keyword
https://read.qxmd.com/read/38530418/patient-reported-symptoms-before-adjuvant-locoregional-radiotherapy-for-breast-cancer-triple-negative-histology-impacts-the-symptom-burden
#1
JOURNAL ARTICLE
Carsten Nieder, Silje K Johnsen, Annette M Winther, Bård Mannsåker
BACKGROUND: Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0-10) at the time of treatment planning since 2016. In this study, we analyzed ESAS symptom severity before locoregional radiotherapy...
March 26, 2024: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/38528755/increases-in-stress-and-adverse-childhood-experiences-are-associated-with-the-co-occurrence-of-anxiety-and-depression-in-oncology-patients
#2
JOURNAL ARTICLE
Katie Coupe, Astrid Block, Sueann Mark, Bruce A Cooper, Steven M Paul, Laura B Dunn, Marilyn J Hammer, Yvette P Conley, Jon D Levine, Christine Miaskowski
PURPOSE: Identify subgroups of patients with distinct joint anxiety AND depression profiles and evaluate for differences in demographic and clinical characteristics, as well as stress, resilience, and coping. DESIGN: Longitudinal study. PARTICIPANTS: Patients ( n  = 1328) receiving chemotherapy. METHODS: Measures of state anxiety and depression were done six times over two cycles of chemotherapy. All of the other measures were completed prior to second or third cycle of chemotherapy...
March 25, 2024: Journal of Psychosocial Oncology
https://read.qxmd.com/read/38509786/exercise-therapy-in-oncology%C3%A2-the-impact-on-quality-of-life-and-side-effects
#3
REVIEW
Freerk T Baumann, Wiebke Jensen, Anika Berling-Ernst, Sebastian Theurich, Michael Leitzmann, Miriam Götte
BACKGROUND: The diagnosis and treatment of cancer are highly stressful. Exercise therapy is often used to mitigate the adverse effects of treatment. But how good is the evidence base, and what has changed in recent years? In this narrative review, we present the current data and what it implies for the care of adults with cancer. METHODS: This review is based on data from meta-analyses and systematic reviews concerning 16 relevant clinical endpoints (outcomes) of exercise therapy for cancer patients RESULTS: The literature evaluated for this paper reveals that targeted exercise therapy is feasible and safe under appropriate supervision...
May 3, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38501703/prognostic-factors-and-outcomes-associated-with-neck-lymphedema-in-head-and-neck-cancer-survivors
#4
JOURNAL ARTICLE
Isabella J Lao, Jacklyn Berry, Jinhong Li, Zainab Balogun, Baher Elgohari, Heath Skinner, Jonas Johnson, Marci L Nilsen
OBJECTIVES: The purpose of this study is to determine the predictors of neck lymphedema and to explore its association with symptoms and patient-reported outcomes (PROs) in Head and Neck Cancer (HNC) patients who underwent non-operative treatment. METHODS: This study involved a cross-sectional secondary analysis of data from patients diagnosed with head and neck squamous cell carcinoma who underwent radiation therapy (±chemotherapy). Patients with visits <6 weeks or >2 years following completion of radiation and those with recurrent or metastatic cancer were excluded...
March 19, 2024: Laryngoscope
https://read.qxmd.com/read/38498049/the-effect-of-a-couple-based-posttraumatic-growth-intervention-in-supporting-couples-coping-with-colorectal-cancer-a-randomized-controlled-study
#5
RANDOMIZED CONTROLLED TRIAL
Zhiming Wang, Xuan Chen, Junrui Zhou, Chunyan Lin, Jie Zhao, Qiuping Li
OBJECTIVES: To promote posttraumatic growth (PTG) in colorectal cancer (CRC) couples, a couple-based PTG intervention was conducted, and the intervention had previously proved be feasible in CRC couples. The current study was conducted to validate the effects of intervention in CRC couples. METHOD: This is a randomized controlled study that included 174 CRC couples. All participants were randomized to either the intervention (usual care plus 5-week PTG intervention, n = 87) or the control group (usual care, n = 87)...
March 2024: Psycho-oncology
https://read.qxmd.com/read/38478329/ovarian-suppression-early-menopause-and-late-effects
#6
REVIEW
Chiara Molinelli, Flavia Jacobs, Guilherme Nader-Marta, Roberto Borea, Graziana Scavone, Silvia Ottonello, Piero Fregatti, Cynthia Villarreal-Garza, Jyoti Bajpai, Hee Jeong Kim, Silvia Puglisi, Evandro de Azambuja, Matteo Lambertini
Around 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cancer is endocrine therapy, tailored according to disease stage, biological characteristics of the tumour, patient's comorbidities, preferences and age. In premenopausal patients with hormone receptor-positive breast cancer, ovarian function suppression is a key component of the adjuvant endocrine treatment in combination with an aromatase inhibitor or tamoxifen...
