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Functional pain

Tim Davis, Eric Loudermilk, Michael DePalma, Corey Hunter, David A Lindley, Nileshkumar Patel, Daniel Choi, Marc Soloman, Anita Gupta, Mehul Desai, Elizabeth Cook, Leonardo Kapural
BACKGROUND AND OBJECTIVES: As a follow-up to the 6-month report,12 this study investigated the analgesic effect of cooled radiofrequency ablation (CRFA) in patients with knee osteoarthritis (OA) 12 months postintervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS). METHODS: Seventy-eight per cent (52/67) of patients originally treated with CRFA were evaluated at 12 months, while at 6 months post-IAS, 82% (58/71) of those patients crossed over to CRFA and assessed 6 months later...
February 16, 2019: Regional Anesthesia and Pain Medicine
Tom D Thacher, John M Pettifor, Peter J Tebben, Ana L Creo, Alison Skrinar, Meng Mao, Chao-Yin Chen, Ting Chang, Javier San Martin, Thomas O Carpenter
The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoclonal antibody, in 52 children with XLH ages 5 to 12 years. Bilateral knee and wrist radiographs were obtained at baseline, week 40, and week 64. We evaluated the relationships of the RSS to the Radiographic Global Impression of Change (RGI-C), serum alkaline phosphatase (ALP), height Z-score, 6-minute walk test (6MWT) percent predicted, and the Pediatric Orthopedic Society of North America Pediatric Outcomes Data Collection Instrument (POSNA-PODCI)...
February 14, 2019: Bone
Cheryl Lans
ETHNOPHARMACOLOGICAL RELEVANCE: There are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset the immune system to normal functioning...
February 14, 2019: Journal of Ethnopharmacology
Michel Bouchoucha, Noëlle Girault-Lidvan, Maria Hejnar, Florence Mary, Gheorges Airinei, Robert Benamouzig
BACKGROUND/AIMS: Psychological factors are involved in many functional gastrointestinal disorders including globus. The aim of the present study was to assess the clinical and psychological correlates associated with globus. PATIENTS AND METHODS: 707 patients (69% female, 45.2 ± 16.5 years, BMI 27.2 ± 11.7 kg/m2 ) filled an MMPI-2 questionnaire and a standard Rome III clinical questionnaire and were included in this cross sectional study. Data analysis was performed using a univariate analysis and a multivariate logistic regression with a backwards selection procedure on significant scales after a univariate analysis...
February 13, 2019: Clinics and Research in Hepatology and Gastroenterology
Arda Kucukguven, Hakan Uzun, Fethiye D Menku, Gokhan Sert, Ali E Aksu
BACKGROUND: The repair of retracted flexor tendons is a challenging problem for hand surgeons. The tendon stump should be handled in an atraumatic manner because any microtrauma to the sheath and tendon can lead to poor functional outcomes. METHODS: Twenty-three patients with flexor zone 2 injuries and intraoperative finding of retracted tendons were randomly divided into two groups: endoscopic retrieval group and proximal incision group. A flexible endoscope and a flexible grasping forceps were used for endoscopic retrieval of the retracted flexor tendons...
January 14, 2019: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Yoshinori Hiyama, Tsukasa Kamitani, Osamu Wada
BACKGROUND: Patients who undergo total knee arthroplasty (TKA) may experience disease-specific problems, including decline in motor function and intense pain, which may result in disease-specific anxiety. This study aimed to investigate disease-specific anxiety at discharge, and any association between anxiety and functional outcomes following TKA. METHODS: The study prospectively included 129 patients who had undergone TKA. Each patient's disease-specific anxiety about wounds, pain, gait, and falling was assessed at discharge using a numerical rating scale, in which 0 represented no anxiety and 10 represented the highest level of anxiety...
February 13, 2019: Knee
Matthew P Ithurburn, Mark V Paterno, Staci Thomas, Michael L Pennell, Kevin D Evans, Robert A Magnussen, Laura C Schmitt
PURPOSE: The purpose of this study was to investigate how patient-reported knee function changed over a two-year period in young athletes after anterior cruciate ligament reconstruction (ACLR) and return-to-sport (RTS), and to determine the impact of clinical measures, after controlling for demographic and surgical covariates. METHODS: At the time of RTS after primary, unilateral ACLR, the following data were collected in 67 young athletes: Quadriceps (QF), hamstring (HS), and hip abduction (HA) strength; knee range-of-motion, effusion, and anterior laxity; and patient-reported function using the Knee injury and Osteoarthritis Outcome Score (KOOS)...
