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Stephen hoole

Kevin P Liou, Sze-Yuan M Ooi, Stephen P Hoole, Nick E J West
Background: The utility of fractional flow reserve (FFR) to guide revascularisation in the management of acute coronary syndrome (ACS) remains unclear. Objective: This study aims to compare the clinical outcomes of patients following FFR-guided revascularisation for either ACS or stable angina (SA) and in particular focuses on the outcome of those with deferred revascularisation after FFR. Methods: A meta-analysis of existing literature was performed...
2019: Open Heart
Daniel J Blackman, Smriti Saraf, Philip A MacCarthy, Aung Myat, Simon G Anderson, Christopher J Malkin, Michael S Cunnington, Kathryn Somers, Paul Brennan, Ganesh Manoharan, Jessica Parker, Omar Aldalati, Stephen J Brecker, Cameron Dowling, Stephen P Hoole, Stephen Dorman, Michael Mullen, Simon Kennon, Melanie Jerrum, Pavan Chandrala, David H Roberts, Justin Tay, Sagar N Doshi, Peter F Ludman, Timothy A Fairbairn, Joanne Crowe, Richard D Levy, Adrian P Banning, Neil Ruparelia, Mark S Spence, David Hildick-Smith
BACKGROUND: Very little is known about long-term valve durability after transcatheter aortic valve replacement (TAVR). OBJECTIVES: This study sought to evaluate the incidence of structural valve degeneration (SVD) 5 to 10 years post-procedure. METHODS: Demographic, procedural, and in-hospital outcome data on patients who underwent TAVR from 2007 to 2011 were obtained from the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) registry...
February 12, 2019: Journal of the American College of Cardiology
Sophie J Clarke, Stephen Pettit, Joel P Giblett, Tian Zhao, Anna C Kydd, Nicolai J W Albrechtsen, Carolyn F Deacon, Jayan Parameshwar, Stephen P Hoole
PURPOSE: Cardiovascular-safety studies assessing glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase 4 inhibitors have provided inconsistent data on the risk for developing heart failure. Animal studies have shown that GLP-1 is a vasodilator; if confirmed in humans, this may ameliorate heart failure symptoms. METHODS: In a single-center, observational pilot study, we recruited 10 patients with advanced heart failure undergoing right heart catheterization, and we recorded pulmonary hemodynamic measures, including cardiac output calculated by thermodilution and the indirect Fick method before and after a 15-minute continuous infusion of native GLP-1 (7-36) NH2 ...
January 2019: Clinical Therapeutics
Sophie J Clarke, Joel P Giblett, Lucy L Yang, Annette Hubsch, Tian Zhao, Muhammad Aetesam-Ur-Rahman, Nick E J West, Michael O'Sullivan, Nichola Figg, Martin Bennett, Nicolai J Wewer Albrechtsen, Carolyn F Deacon, Joseph Cheriyan, Stephen P Hoole
Background The mechanism underlying the beneficial cardiovascular effects of the incretin GLP-1 (glucagon-like peptide 1) and its analogues in humans is elusive. We hypothesized that activating receptors located on vascular smooth muscle cells to induce either peripheral or coronary vasodilatation mediates the cardiovascular effect of GLP -1. Methods and Results Ten stable patients with angina awaiting left anterior descending artery stenting underwent forearm blood flow measurement using forearm plethysmography and post-percutaneous coronary intervention coronary blood flow measurement using a pressure-flow wire before and after peripheral GLP -1 administration...
November 20, 2018: Journal of the American Heart Association
Vincent Floré, Adam J Brown, Joel P Giblett, Kevin Liou, James Cranley, Stephen P Hoole, Nick E J West
AIMS: We investigated the effects of an initial learning period with mandatory optical coherence tomography (OCT) guidance for the implantation of everolimus-eluting bioresorbable vascular scaffolds (BVS). METHODS AND RESULTS: We analyzed procedural and clinical outcomes of all BVS implantations at a single center where OCT guidance was mandatory in the initial rollout (OCT-mandatory) phase. We compared these data with the later phase where use of OCT was at operator discretion (OCT-selective or angiography)...
October 30, 2018: EuroIntervention
Tian Xiao Zhao, Michalis Kostapanos, Charmaine Griffiths, Emma L Arbon, Annette Hubsch, Fotini Kaloyirou, Joanna Helmy, Stephen P Hoole, James H F Rudd, Graham Wood, Keith Burling, Simon Bond, Joseph Cheriyan, Ziad Mallat
INTRODUCTION: Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of the postischaemic injury in myocardial infarction. Regulatory T cells (CD4+ CD25+ FOXP3+ ; Treg) induce immune tolerance and preserve immune homeostasis. Recent in vivo studies suggested that low-dose interleukin-2 (IL-2) can increase Treg cell numbers. Aldesleukin is a human recombinant form of IL-2 that has been used therapeutically in several autoimmune diseases...
