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Living kidney

Sare Mıhçıokur, Gülser Doğan, Gülsüm Kocalar, Rengin Erdal, Mehmet Haberal
OBJECTIVES: In our country, there are few publications evaluating emergency department visits among kidney, liver, and heart transplant recipients. Here, we examined emergency department visits of transplant recipients after initial hospital discharge following organ transplant performed in a medical faculty hospital in Ankara, Turkey. MATERIALS AND METHODS: We retrospectively analyzed hospital records of 1144 transplant recipients (700 kidney, 332 liver, and 112 heart) who underwent living-donor and deceased-donor organ transplant procedures in a university hospital between 2007 and 2017 and were admitted to the emergency department during the same period...
January 2019: Experimental and Clinical Transplantation
Nasser Simforoosh, Abbas Basiri, Ali Tabibi, Mohammad Nadjafi-Semnani
OBJECTIVES: It is usually assumed that an active livingdonor transplant program inhibits the growth of a deceased-donor kidney transplant program. In our 33-year experience, we found the contrary to be true. MATERIALS AND METHODS: From 1984 until 2017, we performed a total of 4966 kidney transplant procedures. All cases were registered through the Collaborating Transplant Study (Heidelberg, Germany). RESULTS: During the first 16 years, only living-donor kidney transplant procedures were done...
January 2019: Experimental and Clinical Transplantation
Sare Mıhçıokur, Ebru Hatice Ayvazoğlu Soy, Ezgi Türkçelik, Ayşe Akın, Mehmet Haberal
OBJECTIVES: The literature search on kidney transplant procedures performed in Turkey showed that few publications are available about gender distribution and the relationships between living donors and recipients. Therefore, this study aimed to examine the gender distributions and the relationships between donors and recipients of living-donor kidney transplants performed in a university hospital in Ankara, Turkey. MATERIALS AND METHODS: In this study, we retrospectively analyzed the hospital records of living kidney donors (1611 cases) and all 1991 kidney recipients who underwent living-donor and deceased-donor kidney transplant procedures in a university hospital between 1985 and 2017...
January 2019: Experimental and Clinical Transplantation
Torki Alotaibi, Mohamed Adel, Osama Gheith, Hasaneen Abo-Atya, Medhat A Halim, Prasad Nair, Tarek Mahmoud, Khaled Abdultawab, Medhat Fouad, Mohamed Mejahed, Sheikha Al-Mohareb
Hemophagocytic syndrome combines febrile hepatosplenomegaly, pancytopenia, hypofibrinemia, and hepatic dysfunction. It is characterized by bone marrow and organ infiltration of activated, nonmalignant macrophages that phagocytize blood cells. It is rare among renal transplant recipients. Here, we present the successful management of late-onset cytomegalovirusinduced hemophagocytic lymphohistiocytosis in a kidney transplant recipient after coronary artery bypass graft surgery. In 2012, our patient had end-stage kidney disease due to diabetic nephropathy and underwent related living-donor renal transplant...
January 2019: Experimental and Clinical Transplantation
Ahmed Akl, Sami Alobaidi, Ghaleb Aboalsamh
Transplantation is the ultimate therapy for end-stage kidney disease. Early graft dysfunction is a devastating event to patients and carries risk of graft loss. Medical causes of early graft loss include graft rejection, drug toxicity, and thrombotic microangiopathy. Here, we report a case of posttransplant thrombotic microangiopathy associated with cellular vascular rejection. Thymoglobulin successfully reversed vascular rejection and thrombotic microangiopathy associated with half dosing of calcineurin inhibitors...
January 2019: Experimental and Clinical Transplantation
Nashwa Othman, Osama Gheith, Torki Al-Otaibi, Heba Abdou, Medhat A Halim, Tarek Mahmoud, Prasad Nair, Jude Yagan, Ayman Maher, Mohamed Dahab, Ahmed Yahya
Posttransplant diabetes is a common complication of solid-organ transplantation. We present the possible role of diabetes education in improvement of posttransplant diabetes in a 36-year-old bodybuilder who was a kidney transplant recipient. The patient had been abusing some medications to help in bodybuilding. He underwent living unrelated-donor renal transplant with thymoglobulin induction and was maintained on steroids, tacrolimus, and mycophenolate mofetil. Posttransplant diabetes was confirmed by blood tests...
January 2019: Experimental and Clinical Transplantation
Mohamed Balaha, Torki Al-Otaibi, Osama A Gheith, Medhat A Halim, Mohamed Shaker, Zohair Fayyad, Prasad Nair, Zakaria Zakaria, Hasaneen Abo-Atya, Yahya Makkeyia
To avoid graft rejection during pregnancy, frequent monitoring of serum drug levels is recommended. Pregnancy induces hyperfiltration in transplanted kidneys, as in native kidneys; therefore, detection of rejection can be difficult when monitoring by serum creatinine. If rejection is suspected, ultrasonographguided graft biopsy can be done; once proven, it can be treated with pulse steroids, but data are scarce regarding other agents. Here, we present a 28-year-old pregnant female patient with resistant acute rejection but with successful pregnancy outcome...
