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https://read.qxmd.com/read/30758871/lipid-loses-and-barrier-function-modifications-of-the-brown-to-white-hair-transition
#1
Marc A Oliver, Meritxell Marti, Luisa Coderch, Victor Carrer, Martin Kreuzer, Clara Barba
BACKGROUND: The main objective of this study was to determine the lipid profile of brown and white Caucasian hair fibres and the effects of lipids on the properties of fibres. MATERIALS AND METHODS: To determine the structures of white and brown hair lipid bilayers, cross sections of fibres of both hair types were examined using synchrotron-based μ-FTIR mapping. Dynamic vapour sorption (DVS) analyses were also performed to determine the differences in the barrier function of both fibres...
February 13, 2019: Skin Research and Technology
https://read.qxmd.com/read/30758400/allele-and-haplotype-frequencies-of-human-platelet-and-leukocyte-antigens-in-platelet-donors
#2
Valeria de Freitas Dutra, Carolina Bonet Bub, Thiago Henrique Costa, Leandro Dinalli Santos, Eduardo Peres Bastos, Maria Giselda Aravechia, José Mauro Kutner
OBJECTIVE: To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. METHODS: We included 867 healthy unrelated volunteer donors who donated platelets between January 2011 and December 2014. Microarray genotyping was performed using a BeadChip microarray. Medium resolution typing of the human leukocyte antigen at loci A and B was carried out using sequence-specific oligonucleotide probe hybridization...
February 7, 2019: Einstein
https://read.qxmd.com/read/30755773/a-novel-mutation-in-the-adult-onset-alexander-s-disease-gfap-gene
#3
Dhillon B Zaver, Nathan T Douthit
The case describes a 25-year-old Caucasian female diagnosed with Alexander's disease (AxD) as an outpatient after extensive inpatient workup. Her presenting complaints included incontinence, clumsiness, seizures, dysphagia, and dysarthria. She was also found to have pancytopenia and dysautonomia. A full neurologic and hematologic workup yielded very little results, until a thorough literature search of her presenting complaints and radiologic findings pointed to adult-onset Alexander's Disease. Alexander's disease is a rare genetic leukodystrophy with a broad variety of presentations...
2019: Case Reports in Medicine
https://read.qxmd.com/read/30755371/are-mmp3-mmp8-and-timp2-gene-variants-associated-with-anterior-cruciate-ligament-rupture-susceptibility
#4
Ewelina Lulińska-Kuklik, Masouda Rahim, Waldemar Moska, Ewelina Maculewicz, Mariusz Kaczmarczyk, Agnieszka Maciejewska-Skrendo, Krzysztof Ficek, Pawel Cieszczyk, Alison V September, Marek Sawczuk
OBJECTIVES: Anterior cruciate ligament rupture (ACLR) is a common and severe knee injury which typically occurs as a result of sports participation, primarily via a non-contact mechanism. A number of extrinsic and intrinsic risk factors, including genetics, have been identified thus far. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs) play a crucial role in extracellular matrix remodeling of ligaments and therefore the genes encoding MMPs and TIMPs are plausible candidates for investigation with ACL rupture risk...
January 29, 2019: Journal of Science and Medicine in Sport
https://read.qxmd.com/read/30753726/maternal-bmi-peripheral-deiodinase-activity-and-plasma-glucose-relationships-among-caucasian-women-in-the-hapo-study
#5
James E Haddow, Boyd E Metzger, Geralyn Lambert-Messerlian, Elizabeth Eklund, Donald Coustan, Patrick Catalano, Glenn E Palomaki
Purpose: Explore maternal BMI relationship with peripheral deiodinase activity further. Examine associations between deiodinase activity, glucose and C-peptide. Consider findings in historical context of related existing literature. Methods: Identify fasting plasma samples and selected demographic, biophysical, and biochemical data from a subset of 600 randomly selected non-Hispanic Caucasian women recruited in the Hyperglycemia Adverse Pregnancy Outcomes (HAPO) study, all with glucose tolerance testing [545 samples sufficient to measure thyrotropin (TSH), free thyroxine (fT4), and triiodothyronine (T3)]...
