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Accelerated aging

Burcu Çevik, Öykü Mançe-Çalışır, Eşref Cem Atbaşoğlu, Meram Can Saka, Köksal Alptekin, Alp Üçok, Burcu Sırmatel, Sinan Gülöksüz, Ajlan Tükün, Jim van Os, Güvem Gümüş-Akay
Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Our hypothesis was that both SCZ patients and their unaffected siblings would have shorter telomere length (TL) compared to of non-clinical controls...
February 8, 2019: Journal of Psychiatric Research
Rongxia Li, Xuenan Mi, Shujun Yang, Yunyun Yang, Shuyuan Zhang, Rutai Hui, Yu Chen, Weili Zhang
The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days...
February 15, 2019: Experimental Gerontology
Jing Wang, Xuena Wang, Yeqing Gu, Mingyue Liu, Thi Quynh Chi Vu, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Xue Bao, Shunming Zhang, Yanyan Wang, Zuolin Lu, Liu Wang, Lixiao Zheng, Xiaona Wang, Chunling Tian, Jingzhu Fu, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
OBJECTIVE: Handgrip strength (HGS) begins an accelerating decline around 50y. Many of the studies performed in old adults have demonstrated a significant relationship between vitamin D and HGS, but the studies performed in participants with a broad age range have yielded conflicting results. The purpose of the study was to investigate the relationship between vitamin D and HGS using age 50 as a specific cutoff. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: 5,102 participants (2,911 males, 2,191 females) from the TCLSIH Cohort...
February 18, 2019: Clinical Endocrinology
J Y M Tang, H Luo, G H Y Wong, M M Y Lau, G M Joe, M A Tse, P Ip, I C K Wong, T Y S Lum
BACKGROUND: While accelerated ageing is recognised among individuals with Down syndrome (DS), the trajectory of their bone health across adulthood remains poorly understood. METHODS: This study aimed to determine the age-related loss of bone mineral density (BMD) of the lumbar spine in 128 adults with DS aged 18 to 54 years compared with 723 counterparts without DS. RESULTS: Men and women with DS had lower level of BMD than counterparts without DS across age groups...
February 18, 2019: Journal of Intellectual Disability Research: JIDR
Elizabeth L Prado, Elizabeth Yakes Jimenez, Stephen Vosti, Robert Stewart, Christine P Stewart, Jérôme Somé, Anna Pulakka, Jean Bosco Ouédraogo, Harriet Okronipa, Eugenia Ocansey, Brietta Oaks, Kenneth Maleta, Anna Lartey, Emma Kortekangas, Sonja Y Hess, Kenneth Brown, Jaden Bendabenda, Ulla Ashorn, Per Ashorn, Mary Arimond, Seth Adu-Afarwuah, Souheila Abbeddou, Kathryn Dewey
Stunting prevalence is an indicator of a country's progress towards United Nations' Sustainable Development Goal 2, which is to end hunger and achieve improved nutrition. Accelerating progress towards reducing stunting requires a deeper understanding of the factors that contribute to linear growth faltering. We conducted path analyses of factors associated with 18-month length-for-age z-score (LAZ) in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements Project in Ghana (n=1039), Malawi (n=684 and 1504) and Burkina Faso (n=2619)...
2019: BMJ Global Health
Yasushi Matsui, Shoji Takayanagi, Takuya Ohira, Masahiro Watanabe, Hiroki Murano, Yasufumi Furuhata, Shumpei Miyakawa
[Purpose] The aim of this study was to determine whether the consumption of a leucine-enriched essential amino acid mixture (LEAA), which is known to increase protein synthesis in muscles, alleviates muscle damage and accelerates recovery by ameliorating muscle damage. [Participants and Methods] A double-blind, randomized crossover trial was conducted over a 5-week period. Ten untrained males (age, 23.0 ± 1.6 years) were asked to repeatedly flex and extend their elbows for 10 counts/set × 5 sets at full power while using a dynamometer...
January 2019: Journal of Physical Therapy Science
Kenneth Ladd Seldeen, Yonas Z Redae, Ramkumar Thiyagarajan, Reem Nagi Berman, Merced Marie Leiker, Bruce Robert Troen
High intensity interval training (HIIT) is emerging as a therapeutic approach to prevent, delay, or ameliorate frailty. In particular short session HIIT, with regimens less than or equal to 10 min is of particular interest as several human studies feature routines as short as a few minutes a couple times a week. However, there is a paucity of animal studies that model the impacts of short session HIIT. Here, we describe a methodology for an individually tailored and progressive short session HIIT regimen of 10 min given 3 days a week for aged mice using an inclined treadmill...