February 13, 2019: Knee
I C van Walree, M E Hamaker, L V van de Poll-Franse, M C Vos, D Boll, L H van Huis-Tanja, N P M Ezendam
OBJECTIVE: To assess long-term differences in health-related quality of life (HRQoL) of older ovarian cancer survivors compared to both an age-matched normative population and to younger survivors. In addition, the differential effect of chemotherapy on HRQoL between older and younger survivors was compared. METHODS: Ovarian cancer survivors (n = 348) diagnosed between 2000 and 2010, as registered by the Dutch population-based Eindhoven Cancer Registry, were invited to complete the EORTC QLQ-C30 HRQoL questionnaire in 2012...
February 13, 2019: Gynecologic Oncology
Pepijn O Sun, Ruud W Selles, Miguel C Jansen, Harm P Slijper, Dietmar J O Ulrich, Erik T Walbeehm
OBJECTIVEThe aim of this study was to evaluate the self-reported outcome of revision surgery in patients with recurrent and persistent carpal tunnel syndrome (CTS) and to identify predictors of clinical outcome of revision surgery.METHODSA total of 114 hands in 112 patients were surgically treated for recurrent and persistent CTS in one of 10 specialized hand clinics. As part of routine care, patients were asked to complete online questionnaires regarding demographic data, comorbidities, and clinical severity measures...
February 15, 2019: Journal of Neurosurgery
D J H A Henssen, R L Witkam, J C M L Dao, D J Comes, A M Van Cappellen van Walsum, T Kozicz, Robert van Dongen, K Vissers, R H M A Bartels, G de Jong, E Kurt
Implantable Motor Cortex Stimulation (iMCS) has been performed for over 25 years to treat various intractable pain syndromes. Its effectiveness shows to be highly variable and although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment of intractable pain. A systematic review provided a database of patient data on an individual level of patients who underwent iMCS to treat refractory pain between 1991 and 2017...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
Amanda L Stone, Lynn S Walker, Lauren C Heathcote, J Maya Hernandez, Molly C Basch, Anna C Wilson, Laura E Simons
Among youth with chroic pain, elevated somatic symptoms across multiple body systems have been associated with greater emotional distress and functional disability and could represent poor adaptation to pain. The Children's Somatic Symptoms Inventory (formerly the Children's Somatization Inventory) is commonly used to assess somatic symptoms in children. However, no studies have evaluated the clinical utility of the measure in the assessment of pediatric patients with chronic pain. This study evaluated the factor structure and clinical relevance of the 24-item Children's Somatic Symptoms Inventory (CSSI-24) in youth (n = 1150) with mixed chronic pain complaints presenting to a tertiary pain clinic...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
Yusuke Sakuhara, Saori Nishio, Fumihiko Hattanda, Takeshi Soyama, Bunya Takahashi, Daisuke Abo, Hidefumi Mimura
PURPOSE: To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD). MATERIALS AND METHODS: This prospective study was approved by our hospital's institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts...
February 15, 2019: Clinical and Experimental Nephrology
Salim Kadhim, Mark F Bird, David G Lambert
Classical opioids (μ: mu, MOP; δ: delta, DOP and κ: kappa, KOP) variably affect immune function; they are immune depressants and there is good clinical evidence in the periphery. In addition, there is evidence for a central role in the control of a number of neuropathologies, e.g., neuropathic pain. Nociceptin/Orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide receptor, NOP; peripheral and central activation can modulate immune function. In the periphery, NOP activation generally depresses immune function, but unlike classical opioids this is in part driven by NOP located on circulating immune cells...
February 16, 2019: Handbook of Experimental Pharmacology
Tae-Hwan Yoon, Sung-Jae Kim, Chong-Hyuk Choi, Soon-Phil Yoon, Yong-Min Chun
PURPOSE: To investigate whether subscapularis integrity and compensatory teres, minor hypertrophy is associated with maintaining relatively good function and tolerable pain levels during non-operative treatment. METHODS: This study included 108 patients with irreparable, massive rotator cuff tears involving at least two tendons and stage III or IV muscle hypotrophy and fatty infiltration on oblique sagittal magnetic resonance imaging, in which even a partial repair does not seem feasible...