March 13, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38466863/identifying-patients-at-risk-for-depression-after-radical-cystectomy
#7
JOURNAL ARTICLE
Ziv Savin, Liron Ben Dayan, Ofer Yossepowitch, Snir Dekalo
INTRODUCTION: We aimed to assess rates of depression in patients with bladder cancer undergoing radical cystectomy and identify its predictors. METHODS: Depressive symptoms in 42 consecutive patients were evaluated using the Beck's Depression Inventory (BDI) on the day prior to surgery, postoperative day (POD) 6, six weeks after surgery, and 12-18 months postoperatively. RESULTS: Fifteen patients (36%) presented with BDI scores ≥10 before the operation; this rate increased to 64% on POD 6 and 69% at six weeks post-surgery...
March 1, 2024: Canadian Urological Association Journal
https://read.qxmd.com/read/38461265/multi-omics-analysis-of-the-gut-microbiome-and-metabolites-associated-with-the-psychoneurological-symptom-cluster-in-children-with-cancer-receiving-chemotherapy
#8
JOURNAL ARTICLE
Jinbing Bai, Ronald Eldridge, Madelyn Houser, Melissa Martin, Christie Powell, Kathryn S Sutton, Hye In Noh, Yuhua Wu, Thomas Olson, Konstantinos T Konstantinidis, Deborah W Bruner
BACKGROUND: Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbiome and its functional metabolites in PNS is rarely studied among children with cancer. This study investigated the associations between the gut microbiome-metabolome pathways and PNS in children with cancer across chemotherapy as compared to healthy children. METHODS: A case-control study was conducted...
March 9, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38307582/post-traumatic-stress-and-depressive-symptoms-in-women-with-ovarian-cancer-3-6-months-after-diagnosis
#9
JOURNAL ARTICLE
Claudia Carmassi, Virginia Pedrinelli, Sara Fantasia, Debora Andreoli, Federico Giovannoni, Enrico Massimetti, Stefania Cosio, Liliana Dell'osso, Angiolo Gadducci
BACKGROUND/AIM: The potentially traumatic role of severe life-threatening medical conditions is still debated in psychiatry and not yet recognized, particularly among post-traumatic stress disorders. However, increasing evidence suggests the psychopathological impact of severe medical conditions related to their poor prognosis, high lethality, treatments heaviness and invasiveness. Ovarian cancer (OC) is one of the malignancies with the highest mortality and the aim of this study was to investigate post-traumatic stress and depressive symptoms in women 3 to 6 months after diagnosis...
February 2024: Anticancer Research
https://read.qxmd.com/read/38302539/exploring-the-links-of-skeletal-muscle-mitochondrial-oxidative-capacity-physical-functionality-and-mental-well-being-of-cancer-survivors
#10
JOURNAL ARTICLE
Stephen G Gonsalves, Leorey N Saligan, Christopher M Bergeron, Philip R Lee, Kenneth W Fishbein, Richard G Spencer, Marta Zampino, Xinyi Sun, Jennifer Yeong-Shin Sheng, Vered Stearns, Michael Carducci, Luigi Ferrucci, Nada Lukkahatai
Physical impairments following cancer treatment have been linked with the toxic effects of these treatments on muscle mass and strength, through their deleterious effects on skeletal muscle mitochondrial oxidative capacity. Accordingly, we designed the present study to explore relationships of skeletal muscle mitochondrial oxidative capacity with physical performance and perceived cancer-related psychosocial experiences of cancer survivors. We assessed skeletal muscle mitochondrial oxidative capacity using in vivo phosphorus-31 magnetic resonance spectroscopy (31 P MRS), measuring the postexercise phosphocreatine resynthesis time constant, τPCr, in 11 post-chemotherapy participants aged 34-70 years...