February 11, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30753301/association-between-antipsychotics-and-all-cause-mortality-among-community-dwelling-older-adults
#6
Raya Elfadel Kheirbek, Ali Fokar, John T Little, Marshall Balish, Nawar M Shara, Malaz A Boustani, Maria Llorente
Background: Antipsychotics are prescribed to treat various symptoms in older adults, however, their safely in this context has not been fully evaluated. The objective was to evaluate mortality risks associated with off- label use of antipsychotics among older adults with no pre-existing mental illness or dementia relative to those with diagnosis of dementia. Methods: Data (2007-2015) were derived from Department of Veterans Affairs registries for 730,226 patients (≥65 years) with no baseline serious mental illness, dementia)...
February 11, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30747611/comparison-of-serum-vitamin-d-levels-in-relation-to-bowel-and-bladder-symptoms-in-women-with-vulvar-diseases
#7
Carolyn W Swenson, Megan O Schimpf, Stacy B Menees, Hope K Haefner, Mitchell B Berger
OBJECTIVES: We sought to investigate associations between vitamin D levels and bowel and bladder disorders in women with vulvar diseases. METHODS: This is a planned sub-analysis of a cross-sectional study comparing the prevalence of bowel and bladder symptoms in women with biopsy-proven vulvar lichen sclerosus (LS) to a control group of women with non-lichenoid vulvar diseases. All subjects were recruited from a tertiary referral vulvar care clinic in a university-based practice...
February 12, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://read.qxmd.com/read/30747489/drug-coated-balloon-versus-uncoated-percutaneous-transluminal-angioplasty-for-the-treatment-of-atherosclerotic-lesions-in-the-superficial-femoral-and-proximal-popliteal-artery-2-year-results-of-the-mdt-2113-sfa-japan-randomized-trial
#8
Osamu Iida, Yoshimitsu Soga, Kazushi Urasawa, Shigeru Saito, Michael R Jaff, Hong Wang, Hiroko Ookubo, Hiroyoshi Yokoi
OBJECTIVES: To assess the longer-term safety and efficacy of the IN.PACT Admiral (MDT-2113) drug-coated balloon (DCB) for the treatment of de novo and non-stented restenotic lesions in the superficial femoral and/or proximal popliteal arteries versus uncoated percutaneous transluminal angioplasty (PTA) in a Japanese cohort. BACKGROUND: Although DCBs are the newest endovascular strategy for patients with peripheral artery disease presenting with femoropopliteal lesions, there remains a paucity of results in non-Caucasian populations...
February 12, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30747356/child-effects-on-lability-in-parental-warmth-and-hostility-moderation-by-parents-internalizing-problems
#9
Melissa A Lippold, Gregory M Fosco, Andrea Hussong, Nilam Ram
Research documents that lability in parent-child relationships-fluctuations up and down in parent-child relationships-is normative during adolescence and is associated with increased risk for negative outcomes for youth. Yet little is known about factors that predict lability in parenting. This study evaluated whether children's behaviors predicted lability in parent-child relationships. Specifically this study tested whether youth maladjustment (delinquency, substance use, internalizing problems) in Grade 6 was associated with greater lability (e...
February 11, 2019: Journal of Youth and Adolescence
https://read.qxmd.com/read/30747355/plenty-of-fish-in-the-ocean-how-do-traits-reflecting-resiliency-moderate-adjustment-after-experiencing-a-romantic-breakup-in-emerging-adulthood
#10
Lucia F O'Sullivan, Kathleen Hughes, France Talbot, Rice Fuller
Breakups are common but often one of the most distressing experiences that young people can have. Poor adjustment to relationship loss is linked to depressive symptoms and rumination. This study assessed traits that reflect resiliency and that might comprise protective factors that ameliorate depressive symptoms and rumination. Online survey participants included 866 male and female late adolescents (18-22 years; Mean age = 20.7; 62% female; 82% White/Caucasian; 7% Asian/Southeast Asian; 6% Black/African American) who recently had experienced the breakup of a romantic relationship...