February 15, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Samira T Miyamoto, Valéria Valim, Benjamin A Fisher
Health-related quality of life (HRQoL) has an increasing role in medical decision-making. This review of the literature aims to provide an overview on HRQoL, costs, and work disability in SS, a disease characterized by focal lymphocytic infiltration of exocrine glands with no therapeutics of proven immunomodulatory potential. HRQoL is markedly reduced in SS in multiple studies across many countries when compared with HRQoL in healthy controls. The reduction in HRQoL is similar to that observed in other chronic diseases such as RA, SLE, FM and, interestingly, non-SS sicca syndrome...
February 15, 2019: Rheumatology
Esi M Morgan, Jane Munro, Jennifer Horonjeff, Ben Horgan, Beverley Shea, Brian Feldman, Hayyah Clairman, Clifton O Bingham, Susan Thornhill, Vibeke Strand, Alessandra Alongi, Silvia Magni-Manzoni, Marion A J van Rossum, Richard Vesely, Jelena Vojinovic, Hermine I Brunner, Julia G Harris, Daniel B Horton, Daniel J Lovell, Melissa Mannion, Homaira Rahimi, Angelo Ravelli, Sarah Ringold, Nicolino Ruperto, M Suzanne Schrandt, Susan Shenoi, Natalie J Shiff, Karine Toupin-April, Nikolay Tzaribachev, Pamela Weiss, Alessandro Consolaro
OBJECTIVE: The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCTs) and longitudinal observational studies (LOS) was developed without input of patients/parents. At OMERACT 2016, a special interest group voted to reconsider the core set incorporating broader stakeholder input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting. METHODS: Candidate domains were identified through literature review, qualitative surveys, and online discussion boards (ODBs) held with JIA patients and parents in Australia, Italy, and the USA...
February 15, 2019: Journal of Rheumatology
Asokumar Buvanendran, Craig J Della Valle, Jeffrey S Kroin, Mahendra Shah, Mario Moric, Kenneth J Tuman, Robert J McCarthy
BACKGROUND: Approximately 15% of patients report persistent knee pain despite surgical success following total knee arthroplasty (TKA). The purpose of this study was to determine the association of acute-postsurgical pain (APSP) with chronic postsurgical pain (CPSP) 6 months after TKA controlling for patient, surgical and psychological confounding factors. METHODS: Adult patients with osteoarthritis undergoing primary elective tricompartmental TKA, with the operated knee the primary source of preoperative pain, were studied between March 2011 and February 2017...
February 15, 2019: Regional Anesthesia and Pain Medicine
Philippe Debeer, Bart Berghs, Nicole Pouliart, Gert Van den Bogaert, Filip Verhaegen, Stefaan Nijs
BACKGROUND: The treatment of glenoid bone deficiencies in primary or revision total shoulder arthroplasty is challenging. This retrospective study evaluated the short-term clinical and radiologic results of a new custom-made patient-specific glenoid implant. METHODS: We treated 10 patients with severe glenoid deficiencies with the Glenius Glenoid Reconstruction System (Materialise NV, Leuven, Belgium). Outcome data included a patient-derived Constant-Murley score, a visual analog score (VAS), a satisfaction score, the 11-item version of the Disabilities of the Arm, Shoulder and Hand score, and the Simple Shoulder Test...
February 13, 2019: Journal of Shoulder and Elbow Surgery
Bertrand Tombal, Fred Saad, David Penson, Maha Hussain, Cora N Sternberg, Robert Morlock, Krishnan Ramaswamy, Cristina Ivanescu, Gerhardt Attard
BACKGROUND: In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here, we report the results of patient-reported outcomes of this study. METHODS: In the randomised, double-blind, placebo-controlled, phase 3 PROSPER trial, done at 254 study sites worldwide, patients aged 18 years or older with non-metastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned (2:1) via an interactive voice web recognition system to receive oral enzalutamide (160 mg per day) or placebo...
February 12, 2019: Lancet Oncology
Roger Mulder, Julie Zarifeh, Joseph Boden, Cameron Lacey, Peter Tyrer, Helen Tyrer, Martin Than, Richard Troughton
BACKGROUND: Non-cardiac chest pain (NCCP) is a common reason for presenting to an emergency department (ED). Many patients re-present with similar symptoms despite reassurance. OBJECTIVE: To investigate the clinical value of a brief cognitive behavioural treatment (CBT) in reducing re-presentations of patients who present with NCCP. METHOD: A randomised controlled trial (RCT) comparing three or four sessions of NCCP directed CBT with treatment as usual (TAU)...
February 5, 2019: International Journal of Cardiology
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