keyword
https://read.qxmd.com/read/38249328/handling-missing-covariates-in-observational-studies-an-illustration-with-the-assessment-of-prognostic-factors-of-survival-outcomes-in-soft-tissue-or-visceral-sarcomas-in-irradiated-fields-sif
#21
JOURNAL ARTICLE
Noémie Huchet, Nicolas Penel, Sylvie Bonvalot, Juliette Thariat, Françoise Ducimetière, Antoine Giraud, Maud Toulmonde, Axel Le Cesne, Jean-Yves Blay, Carine Bellera
BACKGROUND: Missing covariates are common in observational research and can lead to bias and loss of statistical power. Limited data regarding prognostic factors of survival outcomes of sarcomas in irradiated fields (SIF) are available. Because of the long lag time between irradiation of first cancer and scarcity of SIF, missing data are a critical issue when analyzing long-term outcomes. We assessed prognostic factors of overall (OS), progression-free (PFS), and metastatic-progression-free (MPFS) survivals in SIF using three methods to account for missing covariates...
2024: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38248043/coexistence-of-hashimoto-s-thyroiditis-in-differentiated-thyroid-cancer-post-operative-monitoring-of-anti-thyroglobulin-antibodies-and-assessment-of-treatment-response
#22
JOURNAL ARTICLE
Alessandra Donnici, Maria Mirabelli, Stefania Giuliano, Roberta Misiti, Vera Tocci, Marta Greco, Vincenzo Aiello, Francesco S Brunetti, Eusebio Chiefari, Antonio Aversa, Daniela P Foti, Antonio Brunetti
INTRODUCTION: Differentiated thyroid carcinoma (DTC) is frequently found in conjunction with autoimmune thyroid disorders, particularly Hashimoto's thyroiditis (HT). This study investigates the impact of coexisting HT on the persistence of an indeterminate response to therapy due to positive anti-thyroglobulin antibodies (AbTg), measured via competitive immunoassay, in a consecutive patient series from Calabria, Southern Italy. METHODS: This retrospective longitudinal study analyzed 259 consecutive DTC patients managed at the Endocrinology Unit of Renato Dulbecco Hospital (Catanzaro, Italy) up to 2023...
January 11, 2024: Diagnostics
https://read.qxmd.com/read/38234350/choroidal-metastasis-of-pancreatic-adenocarcinoma-case-report
#23
Jahnavi Shriram, Robert Stoltz, Erkut Borazanci
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of all pancreatic carcinomas. Prognosis is poor with a worldwide five-year survival rate of 2-9%. Extent of metastasis is a prognostic factor. Most common metastatic sites include the liver, peritoneum, lung, and bones. We report a case of distant metastasis of PDAC to the left choroid. CASE DESCRIPTION: This patient is a 59-year-old Caucasian male who initially presented with right flank pain progressing to exercise and activity impairment...
2024: AME Case Reports
https://read.qxmd.com/read/38222194/diplopia-and-ptosis-an-unusual-case-of-prostate-cancer-metastasis-to-the-sphenoid-bone-treated-with-palliative-radiotherapy
#24
Mahvish Renzu, Ishaan J Bhatt, Saad Ahmed, Akhil Jain, Oleg M Teytelboym, Gregory C Stachelek, Rajesh Thirumaran
We report a case of a 72-year-old male who presented to the hospital with a chief complaint of diplopia in the setting of a recent onset of urinary incontinence and right-sided back pain. He was subsequently diagnosed with prostate cancer, notably metastasizing to the right sphenoid bone, causing impingement of the oculomotor nerve. Our case is unique in that the patient's initial presentation of prostate cancer was oculomotor nerve palsy with subsequent histologic analysis of the primary tumor showing both small cell neuroendocrine carcinoma along with adenocarcinoma...
December 2023: Curēus
https://read.qxmd.com/read/38216936/an-integrated-model-incorporating-deep-learning-hand-crafted-radiomics-and-clinical-and-us-features-to-diagnose-central-lymph-node-metastasis-in-patients-with-papillary-thyroid-cancer
#25
JOURNAL ARTICLE
Yang Gao, Weizhen Wang, Yuan Yang, Ziting Xu, Yue Lin, Ting Lang, Shangtong Lei, Yisheng Xiao, Wei Yang, Weijun Huang, Yingjia Li
OBJECTIVE: To evaluate the value of an integrated model incorporating deep learning (DL), hand-crafted radiomics and clinical and US imaging features for diagnosing central lymph node metastasis (CLNM) in patients with papillary thyroid cancer (PTC). METHODS: This retrospective study reviewed 613 patients with clinicopathologically confirmed PTC from two institutions. The DL model and hand-crafted radiomics model were developed using primary lesion images and then integrated with clinical and US features selected by multivariate analysis to generate an integrated model...