February 1, 2024: Scientific Reports
https://read.qxmd.com/read/38291312/predictors-of-persistence-of-post-chemotherapy-symptoms-among-survivors-of-solid-tumor-cancers
#11
JOURNAL ARTICLE
Alla Sikorskii, Terry Badger, Chris Segrin, Tracy E Crane, Nathan Cunicelli, Pavani Chalasani, Waqas Arslan, Charles Given
CONTEXT: Late or residual symptoms diminish quality of life for many cancer survivors after completion of treatment. OBJECTIVES: Examine risk factors associated with persisting symptom burden after chemotherapy and the lack of symptom improvement over time. METHODS: Survivors who completed curative-intent chemotherapy within two years for solid tumors were enrolled into a symptom management trial. There were 375 survivors with two or more comorbid conditions or one comorbid condition and elevated depressive symptoms (pre-defined risk factors in the trial design) who received interventions and 71 survivors without these risk factors who did not receive interventions...
January 30, 2024: Quality of Life Research
https://read.qxmd.com/read/38252310/the-comparison-of-functional-status-and-health-related-parameters-in-ovarian-cancer-survivors-with-healthy-controls
#12
JOURNAL ARTICLE
Sukriye Cansu Gultekin, Ahmet Burak Cakir, Zeynep Gulsum Guc, Faruk Recep Ozalp, Merve Keskinkilic, Tugba Yavuzsen, Husnu Tore Yavuzsen, Didem Karadibak
PURPOSE: The primary purpose of this study was to evaluate functional status and health-related parameters in ovarian cancer (OC) survivors and to compare these parameters with healthy controls. The secondary purpose of this study was to compare these parameters in early and advanced OC survivors. METHODS: Thirty-two OC survivors (n = 15 early stage; n = 17 advanced stage) with no evidence/suspicion of cancer recurrence after completing adjuvant local and systemic treatments for at least 12 months and 32 healthy controls were recruited for functional- and health-related assessments...
January 22, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38170289/evaluating-a-shared-care-pathway-intervention-for-people-receiving-chemotherapy-to-reduce-post-treatment-unplanned-hospital-presentations-a-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Judith Fethney, Bora Kim, Chantale Boustany, Heather McKenzie, Lillian Hayes, Keith Cox, Judy M Simpson, Lisa G Horvath, Janette L Vardy, Jodi McLeod, Simon Willcock, Natalie Cook, Louise Acret, Kate White
PURPOSE: The aim of this randomised controlled trial (RCT) was to explore whether a community nursing intervention for outpatients receiving systemic therapy reduced unplanned hospital presentations and improved physical and psychosocial health outcomes over the first three cycles of treatment compared to a control group receiving standard care. METHODS: The number of and reasons for unplanned presentations were obtained for 170 intervention and 176 control group adult patients with solid tumours starting outpatient chemotherapy...
January 3, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38156338/symptoms-of-anxiety-and-depression-among-slovenian-breast-cancer-survivors-post-treatment-during-the-covid-19-pandemic-a-cross-sectional-study
#14
JOURNAL ARTICLE
Špela Miroševič, Judith Prins, Nikola Bešić, Simona Borštnar, Andreja Cirila Škufca Smrdel, Vesna Homar, Marko Popović, Zalika Klemenc-Ketiš
BACKGROUND: Although anxiety and depression are important determinants of mental health, the literature in this area is sparse as most studies focus on the period during treatment. Mental health problems can affect cancer recovery as well as quality of life and survival. In this cross-sectional study, we investigated the prevalence of anxiety and depression in Slovenian cancer survivors after treatment and assessed the associated correlates during the COVID-19 pandemic. METHODS: From September 2021 to January 2022, we collected data from 430 breast cancer survivors one to five years after receiving post-local treatment and (neo)adjuvant chemotherapy...
March 2024: Zdravstveno Varstvo
https://read.qxmd.com/read/38150072/the-effect-of-virtual-reminiscence-therapy-on-depression-and-anxiety-in-patients-with-gastric-cancer-undergoing-chemotherapy
#15
RANDOMIZED CONTROLLED TRIAL
Nasib Babaei, Vahid Zamanzadeh, Maryam Pourabbasi, Marziyeh Avazeh, Ayoub Shokoufamanesh
PURPOSE: To determine the effect of virtual reminiscence therapy on depression and anxiety in patients with gastric cancer (PwGC) undergoing chemotherapy. METHODS: In this quasi-experimental study, we randomly allocated 152 PwGC who met the inclusion criteria as 1:1 ratio to control (N = 76) and intervention (N = 76) groups. The patients in the control group received routine post-chemotherapy care, while those in the intervention group received reminiscence therapy over the phone in addition to routine care...
