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Colorectal Cancer Metastasis

Wei Wu, Ke He, Qian Guo, Jingdi Chen, Mengjiao Zhang, Kai Huang, Dongmei Yang, Lu Wu, Yunchao Deng, Xu Luo, Honggang Yu, Qianshan Ding, Guoan Xiang
In this study, microarray data analysis, real-time quantitative PCR and immunohistochemistry were used to detect the expression levels of SSRP1 in colorectal cancer (CRC) tissue and in corresponding normal tissue. The association between structure-specific recognition protein 1 (SSRP1) expression and patient prognosis was examined by Kaplan-Meier analysis. SSRP1 was knocked down and overexpressed in CRC cell lines, and its effects on proliferation, cell cycling, migration, invasion, cellular energy metabolism, apoptosis, chemotherapeutic drug sensitivity and cell phenotype-related molecules were assessed...
February 14, 2019: Journal of Cellular and Molecular Medicine
R Vera, J Aparicio, F Carballo, M Esteva, E González-Flores, J Santianes, F Santolaya, J M Fernández-Cebrián
Colorectal cancer (CRC) is one of the tumours with the highest incidence and mortality in the Spanish population. Nevertheless, the advances in prevention and treatment have contributed to an increased number of patients who survive for prolonged periods of time. In addition, despite recurrences, improved survival following metastasis resection is likewise on the rise. This underscores the importance of carrying out follow-up programmes even in low-risk patients for the early detection of recurrence. The main objective of this article is to provide a set of recommendations for optimising the follow-up of CRC survivors as well as for managing the sequelae that result from either pharmacological or surgical treatment...
February 14, 2019: Clinical & Translational Oncology
Jun Suzuki, Motohiro Kojima, Keiju Aokage, Takashi Sakai, Hiroshi Nakamura, Yuuki Ohara, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masaaki Ito, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
Metastatic lung cancers from the colon and rectum (MLCR) frequently have necrotic components. The aim of this study is to elucidate clinicopathological factors associated with the amount of necrosis in MLCR. Ninety patients who underwent the first pulmonary metastasectomy for MLCR with a tumor diameter ≦ 3.0 cm and without chemotherapy were enrolled in this study. Analyzing digitally scanned pathological slides, we calculated the necrosis percentage (NP, the necrosis area divided by the tumor area). The relationship between NP and clinicopathological factors was analyzed...
February 14, 2019: Virchows Archiv: An International Journal of Pathology
Gabriele Bellio, Marina Troian, Arianna Pasquali, Nicolò De Manzini
BACKGROUND: Laparoscopy for locally advanced colorectal cancer is not standardized yet and its potential risks and benefits in elderly patients are still under debate. The aim of this study was to evaluate clinical and oncologic results of laparoscopic surgery for pT3/pT4 lesions in both old and young people. METHODS: Between 2006 and 2015, 115 patients aged <70 years and 112 patients aged ≥70 years underwent elective laparoscopic surgery for pT3/pT4 colorectal cancer presenting without distant metastasis at the Department of General Surgery, Trieste...
February 13, 2019: Minerva Chirurgica
Jonathan P Evans, Boleslaw K Winiarski, Paul A Sutton, Lorenzo Ressel, Carrie A Duckworth, D Mark Pritchard, Daniel H Palmer, Christopher E Goldring, Neil R Kitteringham
Improving outcomes in colorectal cancer requires more accurate in vivo modelling of the disease in humans, allowing more reliable pre-clinical assessment of potential therapies. Novel imaging techniques are necessary to improve the longitudinal assessment of disease burden in these models, reducing the number of animals required for translational studies. This report describes the development of an immune-competent syngeneic orthotopic murine model of colorectal cancer, utilising caecal implantation of CT26 cells stably transfected with the luciferase gene into immune-competent BALB/c mice, allowing serial bioluminescent imaging of cancer progression...