February 11, 2019: Journal of Youth and Adolescence
https://read.qxmd.com/read/30746965/evidence-based-psychosocial-interventions-for-ethnic-minority-youth-the-10-year-update
#11
Armando A Pina, Antonio J Polo, Stanley J Huey
This is the official update on the status of evidence-based psychosocial interventions for ethnic minority youth. Compared to a decade ago, there has been expansion of well-designed intervention studies, growth in the number (not type) of interventions meeting evidence-based criteria, and greater focus on testing ethnicity/race moderator effects. In terms of standard of evidence, 4 psychosocial interventions are now well-established and 10 are probably efficacious or possibly efficacious, with most protocols drawing on cognitive and behavioral change procedures and/or family systems models...
February 12, 2019: Journal of Clinical Child and Adolescent Psychology
https://read.qxmd.com/read/30745254/high-sensitivity-troponin-i-for-cardiovascular-risk-stratification-in-the-general-asymptomatic-population-perspectives-from-asia-pacific
#12
Carolyn S P Lam, Rafael Castillo, Dung Thuong Ho, Ravi R Kasliwal, Rohit Khurana, Sudhir Naik, Torbjørn Omland, William Anthony Parsonage, Arintaya Phrommintikul, Daniel Tobing, Kelvin Kai Hang Yiu
Cardiac troponin is a sensitive and specific biomarker for acute myocardial injury and has been used in the diagnosis of acute coronary syndromes, and has emerged as a tool for identifying high risk individuals for primary preventive therapy. Recent evidence has emerged indicating that high-sensitivity cardiac troponin assays, which allow robust detection of very low troponin concentrations, could detect subclinical injury in asymptomatic patients. On 24 March 2018, a group of cardiologists from the Asia Pacific region convened to review the data and discuss the potential utility of high-sensitivity troponin I (hsTnI) in the risk assessment of cardiovascular disease in the general population...
February 1, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30744707/old-residents-and-new-arrivals-of-rhagoletis-species-in-europe
#13
A A Augustinos, C A Moraiti, E Drosopoulou, I Kounatidis, P Mavragani-Tsipidou, K Bourtzis, N T Papadopoulos
The genus Rhagoletis (Diptera: Tephritidae) comprises more than 65 species distributed throughout Europe, Asia and America, including many species of high economic importance. Currently, there are three Rhagoletis species that infest fruits and nuts in Europe. The European cherry fruit fly, Rhagoletis cerasi (may have invaded Europe a long time ago from the Caucasian area of West Asia), and two invasive species (recently introduced from North America): the eastern American cherry fruit fly, R. cingulata, and the walnut husk fly, R...
February 12, 2019: Bulletin of Entomological Research
https://read.qxmd.com/read/30744680/analysis-of-two-birth-tissues-provides-new-insights-into-the-epigenetic-landscape-of-neonates-born-preterm
#14
Yonghui Wu, Xinyi Lin, Ives Yubin Lim, Li Chen, Ai Ling Teh, Julia L MacIsaac, Kok Hian Tan, Michael S Kobor, Yap Seng Chong, Peter D Gluckman, Neerja Karnani
BACKGROUND: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes...
February 11, 2019: Clinical Epigenetics
https://read.qxmd.com/read/30744534/validating-the-radboud-faces-database-from-a-child-s-perspective
#15
Iris A M Verpaalen, Geraly Bijsterbosch, Lynn Mobach, Gijsbert Bijlstra, Mike Rinck, Anke M Klein
Facial expressions play a central role in diverse areas of psychology. However, facial stimuli are often only validated by adults, and there are no face databases validated by school-aged children. Validation by children is important because children still develop emotion recognition skills and may have different perceptions than adults. Therefore, in this study, we validated the adult Caucasian faces of the Radboud Faces Database (RaFD) in 8- to 12-year-old children (N = 652). Additionally, children rated valence, clarity, and model attractiveness...
