Read by QxMD icon Read

Critical burns

Dinis Mateus, Joana Marto, Patrícia Trindade, Humberto Gonçalves, Ana Salgado, Paula Machado, António Melo-Gouveia, Helena M Ribeiro, António J Almeida
The use of morphine applied topically to painful wounds has potential advantages, such as dose reduction, fewer side effects and compound formulations, have been proposed for this purpose. Given the potential high impact of drug product quality on a patient's health, the aim of the present study was to develop two stable sterile hydrogels containing morphine hydrochloride, intended for topical application on painful wounds. Two carboxymethylcellulose sodium-based hydrogels were prepared containing 0.125% w / w (F1-MH semi-solid formulation) and 1...
February 12, 2019: Pharmaceutics
Emma C Burns, Keiko C P Bostwick, Rebecca J Collie, Andrew J Martin
Previous work has established a significant increase in disengagement as students progress through secondary school. This work has also established that rates of disengagement appear to be higher among boys, leading to an increased focus on the underlying causes and factors associated with disengagement within this population. However, less is known about the patterns of disengagement exhibited by girls. Given that disengagement is consistently associated with negative personal and academic outcomes, it is important to more closely examine the disengagement trajectories of girls...
February 11, 2019: Journal of Youth and Adolescence
Trang T H Tu, Miho Takenoshita, Hirofumi Matsuoka, Takeshi Watanabe, Takayuki Suga, Yuma Aota, Yoshihiro Abiko, Akira Toyofuku
Burning Mouth Syndrome (BMS), a chronic intraoral burning sensation or dysesthesia without clinically evident causes, is one of the most common medically unexplained oral symptoms/syndromes. Even though the clinical features of BMS have been astonishingly common and consistent throughout the world for hundreds of years, BMS remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly BMS patients for whom the disease is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of BMS more difficult...
2019: BioPsychoSocial Medicine
Aaron M Cook, Jimmi Hatton-Kolpek
Augmented renal clearance (ARC) is a phenomenon in critically ill patients characterized by increased creatinine clearance and elimination of renally-eliminated medications. Patients with severe neurologic injury, sepsis, trauma, and burn have been consistently identified as at risk for ARC, with mean creatinine clearances ranging from 170 ml/min to over 300 ml/min. Several potential mechanisms may contribute to the occurrence of ARC including endogenous responses to increased metabolism and solute production, alterations in neurohormonal balance, and therapeutic maneuvers such as fluid resuscitation...
February 5, 2019: Pharmacotherapy
P Matejtschuk, C Duru, A F Bristow, C J Burns, B Cowper, A Daas, A Costanzo
The European Pharmacopoeia (Ph. Eur.) monograph 1316 'Erythropoietin concentrated solution' prescribes that the dimer content of therapeutic erythropoietin (EPO) preparations must not exceed 2% as determined by Size-Exclusion Chromatography (SEC). This report describes the evaluation of a candidate Chemical Reference Substance (cCRS) to serve as system suitability reference material for the qualification of SEC systems used to assess dimer and oligomer content in EPO solutions. The study organised by the European Directorate for the Quality of Medicines & HealthCare (EDQM) was performed with the participation of six European laboratories which tested the candidate material and the EPO for physicochemical tests CRS batch 1...
2019: Pharmeuropa Bio & Scientific Notes
Elaine Ballinger, John Mosior, Travis Hartman, Kristin Burns-Huang, Ben Gold, Roxanne Morris, Laurent Goullieux, Isabelle Blanc, Julien Vaubourgeix, Sophie Lagrange, Laurent Fraisse, Stéphanie Sans, Cedric Couturier, Eric Bacqué, Kyu Rhee, Sarah M Scarry, Jeffrey Aubé, Guangbin Yang, Ouathek Ouerfelli, Dirk Schnappinger, Thomas R Ioerger, Curtis A Engelhart, Jennifer A McConnell, Kathrine McAulay, Allison Fay, Christine Roubert, James Sacchettini, Carl Nathan
Mycobacterium tuberculosis (Mtb) is the leading infectious cause of death in humans. Synthesis of lipids critical for Mtb's cell wall and virulence depends on phosphopantetheinyl transferase (PptT), an enzyme that transfers 4'-phosphopantetheine (Ppt) from coenzyme A (CoA) to diverse acyl carrier proteins. We identified a compound that kills Mtb by binding and partially inhibiting PptT. Killing of Mtb by the compound is potentiated by another enzyme encoded in the same operon, Ppt hydrolase (PptH), that undoes the PptT reaction...
