Read by QxMD icon Read

Enhance photothermal therapy

Huabing Zhang, Yang Li, Zhou Pan, Yilin Chen, Zhongxiong Fan, Haina Tian, Song Zhou, Yubin Zhang, Jiajia Shang, Beili Jiang, Fanfan Wang, Fanghong Luo, Zhenqing Hou
Locating nanomedicines at the active sites plays a pivotal role in nanoparticle-based cancer therapy field. Herein, a multifuntional nanotherapeutic is designed by using graphene oxide (GO) nanosheets with rich carboxyl groups as the supporter for hyaluronic acid (HA)-methotrexate (MTX) prodrug modification via adipic dihydrazide crosslinker, achieving synergistic tumor-targeting and combined chemo-photothermal therapy. As a tumor-targeting biomaterials, HA can increase affinity of the nanocarrier towards CD44 receptor for enhanced cellular uptake...
March 20, 2019: Molecular Pharmaceutics
Qianyun Tang, Zijin Cheng, Nan Yang, Qinzhe Li, Peng Wang, Dapeng Chen, Wenjun Wang, Xuejiao Song, Xiaochen Dong
Developing new strategies to alleviate tumor hypoxia and enhance the therapeutic efficacy towards solid tumors is of great significance to tumor therapy. Herein, to overcome tumor hypoxia, specifically designed aza-BODIPY photosensitizer is co-loaded with anti-cancer drug (doxorubicin, DOX) onto the hydrangea-structured MnO2 nanoparticles, and a tumor microenvironment (TME) responsive degradable nanoplatform (MDSP NP) is established. MDSP NPs (∼54 nm), with near infrared absorption (∼853 nm), can be rapidly dissociated to generate oxygen in response to TME, whereby improving tumor hypoxia, in favor of effective drugs release and enhanced chemo/photodynamic therapy...
March 15, 2019: Biomaterials
Fengrong Zhang, Xianlin Han, Yanyan Hu, Shunhao Wang, Shuang Liu, Xueting Pan, Hongyu Wang, Junjie Ma, Weiwei Wang, Shanshan Li, Qingyuan Wu, Heyun Shen, Xiaoling Yu, Qipeng Yuan, Huiyu Liu
Photothermal-radiotherapy (PT-RT) is an effective strategy for relieving hypoxia-related radiotherapy resistance and inducing tumor-specific cell apoptosis/necrosis. Nevertheless, limited tissue penetration of near-infrared (NIR) laser and the serious side effects of high-dose radiation severely hinder its applications for deep tumors. An interventional photothermal-brachytherapy (IPT-BT) technology is proposed here for the internal site-specific treatment of deep tumors. This technology utilizes a kind of biodegradable honeycomb-like gold nanoparticles (HGNs) acting as both internal photothermal agents and radiosensitizers...
March 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Jincan He, Jianwei Dong, Yufei Hu, Gongke Li, Yuling Hu
Nanoscale metal-organic frameworks (NMOFs) with ultrahigh porosities and incredibly high internal surface areas are potential nanomaterials to fabricate multifunctional theranostic platforms. This work describes the design of Raman tag-bridged core-shell nanoparticles (NPs) for multifunctional Raman imaging and chemo-phototherapy. Au@Cu3(BTC)2 NPs are characterized with the core of gold nanoparticles (Au NPs), the bridging of the Raman reporter molecule 4-mercaptobenzoic acid (4-MBA), and the shell of copper(ii) carboxylate MOFs (Cu3(BTC)2)...
March 14, 2019: Nanoscale
Lin Wu, Ling Zong, Haihua Ni, Xuexue Liu, Wen Wen, Lei Feng, Jin Cao, Xueyong Qi, Yanru Ge, Song Shen
Smart micelles which undergo dramatic property changes in response to temperature have aroused extensive interest in specific cancer therapy. To date, studies on thermosensitive polymers have mainly focused on lower critical solution temperature (LCST) polymers. Materials with upper critical solution temperature (UCST) which can swell and disassemble at elevated temperatures have much less been documented, although they have been reported to be ideal carriers for quick and complete drug release upon applying a stimulus...
March 14, 2019: Biomaterials Science
Austin C V Doughty, Ashley R Hoover, Elivia Layton, Cynthia K Murray, Eric W Howard, Wei R Chen
As a result of their unique compositions and properties, nanomaterials have recently seen a tremendous increase in use for novel cancer therapies. By taking advantage of the optical absorption of near-infrared light, researchers have utilized nanostructures such as carbon nanotubes, gold nanorods, and graphene oxide sheets to enhance photothermal therapies and target the effect on the tumor tissue. However, new uses for nanomaterials in targeted cancer therapy are coming to light, and the efficacy of photothermal therapy has increased dramatically...