February 11, 2019: Cognition & Emotion
https://read.qxmd.com/read/30744477/the-effect-of-smoking-on-residual-platelet-reactivity-to-clopidogrel-a-systematic-review-and-meta-analysis
#16
Zhiyan Liu, Qian Xiang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Zining Wang, Shuqing Chen, Kun Hu, Yanjun Gong, Jie Jiang, Yimin Cui
Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency. Thus, we conducted a systematic review and meta-analysis of already existing data/studies to further explore this issue. PubMed, Web of science, EMBASE, Clinical Trials, and the Cochrane Library were searched from inception to March 2018. Studies investigating the residual platelet reactivity categorized by smoking status and patients treated with platelet ADP-P2Y12 receptor inhibitors qualified the inclusion criteria...
February 11, 2019: Platelets
https://read.qxmd.com/read/30744473/accuracy-of-the-%C3%AE-defensin-lateral-flow-assay-for-diagnosing-periprosthetic-joint-infection-in-asians
#17
Benjamin Tk Ding, Kelvin Guoping Tan, Chung Yuan Kau, Henry Ying Ho Chan, Muhd Farhan Bin Mohd Fadil
OBJECTIVE: This study aimed to test the accuracy of the Synovasure®, α-defensin lateral flow test kit, in diagnosing periprosthetic joint infections (PJIs) in a predominantly Asian population and to evaluate whether other patient or disease factors may affect its results. METHODS: 61 Asian patients comprising 70 hip or knee prosthetic joints, performed between November 2015 and November 2018, were retrospectively evaluated. Cases were categorized as infected or not infected using Musculoskeletal Infection Society (MSIS) Criteria...
January 2019: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/30742748/descriptive-study-of-rubella-titer-status-in-infertility-patients
#18
Jennifer L Keating, Keith Hansen, Tiffany Von Wald
INTRODUCTION: There is a 6.4 percent incidence of rubella exposure during pregnancy in the U.S. Given the severe effects rubella can have on a developing fetus, vaccination of women prior to pregnancy is important. Women seeking fertility treatment therefore present a population of patients primed for the vaccination. This study collected and analyzed rubella-specific immunoglobulin G (RV-IgG) titer statuses and corresponding demographics of infertility patients to identify patients at risk of rubella nonimmunity...
November 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://read.qxmd.com/read/30742558/one-size-does-not-fit-all-examining-ethnicity-in-gestational-weight-gain-guidelines
#19
Melissa K Melby, Goro Yamada, David A Schwartz, Pamela J Surkan
Pregnancy-related metrics vary by race/ethnicity, yet most gestational weight gain (GWG) guidelines are ethnicity-blind. We estimated small-for-gestational age (SGA) risk in a Japanese population, examining GWG adequacy categorized by Institute of Medicine (IOM) and Japanese guidelines in male (N  = 192) and female (N = 191) full-term singleton infants. For predicting SGA, IOM guidelines had high sensitivity ( ≥ 0.75), but low specificity ( ≤ 0.25); Japanese guidelines had high specificity ( ≥ 0...
February 11, 2019: Health Care for Women International
https://read.qxmd.com/read/30741858/genetic-basis-for-the-dominance-of-israeli-long-distance-runners-of-ethiopian-origin
#20
Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Eias Kassem, Alon Eliakim
Ben-Zaken, S, Meckel, Y, Nemet, D, Kassem, E, and Eliakim, A. Genetic basis for the dominance of Israeli long-distance runners of Ethiopian origin. J Strength Cond Res XX(X): 000-000, 2018-Israeli long-distance runners of Ethiopian origin have a major influence on the track and field long-distance record table. The aim of this study was to determine whether genetic characteristics contribute to this long-distance dominance. We assessed polymorphisms in genes related to endurance (PPARD T/C), endurance trainability (ACSL A/G), speed (ACTN3 R/X), strength (AGT T/C), and the recovery from training (MTC1 A/T and IL6 G/C) among top Israeli long-distance runners of Ethiopian origin (n = 37), Israeli non-Ethiopian origin runners of Caucasian origin (n = 76), and Israeli nonathletic controls (n = 55)...
February 6, 2019: Journal of Strength and Conditioning Research
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