February 13, 2019: Laboratory Animals
Stevephen Hung, Alina Saiakhova, Zachary J Faber, Cynthia F Bartels, Devin Neu, Ian Bayles, Evelyn Ojo, Ellen S Hong, W Dean Pontius, Andrew R Morton, Ruifu Liu, Matthew F Kalady, David N Wald, Sanford Markowitz, Peter C Scacheri
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colorectal cancer (CRC). Analysis of a genetically-diverse cohort of CRC specimens revealed that microsatellite instable (MSI) samples have a high indel rate within active enhancers. Enhancers with indels show evidence of positive selection, increased target gene expression, and a subset is highly recurrent...
February 13, 2019: ELife
Zheng-Qian Bian, Yang Luo, Feng Guo, Yi-Zhou Huang, Ming Zhong, Hui Cao
The tartrate-resistant acid phosphatase (TRAP/ACP5) correlated with tumor progression in many malignancies. However, the role of ACP5 in colorectal cancer (CRC) has not been thoroughly elucidated. In this study, we sought to identify the role for ACP5 in CRC progression. Immunohistochemistry revealed that high ACP5 expression is positively associated with tumor size, tumor classification, lymph node metastasis, distant metastasis and advanced stage cancer in 285 CRC patients. Moreover, high ACP5 expression was significantly associated with poor overall survival and disease-free survival...
2019: American Journal of Cancer Research
Xiaoxiang Chen, Kaixuan Zeng, Mu Xu, Xiangxiang Liu, Xiuxiu Hu, Tao Xu, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang
MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our study is to discover the expression pattern of miR-1249 in CRC and investigate its clinical significance as well as biological role in CRC progression. In our study, we found that miR-1249 was markedly downregulated in CRC tissues and cell lines, and negatively related to pN stage, pM stage, TNM stage, and overall survival (OS)...
February 12, 2019: Cell Death & Disease
Hao Gao, Xiao-Yan Meng, Hong-Qian Wang, Feng-Feng Zhu, Ai-Ling Guo, Mei Zhu, Jin-Chao Song, Wei-Feng Yu
Background: Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. Methods: We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017...
2019: International Journal of Medical Sciences
Bo Lei, Zhiqiang Tian, Weiping Fan, Bing Ni
Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors...
2019: International Journal of Medical Sciences
Shihou Sheng, Lin Xie, Yuanyu Wu, Meng Ding, Tao Zhang, Xu Wang
PURPOSE: MicroRNAs (MiRs) are thought to display regulator action in tumor suppression and oncogenesis. MiR-144 plays an important role in the development of various cancers, such as colorectal cancer, breast cancer and lung cancer, by targeting different molecules potentially involved in many signalling pathways. SMAD4 is a common signaling during tumor progression, and it can inhibit cell proliferation and promote cell motility in most epithelial cells. This study focused on the effect of miR-144 and SMAD4 on colon cancer in order to find the novel gene therapy target for the treatment of colon cancer...
February 11, 2019: Bioscience Reports
Thomas M Drake, Kjetil Søreide
Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic changes are now increasingly appreciated as an essential driver to the cancer phenotype. The epigenetic regulation of cancer is complex and not yet fully understood, but application of epigenetics to clinical practice and in cancer research has the potential to improve cancer care. Epigenetics changes do not cause changes in the DNA base-pairs (and, hence, does not alter the genetic code per se) but rather occur through methylation of DNA, by histone modifications, and, through changes to chromatin structure to alter genetic expression...
February 5, 2019: European Journal of Surgical Oncology
Kimihiro Shimizu, Yoichi Ohtaki, Takehiro Okumura, Narikazu Boku, Hirotoshi Horio, Mitsuhiro Takenoyama, Motohiro Yamashita, Ichinosuke Hyodo, Keita Mori, Haruhiko Kondo
OBJECTIVES: Outcomes and prognostic factors remain obscure in patients with colorectal cancer after pulmonary metastasectomy who had previously received a curative hepatic metastasectomy. METHODS: We collected data of 757 patients with pulmonary metastasis from colorectal cancer who underwent curative metastasectomy between 2004 and 2008 from 46 Japanese institutions, from which we extracted data on patients who previously received curative hepatic metastasectomy...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
Shimeng Pan, Yanqiu Liu, Qianqian Liu, Yang Xiao, Bing Liu, Xiang Ren, Xia Qi, Huimin Zhou, Changqian Zeng, Li Jia
Metastasis is the main cause of death in colorectal cancer (CRC) patients. Aberrant fucosylation, catalyzed by the specific fucosyltransferases (FUTs), is associated with malignant behaviors. Non-conding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), emerge as key molecules in cancer malignancy. The aim of this study was to investigate HOTAIR/miR-326/FUT6 axis modified fucosylation on sLeX -CD44 (HCELL), which served as E-selectin ligand during CRC progression. Higher levels of HOTAIR and FUT6 were verified in CRC tissues and cell lines, with a positive correlation...
