregulation of autophagy-dependent ferroptosis play critical roles in cancer chemoresistance. Herein, for the first time we report that circHIPK3 has a vital role in GC cisplatin resistance. CircHIPK3 regulated cisplatin resistance by targeting autophagy and ferroptosis...
August 11, 2023: Journal of Cellular Physiology
https://read.qxmd.com/read/37426414/development-of-a-circhipk3-based-cerna-network-and-identification-of-mrna-signature-in-breast-cancer-patients-harboring-brca-mutation
#16
JOURNAL ARTICLE
Qi-Xin Lian, Yang Song, Lili Han, Zunxian Wang, Yinhui Song
BACKGROUND: Exploring the regulatory network of competing endogenous RNAs (ceRNAs) as hallmarks for breast cancer development has great significance and could provide therapeutic targets. An mRNA signature predictive of prognosis and therapy response in BRCA carriers was developed according to circular RNA homeodomain-interacting protein kinase 3 (circHIPK3)-based ceRNA network. METHOD: We constructed a circHIPK3-based ceRNA network based on GSE173766 dataset and identified potential mRNAs that were associated with BRCA mutation patients within this ceRNA network...
2023: PeerJ
https://read.qxmd.com/read/37269429/circhipk3-negatively-regulates-autophagy-by-blocking-vcp-binding-to-the-beclin-1-complex-in-bladder-cancer
#17
JOURNAL ARTICLE
Chong Wang, Tiantian Liu, Jiawei Wang, Chao Cheng, Ze Zhang, Jingwei Zhang, Houbao Huang, Yawei Li
Circular RNA HIPK3 (circHIPK3) mediates the progression of multiple cancers, including bladder cancer, by regulating cell migration, autophagy and epithelial mesenchymal transition. However, the mechanism by which circHIPK3 regulates autophagy in bladder cancer cells remains unclear. Autophagy is a common self-protection mechanism in eukaryotic cells and is essential for cell survival and death regulation. However, it is unclear whether circHIPK3 affects the level of autophagy in bladder cancer through binding proteins, and the potential regulatory mechanism is unknown...
June 3, 2023: Discover. Oncology
https://read.qxmd.com/read/37253602/circular-rna-hipk3-facilitates-ferroptosis-in-gestational-diabetes-mellitus-by-regulating-glutathione-peroxidase-4-dna-methylation
#18
JOURNAL ARTICLE
Jinna Jiang, Haijie Gao, Weidong Zhou, Hongxia Cai, Liming Liao, Chenhong Wang
BACKGROUND: Gestational diabetes mellitus (GDM) is the most frequently occurring complication during pregnancy, with a high prevalence rate. Ferroptosis, a type of iron-dependent cell death, is closely associated with GDM nosogenesis. The present study aimed to examine the potential role and mechanism of circHIPK3 in GDM. METHODS: Placental tissues, plasma samples, and HTR-8/SVneo cells were used. A receiver operating characteristic curve was used to analyze the diagnostic value of circHIPK3 in GDM...
May 30, 2023: Journal of Gene Medicine
https://read.qxmd.com/read/36846202/circular-rna_hipk3-targeting-mir-93-5p-regulates-klf9-expression-level-to-control-acute-kidney-injury
#19
JOURNAL ARTICLE
Zha Zhengbiao, Chen Liang, Zheng Zhi, Pan Youmin
Acute kidney injury (AKI) is a clinical syndrome caused by various reasons that results in the rapid decline of renal function in a short period of time. Severe AKI can lead to multiple organ dysfunction syndrome. Circular RNA HIPK3 (circHIPK3) derived from the HIPK3 gene is involved in multiple inflammatory processes. The present research was performed to explore the function of circHIPK3 on AKI. The AKI model was established by ischemia/reperfusion (I/R) in C57BL/6 mice or hypoxia/reoxygenation (H/R) in HK-2 cells...
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/36769123/bmsc-derived-exosomal-circhipk3-promotes-osteogenic-differentiation-of-mc3t3-e1-cells-via-mitophagy
#20
JOURNAL ARTICLE
Shaoyang Ma, Sijia Li, Yuchen Zhang, Jiaming Nie, Jiao Cao, Ang Li, Ye Li, Dandan Pei
Exosome-based therapy is emerging as a promising strategy to promote bone regeneration due to exosomal bioactive cargos, among which circular RNA (circRNA) has recently been recognized as the key effector. The role of exosomal circRNA derived from bone marrow mesenchymal stem cells (BMSCs) has not been well-defined. The present study aimed to clarify the regulatory function and molecular mechanism of BMSC-derived exosomal circRNA in osteogenesis. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) were isolated and identified...
February 1, 2023: International Journal of Molecular Sciences
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