February 2, 2019: Journal of Visualized Experiments: JoVE
Q Su, X Peng, C X Zhou, G Y Yu
OBJECTIVE: To investigate the clinicopathological features and prognostic factors in lymphoma of parotid origin. METHODS: Clinicopathological data of the patients with parotid lymphoma who were initially diagnosed in Peking University Hospital of Stomatology from 2006 to 2016 were collected and analyzed retrospectively. The patients were followed-up for 5 to 149 months with a median period of 45 months, and the factors influencing the prognosis were evaluated. RESULTS: A total of 41 patients with primary parotid lymphoma were included in this retrospective study...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Cristina Morsiani, Maria Giulia Bacalini, Aurelia Santoro, Paolo Garagnani, Salvatore Collura, Antonia D'Errico, Magda de Eguileor, Gian Luca Grazi, Matteo Cescon, Claudio Franceschi, Miriam Capri
An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents...
February 14, 2019: Ageing Research Reviews
Yong Zhuo, Lun Hua, Bin Feng, Xuemei Jiang, Jing Li, Dandan Jiang, Xiaohua Huang, Yingguo Zhu, Zhen Li, Lijun Yan, Chao Jin, Lianqiang Che, Zhengfeng Fang, Yan Lin, Shengyu Xu, Jian Li, De Wu
BACKGROUND: Global consumption of protein per capita is rising, while rates of infertility are increasing. However, a clear relationship between protein intake and reproductive health has not been demonstrated. The activation of the quiescent primordial follicles is the first step of folliculogenesis, and their activation must be tightly controlled to prevent premature exhaustion of the ovarian follicular reserve. METHODS: The primordial follicle reserve of wild-type or liver-specific ablation of fibroblast growth factor 21 (FGF21) in mice, subjected to limited or excessive protein diets or oral gavage test, were detected in vivo...
February 13, 2019: EBioMedicine
Jessica B Langbaum, Jason Karlawish, J Scott Roberts, Elisabeth M Wood, Angela Bradbury, Nellie High, Trisha L Walsh, David Gordon, Raj Aggarwal, Peter Davis, Carter Stowell, Lane Trisko, Carolyn M Langlois, Eric M Reiman, Pierre N Tariot
INTRODUCTION: Recruitment for Alzheimer's disease (AD) prevention research studies is challenging because of lack of awareness among cognitively healthy adults coupled with the high screen fail rate due to participants not having a genetic risk factor or biomarker evidence of the disease. Participant recruitment registries offer one solution for efficiently and effectively identifying, characterizing, and connecting potential eligible volunteers to studies. METHODS: Individuals aged 55-75 years who live in the United States and self-report not having a diagnosis of cognitive impairment such as MCI or dementia are eligible to join GeneMatch...
February 6, 2019: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Aniela Petrescu, Pedro Santos, Marta Orlowska, João Pedrosa, Stéphanie Bézy, Bidisha Chakraborty, Marta Cvijic, Monica Dobrovie, Michel Delforge, Jan D'hooge, Jens-Uwe Voigt
OBJECTIVES: This study sought to evaluate whether velocity of naturally occurring myocardial shear waves (SW) could relate to myocardial stiffness (MS) in vivo. BACKGROUND: Cardiac SW imaging has been proposed as a noninvasive tool to assess MS. SWs occur after mechanical excitation of the myocardium (e.g., mitral valve closure [MVC] and aortic valve closure [AVC]), and their propagation velocity is theoretically related to MS, thus providing an opportunity to assess stiffness at end-diastole (ED) and end-systole...
February 11, 2019: JACC. Cardiovascular Imaging
Xu Gao, Xīn Gào, Yan Zhang, Bernd Holleczek, Ben Schöttker, Hermann Brenner
Oxidative stress (OS) has been found to be related to accelerated aging and many aging-related health outcomes. Recently, an epigenetic "mortality risk score" (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be associated with all-cause mortality. This study aimed to address the association between OS and MS, and to assess and compare their performance in the prediction of all-cause mortality. For 1448 participants aged 50-75 of the German ESTHER cohort study, the MS was derived from the DNA methylation profiles measured by Illumina HumanMethylation450K Beadchip and the levels of two urinary OS markers, 8-isoprostane (8-iso) and oxidized guanine/guanosine [including 8-hydroxy-2'-deoxyguanosine (8-oxo)], were measured by ELISA kits...
