keyword
https://read.qxmd.com/read/38350903/co-transfer-of-incfii-incfib-and-incfii-plasmids-mediated-by-is26-facilitates-the-transmission-of-mcr-8-1-and-tmexcd1-toprj1
#21
JOURNAL ARTICLE
Qian Wang, Meng Zhang, Yue Liu, Jinmei Li, Ran Chen, Yueling Wang, Yan Jin, Yuanyuan Bai, Zhen Song, Xinglun Lu, Changyin Wang, Yingying Hao
PURPOSE: This study aimed to characterise the whole-genome structure of two clinical Klebsiella pneumoniae strains co-harbouring mcr-8.1 and tmexCD1-toprJ1, both resistant to colistin and tigecycline. METHODS: K. pneumoniae strains TGC-02 (ST656) and TGC-05 (ST273) were isolated from urine samples of different patients hospitalised at separate times in 2021. Characterisation involved antimicrobial susceptibility testing (AST), conjugation assays, whole-genome sequencing (WGS), and bioinformatics analysis...
February 13, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38342913/case-report-atypical-presentation-of-mpox-with-massive-hematochezia-and-prolonged-viral-shedding-despite-tecovirimat-treatment
#22
JOURNAL ARTICLE
Sung Un Shin, Younggon Jung, Seong Eun Kim, Dong Min Kim
BACKGROUND: The outbreak of mpox that occurred between 2022 and 2023 is primarily being transmitted through sexual contact. As of now, there is no consensus on the recommended duration of isolation to prevent sexual transmission of the virus. Moreover, this particular mpox outbreak has presented with distinct complications in comparison to previous occurrences. In this report, we present a case involving severe rectal bleeding from an ulcer in a mpox patient with a history of engaging in receptive sexual contact...
February 12, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38298221/a-rare-case-of-bacillus-subtilis-variant-natto-induced-persistent-bacteremia-with-liver-and-splenic-abscesses-in-an-immunocompetent-patient
#23
Tetsuro Amemiya, Kiyofumi Ohkusu, Miku Murayama, Tomokiyo Yamamoto, Naoya Itoh
Bacillus subtilis var. natto , a low-pathogenic bacterium used in the traditional Japanese food "natto" (fermented soybeans), has rarely been reported as a pathogen of infectious diseases in humans. Herein, we report the first case of persistent bacteremia caused by B. subtilis var. natto in an immunocompetent patient without any gastrointestinal involvement. A 53-year-old Japanese woman who had been consuming natto every day was admitted to our hospital with complaints of fever and chills. B. subtilis was isolated from blood cultures collected during the initial visit...
2024: IDCases
https://read.qxmd.com/read/38296540/efficacy-of-cefiderocol-a-novel-siderophore-cephalosporin-against-multi-drug-resistant-acinetobacter-baumannii-clinical-isolates-in-japan
#24
JOURNAL ARTICLE
Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Satoshi Nishida, Yusuke Yoshino
Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important pathogen that causes nosocomial infections and is resistant to almost all antibiotics, including carbapenems. Cefiderocol is a novel siderophore cephalosporin that is active against a broad spectrum of Gram-negative bacteria. However, the susceptibility of MDRAB from Japan to cefiderocol has not yet been reported. In this study, we measured the minimum inhibitory concentrations (MICs) of antibiotics, including cefiderocol, against MDRAB clinical isolates collected during a nosocomial outbreak from 2009 to 2010 at Teikyo University Hospital in Japan...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38245682/brain-abscess-caused-by-actinomyces-turicensis-in-a-non-immunocompromised-adult-patient-a-case-report-and-systematic-review-of-the-literature
#25
Alessandra Imeneo, Lorenzo Vittorio Rindi, Andrea Di Lorenzo, Rosario Alessandro Cavasio, Pietro Vitale, Ilaria Spalliera, Mario Dauri, Daniele Guerino Biasucci, Ilaria Giuliano, Cartesio D'Agostini, Silvia Minelli, Maria Cristina Bossa, Anna Altieri, Massimo Andreoni, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati
BACKGROUND: Actinomyces turicensis is rarely responsible of clinically relevant infections in human. Infection is often misdiagnosed as malignancy, tuberculosis, or nocardiosis, therefore delaying the correct identification and treatment. Here we report a case of a 55-year-old immunocompetent adult with brain abscess caused by A. turicensis. A systematic review of A. turicensis infections was performed. METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
January 20, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38222167/lemierre-syndrome-with-streptococcus-constellatus-bacteremia
#26
Miles Thomas, Christopher J Peterson, Lauren N Mazin, Jonas Rawlins
Lemierre syndrome is characterized by thrombophlebitis of the internal jugular vein (IJV) secondary to bacterial pharyngitis or tonsillitis. Though antibiotic use has made this a rarer syndrome, it can nevertheless manifest in patients presenting with pharyngitis. Herein, we describe a 20-year-old male patient with no relevant medical history presenting with signs concerning for pneumonia and was ultimately diagnosed with Lemierre syndrome with Streptococcus constellatus bacteremia. Complications included IJV thrombus with presumed septic emboli to the lungs...
December 2023: Curēus
https://read.qxmd.com/read/38211774/clinical-and-microbiological-characteristics-of-ruminococcus-gnavus-bacteremia-and-intra-abdominal-infection
#27
JOURNAL ARTICLE
Naoki Watanabe, Tomohisa Watari, Yoshihito Otsuka, Naoto Hosokawa, Kazufumi Yamagata, Miyuki Fujioka
OBJECTIVES: Ruminococcus gnavus is a rare human pathogen, and clinical data on R. gnavus infection are insufficient. This retrospective study aimed to investigate the clinical characteristics of R. gnavus infections. METHODS: This study included 13 cases of bacteremia and three cases of non-bacteremia infections caused by R. gnavus. We evaluated the patient data, infection source, clinical outcomes, and antimicrobial susceptibility of R. gnavus isolates for these cases...
