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"traumatic Brain Injury"

Andreea Rădoi, Maria A Poca, Darío Gándara, Lidia Castro, Mauricio Cevallos, Maria E Pacios, Juan Sahuquillo
Self-report measures, particularly symptom inventories, are critical tools for identifying patients with persistent post-concussion symptoms and their follow-up. Unlike in military or sports-related assessment, in general civilian settings pre-injury levels of concussion-like symptoms are lacking. Normative data are available in adolescent and college populations, but no reference data exist to guide clinical adult explorations. The purpose of this study was to use the second edition of the Sport Concussion Assessment Tool (SCAT2) to profile a cohort of 60 healthy community volunteers who had not sustained a head injury...
2019: PloS One
Erica L Epstein, Sarah L Martindale, Va Mid-Atlantic Mirecc Workgroup, Holly M Miskey
Around half of Iraq and Afghanistan war veterans with traumatic brain injury (TBI) have co-occurring posttraumatic stress disorder (PTSD). Research on the differences between male and female veterans with co-occurring PTSD/TBI is sparse. This study evaluated behavioral health differences between sexes with these conditions. Veterans (N = 1577) completed a structured psychiatric interview, TBI interview, and self-report interviews assessing sleep quality, alcohol use, substance use, pain, depression symptoms, PTSD symptoms, and combat exposure...
January 31, 2019: Psychiatry Research
Ji-Yao Jiang, Guo-Yi Gao, Jun-Feng Feng, Qing Mao, Li-Gang Chen, Xiao-Feng Yang, Jin-Fang Liu, Yu-Hai Wang, Bing-Hui Qiu, Xian-Jian Huang
China has more patients with traumatic brain injury (TBI) than most other countries in the world, making this condition a major public health concern. Population-based mortality of TBI in China is estimated to be approximately 13 cases per 100 000 people, which is similar to the rates reported in other countries. The implementation of various measures, such as safety legislation for road traffic, establishment of specialised neurosurgical intensive care units, and the development of evidence-based guidelines, have contributed to advancing prevention and care of patients with TBI in China...
March 2019: Lancet Neurology
Humain Baharvahdat, Babak Ganjeifar, Hamid Etemadrezaie, Mohammad Farajirad, Samira Zabihyan, Ashkan Mowla
Background: Enoxaparin was shown to have a neuroprotective effect in animal models as well as a human study following traumatic brain injury. This study was conducted to assess the effect of enoxaparin on the clinical outcome of severe traumatic brain injury (TBI) and its safety. Methods: This study is a randomized double-blinded placebo-controlled trial. The inclusion criteria were age 16-70, a closed head injury, a postresuscitation Glasgow Coma Scale (GCS) between 5 and 8, and a latency time between the injury and entering the study of less than 5 h...
2019: Surgical Neurology International
Jingjing Liu, Xin Xiong, Yutong Sui
OBJECTIVES: Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. This study aims to investigate the potential effects of isoliquiritigenin on neuroinflammation in a rat model of TBI. METHODS: The SH-SY5Y cells were subjected to cell injury induced by shear stress and the effect of isoliquiritigenin on cell apoptosis was measured...
February 15, 2019: Neuroimmunomodulation
Kasim L Qureshi, Rachel Upthegrove, Emma Toman, Vijay Sawlani, David James Davies, Antonio Belli
OBJECTIVES: To estimate the prevalence of post-traumatic stress disorder (PTSD) in a large civilian population with traumatic brain injury (TBI), and to assess whether brain injury severity is correlated with PTSD symptoms. DESIGN: Observational, cross-sectional study. SETTING AND PARTICIPANTS: Outpatient clinic in a major UK trauma centre and secondary care hospital. Estimates of PTSD prevalence are based on 171 sampled individuals attending TBI clinic within an 18-month period...
February 19, 2019: BMJ Open
Sarianna Ilmaniemi, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
BACKGROUND: Injuries caused by falling are a major health concern among older population. For older people, falls are the leading cause of head injuries; especially, persons with cognitive disorders have an increased risk of falling. OBJECTIVE: To compare the incidence of head injury and traumatic brain injury (TBI) among persons with Alzheimer's disease (AD) with persons without AD. METHODS: This register-based study was conducted on a nationwide cohort, which includes all community-dwelling persons diagnosed with AD in Finland in 2005-2011...