February 8, 2019: Biochimica et biophysica acta. Molecular cell research
O I Sushkov, M S Likhter, O A Maynovskaya, K R Saifutdinova, D G Shahmatov
Kidney metastasis in colorectal cancer are rare. A number of publications dedicated to this topic is quite limited. In this article a rare observation of metastasis of colorectal cancer to the kidney is described.
December 2018: Urologii︠a︡
Guang-Xi Zhao, Ying-Ying Xu, Shu-Qiang Weng, Si Zhang, Ying Chen, Xi-Zhong Shen, Ling Dong, She Chen
Colorectal cancer (CRC) is a common gastrointestinal cancer with high mortality rate mostly due to metastasis. Ca2+ -dependent activator protein for secretion 1 (CAPS1) was originally identified as a soluble factor that reconstitutes Ca2+ -dependent secretion. In this study, we discovered a novel role of CAPS1 in CRC metastasis. CAPS1 is frequently up-regulated in CRC tissues. Increased CAPS1 expression is associated with frequent metastasis and poor prognosis of CRC patients. Overexpression of CAPS1 promotes CRC cell migration and invasion in vitro, as well as liver metastasis in vivo, without affecting cell proliferation...
February 11, 2019: Oncogene
Fang Yuan, Xiao Xiao, Guanglu Che, Yanyun Wang, Tao Wang, Xiaolei Luo, Weibo Liang, Linbo Gao, Lin Zhang
Let-7f was reported to be downregulated in patients with colorectal cancer (CRC). However, little is known about the role of let-7f in CRC carcinogenesis. The aim of this study was to investigate the correlation between genetic polymorphisms in the flanking region of pri-let-7f and CRC risk, as well as the potential role of let-7f in CRC cell migration and invasion. The pri-let-7f-1 rs10739971 and pri-let-7f-2 rs17276588 were genotyped using TaqMan (Applied Biosystems, Foster City, CA) assay. The luciferase activity was detected using Dual-Luciferase Reporter Assay...
February 10, 2019: Journal of Cellular Physiology
Eric Smith, Yoko Tomita, Helen M Palethorpe, Stuart Howell, Maryam Nakhjavani, Amanda R Townsend, Timothy J Price, Joanne P Young, Jennifer E Hardingham
Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of AQP1 transcript expression and the association between expression and promoter methylation in normal colonic mucosa, CRC tissues and cell lines. Analysis of publicly available datasets from The Cancer Genome Atlas revealed that AQP1 expression was significantly decreased in CRC compared to normal mucosa (12...
February 9, 2019: Epigenetics: Official Journal of the DNA Methylation Society
Michelle E Penney, Patrick S Parfrey, Sevtap Savas, Yildiz E Yilmaz
BACKGROUND: Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis...
February 9, 2019: BMC Cancer
Guiyue Wang, Yuhang Li, Miao Liu, Nana Guo, Ci Han, Desheng Liu, Dandan Li, Mengyuan Yang, Yahui Peng, Yansong Liu, Kaijiang Yu, Changsong Wang
Early diagnosis and early treatment are important factors in reducing colorectal cancer (CRC) metastasis and mortality. Volatile organic compounds (VOCs) released by the human body have great potential for use in clinical diagnosis and therapeutic monitoring for CRC. The aim of our study was to identify VOCs with high specificity and high sensitivity for CRC and to provide a method for early diagnosis of CRC. Gas chromatography-mass spectrometry (GC-MS) was utilized to analyze metabolites in both the in vivo and in vitro experimental groups...
January 30, 2019: Journal of Pharmaceutical and Biomedical Analysis
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