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Missing Metastasis

Nadine Klusmeier, Hans-Joachim Schnittler, Jochen Seebach
Blood vessels are covered with endothelial cells on their inner surfaces, forming a selective and semipermeable barrier between the blood and the underlying tissue. Many pathological processes, such as inflammation or cancer metastasis, are accompanied by an increased vascular permeability. Progress in live cell imaging techniques has recently revealed that the structure of endothelial cell contacts is constantly reorganized and that endothelial junctions display high heterogeneities at a subcellular level even within one cell...
February 22, 2019: Biophysical Journal
Petar Petrov, Alexey V Sarapulov, Lel Eöry, Cristina Scielzo, Lydia Scarfò, Jacqueline Smith, David W Burt, Pieta K Mattila
Missing in Metastasis (MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved protein, which links the plasma membrane to the actin cytoskeleton. MIM has been implicated in various cancers, however, its modes of action remain largely enigmatic. Here, we performed an extensive in silico characterisation of MIM to gain better understanding of its function. We detected previously unappreciated functional motifs including adaptor protein (AP) complex interaction site and a C-helix, pointing to a role in endocytosis and regulation of actin dynamics, respectively...
March 11, 2019: Scientific Reports
Julia Grimm, Philip Zeuschner, Martin Janssen, Stefan Wagenpfeil, Arndt Hartmann, Christine Stöhr, Bastian Keck, Andreas Kahlmeyer, Michael Stöckle, Kerstin Junker
Prognostic markers for the definition of the individual metastatic risk in renal cell carcinoma are still missing. The aim of our study was to establish a total number of specific aberrations (TNSA) genetic score as a new prognostic test for metastatic risk evaluation. FISH was performed on isolated cell nuclei of 100 ccRCCs (50 M1/50 M0) and 100 FFPE sections (2nd cohort, 32 M1/68 M0). For each chromosomal region (1q21.3, 7q36.3, 9p21.3p24.1, 20q11.21q13.32) cut-off values were determined by ROC-curve analysis...
March 9, 2019: Genes, Chromosomes & Cancer
Felix Che-Lok Chow, Kenneth Siu-Ho Chok
Liver metastasis is the commonest form of distant metastasis in colorectal cancer. Selection criteria for surgery and liver-directed therapies have recently been extended. However, resectability remains poorly defined. Tumour biology is increasingly recognized as an important prognostic factor; hence molecular profiling has a growing role in risk stratification and management planning. Surgical resection is the only treatment modality for curative intent. The most appropriate surgical approach is yet to be established...
February 27, 2019: World Journal of Hepatology
Lushen Li, Shaneen S Baxter, Peng Zhao, Ning Gu, Xi Zhan
Missing in metastasis (MIM), an inverse BAR (I-BAR) domain protein, promotes endocytosis of C-X-C motif chemokine receptor 4 (CXCR4) in mammalian cells. In response to the CXCR4 ligand stromal cell-derived factor 1 (SDF-1 or CXCL12), MIM associates with RAS-related GTP-binding protein 7 (RAB7) 30 min after stimulation. Yet, RAB7's role in MIM function remains undefined. Here, we show that RNAi-mediated suppression of RAB7 expression in human HeLa cells has little effect on the binding of MIM to RAB5 and on the recruitment of CXCR4 to early endosomes, but effectively abolishes MIM-mediated CXCR4 degradation, chemotactic response, and sorting into late endosomes and lysosomes...
February 26, 2019: Journal of Biological Chemistry
Hao Lin, Qingqing Guo, Shiyun Lu, Jie Chen, Xing Li, Min Gong, Lin Tang, Jianbo Wen
Colorectal cancer (CRC) is a prevalent malignancy characterized with high morbidity and death rate. Due to late diagnosis, most CRC patients missed the proper timing for radical operation, which led to the high mortality in CRC. Therefore, identifying new prognostic and therapeutic targets is important. Long non-coding RNAs are reported as essential regulators for tumor progression, including in CRC. LncRNA SUMO1P3 has been documented as an oncogene promoting proliferation, cell cycle, and metastasis in several cancers, but its role in CRC has never been unveiled...