February 19, 2019: Journal of Epidemiology and Community Health
Ameeta Retzer, Grace M Turner, Anita Slade, Derek Kyte, Christel McMullan, Laura Jones, Antonio Belli, Melanie Calvert
INTRODUCTION: Traumatic brain injury (TBI) represents a major health and socioeconomic problem internationally. The expansive nature of injuries results in a heterogeneous population. The degree and type of long-term impacts following TBI and improvement following injury are highly variable. The use of electronic Patient Reported Outcomes Measures (ePROMs) could help identify residual impacts of TBI and support patient management and care. The Patient Reported Outcomes Research in Trauma study is a qualitative study exploring the long-term symptoms and impacts that are experienced by those with TBI and the potential utility of an ePROM platform to collect real-time information on patient symptoms and quality of life to inform treatment and identify support needs...
January 25, 2019: BMJ Open
Jerrold B Leikin
No abstract text is available yet for this article.
February 16, 2019: Disease-a-month: DM
Wei-Jun Lin, Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
Aim: Use the National Health Insurance Research Database of Taiwan to determine whether patients with posttraumatic epilepsy (PTE) have an increased risk of mortality. Methods: Patients ≥20 years old ever admitted because of head injury (per International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 850⁻854 and 959.01) during 2000⁻2012 were enrolled into a traumatic brain injury (TBI) cohort. The TBI cohort was divided into with PTE (ICD-9-CM code 345) and posttraumatic nonepilepsy (PTN) cohorts...
February 18, 2019: International Journal of Environmental Research and Public Health
Gabrielle Lalonde, Annie Bernier, Cindy Beaudoin, Jocelyn Gravel, Miriam H Beauchamp
There is emerging evidence that parent-child interactions are affected by early childhood traumatic brain injury (TBI). These findings are of functional importance when considering the high prevalence of TBI in early childhood alongside evidence that young children exposed to positive relationships with their parents early in life exhibit better social functioning concurrently and longitudinally. Given that the overall quality of parent-child interactions is the result of both parent and child emotional and behavioural dispositions, it remains unclear which parental or child-related factors contribute to the quality of interactions post-TBI...
February 19, 2019: Journal of Neuropsychology
N N Zavadenko, Yu E Nesterovskiy, A A Kholin, I S Vorobyeva
Traumatic brain injury (TBI) clinical course and outcomes in children have peculiarities as the damage impacts brain, which growth and maturation are continuing. Thus, TBI interferes into normal processes of neuroontogenesis leading to negative consequences on the cognitive functions development, school education, social skills acquisition. Cognitive and behavioral disorders in children and adolescents in the long-term period of TBI become more prominent in co-occurrence with paroxysmal disorders, including posttraumatic headaches, posttraumatic epilepsy and subclinical epileptiform activity on the EEG...
2019: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Doug King, Patria A Hume, Natalie Hardaker, Alan Pearce, Cloe Cummins, Trevor Clark
AIM: To provide epidemiological data and related costs to the national health insurance scheme for traumatic brain injury (TBI) in New Zealand. METHOD: A retrospective analytical review utilising detailed descriptive minor and moderate-to-severe epidemiological TBI data obtained from the Accident Compensation Corporation (ACC) for 2012-2016. Injuries were analysed by three levels of increasing severity: moderate, moderate-to-serious (MSC) and severe claims categories...
February 12, 2019: Journal of the Neurological Sciences
Simon Driver, Shannon Juengst, Evan Elizabeth McShan, Monica Bennett, Kathleen Bell, Rosemary Dubiel
Weight gain is prevalent among people with traumatic brain injury (TBI) and may be attributable to environmental or injury-specific factors such as mobility impairment, endocrine dysfunction, behavioral and emotional disorders, and sensory loss. Few weight management programs exist to meet the unique needs of this population. Researchers modified a nationally recognized, evidence-based weight-loss program, Group Lifestyle Balance™ (GLB), to address the needs of over-weight and obese people post TBI (GLB-TBI)...