December 27, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38135214/work-productivity-among-younger-breast-cancer-survivors-the-impact-of-behavioral-interventions-for-depression
#16
JOURNAL ARTICLE
Catherine M Crespi, Patricia A Ganz, Ann H Partridge, Antonio Wolff, Hadine Joffe, Michael R Irwin, Katie Thure, Laura Petersen, Ya-Chen Tina Shih, Julienne E Bower
OBJECTIVES: The Pathways to Wellness randomized controlled trial found that two behavioral interventions, mindfulness awareness practices and survivorship education, reduced depressive symptoms in younger breast cancer survivors (BCS) compared to wait-list control. This secondary analysis examines whether the interventions led to reduced loss of work productivity among younger BCS and whether such reductions were mediated by reductions in depressive symptoms. METHODS: The Work Productivity and Activity Impairment scale was used to measure work productivity loss at four assessment time points...
December 20, 2023: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38133149/expressive-writing-to-address-distress-in-hospitalized-adults-with-acute-myeloid-leukemia-a-pilot-randomized-clinical-trial
#17
JOURNAL ARTICLE
Morgan M Nakatani, Susan C Locke, Kris W Herring, Tamara Somers, Thomas W LeBlanc
PURPOSE: Patients with acute myeloid leukemia (AML) experience significant distress. Expressive writing is an intervention designed to improve well-being by encouraging expression of emotions related to traumatic experiences. Expressive writing has been shown to be generally feasible and effective at improving the cancer experience but has not been examined in patients with recently diagnosed hematologic malignancies. We examined the feasibility of an expressive writing intervention for hospitalized patients with AML receiving induction chemotherapy...
December 22, 2023: Journal of Psychosocial Oncology
https://read.qxmd.com/read/38132022/cancer-related-neuropathic-pain-chemotherapy-induced-peripheral-neuropathy-and-cognitive-decline-in-a-5-year-prospective-study-of-patients-with-breast-cancer-neon-bc
#18
JOURNAL ARTICLE
Susana Pereira, Natália Araújo, Filipa Fontes, Luisa Lopes-Conceição, Teresa Dias, Augusto Ferreira, Samantha Morais, Vítor Tedim Cruz, Nuno Lunet
This study aims to estimate the prevalence and to identify the determinants of cancer-related neuropathic pain (CRNP), chemotherapy-induced peripheral neuropathy (CIPN) and cognitive decline among patients with breast cancer over five years after diagnosis. Women with an incident breast cancer (n = 462) and proposed for surgery were recruited at the Portuguese Institute of Oncology-Porto in 2012 and underwent systematic neurological examinations and evaluations with the Montreal Cognitive Assessment (MoCA) before treatment and after one, three, and five years...
December 9, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38040507/cognitive-functions-of-patients-treated-with-chemotherapy-a-comparative-study
#19
JOURNAL ARTICLE
Rami Bou Khalil, Fady Haddad, Colin Charbel Cordahi, Dimitri Fiani, Jean-Marie Moukarzel, Yara Chamoun, Hampig Raphael Kourie, Sami Richa, Joseph Kattan
OBJECTIVES: Chemobrain is a well-established clinical syndrome that has become an increasing concern because of the growing number of long-term cancer survivors. It refers to the post-chemotherapy related cognitive dysfunction. The aim of this study was to objectively assess the impact of cancer treatment on the cognition of cancer patients. METHODS: This was a convenience sample comparative study conducted at the Hematology and Oncology Department of Hôtel Dieu de France University Hospital in Beirut, Lebanon...
November 30, 2023: L'Encéphale
https://read.qxmd.com/read/37975923/effects-of-chronotype-tailored-bright-light-intervention-on-post-treatment-symptoms-and-quality-of-life-in-breast-cancer-survivors
#20
RANDOMIZED CONTROLLED TRIAL
Horng-Shiuann Wu, Feng Gao, Jean E Davis, Charles W Given
PURPOSE: Bright light therapy holds promise for reducing common symptoms, e.g., fatigue, experienced by individuals with cancer. This study aimed to examine the effects of a chronotype-tailored bright light intervention on sleep disturbance, fatigue, depressive mood, cognitive dysfunction, and quality of life among post-treatment breast cancer survivors. METHODS: In this two-group randomized controlled trial (NCT03304587), participants were randomized to receive 30-min daily bright blue-green light (12,000 lx) or dim red light (5 lx) either between 19:00 and 20:00 h or within 30 min of waking in the morning...
November 17, 2023: Supportive Care in Cancer
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