February 1, 2019: Science
Robin J Slaughter, Martin Watts, J Allister Vale, Jacob R Grieve, Leo J Schep
INTRODUCTION: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach. OBJECTIVE: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning. METHODS: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication"...
January 28, 2019: Clinical Toxicology
Abu Asaduzzaman, Demian Riccardi, Akef T Afaneh, Sarah J Cooper, Jeremy C Smith, Feiyue Wang, Jerry M Parks, Georg Schreckenbach
Mercury (Hg) is a global environmental contaminant. Major anthropogenic sources of Hg emission include gold mining and the burning of fossil fuels. Once deposited in aquatic environments, Hg can undergo redox reactions, form complexes with ligands, and adsorb onto particles. It can also be methylated by microorganisms. Mercury, especially its methylated form methylmercury, can be taken up by organisms, where it bioaccumulates and biomagnifies in the food chain, leading to detrimental effects on ecosystem and human health...
January 28, 2019: Accounts of Chemical Research
Itay Wiser, Roni Averbuch Sagie, Liran Barzilai, Moti Haratz, Josef Haik
BACKGROUND: Burn injury pathophysiology is characterized by severe catabolic state and poor glycemic control. A tight glycemic control protocol using insulin for burn victims has yielded inconsistent mortality and morbidity outcomes. OBJECTIVES: To compare the effect of standard and tight glycemic control protocols on mortality and hypoglycemia events in critical care burn patients. METHODS: We conducted a case-control study of burn victims admitted to the burn intensive care unit between 2005 and 2011...
January 2019: Israel Medical Association Journal: IMAJ
Ioannis Mitsopoulos, Irene Chrysafi, Diamantis Bountis, Giorgos Mallinis
Fire severity is an increasingly critical issue for forest managers for estimating fire impacts. Estimating high fire severity potential and accurate classification between fire severity levels are essential for integrated fire management planning in fire prone Mediterranean pine ecosystems. This study attempts to determine the role of topography, pre-fire forest stand structure, fuel complex characteristics and fire behavior parameters on high fire severity potential and classification based on a large fire event occurred in Thasos, Greece...
January 24, 2019: Journal of Environmental Management
Kate Curtis, Belinda Kennedy, Andrew J A Holland, Gary Tall, Holly Smith, Soundappan S V Soundappan, Brian Burns, Rebecca J Mitchell, Kellie Wilson, Allan Loudfoot, Michael Dinh, Timothy Lyons, Tona Gillen, Stuart Dickinson
BACKGROUND: There is known variability in the quality of care delivered to injured children. Identifying where care improvement can be made is critical. This study aimed to review paediatric trauma cases across the most populous Australian State to identify factors contributing to clinical incidents. METHODS: Medical records from three New South Wales Paediatric Trauma Centres were reviewed for children <16 years requiring intensive care; with an injury severity score of ≥9, or who died following injury between July 2015 and September 2016...
January 16, 2019: Injury
Hui Xing, Sevan D Houston, Xuejie Chen, Sussan Ghassabian, Tyler Fahrenhorst-Jones, Andy Kuo, Cody-Ellen P Murray, Kyna-Anne Conn, Kara N Jaeschke, Da-Yun Jin, Cielo Pasay, Paul V Bernhardt, Jed M Burns, John Tsanaktsidis, G Paul Savage, Glen M Boyle, James J De Voss, James McCarthy, Gimme H Walter, Thomas H J Burne, Maree T Smith, Jian-Ke Tie, Craig M Williams
Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associated with cubane has been addressed herein with cyclooctatetraene (COT), using known pharmaceutical and agrochemical compounds as templates. COT either outperformed or matched cubane in multiple cases suggesting that versatile complementarity exists between the two systems for enhanced bioactive molecule discovery...
January 25, 2019: Chemistry: a European Journal
Margie Burns, Shelley Peacock
Phenomenology is one of the most popular qualitative research methodologies used in nursing research. Although interpretive phenomenology is often a logical choice to address the concerns of nursing, the vast number of methods of phenomenology means choosing an appropriate method can be daunting, especially for novice researchers. It is critical that nurse researchers select a phenomenological method that fits the research problem and the skill and world view of the researcher; doing so will result in a research experience that resonates with and excites the researcher...