February 21, 2019: Biochemical and Biophysical Research Communications
Joung Ha Park, Jooae Choe, Moonsuk Bae, Sungim Choi, Kyung Hwa Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Kyung-Wook Jo, Tae Sun Shim, Mi Young Kim, Sung-Han Kim
Background: Pauci-bacillary pulmonary tuberculosis (TB) can be delayed to diagnose and start anti-TB therapy, especially in immunocompromised patients. We therefore evaluated the clinical and radiologic features of these delayed cases. Methods: Immunocompromised adult patients with pauci-bacillary pulmonary TB were retrospectively enrolled in a tertiary hospital in an intermediate-TB burden country over a 5-year period. We defined "missed TB" or "not-missed TB" patients as those who started anti-TB therapy after or before positive mycobacterial culture results, respectively...
February 2019: Open Forum Infectious Diseases
Felix Preisser, Felix K H Chun, Raisa S Pompe, Alexander Heinze, Georg Salomon, Markus Graefen, Hartwig Huland, Derya Tilki
BACKGROUND: Persistent prostate-specific antigen (PSA) represents a poor prognostic factor for recurrence after radical prostatectomy (RP). OBJECTIVE: To investigate the impact of persistent PSA at 6wk after RP on long-term oncologic outcomes and to assess patient characteristics associated with persistent PSA. DESIGN, SETTING, AND PARTICIPANTS: Within a high-volume center database we identified patients who harbored persistent (≥0.1ng/ml) versus undetectable PSA (<0...
February 13, 2019: European Urology
Se Hyun Paek, Kyoung Eun Lee, Han Su Kim, Joohyun Woo, Woosung Lim
BACKGROUND Sarcomas can develop de novo or secondary to radiotherapy after or during breast cancer treatment. Diagnosis can be challenging, as such, a sarcoma is often missed on routine follow-up imaging and often presents with dermatologic findings. CASE REPORT Here, we present a case of a 45-year-old female who developed spindle cell sarcoma on her neck, which was mimicking supraclavicular lymph node metastasis of breast cancer. CONCLUSIONS Based on our report, we recommend a tissue biopsy with an immunohistochemistry profile when a mass suspicious for metastasis is found in patients with breast cancer...
February 14, 2019: American Journal of Case Reports
Firas Al-Qarqaz, Khaldon Bodoor, Awad Al-Tarawneh, Haytham Eloqayli, Wisam Al Gargaz, Diala Alshiyab, Jihan Muhaidat, Mohammad Alqudah, Rowida Almomani, Maha Marji
Introduction: Basal cell carcinoma (BCC) is the most common cancer affecting humans. Luckily it has negligible risk for metastasis; however it can be locally destructive to surrounding tissue. The diagnosis of this tumor relies on clinical and dermoscopic features; however confirmation requires biopsy and histologic examination. Based on clinical and pathologic findings, BCC is classified as low or high risk subtype. The clinician requesting pathology examination for BCC should provide the pathologist with detailed information including patient details, relevant clinical and medical history, site and type of the biopsy, and whether this is a primary or recurrent lesion...
2019: Journal of Skin Cancer
Chia-Jung Liao, Chia-Hsun Hsieh, Tzu-Keng Chiu, Yu-Xian Zhu, Hung-Ming Wang, Feng-Chun Hung, Wen-Pin Chou, Min-Hsien Wu
Circulating tumour cells (CTCs) in blood circulation play an important role in cancer metastasis. CTCs are generally defined as the cells in circulating blood expressing the surface antigen EpCAM (epithelial cell adhesion molecule). Nevertheless, CTCs with a highly metastatic nature might undergo an epithelial-to-mesenchymal transition (EMT), after which their EpCAM expression is downregulated. In current CTC-related studies, however, these clinically important CTCs with high relevance to cancer metastasis could be missed due to the use of the conventional CTC isolation methodologies...
October 31, 2018: Micromachines
Ajay Gogia, S Vs Deo, N K Shukla, Sandeep Mathur, D N Sharma, Akash Tiwari
INTRODUCTION: This study was undertaken to evaluate the clinicopathological characteristics of patients with breast cancer at our institute, a tertiary-care cancer center in northern India. MATERIALS AND METHODS: This retrospective study included all patients with breast cancer registered at our institute from January 1st , 2014 to December 31st , 2016. We retrieved data (demographic, baseline clinical characteristics, pathology, and treatment details) from prospectively maintained clinical case records...
July 2018: Indian Journal of Cancer
D Dong, L Tang, Z-Y Li, M-J Fang, J-B Gao, X-H Shan, X-J Ying, Y-S Sun, J Fu, X-X Wang, L-M Li, Z-H Li, D-F Zhang, Y Zhang, Z-M Li, F Shan, Z-D Bu, J Tian, J-F Ji
Background: Occult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on CT images. Patients with occult PMs are subject to late detection or even improper surgical treatment. We therefore aimed to develop a radiomic nomogram to preoperatively identify occult PMs in AGC patients. Patients and methods: 554 AGC patients from four centers were divided into one training, one internal validation, and two external validation cohorts...