January 12, 2024: BMC Cancer
https://read.qxmd.com/read/38202168/hyperthermic-intraperitoneal-chemotherapy-hipec-oncological-outcomes-and-long-term-survival-among-patients-with-gastric-cancer-and-limited-peritoneal-disease-progression-after-neoadjuvant-chemotherapy
#26
JOURNAL ARTICLE
Sebastian Kobiałka, Katarzyna Sędłak, Zuzanna Pelc, Radosław Mlak, Yutaka Endo, Paweł Bogacz, Andrzej Kurylcio, Wojciech P Polkowski, Timothy M Pawlik, Karol Rawicz-Pruszyński
INTRODUCTION: The role of surgery in stage IV gastric cancer with peritoneal metastasis (PM) remains unclear. The objective of the current single-center study was to define the impact of gastrectomy with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on outcomes among Central European GC patients with limited peritoneal disease progression after neoadjuvant chemotherapy (NAC). METHODS: Patients with histologically confirmed GC who underwent curative-intent multimodal treatment between 2013 and 2023 were included...
December 27, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38197954/surgical-evidence-based-comparison-of-68-ga-ga-fapi-04-pet-and-mri-dwi-for-assisting-debulking-surgery-in-ovarian-cancer-patients
#27
JOURNAL ARTICLE
Xiang Li, Xiaohui Lv, Zhiyong Quan, Tingting Han, Yongqiang Tang, Ying Liu, Mengxin Wang, Guiyu Li, Jiajun Ye, Jingyi Wang, Xiaoli Lan, Xiao Zhang, Mengting Li, Shujuan Liu, Fei Kang, Jing Wang
PURPOSE: Imaging assessment of abdominopelvic tumor burden is crucial for debulking surgery decision in ovarian cancer patients. This study aims to compare the efficiency of [68 Ga]Ga-FAPI-04 FAPI PET and MRI-DWI in the preoperative evaluation and its potential impact to debulking surgery decision. METHODS: Thirty-six patients with suspected/confirmed ovarian cancer were enrolled and underwent integrated [68 Ga]Ga-FAPI-04 PET/MRI. Nineteen patients (15 stage III-IV and 4 I-II stage) who underwent debulking surgery were involved in the diagnostic efficiency analysis...
January 10, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38188215/iris-metastasis-from-clear-cell-renal-cell-carcinoma-a-case-report
#28
Tong-Tong Wang, Xiao-Yue Chen, Qiao-Yun Min, Yi-Ze Han, Huan-Fen Zhao
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a common type of tumor that can metastasize to any organs and sites. However, it is extremely rare for ccRCC to metastasize to the iris. Here, we describe a rare case of iris metastasis from ccRCC with a history of left nephrectomy in 2010. CASE SUMMARY: A 62-year-old male was admitted to the hospital due to blurred vision and red eyes, and a mass was found on the iris in the right eye. B-scan ultrasonography revealed a well-bounded high-density lesion at the corner of the anterior chamber at the 3-4 o'clock position...
December 26, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/38185762/a-case-of-rapidly-progressing-sarcomatous-intrahepatic-cholangiocarcinoma-with-suddenly-appearing-lymph-node-metastasis
#29
JOURNAL ARTICLE
Eisho Kanemitsu, Rei Takahashi, Setsuko Nakanishi, Satoru Sueyoshi, Atsushi Kobayashi, Takao Nishimura, Hiromitsu Nagata
BACKGROUND: The sarcomatous variant of carcinoma is relatively rare in intrahepatic cholangiocarcinoma (ICC). Sarcomatous ICC (SICC) is associated with a poorer prognosis compared with ICC. SICC is rarely diagnosed before surgery due to non-descriptive findings; it progresses rapidly, resulting in miserable prognosis. Here, we report a case of rapidly progressing SICC that showed a clinically significant tumor growth rate. CASE PRESENTATION: A 77-year-old woman who had undergone ileocecal resection for cecal cancer 5 years previously was found to have elevated levels of the tumor marker carbohydrate antigen 19-9...
January 8, 2024: Surgical Case Reports
https://read.qxmd.com/read/38184586/cutaneous-melanocytic-tumor-with-crtc1-trim11-fusion-a-case-report
#30
JOURNAL ARTICLE
Rong Duan, Xiaojuan He, Xiaojing Ma, Fengbo Huang, Xiangrong Hu
BACKGROUND: Cutaneous Melanocytic Tumor with CRTC1::TRIM11 Fusion (CMTCT) represents a novel and rare entity in the realm of dermatological oncology, characterized by distinct melanocytic differentiation. This particular tumor type has yet to be officially recognized by the World Health Organization (WHO). CMTCT is generally perceived as a tumor with a relatively indolent nature; however, it is not devoid of metastatic potential. Therefore, ensuring complete surgical excision of the tumor, coupled with rigorous long-term follow-up, is paramount for patient management...
