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Migraine OR Migraines

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https://read.qxmd.com/read/30771578/increased-cerebrospinal-fluid-neurofilament-light-chain-in-central-nervous-system-inflammatory-demyelinating-disease
#1
Lijun Peng, Chongfeng Bi, Deyu Xia, Linling Mao, Hairong Qian
BACKGROUND: Central nervous system (CNS) inflammatory demyelinating disease (IDD) is an immune-mediated disease that is pathologically characterized by demyelination and inflammatory infiltration in the CNS and includes clinically isolated syndrome (CIS), multiple sclerosis (MS), and neuromyelitis optica spectrum disorders (NMOSD). IDD is usually characterized by variable symptoms, multivariate imaging, uncertain reactions to treatment, and a variable prognosis, which makes it difficult to diagnose early...
February 8, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30771365/nitroglycerin-as-a-comparative-experimental-model-of-migraine-pain-from-animal-to-human-and-back
#2
REVIEW
Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Grazia Sances, Roberto De Icco, David Borsook, Cristina Tassorelli
Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack...
February 13, 2019: Progress in Neurobiology
https://read.qxmd.com/read/30770719/real-world-preventative-drug-management-of-migraine-among-spanish-neurologists
#3
D García-Azorin, S Santos-Lasaosa, A B Gago-Veiga, J Viguera Romero, A L Guerrero-Peral
BACKGROUND: Many different preventatives have showed efficacy in the treatment of migraine. National guidelines differ in their recommendations and patients' characteristics are usually taken into account in their selection. In Spain, real life use of preventive therapies seems to be heterogeneous. We aimed to evaluate differences in clinical practice and adherence to national guidelines among Spanish neurologists. METHODS: Observational descriptive study. A survey was conducted among neurologists ascribed to the Spanish Society of Neurology...
February 15, 2019: Journal of Headache and Pain
https://read.qxmd.com/read/30768945/mechanosensitive-meningeal-nociception-via-piezo-channels-implications-for-pulsatile-pain-in-migraine
#4
Nikita Mikhailov, Jarkko Leskinen, Ilkka Fagerlund, Ekaterina Poguzhelskaya, Raisa Giniatullina, Oleg Gafurov, Tarja Malm, Tero Karjalainen, Olli Gröhn, Rashid Giniatullin
BACKGROUND: Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain. However, the contribution of Piezo channels in migraine pathology was not tested yet. Therefore, in this study, we explored a potential involvement of Piezo channels in peripheral trigeminal nociception implicated in generation of migraine pain. METHODS: We used immunohistochemistry, calcium imaging, calcitonin gene related peptide (CGRP) release assay and electrophysiology in mouse and rat isolated trigeminal neurons and rat hemiskulls to study action of various stimulants of Piezo receptors on migraine-related peripheral nociception...
February 12, 2019: Neuropharmacology
https://read.qxmd.com/read/30768809/involvement-of-the-na-k-atpase-isoforms-in-control-of-cerebral-perfusion
#5
Christian Staehr, Rajkumar Rajanathan, Vladimir Matchkov
NEW FINDINGS: What is the topic of this review? This review considers the role of the Na,K-ATPase in cerebrovascular function and how it might be changed in familial hemiplegic migraine type 2 (FHM2). The primary focus will be involvement of the Na,K-ATPase isoforms in regulation of cerebrovascular tone. What advances does it highlight? The review discusses three overall distinct mechanisms whereby the Na,K-ATPase might be capable of regulating cerebrovascular tone. Furthermore, it discusses how changes in the Na,K-ATPase in cerebral arteries might affect brain perfusion and thereby be involved in the FHM2 pathology...
February 15, 2019: Experimental Physiology
https://read.qxmd.com/read/30767896/focal-visual-status-epilepticus
#6
Caspar Stephani, Walter Paulus, Niels K Focke
Epileptic visual auras are elementary to complex and sometimes occur as colourful visual phenomena located close to or within the central part of the contralateral hemi-field. They typically last from seconds to a few minutes, which discriminates them from the usually longer-lasting visual auras (5-30 minutes) of patients suffering from migraine. We present an adult patient with occipital lobe epilepsy whose visual aura under epilepsy monitoring lasted for more than 30 minutes with almost no propagation, demonstrating a rare, but remarkable, sustained local epileptic network activity associated with resection of an occipital arterio-venous malformation...