March 7, 2019: Materials
Shunjie Liu, Xin Zhou, Haoke Zhang, Hanlin Ou, Jacky W Y Lam, Yang Liu, Linqi Shi, Dan Ding, Ben Zhong Tang
Planar donor and acceptor (D-A) conjugated structures are generally believed as the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramolecular motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on: molecular motion in aggregates. Molecular rotors and bulky alkyl chains are grafted to the central D-A core to lower intermolecular interaction...
March 13, 2019: Journal of the American Chemical Society
Yanshu Shi, Sainan Liu, Ying Liu, Chunqiang Sun, Mengyu Chang, Xueyan Zhao, Chunling Hu, Maolin Pang
Photodynamic therapy (PDT) of cancers is usually inefficient due to the relatively low level of oxygen in cancer cells, therefore, it needs to combine with other treatment strategies such as chemotherapy or photothermal therapy (PTT) to achieve the best anticancer efficacy. Although porphyrin-containing materials have been widely studied for PDT, the photothermal effect is rarely reported. Herein, nanoscale porphyrin-containing covalent organic polymers (PCOP) were produced via a room temperature solution-based aging method...
March 11, 2019: ACS Applied Materials & Interfaces
Xuerong Liu, Cheng Wang, Huisong Ma, Fangying Yu, Fuqiang Hu, Hong Yuan
Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water-responsive phospholipid-calcium-carbonate hybrid nanoparticle (PL/ACC-DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near-infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer...
March 11, 2019: Advanced Healthcare Materials
Qingxin Mu, Hui Wang, Xinyu Gu, Zachary R Stephen, Charles Yen, Fei-Chien Chang, Christopher J Dayringer, Miqin Zhang
It is considered a significant challenge to construct nanocarriers that have high drug loading capacity and can overcome physiological barriers to deliver efficacious amounts of drugs to solid tumors. Here, the development of a safe, biconcave carbon nanodisk to address this challenge for treating breast cancer is reported. The nanodisk demonstrates fluorescent imaging capability, an exceedingly high loading capacity (947.8 mg g-1 , 94.78 wt%) for doxorubicin (DOX), and pH-responsive drug release. It exhibits a higher uptake rate by tumor cells and greater accumulation in tumors in a mouse model than its carbon nanosphere counterpart...
March 11, 2019: Advanced Healthcare Materials
Barbara Poinard, Sharon Ai Er Lam, Koon Gee Neoh, James Chen Yong Kah
Urine voiding and the presence of a mucus layer on the apical surface of the urothelium are two major challenges towards an effective intravesical drug delivery for bladder malignancies. Improved bioavailability to the underlying bladder tissue could be achieved with delivery vectors that diffuse efficiently through the bladder mucus. Pegylation of delivery vectors remains the existing "gold standard" to enhance mucosal delivery despite known poor cell uptake and reported PEG sensitivity. Here, we showed improved mucopenetration of carboxylated polystyrene (PS) nanoparticles (NPs) passivated with a polydopamine (PDA) surface, at similar level as PEG...
March 7, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Zhengjie Zhou, Yang Yan, Li Wang, Qiang Zhang, Yiyun Cheng
Photothermal therapy efficiently ablates tumors via hyperthermia but inevitably induces serious side effects including thermal damage to normal tissues, inflammations and enhanced risk of tumor metastasis. In this study, we fabricated a dual peptide decorated melanin-like nanoparticle for tumor-targeted and autophagy-promoted photothermal therapy in pursuit of improved cancer treatment. The multifunctional nanoparticle was composed of dual peptide RGD- and beclin 1-modified and PEGylated melanin-like polydopamine nanoparticles...
March 1, 2019: Biomaterials
Fangfang Xia, Jiaqi Niu, Yuping Hong, Chenlu Li, Wen Cao, Lirui Wang, Wenxiu Hou, Yanlei Liu, Daxiang Cui
Nanotheranostics has gained increasing interest, as it offers a great potential to realize personalized diagnostics and therapy. In this work, we report a facile approach of the fabrication of gold nanostars (GNS) attached with matrix metalloproteinases (MMP2) polypeptides (Ac-GPLGIAGQ) and IR-780 iodide through bovine serum albumin (BSA) for targeted dual-modal photoacoustic (PA)/near-infrared (NIR) fluorescence imaging and enhanced photothermal therapy (PTT)/photodynamic therapy (PDT) for lung cancer. MMP2 polypeptides served as the targeting ligand, IR-780 iodide functioned as the NIR fluorescence imaging agent as well as PTT/PDT agent, and GNS acted as the carrier of IR-780 molecules and performed PA imaging and PTT...