January 6, 2024: Diagnostic Pathology
https://read.qxmd.com/read/38176719/-18-f-fapi-04-outperforms-18-f-fdg-pet-ct-in-clinical-assessments-of-patients-with-pancreatic-adenocarcinoma
#31
JOURNAL ARTICLE
Xiang Li, Na Lu, Lili Lin, Yiwen Chen, Shuye Yang, Huatao Wang, Xinyuan Liu, Chengyi Wu, Xing Xue, Xinhui Su, Xueli Bai, Tingbo Liang
Accurate diagnosis and staging are crucial for selecting treatment for patients with pancreatic ductal adenocarcinoma (PDAC). The desmoplastic responses associated with PDAC are often characterized by hypometabolism. Here, we investigated 18 F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT in evaluation of PDAC and compared the findings with those obtained using 18 F-FDG. Methods: Sixty-two PDAC patients underwent 18 F-FAPI-04 PET/CT and 18 F-FDG PET/CT. Identification of primary lesions, lymph node (LN) metastasis, and distant metastasis (DM) by these methods was evaluated, and TNM staging was performed...
February 1, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38169509/aldh1a1-drives-prostate-cancer-metastases-and-radioresistance-by-interplay-with-ar-and-rar-dependent-transcription
#32
JOURNAL ARTICLE
Ielizaveta Gorodetska, Anne Offermann, Jakob Püschel, Vasyl Lukiyanchuk, Diana Gaete, Anastasia Kurzyukova, Vera Freytag, Marie-Therese Haider, Christina S Fjeldbo, Simona Di Gaetano, Franziska Maria Schwarz, Shivaprasad Patil, Angelika Borkowetz, Holger H H Erb, Aria Baniahmad, Jovan Mircetic, Heidi Lyng, Steffen Löck, Annett Linge, Tobias Lange, Franziska Knopf, Ben Wielockx, Mechthild Krause, Sven Perner, Anna Dubrovska
Rationale: Current therapies for metastatic osseous disease frequently fail to provide a durable treatment response. To date, there are only limited therapeutic options for metastatic prostate cancer, the mechanisms that drive the survival of metastasis-initiating cells are poorly characterized, and reliable prognostic markers are missing. A high aldehyde dehydrogenase (ALDH) activity has been long considered a marker of cancer stem cells (CSC). Our study characterized a differential role of ALDH1A1 and ALDH1A3 genes as regulators of prostate cancer progression and metastatic growth...
2024: Theranostics
https://read.qxmd.com/read/38153787/single-cell-deconvolution-reveals-high-lineage-and-location-dependent-heterogeneity-in-mesenchymal-multivisceral-stage-iv-colorectal-cancer
#33
JOURNAL ARTICLE
Christopher Berlin, Bernhard Mauerer, Pierre Cauchy, Jost Luenstedt, Roman Sankowski, Lisa Marx, Reinhild Feuerstein, Luisa Schäfer, Florian R Greten, Marina Pesic, Olaf Groß, Marco Prinz, Naomi Rühl, Laura Miketiuk, Dominik Jauch, Claudia Laessle, Andreas Jud, Esther A Biesel, Hannes P Neeff, Stefan Fichtner-Feigl, Philipp A Holzner, Rebecca Kesselring
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in UICC (Union for International Cancer Control) stage IV CRC patients. Insights into differential site-specific reconstitution of tumour cells and the corresponding tumour microenvironment are still missing. Here, we analysed the transcriptome of single cells derived from murine multivisceral CRC and delineated the inter-metastatic cellular heterogeneity regarding tumour epithelium, stroma and immune cells...
December 28, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/38153641/sufficient-regional-lymph-node-examination-for-staging-adenocarcinoma-of-the-appendix
#34
JOURNAL ARTICLE
Felipe Lopez-Ramirez, Armando Sardi, Mary Caitlin King, Andrei Nikiforchin, Luis Felipe Falla-Zuniga, Philipp Barakat, Carol Nieroda, Vadim Gushchin
BACKGROUND: The presence of lymph node (LN) metastasis is a known negative prognostic factor in appendix cancer (AC) patients. However, currently the minimum number of LNs required to adequately determine LN negativity is extrapolated from colorectal studies and data specific to AC is lacking. We aimed to define the lowest number of LNs required to adequately stage AC and assess its impact on oncologic outcomes. METHODS: Patients with stage II-III AC from the National Cancer Database (NCDB 2004-2019) undergoing surgical resection with complete information about LN examination were included...