February 15, 2019: European Journal of Epidemiology
Meng-Zhu Shi, Jian-Yu Li, Bo Ding, Jian-Wei Fu, Li-Zhen Zheng, Hsin Chi
Alligatorweed, Alternanthera philoxeroide (Mart.) Griseb. (Amaranthaceae) is an invasive weed in China that is often kept under control by the alligatorweed flea beetle, Agasicles hygrophila Selman and Vogt (Coleoptera: Chrysomelidae) introduced into China from Argentina in the 1980s. Elevated CO2 levels have been shown to have a direct effect on Ag. hygrophila. In order to fully evaluate the indirect effects of three different atmospheric concentrations of CO2 (420, 550, and 750 ppm) on the population parameters of Ag...
February 16, 2019: Journal of Economic Entomology
(no author information available yet)
Large cell size affects multiple cellular processes, inhibits proliferation, and accelerates aging.
February 15, 2019: Cancer Discovery
Ángela Ros-Sanjuán, Sara Iglesias-Moroño, Marta Troya-Castilla, Bernarda Márquez-Márquez, Ismael Herruzo-Cabrera, Miguel Ángel Arráez-Sánchez
OBJECTIVE: The aims of our study were to evaluate tumour response in a series of patients with vestibular schwannoma (VS) treated with linear accelerator stereotactic radiosurgery (LINAC-RS), to describe the complications and to analyze the variables associated with the response to treatment. MATERIAL AND METHODS: This retrospective descriptive study included 64 patients treated from 2010 to 2016 with a minimum follow-up of one year, excluding patients with neurofibromatosis...
February 12, 2019: Neurocirugía
David Mischoulon
No abstract text is available yet for this article.
January 16, 2019: American Journal of Geriatric Psychiatry
Han Liu, Shiqi Dong, Longwen Tang, N M Anoop Krishnan, Enrico Masoero, Gaurav Sant, Mathieu Bauchy
When subjected to a sustained load, jammed colloidal gels can feature some delayed viscoplastic creep deformations. However, due to the long timescale of creep (up to several years), its modeling and, thereby, prediction has remained challenging. Here, based on mesoscale simulations of calcium-silicate-hydrate gels (CSH, the binding phase of concrete), we present an accelerated simulation method-based on stress perturbations and overaging-to model creep deformations in CSH. Our simulations yield a very good agreement with nanoindentation creep tests, which suggests that concrete creep occurs through the reorganization of CSH grains at the mesoscale...
February 7, 2019: Journal of Colloid and Interface Science
Yada Kanjanapan, Daphne Day, Lisa Wang, Hamad Al-Sawaihey, Engy Abbas, Amirali Namini, Lillian L Siu, Aaron Hansen, Albiruni Abdul Razak, Anna Spreafico, Natasha Leighl, Anthony M Joshua, Marcus O Butler, David Hogg, Mary Anne Chappell, Ludmilla Soultani, Kayla Chow, Samantha Boujos, Philippe L Bedard
BACKGROUND: A subset of patients treated with immune checkpoint inhibitors experience an accelerated tumor growth rate (TGR) in comparison with pretreatment kinetics; this is known as hyperprogression. This study assessed the relation between hyperprogressive disease (HPD) and treatment-related toxicity and clinical factors. METHODS: This study reviewed patients with solid tumors who were enrolled in early-phase immunotherapy trials at Princess Margaret Cancer Centre between August 2012 and September 2016 and had computed tomography scans in the pre-immunotherapy (reference) and on-immunotherapy (experimental) periods...
February 15, 2019: Cancer
Claudio Franceschi, Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli
Down syndrome (DS) has been proposed by George Martin as a segmental progeroid syndrome since 1978. In fact, DS persons suffer from several age-associated disorders much earlier than euploid persons. Furthermore, a series of recent studies have found that DS persons display elevated levels of age biomarkers, thus supporting the notion that DS is a progeroid trait. Nowadays, due to the progressive advancements in social inclusion processes and medical assistance, DS persons live much longer than in the past; therefore, the early-onset health problems of these persons are becoming an urgent and largely unmet social and medical burden...
February 15, 2019: Aging Cell
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