September 17, 2018: BMJ Open
Nick E J West, Joseph P Corrigan, Richard H G Owen, Stephen P Hoole, Adam J Brown, Stephen Blatcher, Andrew C Newby
A percutaneous catheter device, the Liquid Biopsy System, was developed to sample the unstirred boundary layer of blood upstream and downstream of intact and disrupted human coronary atherosclerotic plaques. Using multiplexed proximity extension assays, release of 20 biomolecules was simultaneously detected in samples taken across plaques before balloon angioplasty, including the soluble form of the endothelial lectin-like oxidized LDL receptor. Additional biomolecules, including matrix metalloproteinase-12, were released after plaque disruption with angioplasty...
December 2017: JACC. Basic to Translational Science
Vincent Floré, Adam J Brown, Stephen J Pettit, Nick E J West, Clive Lewis, Jayan Parameshwar, Stephen P Hoole
OBJECTIVE: Cardiac allograft vasculopathy (CAV) can be detected early with intravascular ultrasound (IVUS), but there is limited information on the most efficient imaging protocol. METHODS: Coronary angiography and IVUS of the three coronary arteries were performed. Volumetric IVUS analysis was performed, and a Stanford grade determined for each vessel. RESULTS: Eighteen patients were included 18 (range 12-24) months after transplantation...
February 2018: Clinical Transplantation
Stephen P Hoole, Jules Hernández-Sánchez, William R Davies, Duncan C McNab, Patrick A Calvert, Bushra S Rana, Leonard M Shapiro, Michael G Davies
BACKGROUND: Previous studies have shown a higher prevalence of patent foramen ovale (PFO) in patients with obstructive sleep apnea syndrome (OSAS). Right to left shunting through a PFO may be encouraged by the respiratory physiology of OSAS, contributing to the disease pathophysiology. We assessed whether PFO closure would improve respiratory polygraphy parameters compared with baseline measurements in patients with OSAS. METHODS: Twenty-six patients with newly diagnosed OSAS and a moderate-large PFO (prevalence, 18% of 143 patients screened) were referred for PFO closure...
December 2017: Canadian Journal of Cardiology
Stephen P Hoole, Jules Hernández-Sánchez, Adam J Brown, Joel P Giblett, Martin R Bennett, Nick E J West
BACKGROUND: Percutaneous coronary intervention-induced myocardial infarction (PMI) has prognostic significance. Identifying patients at high risk for PMI is desirable as it may alter strategy and facilitate early preventative therapy. We therefore sought to establish whether preprocedural demographic, interventional (plaque characteristics and coronary microcirculatory function), and inflammatory, endothelial damage, and platelet-derived biomarker data could predict the risk of PMI. PATIENTS AND METHODS: We performed target vessel pressure wire to assess fractional flow reserve, index of microcirculatory resistance (IMR) and coronary flow reserve, plaque characterization by virtual histology intravascular ultrasound, and assayed peripheral biomarkers before uncomplicated PCI in 88 patients...
May 2018: Coronary Artery Disease
Adam J Brown, Joel P Giblett, Martin R Bennett, Nick E J West, Stephen P Hoole
OBJECTIVES: To assess the relationship between anatomical form and physiological function in atherosclerotic coronary arteries. BACKGROUND: Although adverse cardiovascular events are predicted by plaque morphology or invasively-derived hemodynamic indices, the link between these important prognostic measures remains unexplored. METHODS: Patients with stable angina underwent fractional flow reserve (FFR), coronary flow reserve (CFR), pressure-derived collateral flow index (CFIp), trans-myocardial biomarker sampling and radiofrequency intravascular ultrasound (IVUS) imaging prior to intervention...
December 1, 2017: International Journal of Cardiology
Charis Costopoulos, Yuan Huang, Adam J Brown, Patrick A Calvert, Stephen P Hoole, Nick E J West, Jonathan H Gillard, Zhongzhao Teng, Martin R Bennett
OBJECTIVES: The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. BACKGROUND: Plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound-virtual histology studies indicate that <10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture...
December 2017: JACC. Cardiovascular Imaging
Richard G Axell, Joel P Giblett, Paul A White, Andrew Klein, James Hampton-Til, Michael O'Sullivan, Denise Braganza, William R Davies, Nick E J West, Cameron G Densem, Stephen P Hoole
BACKGROUND: We sought to determine whether right ventricular stunning could be detected after supply (during coronary balloon occlusion [BO]) and supply/demand ischemia (induced by rapid pacing [RP] during transcatheter aortic valve replacement) in humans. METHODS AND RESULTS: Ten subjects with single-vessel right coronary artery disease undergoing percutaneous coronary intervention with normal ventricular function were studied in the BO group. Ten subjects undergoing transfemoral transcatheter aortic valve replacement were studied in the RP group...