February 15, 2019: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/30765967/migraine-and-mood-disorders-prevalence-clinical-correlations-and-disability
#7
K Rammohan, Shyma Manikkoth Mundayadan, Soumitra Das, C Velayudhan Shaji
Introduction: Both migraine and mood disorders are prevalent disorders with many studies demonstrating that they are comorbid with each other with increased migraine-related disability in such patients. Aim: The aim of the study is to test the hypothesis that mood disorders are comorbid with migraine with increased disability and to identify any clinical features in migraineurs which may be associated with mood disorders. Materials and Methods: Patients presenting with complaints of headache to the Neurology Outpatient Department of a Tertiary CARE Hospital from August 01, 2016 to February 28, 2017, were subjected to International Classification of Headache Disorder 3 beta criteria to satisfy a diagnosis of migraine and were assessed in detail as to headache characteristics...
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30765961/anxiety-depression-and-its-relationship-with-migraine
#8
EDITORIAL
Vimal Kumar Paliwal
No abstract text is available yet for this article.
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30765959/migraine-and-mood-disorders-prevalence-clinical-correlations-and-disability
#9
EDITORIAL
Sita Jayalakshmi, Sudhindra Vooturi
No abstract text is available yet for this article.
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30764890/vitamins-and-minerals-for-migraine-prophylaxis-a-systematic-review-and-meta-analysis
#10
George N Okoli, Rasheda Rabbani, Hessam H Kashani, Aleksandra K Wierzbowski, Christine Neilson, Behzad Mansouri, Ryan Zarychanski, Ahmed M Abou-Setta
OBJECTIVE: To summarize the findings of randomized controlled trials (RCTs) on the efficacy and safety of vitamins and minerals for migraine prophylaxis. METHODS: We systematically searched bibliographic databases and relevant websites for parallel and crossover RCTs reporting efficacy and/or safety of vitamins and/or minerals for migraine prophylaxis. Our primary outcomes were migraine frequency (number of attacks) and duration (hours). Secondary outcomes were severity (intensity), days with migraine, and adverse events...
February 15, 2019: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/30764776/migraine-provoking-substances-evoke-periorbital-allodynia-in-mice
#11
Francesco De Logu, Lorenzo Landini, Malvin N Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti, Romina Nassini
BACKGROUND: Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks. Although migraine provoking substances are normally vasodilators, dilation of arterial vessels does not seem to be the sole contributing factor, and the underlying mechanisms of the delayed migraine pain are mostly unknown. Sustained mechanical allodynia is a common response associated with the local administration of various proalgesic substances in experimental animals and humans...
February 14, 2019: Journal of Headache and Pain
https://read.qxmd.com/read/30764753/the-effect-of-aerobic-exercise-on-the-number-of-migraine-days-duration-and-pain-intensity-in-migraine-a-systematic-literature-review-and-meta-analysis
#12
Joris Lemmens, Joke De Pauw, Timia Van Soom, Sarah Michiels, Jan Versijpt, Eric van Breda, René Castien, Willem De Hertogh
BACKGROUND: In patients with frequent migraine, prophylactic treatments are used. Patients often request non-pharmacological alternatives. One treatment option can be aerobic exercise. The value of aerobic exercise as prophylactic treatment however needs to be determined. METHODS: A systematic review and meta-analysis was performed to investigate the result of aerobic exercise on the number of migraine days, duration and pain intensity in patients with migraine...
February 14, 2019: Journal of Headache and Pain
https://read.qxmd.com/read/30764752/efficacy-of-psychological-treatment-for-headache-disorder-a-systematic-review-and-meta-analysis
#13
Hye Jeong Lee, Jin Hyeok Lee, Eun Young Cho, Sun Mi Kim, Seoyoung Yoon
BACKGROUND: Headache disorder is not only a common complaint but also a global burden. Pharmacotherapeutic and non-pharmacotherapeutic approaches have been developed for its treatment and prophylaxis. The present study included a systematic review of psychological treatments for primary headache disorder accessible in Korea. METHODS: We included English and Korean articles from EMBASE, MEDLINE, Cochrane library database, SCOPUS, ScienceDirect, Web of Science, CINAHL, PsycArticles and Korean database, KoreaMed and KMBASE which studied primary headache and medication-overuse headache...
