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https://read.qxmd.com/read/30758705/review-of-the-management-of-pediatric-post-concussion-syndrome-a-multi-disciplinary-individualized-approach
#1
REVIEW
Mitul Kapadia, Alison Scheid, Eric Fine, Rachel Zoffness
PURPOSE OF REVIEW: Post-concussion syndrome (PCS), when the patient's concussion symptoms last longer than 4-6 weeks, affects 10-30% of concussion patients. PCS presents a significant source of morbidity to patients and a management challenge to providers. In this review, we present the current evidence and best management approaches for pediatric PCS. RECENT FINDINGS: There is limited high-quality evidence in pediatric PCS. There is some evidence supporting pharmaceutical management of post-traumatic headaches, cognitive symptoms, and emotional symptoms...
February 13, 2019: Current Reviews in Musculoskeletal Medicine
https://read.qxmd.com/read/30758229/dolutegravir-rilpivirine-dual-antiretroviral-therapy-for-the-treatment-of-hiv-1-infection
#2
E Kelly Hester, Kevin Astle
OBJECTIVE: To review the efficacy and safety of dolutegravir (DTG) with rilpivirine (RPV) as a dual therapy regimen in the treatment of HIV-1 infection. DATA SOURCES: A literature search was performed using PubMed (1966 to January 2019) and Google Scholar (2014 to January 2019) with the search terms dolutegravir, rilpivirine, dual, and switch. Other resources included review articles and the manufacturer product label. STUDY SELECTION AND DATA EXTRACTION: All relevant English-language articles of studies assessing the efficacy and safety of switch therapy to DTG with RPV and review articles were included...
February 13, 2019: Annals of Pharmacotherapy
https://read.qxmd.com/read/30756467/active-trigger-points-are-associated-with-anxiety-and-widespread-pressure-pain-sensitivity-in-women-but-not-men-with-tension-type-headache
#3
Margarita Cigarán-Méndez, Carmen Jiménez-Antona, Paula Parás-Bravo, Stella Fuensalida-Novo, Jorge Rodríguez-Jiménez, César Fernández-de-Las-Peñas
BACKGROUND: A better understanding of gender differences can assist clinicians in further developing therapeutic programs in tension type headache (TTH). OBJECTIVE: To evaluate gender differences in the presence of trigger points (TrPs) in the head, neck, and shoulder muscles and their relationship with headache features, pressure pain sensitivity, and anxiety in people with TTH. METHODS: Two hundred and ten (59 men, 151 women) TTH patients participated...
February 13, 2019: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/30756374/cough-headache-in-a-patient-with-an-intradiploic-leptomeningeal-cyst-a-case-report
#4
Tamara Y Heijkoop, Sebastiaan Hammer, Hille Koppen
No abstract text is available yet for this article.
February 13, 2019: Headache
https://read.qxmd.com/read/30756078/posterior-reversible-encephalopathy-syndrome-and-azathioprine
#5
Sara Vilas-Boas, Ana Corte-Real
Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. A 27-year-old woman, with mixed connective tissue disease under azathioprine, was admitted in the emergency room in status epilepticus and with severe hypertension...
2019: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/30755423/posterior-reversible-encephalopathy-syndrome-due-to-hypercalcaemia-a-rare-cause
#6
Nandakrishna Bolanthakodi, Sudha Vidyasagar, Muralidhar Varma, Avinash Holla
Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey et al in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism...
February 11, 2019: BMJ Case Reports
https://read.qxmd.com/read/30755384/pulmonary-nodules-in-a-patient-with-giant-cell-arteritis
#7
D Pinho Dos Santos, J P Fonseca, V Romão, J Capelo, A Carragoso
Giant Cell Arteritis (GCA) is a common systemic vasculitis that involves medium and large arteries, most frequently extracranial branches of the carotid artery. Prompt diagnosis and treatment is essential to prevent devastating complications, such as blindness, stroke and aortic aneurysm or dissection. Typical symptoms include headache, temporal artery tenderness and jaw claudication. On rare occasions patients present with complaints related to pulmonary involvement. These include interstitial infiltration, pulmonary nodules, pleural effusion and pulmonary haemorrhage...
February 9, 2019: Pulmonology
https://read.qxmd.com/read/30755178/melioidosis-with-a-subdural-collection-a-case-report
#8
H L P Amarasena, F H D S Silva, P M Y I Tilakaratna, S F Jayamanne, U K Ranawaka
BACKGROUND: Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions and abscesses, and can present with varied clinical manifestations. Melioidosis involving the central nervous system is uncommon. CASE PRESENTATION: A 42-year-old Sri Lankan male with type 2 diabetes presented with a febrile illness of 6 days with headache and constitutional symptoms...