January 2019: Experimental and Clinical Transplantation
Erhan Tatar, Murat Karataş, Mustafa Kılıç, Ismail Can Tercan, Gokalp Okut, Berkant Usoğlu, Ahmet Aykas, Adam Uslu
OBJECTIVES: The development of hypertension can negatively affect cardiovascular and renal outcomes in renal kidney donors. Here, we retrospectively investigated the frequency and risk factors of hypertension development in healthy renal donors at our center. MATERIALS AND METHODS: Living donors of kidney transplants performed between January 1998 and December 2016 were evaluated. Those > 18 years old, having glomerular filtration rate > 70 mL/min/1.72 m², body mass index ≤ 35 kg/m², and proteinuria < 300 mg/day were eligible...
January 2019: Experimental and Clinical Transplantation
Juan Carlos Delgado Márquez, Jesus Eloy O Dominguez, Oscar Cervantes, Ana Del Carmen Ibarra López, Juan M Sandoval, Margarita Santiago
Chronic kidney disease is defined as irreversible and progressive damage of the kidney. Chronicity is defined by the presence of renal dysfunction for at least 3 months, and renal dysfunction is defined through combinations of investigation (abnormal radiologic findings, abnormal urine or abnormal biochemistry reflecting renal dysfunction) and/or documentation of glomerular filtration rate below 60 mL/min/1.73 m². The case patient was a girl of 11 years of age, with diagnosis of chronic renal disease, of unknown cause, under renal replacement therapy with peritoneal dialysis, with progressive deterioration of general status and decrease of functional capacity and tolerance to physical activity, presence of fatigue, pulmonary congestion, retention of liquids, and edema in lower extremities, even with adjustment of medical treatment...
January 2019: Experimental and Clinical Transplantation
Nasser Simforoosh, Mohammad Nadjafi-Semnani
Multifocal synchronous renal cell carcinoma in the functioning allograft is a rare disease; there is no consensus regarding its treatment, and few cases have been reported. In isolated masses, some authorities advocate graft nephrectomy, and some recommend partial nephrectomy. To our knowledge, we describe the first experience of nephron-sparing surgery in multifocal synchronous renal cell carcinoma in an allograft with its long-term outcome. A 42-year-old male patient with a history of living related-donor kidney transplant from his brother (18 years previously) presented with a history of gross hematuria over the past few months...
January 2019: Experimental and Clinical Transplantation
Osama Gheith, Medhat A Halim, Torki Al-Otaibi, Ayman El-Sayed, Prasad Nair, Tarek Mahmoud, Ahmed Fathy, Mohamed Abdul Hameed, Ahmed Samy, Nabil El Serwy, Ayman M Nagib
OBJECTIVES: The number of renal transplants in elderly patients is increasing as age per se does not constitute a contraindication to transplant. We compared renal transplant outcomes in elderly recipients versus a group of middle-aged patients. MATERIALS AND METHODS: Our retrospective casecontrolled study compared elderly transplant recipients (n = 252; > 60 y old) with a matched cohort of younger adult recipients (n = 710; between 40 and 60 years old) who underwent renal transplant at the Hamed Al-Essa Organ Transplant Center of Kuwait between 2000 and 2014...
January 2019: Experimental and Clinical Transplantation
Yuko Hamasaki, Atsushi Aikawa, Yoshihiro Itabashi, Masaki Muramatsu, Yoji Hyoudou, Kazunobu Shinoda, Yusuke Takahashi, Kei Sakurabayashi, Toshihide Mizutani, Hideyo Oguchi, Takeshi Kawamura, Ken Sakai, Seiichiro Shishido
OBJECTIVES: Rituximab treatment strategies vary in ABOincompatible pediatric kidney transplant recipients. Here, we present the efficacy of 2 doses of rituximab and subsequent outcomes in ABO-incompatible pediatric kidney transplant patients. MATERIALS AND METHODS: Our study of ABO-incompatible pediatric kidney transplant recipients included 21 who were pretreated with desensitization that included 2 doses of 100 mg rituximab (rituximab group) at 10 and 1 day pretransplant and 14 who received splenectomy without rituximab (splenectomy group)...
January 2019: Experimental and Clinical Transplantation
Meltem Savran Karadeniz, Hayriye Senturk Ciftci, Tzevat Tefik, Tayfun Oktar, Ismet Nane, Aydin Turkmen, Fatma Oguz, Kamil Mehmet Tugrul
OBJECTIVES: Renal transplant is the treatment of choice for patients with end-stage renal disease. Ischemiareperfusion damage is a major cause of early renal dysfunction during the perioperative period. Ischemic hypoxic damage increases local inflammation, leading to secretion of cytokines and chemokines. Anesthetic conditioning is a widely described strategy to attenuate ischemia-reperfusion injury. Here, we compared the effects of desflurane and sevoflurane on serum proinflammatory cytokines and urine chemokines in living-donor kidney transplant recipients...