June 6, 2017: Journal of the American Heart Association
Joel P Giblett, Stephen P Hoole
This review examines the rationale for using remote ischemic conditioning (RIC) in elective percutaneous coronary intervention (PCI) to prevent procedure-related ischemia-reperfusion injury and justifies the importance of periprocedural biomarker elevation following elective PCI as a valid target for RIC. We review the evidence for the use of RIC as a treatment in this setting and document the salutary rules that must be followed to successfully translate RIC for clinical benefit.
July 2017: Journal of Cardiovascular Pharmacology and Therapeutics
Richard G Axell, Simon J Messer, Paul A White, Colm McCabe, Andrew Priest, Thaleia Statopoulou, Maja Drozdzynska, Jamie Viscasillas, Elizabeth C Hinchy, James Hampton-Till, Hatim I Alibhai, Nicholas Morrell, Joanna Pepke-Zaba, Stephen R Large, Stephen P Hoole
Chronic thromboembolic disease (CTED) is suboptimally defined by a mean pulmonary artery pressure (mPAP) <25 mmHg at rest in patients that remain symptomatic from chronic pulmonary artery thrombi. To improve identification of right ventricular (RV) pathology in patients with thromboembolic obstruction, we hypothesized that the RV ventriculo-arterial (Ees/Ea) coupling ratio at maximal stroke work (Ees/Eamax sw ) derived from an animal model of pulmonary obstruction may be used to identify occult RV dysfunction (low Ees/Ea) or residual RV energetic reserve (high Ees/Ea)...
April 2017: Physiological Reports
Joel P Giblett, Adam J Brown, Stephen P Hoole, Nick E J West
No abstract text is available yet for this article.
April 2018: Cardiovascular Intervention and Therapeutics
Joel P Giblett, Adam J Brown, Harry Keevil, Catherine Jaworski, Stephen P Hoole, Nick E J West
AIMS: Registry data have suggested higher than anticipated rates of scaffold thrombosis following bioresorbable vascular scaffold (BVS) implantation. We examined early neointimal growth and strut coverage in BVS to ascertain whether this was affected by clinical presentation. METHODS AND RESULTS: Patients undergoing optical coherence tomography (OCT)-guided BVS implantation, either for stable angina (SA) or acute coronary syndrome (ACS), were recruited to this observational study...
August 20, 2016: EuroIntervention
Andrew Ladwiniec, Paul A White, Sukhjinder S Nijjer, Michael O'Sullivan, Nick E J West, Justin E Davies, Stephen P Hoole
BACKGROUND: Wave intensity analysis can distinguish proximal (propulsion) and distal (suction) influences on coronary blood flow and is purported to reflect myocardial performance and microvascular function. Quantifying the amplitude of the peak, backwards expansion wave (BEW) may have clinical utility. However, simultaneously acquired wave intensity analysis and left ventricular (LV) pressure-volume loop data, confirming the origin and effect of myocardial function on the BEW in humans, have not been previously reported...
September 2016: Circulation. Cardiovascular Interventions
Joel P Giblett, Richard G Axell, Paul A White, Sophie J Clarke, Liam McCormick, Philip A Read, Johannes Reinhold, Adam J Brown, Michael O'Sullivan, Nick E J West, David P Dutka, Stephen P Hoole
BACKGROUND: Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion to ischemic conditioning. We investigated whether blockade of K-ATP channels with glibenclamide abrogated the protective effect of GLP-1 in humans. METHODS: Thirty-two non-diabetic patients awaiting stenting of the left anterior descending artery (LAD) were allocated into 4 groups (control, glibenclamide, GLP-1, and GLP-1 + glibenclamide)...
July 19, 2016: Cardiovascular Diabetology
Adam J Brown, Zhongzhao Teng, Patrick A Calvert, Nikil K Rajani, Orla Hennessy, Nitesh Nerlekar, Daniel R Obaid, Charis Costopoulos, Yuan Huang, Stephen P Hoole, Martin Goddard, Nick E J West, Jonathan H Gillard, Martin R Bennett
BACKGROUND: Although plaque rupture is responsible for most myocardial infarctions, few high-risk plaques identified by intracoronary imaging actually result in future major adverse cardiovascular events (MACE). Nonimaging markers of individual plaque behavior are therefore required. Rupture occurs when plaque structural stress (PSS) exceeds material strength. We therefore assessed whether PSS could predict future MACE in high-risk nonculprit lesions identified on virtual-histology intravascular ultrasound...
June 2016: Circulation. Cardiovascular Imaging
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