February 12, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30753168/a-unique-androgen-excess-signature-in-idiopathic-intracranial-hypertension-is-linked-to-cerebrospinal-fluid-dynamics
#9
Michael W O'Reilly, Connar Sj Westgate, Catherine Hornby, Hannah Botfield, Angela E Taylor, Keira Markey, James L Mitchell, William J Scotton, Susan P Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C Gilligan, Mark Sherlock, James Gibney, Jeremy W Tomlinson, Gareth G Lavery, David J Hodson, Wiebke Arlt, Alexandra J Sinclair
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison to sex-, body mass index- and age-matched control groups with either simple obesity and PCOS, i...
February 12, 2019: JCI Insight
https://read.qxmd.com/read/30747787/reduction-in-head-computed-tomography-ordering-in-pediatric-emergency-patients-effect-of-national-publication-and-local-availability-of-urgent-neurology-appointments
#10
David Leo Jolley, Bryan Upham, Lynne Fullerton, Robert D Annett
OBJECTIVE: The objective of this study was to evaluate the effect of the Pediatric Emergency Care Applied Research Network (PECARN) blunt head trauma guidelines and implementation of urgent neurology follow-up (UNF) appointments on an observed decline in head computed tomography (CT) use for pediatric emergency department (PED) patients presenting with headache, seizure, and trauma. METHODS: Patients ages 0 to 18 years presenting to and discharged from an urban tertiary care PED with chief complaint of trauma, headache, and seizure between 2007 and 2013 were retrospectively included...
February 8, 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30747332/hypertrophic-chronic-pachymeningitis-associated-with-epstein-barr-virus-reactivation-a-case-report
#11
Raffaele Nardone, Francesco Brigo, Markus Covi, Luca Carnicelli, Francesca Caleri, Hannes Tischler, Larissa Hauer, Johann Sellner
Hypertrophic pachymeningitis is a rare inflammatory condition characterized by the thickening of the dura mater. We describe a patient who presented with intractable headache and complex cranial nerve palsy. Hypertrophy of the frontal dura was accompanied by pleocytosis and detection of Epstein-Barr virus (EBV) by PCR in cerebrospinal fluid. Clinical symptoms gradually improved after acyclovir and corticosteroid treatment, whereas dural pathology remained unchanged on neuroimaging. This case points at an expansion of the spectrum of neurological manifestations for EBV...
February 11, 2019: Journal of Neurovirology
https://read.qxmd.com/read/30747288/protean-neurologic-manifestations-of-two-rare-dermatologic-disorders-sweet-disease-and-localized-craniofacial-scleroderma
#12
REVIEW
Asya I Wallach, Cynthia M Magro, Andrew G Franks, Lee Shapiro, Ilya Kister
PURPOSE OF REVIEW: To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea). RECENT FINDINGS: Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. A variety of steroid-sparing treatments and biologics have been used for relapsing NSD...
February 12, 2019: Current Neurology and Neuroscience Reports
https://read.qxmd.com/read/30746014/convexity-subarachnoid-hemorrhage-secondary-to-adalidumab-in-a-patient-with-ulcerative-colitis
#13
Lucrecia Bandeo, Astrid Rausch, Miguel Saucedo, Anibal Chertcoff, Luciana Leon Cejas, Claudia Uribe Roca, Sol Pacha, Manuel Fernandez Pardal, Ricardo Reisin, Pablo Bonardo
The TNF-α antagonists are the drugs used for the treatment of ulcerative colitis (UC). Nontraumatic convexity subarachnoid hemorrhage is an infrequent nonaneurysmal subtype of subarachnoid bleeding caused mainly by reversible cerebral vasoconstriction syndrome (RCVS), cerebral amyloid angiopathy, and posterior reversible encephalopathy syndrome (PRES). We present a 26-year-old female patient with a diagnosis of UC taking Adalimumab. She received her last doses the same day she was admitted to our hospital for an acute severe UC exacerbation...
November 2018: Journal of Vascular and Interventional Neurology
https://read.qxmd.com/read/30746013/primary-intraventricular-hemorrhage-isolated-in-cerebral-aqueduct-secondary-to-dural-arteriovenous-fistula
#14
Elanagan Nagarajan, Keerthivaas Premkumar, Priyadarshee Patel, Adnan I Qureshi, Premkumar C Nattanmai
Objective: We report a case of dural arteriovenous fistula (dAVF) presenting as isolated cerebral aqueduct hemorrhage. Result: A 73-year-old man with a history of hypertension and chronic alcoholism presented with altered mental status and gait difficulties, bilateral fronto-occipital headaches, and intermittent dizziness. He had bilateral upward gaze restriction. Computerized tomography scan showed hyperdensity in the cerebral aqueduct and dilation of the lateral and third ventricles...
November 2018: Journal of Vascular and Interventional Neurology
https://read.qxmd.com/read/30746007/multiple-exostoses-syndrome-and-basilar-artery-aneurysm-a-case-report
#15
Avraam Ploumis, Andreas Liampas, Michail Angelidis, Areti Theodorou, Vasilios Xydis, Ioannis Gelalis, Peter Zampakis, Vasilios Panagiotopoulos
Background: Hereditary multiple exostoses (HME) is an inherited genetic condition, characterized by the formation of multiple osteochondromas, developing throughout childhood and into puberty. Vascular complications associated with HME are uncommon. Methods: A case of a patient with HME who was admitted to hospital with subarachnoid hemorrhage (SAH), as a result of acute rupture of a basilar tip aneurysm (BTA), will be presented. Relevant literature on this topic will be systematically reviewed...