January 23, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Hugo Loureiro, Eunice Carrasquinha, Irina Alho, Arlindo R Ferreira, Luís Costa, Alexandra M Carvalho, Susana Vinga
BACKGROUND: Joint models (JM) have emerged as a promising statistical framework to concurrently analyse survival data and multiple longitudinal responses. This is particularly relevant in clinical studies where the goal is to estimate the association between time-to-event data and the biomarkers evolution. In the context of oncological data, JM can indeed provide interesting prognostic markers for the event under study and thus support clinical decisions and treatment choices. However, several problems arise when dealing with this type of data, such as the high-dimensionality of the covariates space, the lack of knowledge about the function structure of the time series and the presence of missing data, facts that may hamper the accurate estimation of the JM...
January 17, 2019: BMC Medical Informatics and Decision Making
Hojjat Naderi-Meshkin, Xin Lai, Raheleh Amirkhah, Julio Vera, John E J Rasko, Ulf Schmitz
Motivation: Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs). Results: This review outlines the links between EVs, lncRNAs and cancer...
January 15, 2019: Bioinformatics
Wei Jiang, Hong-Yan Wei, Hai-Yan Zhang, Qiu-Luan Zhuo
BACKGROUND: Cervical lymph node metastasis in papillary thyroid carcinoma (PTC) affects the treatment and prognosis of patients. Ultrasound is a common imaging method for detecting cervical lymph nodes in PTC patients; however, it is not accurate in determining lymph node metastasis. AIM: To evaluate the value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in PTC. METHODS: A total of 94 patients with PTC were recruited...
January 6, 2019: World Journal of Clinical Cases
Marialuisa Framarino-Dei-Malatesta, Annalisa Chiarito, Federico Bianciardi, Marco Fiorelli, Azzurra Ligato, Giuseppe Naso, Irene Pecorella
BACKGROUND: Unilateral or bilateral metastases to extraocular muscles are very rare in breast cancer. CASE PRESENTATION: We describe a case of inferior rectus extraocular muscle involved by ductal luminal B/Her-2 neu negative breast cancer, observed in a cohort of 580 patients. Our patient had received chemotherapy and hormonal therapy (tamoxifen for 3 years and letrozole in the following 3 years) for her primary cancer and developed an orbital metastasis while she was under aromatase inhibitor-based therapy...
January 8, 2019: BMC Cancer
Annette Zimpfer, Bjoern Schneider, Oliver Blanck, Katrin Riedel, Andrey Zhivov, Danny Jonigk, Andreas Erbersdobler, Anselm Jünemann, Nicolaus Andratschke, Guido Hildebrandt, Rudolf F Guthoff, Vinodh Kakkassery
To evaluate uveal melanoma cell activity and pathologic features after stereotactic CyberKnife radiosurgery in specimens from five patients. Specimens from five patients treated by CyberKnife radiosurgery in three fractions were included in this study. Because of persistent retinal detachment in 3 patients, tumour endoresection was performed at four, seven and ten month after CyberKnife radiosurgery. At nine and twelve months after treatment, enucleation of the eye globe was performed in 2 patients because of secondary tumour bleeding and missing regression...
January 7, 2019: Pathology Oncology Research: POR
Sung Mo Ryu, Sun-Ho Lee, Eun-Sang Kim, Whan Eoh
OBJECTIVE: This study was conducted to understand the clinical and demographic factors influencing the overall survival (OS) of spinal ependymoma patients and to predict the OS with machine learning (ML) algorithms. METHODS: We compiled spinal ependymoma cases diagnosed between 1973 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) registry. To identify the factors influencing survival, statistical analyses were performed using the Kaplan-Meier method and Cox proportional hazards regression model...
December 28, 2018: World Neurosurgery
Sunny Trivedi, Michelle Starz-Gaiano
Over the past three-decades, Janus kinase (Jak) and signal transducer and activator of transcription (STAT) signaling has emerged as a paradigm to understand the involvement of signal transduction in development and disease pathology. At the molecular level, cytokines and interleukins steer Jak/STAT signaling to transcriptional regulation of target genes, which are involved in cell differentiation, migration, and proliferation. Jak/STAT signaling is involved in various types of blood cell disorders and cancers in humans, and its activation is associated with carcinomas that are more invasive or likely to become metastatic...
December 14, 2018: International Journal of Molecular Sciences
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