December 28, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/38150877/diosmetin-alleviates-neuropathic-pain-by-regulating-the-keap1-nrf2-nf-%C3%AE%C2%BAb-signaling-pathway
#35
JOURNAL ARTICLE
Lin Zhao, Xueshu Tao, Qian Wang, Xue Yu, Daosong Dong
BACKGROUND: Neuropathic pain, a chronic condition with a high incidence, imposes psychological burdens on both patients and society. It is urgent to improve pain management and develop new analgesic drugs. Traditional Chinese medicine has gained popularity as a method for pain relief. Diosmetin (Dio) is mainly found in Chinese herbal medicines with effective antioxidant, anti-cancer, and anti-inflammatory properties. There are few known mechanisms underlying the effectiveness of Dio in treating neuropathic pain...
January 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38115779/lumbosacral-pain-in-a-patient-with-psoriatic-arthritis-when-the-rheumatic-disease-is-innocent
#36
JOURNAL ARTICLE
H Parente, M Pontes Ferreira, C Soares, F Guimarães, S Azevedo, D Santos-Faria, J Tavares-Costa, D Peixoto, C Afonso, D Roriz, F Teixeira
Lumbar pain is a very common symptom that derives from benign musculoskeletal conditions, rheumatic inflammatory diseases, neoplasms, and referred and/or nociplastic pain. A 70-year-old man with psoriatic arthritis presented with early-onset lumbosacral pain without evident red flags. Symptomatic treatment was unhelpful. Radiographic imaging showed subtle signs of a disease that could easily be missed. Magnetic resonance imaging revealed a massive prostatic malignancy with bone (sacral and iliopubic) metastasis...
December 19, 2023: Reumatismo
https://read.qxmd.com/read/38111446/challenging-diagnosis-of-lytic-bone-lesions-between-multiple-myeloma-and-bone-metastasis-of-primary-breast-cancer
#37
Tao Edahiro, Hiroshi Ureshino, Tetsumi Yoshida, Noriyasu Fukushima, Tatsuo Ichinohe
Lytic bone lesions include various differential diagnoses, such as bone metastasis of cancer, multiple myeloma, primary bone cancers, and infections. Here, we report a rare case of primary breast cancer complicated by lytic bone lesions mimicking bone metastasis, which was subsequently diagnosed as multiple myeloma. Despite the development of several imaging modalities, such as magnetic resonance imaging and positron emission tomography/computed tomography, diagnosing lytic bone lesions with either multiple myeloma or tumor metastasis is highly challenging...
November 2023: Curēus
https://read.qxmd.com/read/38107521/multiple-myeloma-following-bone-metastasis-of-renal-cell-carcinoma-a-case-report
#38
Hong Yu, Shengnan Zhang, Xiaohui Feng, Feng Gao
BACKGROUND: The clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis. CASE SUMMARY: We reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38100925/paget-s-disease-of-the-nipple-with-underlying-occult-invasive-carcinoma-detected-by-magnetic-resonance-imaging-and-second-look-ultrasound-case-report
#39
Hao-Ming Li, Tzu-Yu Huang, Tsun-Hou Chang, Tzu-Ning Wen
INTRODUCTION: Paget's disease of the nipple (PDN) is a rare and often misdiagnosed condition characterized by the infiltration of adenocarcinoma cells into the nipple epidermis. It poses substantial diagnostic and therapeutic challenges due to its similarity to benign dermatological conditions and its association with in situ or invasive carcinoma. CASE PRESENTATION: This report details the case of a 47-year-old woman with persistent nipple itching, rash, and occasional bloody discharge...
December 13, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38097484/indocyanine-green-fluorescence-versus-blue-dye-technetium-99m-and-the-dual-marker-combination-of-technetium-99m%C3%A2-blue-dye-for-sentinel-lymph-node-detection-in-early-breast-cancer-meta-analysis-including-consistency-analysis
#40
REVIEW
Kevin P White, Diego Sinagra, Fernando Dip, Raul J Rosenthal, Edgar A Mueller, Emanuele Lo Menzo, Alberto Rancati
BACKGROUND: Axillary sentinel lymph node biopsies are standard of care in patients with breast cancer and no clinically apparent metastases. Traditionally, technetium-99m, blue dye, or both have been used to identify sentinel lymph nodes. However, blue dyes miss up to 40% of sentinel lymph nodes, while technetium-99m use is complex, costly, and exposes patients to radiation. Over the past decade, studies have consistently found the biologically inert fluorescent indocyanine green to be 95% to 100% sensitive in detecting breast cancer sentinel lymph nodes, yet indocyanine green remains infrequently used...
December 13, 2023: Surgery
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