November 2018: Journal of Vascular and Interventional Neurology
https://read.qxmd.com/read/30745260/inter-ictal-assay-of-peripheral-circulating-inflammatory-mediators-in-migraine-patients-under-adjunctive-cervical-non-invasive-vagus-nerve-stimulation-nvns-a-proof-of-concept-study
#16
Shafqat R Chaudhry, Ilana S Lendvai, Sajjad Muhammad, Philipp Westhofen, Johannes Kruppenbacher, Lukas Scheef, Henning Boecker, Dirk Scheele, Rene Hurlemann, Thomas M Kinfe
OBJECTIVE: To assay peripheral inter-ictal cytokine serum levels and possible relations with non-invasive vagus nerve stimulation (nVNS) responsiveness in migraineurs. METHODS: This double-blinded, sham-controlled study enrolled 48 subjects and measured headache severity, frequency [headache days/month, number of total and mild/moderate/severe classified attacks/month], functional state [sleep, mood, body weight, migraine-associated disability] and serum levels of inflammatory markers [inter-ictal] using enzyme-linked immunoassays at baseline and after 2 months of adjunctive nVNS compared to sham stimulation and suitably matched controls...
January 19, 2019: Brain Stimulation
https://read.qxmd.com/read/30745198/spontaneous-intracranial-and-lumbar-subdural-hematoma-presenting-as-vaginal-pain
#17
Lindsay A Weiner, Adam C Richardson, Semhar Z Tewelde
BACKGROUND: Spontaneous spinal and intracranial subdural hematomas are rarely reported, especially occurring simultaneously. Anticoagulation use has been associated with spontaneous hemorrhages. Prompt diagnosis is required to prevent permanent neurological sequelae. In this case report, we describe a spontaneous spinal and intracranial subdural hematoma in a woman taking warfarin and initially presenting with severe vaginal pain. CASE REPORT: A 42-year-old woman who had a history of mechanical valve replacement and was therefore taking warfarin, came to an emergency department for relief of severe vaginal pain...
February 8, 2019: Journal of Emergency Medicine
https://read.qxmd.com/read/30745196/bedside-transorbital-ultrasound-in-the-clinical-evaluation-of-pediatric-optic-neuritis-in-the-emergency-department
#18
Junaidah Badron, Gene Yong-Kwang Ong
BACKGROUND: Headache and monocular visual disturbance are worrisome pediatric presenting complaints in the emergency department. Appropriate and timely initial evaluation is critical. Most would opt for urgent computer tomography in such cases. Pediatric optic neuritis is a rare condition and is better evaluated by magnetic resonance imaging. With the increase in the use and scope of bedside ultrasound, there might be a potential role for transorbital ultrasound to be part of the emergency department evaluation of pediatric optic neuritis...
February 8, 2019: Journal of Emergency Medicine
https://read.qxmd.com/read/30744958/chiari-malformations-in-adults-a-single-center-surgical-experience-with-special-emphasis-on-the-kinetics-of-clinical-improvement
#19
S Y Elhadji Cheikh Ndiaye, L Troude, M Al-Falasi, M Faye, A Melot, P-H Roche
BACKGROUND: The Chiari malformation type I (CM-I) is the most commonly found type in adults. The efforts to further improve the treatment offered for these malformations are hampered by the existence of controversial methods and the absence of a uniform scoring system to evaluate clinical outcomes. OBJECTIVES: The goal of our study is to analyze the clinical and radiological data concerning patients operated for CM and to expose surgical techniques. PATIENTS AND TREATMENT: This is a retrospective study concerning patients of more than 16 years of age, operated on (from 2000 to 2016) in our institution...
February 8, 2019: Neuro-Chirurgie
https://read.qxmd.com/read/30744594/the-use-of-quetiapine-in-treatment-of-acute-psychotic-symptoms-in-an-adolescent-patient-with-primary-brain-calcification-a-case-report
#20
Barbara Plemeniti Tololeski, Maruša Debeljak, Mirjana Perkovič Benedik, Tristan Rigler, Marinos Kyriakopoulos, Primož Kotnik, Katarina Šurlan Popovič, Maja Drobnič Radobuljac
BACKGROUND: Primary brain calcification (PBC), a neurodegenerative disorder with characteristic calcium deposits in the basal ganglia and other brain areas, typically presents with various neurological and psychiatric symptoms in the fourth or fifth decade of life or later. We present the case of a patient with psychiatric manifestations much earlier than usual, in the second decade of life. CASE PRESENTATION: The case of an adolescent female with acute psychotic symptoms, emotional instability, disorganized and suicidal behavior, stereotypical movements, below average intelligence and a three-year history of headaches is reported...
February 11, 2019: BMC Psychiatry
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