January 2019: Experimental and Clinical Transplantation
Ifeoma I Ulasi, Chinwuba Ijoma, Obinna Onodugo, Ejikeme Arodiwe, Julius Okoye, Ugochi Onu, Uchenna Ijoma, Ngozi Ifebunandu, Olaronke Afolabi, Ume Nwobodo
OBJECTIVES: Kidney transplantation is not readily available in low-resource settings because of poor health structure, dearth of experts, and pervading poverty. Although many centers now offer kidney transplant, patients still travel outside Nigeria for this service for many reasons and many return home without a detailed medical report. MATERIALS AND METHODS: Medical records of individuals who underwent kidney transplant in Nigeria and elsewhere and who were presently receiving posttransplant care or had received such care from 2002 to 2018 at 4 Nigerian hospitals were retrospectively reviewed and analyzed...
January 2019: Experimental and Clinical Transplantation
Yoshihiro Itabashi, Atsushi Aikawa, Masaki Muramatsu, Youji Hyoudou, Kazunobu Shinoda, Yusuke Takahashi, Kei Sakurabayashi, Toshihide Mizutani, Hideyo Oguchi, Taichi Arai, Takeshi Kawamura, Yuko Hamasaki, Ken Sakai, Seiichiro Shishido
OBJECTIVES: We investigated outcomes in living-donor kidney transplant recipients with preformed donor-specific antibodies (detected with flow cytometry and specified with the LABScreen single antigen test) under desensitization pretransplant and immunosuppression posttransplant. MATERIALS AND METHODS: Of 15 recipients included, 8 had ABO-incompatible kidney transplant. Six patients had sensitization caused by pregnancy, 8 by blood transfusion, 5 by previous transplants, and 1 by unknown cause...
January 2019: Experimental and Clinical Transplantation
Saleh Hammad, Abdel-Hadi Albreizat
In Jordan, the history of organ transplantation started in 1972 with a kidney transplant from a deceased donor. At present, Jordan is in a good position with regard to organ transplantation among developing countries. It remains important to follow through with some decisions and enact laws that would increase the percentage of legal organ donations and transplant procedures. This has involved the expansion of relative degree donation. Until 2013, most relative degree donations involved 1st-degree and 2nd-degree relatives...
January 2019: Experimental and Clinical Transplantation
Vinay R Sonawane, Mohd Usman Mohd Siddique, Linda Gatchie, Ibidapo S Williams, Sandip B Bharate, Venkatesan Jayaprakash, Barij N Sinha, Bhabatosh Chaudhuri
Microsomal cytochrome P450 (CYP) enzymes, isolated from recombinant bacterial/insect/yeast cells, are extensively used for drug metabolism studies. However, they may not always portray how a developmental drug would behave in human cells with intact intracellular transport mechanisms. This study emphasizes the usefulness of human HEK293 kidney cells, grown in 'suspension' for expression of CYPs, in finding potent CYP1A1/CYP1B1 inhibitors, as possible anticancer agents. With live cell-based assays, quinazolinones 9i/9b were found to be selective CYP1A1/CYP1B1 inhibitors with IC50 values of 30/21 nM, and > 150-fold selectivity over CYP2/3 enzymes, whereas they were far less active using commercially-available CYP1A1/CYP1B1 microsomal enzymes (IC50 , >10/1...
February 15, 2019: European Journal of Pharmaceutical Sciences
Yang Yang, Yan Feng, Yong Jiang, Fangzhou Qiu, Yingzhe Wang, Xuerui Song, Xiaoliang Tang, Guolin Zhang, Weisheng Liu
Hydrogen sulfide (H2 S) plays a vital role in numerous biological processes in living organisms. To better understand its functions, a fluorescent probe to fast and sensitively detect H2 S is imminently needed. Keep this in mind, we reasonably designed probe DHC for detecting H2 S based on α, β-unsaturated ethanoylcoumarin fluorophore. The limit of detection (LOD) is found to be as low as 5 × 10-8 M, which is superior to most reported fluorescent probes to detect H2 S. Furthermore, the wide pH range of 4-11 makes it capable of application in biological systems...
May 15, 2019: Talanta
Kristin K Clemens, Niamh O'Regan, Jinnie J Rhee
PURPOSE OF REVIEW: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management. RECENT FINDINGS: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities...
February 15, 2019: Current Diabetes Reports
Sergey Gautier, Artem Monakhov, Igor Miloserdov, Sergey Arzumanov, Olga Tsirulnikova, Konstantin Semash, Timur Dzhanbekov
With the presence of organ shortage, living donors remain important sources of grafts, especially for pediatric recipients. Laparoscopic nephrectomy has become the gold standard for living donors. Additionally, laparoscopic partial liver procurement in living donors has proven its safety and feasibility in the latest studies. We have combined both approaches to perform a simultaneous liver-kidney transplantation in a pediatric patient from the same living donor. Our experience of laparoscopic left lateral sectionectomy and laparoscopic nephrectomy in living donors was the basis for adapting to this procedure...
February 15, 2019: American Journal of Transplantation
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