February 14, 2019: Journal of Headache and Pain
https://read.qxmd.com/read/30763903/volume-alterations-of-brainstem-subregions-in-migraine-with-aura
#14
Igor Petrusic, Marko Dakovic, Jasna Zidverc-Trajkovic
BACKGROUND: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions. METHODS: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study...
February 4, 2019: NeuroImage: Clinical
https://read.qxmd.com/read/30763049/manipulative-therapies-what-works
#15
Michael Seth Smith, Jairo Olivas, Kristy Smith
Manipulative therapies include osteopathic manipulative treatment and many other forms of manual therapies used to manage a variety of conditions in adults and children. Spinal manipulative therapy may provide short-term improvement in patients with acute or chronic low back pain, comparable with other standard treatments. When compared with oral analgesics, cervical manipulation and/or mobilization appears to provide better short-term pain relief and improved function in patients with neck pain. Manipulative therapies may be as effective as amitriptyline for treating migraine headaches and can reduce the frequency and intensity of pain...
February 15, 2019: American Family Physician
https://read.qxmd.com/read/30762763/increased-risk-of-neurodegenerative-dementia-in-women-with-migraines-a-nested-case-control-study-using-a-national-sample-cohort
#16
Sang-Yeon Lee, Jae-Sung Lim, Dong Jun Oh, Il Gyu Kong, Hyo Geun Choi
The present study aimed to evaluate the association between migraines and dementia.Data were collected from 11,438 dementia participants who were 1:4 matched by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,752 controls from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Dementia was diagnosed using the International Classification of Disease-10 (ICD-10) codes (G30 or F00). For the integrity of diagnoses, we included only participants ≥60 years old who had been diagnosed with an ICD-10 code twice or more during ambulatory visits for the same episode...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762717/neurobiology-of-photophobia
#17
Rami Burstein, Rodrigo Noseda, Anne B Fulton
BACKGROUND: Photophobia is commonly associated with migraine, meningitis, concussion, and a variety of ocular diseases. Advances in our ability to trace multiple brain pathways through which light information is processed have paved the way to a better understanding of the neurobiology of photophobia and the complexity of the symptoms triggered by light. PURPOSE: The purpose of this review is to summarize recent anatomical and physiological studies on the neurobiology of photophobia with emphasis on migraine...
March 2019: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/30762716/headaches-in-idiopathic-intracranial-hypertension
#18
Deborah I Friedman
BACKGROUND: Headache is the most common symptom of idiopathic intracranial hypertension (IIH) and may not resolve with intracranial pressure-lowering treatments. Many patients with IIH have a pre-existing history of migraine. Approximately two-thirds of patients with IIH continue to experience headaches after the other manifestations of the disorder resolve. There are no evidence-based guidelines for treating IIH-related headaches. EVIDENCE ACQUISITION: This review proposes mechanisms by which IIH produces both acute and ongoing headache...
March 2019: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/30762715/migraine-the-disease-of-the-year
#19
Deborah I Friedman, Kathleen B Digre
No abstract text is available yet for this article.
March 2019: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/30762208/retinal-vascular-density-evaluation-of-migraine-patients-with-and-without-aura-and-association-with-white-matter-hyperintensities
#20
Mahmut Oğuz Ulusoy, Bahriye Horasanlı, Ali Kal
Underlying pathophysiological mechanism of migraine is not all clear; however, recent reports suggested that neurovascular system is involved. We aimed to evaluate the retinal vessel densities of migraine patients with and without aura and the associations with white matter hyperintensities (WMH), using optical coherence tomography angiography (OCTA). We recruited 28 migraine with aura (MWA) patients, 26 migraine without aura (MWO) and age and sex-matched 34 healthy controls in our study. All participants were evaluated with optical coherence tomography (OCT) and OCTA for optic nerve parameters and retinal vessel densities with RTVue XR AVANTI...
February 14, 2019: Acta Neurologica Belgica
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