June 2019: Contemporary Clinical Trials Communications
Hui He, Xiufang Li, Yuling He
Background: Given that the therapeutic effect of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) has been debated for a long time, it is necessary to clarify the mechanism underlying the effect of HBO on acute TBI. Methods: This study investigated the effect of HBO therapy on neuronal apoptosis induced by acute TBI using the mouse model of TBI. The number of apoptotic cells and expression of apoptosis-associated factors (including caspase 3, pAkt/Akt, pGSK3β/GSK3β, and β-catenin) in pericontusional cortices of mice exposed to sham, TBI, and TBI + HBO treatment were measured and analyzed using TUNEL assay, quantitative reverse-transcription PCR, and Western blot...
2019: Neuropsychiatric Disease and Treatment
Jessica Dennis, Aaron Michael Yengo-Kahn, Paul Kirby, Gary S Solomon, Nancy J Cox, Scott L Zuckerman
Post-concussion syndrome (PCS) is characterized by persistent cognitive, somatic, and emotional symptoms after a mild traumatic brain injury (mTBI). Genetic and other biological variables may contribute to PCS etiology, and the emergence of biobanks linked to electronic health records (EHR) offers new opportunities for research on PCS. We sought to validate the use of EHR data of PCS patients by comparing two diagnostic algorithms deployed in the Vanderbilt University Medical Center de-identified database of 2...
February 16, 2019: Journal of Neurotrauma
Samer S Hoz, Ali A Dolachee, Husain A Abdali, Hidetoshi Kasuya
PURPOSE: We report a series of 29 pediatric patients who sustained head injuries due to metallic ceiling fans. They all were admitted to the Emergency Department of Neurosurgery Teaching Hospital in Baghdad, Iraq, during January 2015 to January 2017. RESULTS: Pediatric ceiling fan head injuries are characterized by four traits which distinguish them from other types of head injuries; 1- Most of them were because of climbing on or jumping from furniture between the ages of two and five...
February 18, 2019: British Journal of Neurosurgery
Seyed Saeed Ahmadisoleymani, Samy Missoum
This article introduces a new approach for the construction of a risk model for the prediction of Traumatic Brain Injury (TBI) as a result of a car crash. The probability of TBI is assessed through the fusion of an experiment-based logistic regression risk model and a finite element (FE) simulation-based risk model. The proposed approach uses a multilevel framework which includes FE simulations of vehicle crashes with dummy and FE simulations of the human brain. The loading conditions derived from the crash simulations are transferred to the brain model thus allowing the calculation of injury metrics such as the Cumulative Strain Damage Measure (CSDM)...
February 18, 2019: Computer Methods in Biomechanics and Biomedical Engineering
Shu-Jun Lin, Yu-Juan Zhang, Ji-Huan Lin, Yi-Min Zhang, Ming-Min Zhu, Yu-Qing Zhang, Liu Pu, Shu-Lian Chen, Wei-Hao Chen, Shao-Bing Cheng
OBJECTIVE: To observe the effect of acupuncture on activities of microglia in traumatic brain injury (TBI) rats. METHODS: Fifty-four male SD rats were randomly and equally divided into normal control, model and acupuncture groups according to the random number table ( n =18 rats in each group). The TBI model was established by using a free fall brain injury striking device after exposing the local cranial bone (to induce the left parietal cerebral contusion). Acupoints "Baihui" (GV20), "Shuigou" (GV26), "Fengfu" (GV16), "Yamen" (GV15) and bilateral "Hegu" (LII4) were stimulated intensively by twirling the filiform needles with force at a range of >360° and a frequency of 160-180 cycles/min for 10 sec in every acupoint, once every 5 min during the 15 minutes' needle retaining...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
Luciano Giromini, Fernando Barbosa, Giulia Coga, Andreia Azeredo, Donald J Viglione, Alessandro Zennaro
This study tested whether combining the Inventory of Problems - 29 (IOP-29) with the Test of Memory Malingering (TOMM) would increase sensitivity in the detection of experimentally feigned mental health problems, compared to using either test alone. Additionally, it also evaluated (a) the effects of administration order of these two tests and (b) the cultural and linguistic applicability of these tests to a European Portuguese population. The IOP-29 and TOMM were administered to a community sample of 100 nonclinical, adult volunteers from Portugal, with the instruction to feign mental health problems...
February 17, 2019: Applied Neuropsychology. Adult
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