Nikolaos Machairiotis, Athanasios G Pantelis, Anastasios Potiris, Theodoros Karampitsakos, Petros Drakakis, Eirini Drakaki, Panagoula Oikonomou, Christina Nikolaou, Dimitrios Matthaios, Charalampos Charalampidis, Aris Ioannidis, Paul Zarogoulidis, Stavros Sofoklis
Obesity and cancer represent two pandemics of current civilization, the progression of which has followed parallel trajectories. To time, thirteen types of malignancies have been recognized as obesity-related cancers, including breast (in postmenopausal women), endometrial, and ovarian cancer. Pathophysiologic mechanisms that connect the two entities include insulin resistance, adipokine imbalance, increased peripheral aromatization and estrogen levels, tissue hypoxia, and disrupted immunity in the cellular milieu...
2024: Journal of Cancer