March 6, 2019: Acta Biomaterialia
Ziaeddin Abed, Jaber Beik, Sophie Laurent, Neda Eslahi, Tahereh Khani, Elnaz S Davani, Habib Ghaznavi, Ali Shakeri-Zadeh
Recent efforts in the area of photothermal therapy (PTT) follow two important aims: (i) selective targeting of plasmonic nanoparticles to the tumor and (ii) real-time guidance of PTT operation through employing multimodal imaging modalities. In the present study, we utilized a multifunctional theranostic nanoplatform constructed from iron (III) oxide-gold (Fe2 O3 @Au) core-shell nanoparticles to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT...
March 7, 2019: Journal of Cancer Research and Clinical Oncology
Jingchao Li, Hongzhi Liu, Jiang Ming, Duo Sun, Xiaolan Chen, Xiaolong Liu, Nanfeng Zheng
On account of the fascinating surface plasmon resonance (SPR) properties, the ability of passively targeting tumors and remarkable biocompatibility, two-dimensional (2D) Pd-based nanomaterials have demonstrated wide application prospects in cancer theranostics. However, the used animal models for exploring the bioapplications and biosafety of 2D Pd-based nanomaterials were usually limited to mice. To further widen their biomedical applications and promote future clinical transformation, it is necessary to make a breakthrough in animal models...
February 14, 2019: Chemical Science
Yuqian Wang, Hong Zhao, Dezhou Wang, Miao Hao, Chenfei Kong, Xiaoming Zhao, Yiyao Gao, Jing Li, Baocai Liu, Bai Yang, Hao Zhang, Jinlan Jiang
Photothermal therapy (PTT) is a recently developed and promising strategy for the treatment of hepatocellular carcinoma (HCC). However, apoptosis has been extensively investigated as the mechanism of the underlying effect of PTT on cancer to date. Here, we explored alternative mechanisms of these therapeutic effects, including the activation of cell-cycle arrest and autophagy during PTT in addition to apoptosis under mild temperature. We treated the HCC cell line HepG2 with polydopamine (PDA)-coated branched Au-Ag nanoparticles at various concentrations along with PTT using an 808-nm laser...
April 1, 2019: Journal of Biomedical Nanotechnology
Lehui Lu, Weihua Chen, Jianhua Liu, Ying Wang, Chunhuan Jiang, Bin Yu, Zhen Sun
Intracellular targeting has the same potential as tissue targeting to increase therapy efficacy, especially for the DNA toxic drugs. Here, for the first time, adjusting the intracellular traffic, we developed a novel C5N2 nanoparticles (NPs)-based direct nucleus delivery platform. Supramolecular interactions of C5N2 NPs with the cell membrane enhanced the cell uptake; abundant edge amino groups promoted fast and effective rupture of early endosomes; and the suitable size was also crucial for size-dependent nuclear entry...
March 5, 2019: Angewandte Chemie
Milan Gautam, Raj Kumar Thapa, Bijay Kumar Poudel, Biki Gupta, Hima Bindu Ruttala, Hanh Thuy Nguyen, Zar Chi Soe, Wenquan Ou, Kishwor Poudel, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim
Near-infrared (NIR)-responsive drug delivery systems have enhanced tumor ablative efficiency through permeation and retention effects. Graphene oxide (GO) has shown great potential both in photothermal therapy and in drug delivery. Thus, in this study, we designed an ambient spark-generated GO, wrapped on topotecan (TPT)-loaded hollow mesoporous silica nanoparticles (HMSN-NH2-TPT-CGO), to function as an efficient platform for pH-dependent sustained release of TPT. HMSN-NH2-TPT-CGO also exhibited a combined chemo-photothermal effect within a single carrier system...
February 25, 2019: Acta Biomaterialia
Li-Li Tan, Li Shang
Smart delivery systems have gained momentum over the last few decades due to their potential to realize enhanced therapeutic efficacy. Poly(glycidyl methacrylate)s (PGMAs), which spring up like mushrooms, have drawn great attention in the theranostics field, especially in multifunctional theranostic systems. The marriage of PGMAs with functional inorganic cores is expected to integrate diagnosis (e.g., fluorescence, X-ray computed tomography, magnetic resonance, photoacoustic and upconversion luminescence imaging), treatment, or multimodal synergistic therapies (e...
February 28, 2019: Macromolecular Rapid Communications
Abhijeet Pandey, Kritarth Singh, Sagar Patel, Rajesh Singh, Kirti Patel, Krutika Sawant
In the present investigation, FePt alloy nanoparticles were synthesized with controlled size and elemental composition followed by surface modification using (3-Aminopropyl) triethoxysilane (APTES). Lenalidomide was covalently bound to FePt-NH2 by pH sensitive hydrazone bonding. Hyaluronic acid was conjugated to amino groups of APTES while lactoferrin (Lf) was directly conjugated to excess carboxylic group present on hyaluronic acid (HA) to form surface modified pH sensitive alloy-drug nanoconjugates (SPANs)...
May 2019: Materials Science & Engineering. C, Materials for Biological Applications
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"