January 22, 2019: Nursing Inquiry
Muhammad Bilal, Muhammad Adeel, Tahir Rasheed, Yuping Zhao, Hafiz M N Iqbal
The widespread occurrence and adverse environmental and health-related impacts of various types of emerging contaminants (ECs) have become an issue of high concern. With ever increasing scientific knowledge, socio-economic awareness, health-related problems and ecological apprehensions, people are more concerned about the widespread ECs, around the globe. Among ECs, biologically active compounds from pharmaceutical, cosmeceutical, biomedical, personal care products (PPCPs), endocrine-disrupting chemicals (EDCs), and flame-retardants are of paramount concern...
January 17, 2019: Environment International
Richard A Burns, Dimity A Crisp, Robert B Burns
BACKGROUND: The cross-lagged panel (regression) model (CLPM) is the usual framework of choice to test the longitudinal reciprocal effects between self-concept and achievement. Criticisms of the CLPM are that causal paths are over-estimated as they fail to discriminate between- and within-person variation. The random-intercept cross-lagged panel model (RI-CLPM) is one alternative that extends the CLPM by partialling out between-person variance. AIMS: We compare analyses from a CLPM and a RI-CLPM which examine the reciprocal relationships between self-concept, self-efficacy, and achievement and determine the extent CLPM estimates are inflated by between-person variance...
January 17, 2019: British Journal of Educational Psychology
Ian Ferguson, James Milligan, Alex Buttfield, Shamus Shepherd, Brian Burns, Cliff Reid, Anders Aneman, Ian Harris
BACKGROUND: Some critically ill patients require rapid sequence intubation in the emergency department, and ketamine is one sedative agent employed, due to its relative haemodynamic stability. Tachycardia and hypertension are frequent side effects, and in less stable patients, shock can be unmasked or exacerbated. The use of fentanyl as a co-induction agent may lead to a smoother haemodynamic profile post-induction, which may lead to reduced mortality in this critically ill cohort. This randomised controlled trial aims to compare the effect of administering fentanyl vs placebo in a standardised induction regimen with ketamine and rocuronium on (a) the percentage of patients in each group with a systolic blood pressure outside the range of 100-150 mm Hg within 10 minutes of induction, (b) the laryngoscopic view, and (c) 30-day mortality...
January 17, 2019: Acta Anaesthesiologica Scandinavica
Christoph Wallner, Julika Huber, Marius Drysch, Sonja V Schmidt, Johannes Maximilian Wagner, Mehran Dadras, Stephanie Dittfeld, Mustafa Becerikli, Henriette Jaurich, Marcus Lehnhardt, Björn Behr
Tumors, traumata, burn injuries or surgeries can lead to critical-sized bony defects which need to be reconstructed. Mesenchymal stem cells (MSCs) have the ability to differentiate into multiple cell lineages and thus present a promising alternative for use in tissue engineering and reconstruction. However there is an ongoing debate whether all MSCs are equivalent in their differentiation and proliferation ability. The goal of this study was to asses osteogenic and adipogenic characteristic changes of adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs) upon Myostatin inhibition with Follistatin...
January 18, 2019: Stem Cells and Development
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
The gaseous transmitter hydrogen sulfide (H2S) has been implicated in various forms of critical illness. Here we have compared the outcome of scald burn injury in wild-type mice and in mice deficient in 3-mercaptopyruvate sulfurtransferase (3-MST), a mammalian H2S-generating enzyme. Outcome variables included indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. Plasma levels of H2S significantly increased in response to burn in wild-type mice, but remained unchanged in 3-MST-/- mice...
January 12, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
Michel M Sun, Ann M Chan, Samuel M Law, Sergio Duarte, Daniel Diaz-Aguilar, Madhuri Wadehra, Lynn K Gordon
Purpose: Pathologic corneal neovascularization is a major cause of blindness worldwide, and treatment options are currently limited. VEGF is one of the critical mediators of corneal neovascularization but current anti-VEGF therapies have produced limited results in the cornea. Thus, additional therapeutic agents are needed to enhance the antiangiogenic arsenal. Our group previously demonstrated epithelial membrane protein-2 (EMP2) involvement in pathologic angiogenesis in multiple cancer models including breast cancer and glioblastoma...
January 2, 2019: Investigative Ophthalmology & Visual Science
Bertha F Polegato, Amanda G Pereira, Paula S Azevedo, Nara A Costa, Leonardo A M Zornoff, Sergio A R Paiva, Marcos F Minicucci
Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure...
January 15, 2019: Nutrition in Clinical Practice
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"