January 10, 2024: Anaerobe
https://read.qxmd.com/read/38145982/microbiological-analysis-and-antibiotic-selection-strategy-in-neck-abscesses-among-patients-with-diabetes-mellitus
#28
JOURNAL ARTICLE
Weili Kong, Xiaoyun Zhang, Mei Li, Hui Yang
PURPOSE: This study aimed to analyze the clinical characteristics, pathogen distribution, drug sensitivity, and antibiotic treatment strategies of patients with neck abscesses with or without diabetes. METHODS: A retrospective analysis was conducted on 2194 patients who underwent neck abscess surgery at our hospital over the past 13 years. Patients were grouped as NAwith DM (neck abscess with diabetes mellitus) or NAwithout DM (neck abscess without diabetes mellitus)...
December 26, 2023: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38136743/dosage-forms-suitability-in-pediatrics-acceptability-of-antibiotics-in-a-german-hospital
#29
JOURNAL ARTICLE
Viviane Klingmann, Thibault Vallet, Juliane Münch, Lena Wolters, Robin Stegemann, Hans Martin Bosse, Fabrice Ruiz
Although drug acceptability can have a significant impact on patient adherence in pediatric therapy, data are limited, even for common therapeutic areas. We present the second part of an acceptability study conducted at the University Children's Hospital Düsseldorf, Germany. The study investigated the acceptability of most commonly used antibiotics in a pediatric hospital setting. The researchers used the acceptability reference framework to score the acceptability of five antibiotics based on 150 real-life observer reports of medicine intake...
December 7, 2023: Antibiotics
https://read.qxmd.com/read/38136700/the-impact-of-cefepime-and-ampicillin-sulbactam-on-preventing-post-cesarean-surgical-site-infections-randomized-controlled-trail
#30
JOURNAL ARTICLE
Mona A Abdelrahman, Asmaa Zaki, Sara A M Salem, Heba F Salem, Ahmed R N Ibrahim, Ahmed Hassan, Marwa O Elgendy
Over the previous three decades, the rate of caesarean sections performed worldwide has grown exponentially. In comparison to a vaginal birth, the risk of all postpartum infections is higher with a cesarean section. One of the key factors contributing to maternal morbidity is the development of infectious complications in the surgical site after a caesarean section. The primary goal of the research was to compare the efficiency of using ampicillin/sulbactam (AMS) and cefepime (CEF) to reduce the incidence of surgical site infections (SSI) following caesarean delivery...
November 27, 2023: Antibiotics
https://read.qxmd.com/read/38135115/the-effects-of-antibiotic-therapy-on-neonatal-sepsis-associated-acute-kidney-injury
#31
JOURNAL ARTICLE
Irina B Pevzner, Anna A Brezgunova, Vasily A Popkov, Mikhail Y Sintsov, Nadezda V Andrianova, Ljubava D Zorova, Denis N Silachev, Artem A Burov, Yulia L Podurovskaya, Dmitry B Zorov, Egor Y Plotnikov, Gennady T Sukhikh
AIM: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost always involves antibiotic therapy, which by itself may cause some adverse effects, including nephrotoxicity. We analyzed the mutual effect of antibiotic therapy and sepsis on AKI in an experimental and clinical study in neonatal infants and rats...
December 20, 2023: Life Sciences
https://read.qxmd.com/read/38122981/genomic-and-epidemiological-characterization-of-a-bla-ctx-m-27-carrying-st34-salmonella-enterica-serotype-typhimurium-in-china
#32
JOURNAL ARTICLE
Xiaohong Xu, Minfei Peng, Yizhang Wang, Fengjiao Zhu, Weiwei Shen, Danni Bao
OBJECTIVES: Consuming contaminated food and water is a leading cause of food poisoning, with Salmonella being one of the primary culprits. The aim of this study is to elucidate the genomic characteristics of a blaCTX-M-27 -carrying S. enterica strain recovered from a patient with diarrhea in China. METHODS: Antimicrobial susceptibility of S. enterica strain 123 was determined by microdilution broth assay. Whole-genome sequencing was performed using both long-read MinION and short-read Illumina platforms to fully characterize the genetic structure of the blaCTX-M-27 -carrying plasmid of the S...
December 18, 2023: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38116362/catheter-associated-vancomycin-resistant-enterococcus-faecium-ventriculitis-and-multidrug-resistant-acinetobacter-baumannii-pneumonia-with-subsequent-acinetobacter-ventriculitis-a-case-report
#33
Kyle M Rei, Vedhika Reddy, Christopher Andraos, James Brazdzionis, Javed Siddiqi
Ventriculitis is associated with cerebrospinal fluid (CSF) shunts, and rare microorganisms associated with infection include vancomycin-resistant Enterococcus (VRE) faecium and Acinetobacter baumannii . Both organisms are known to cause nosocomial infections, and the emergence of multidrug-resistant (MDR) strains presents a treatment challenge. There is a lack of consensus on antimicrobial agent selection for ventriculitis involving VRE faecium or MDR A. baumannii , which are life-threatening conditions. We present a case of a 59-year-old male presenting with CSF catheter-associated VRE faecium ventriculitis and MDR A...
November 2023: Curēus
https://read.qxmd.com/read/38103906/cefiderocol-associated-brown-chromaturia
#34
JOURNAL ARTICLE
Michael Smith, Kap Sum Foong
Cefiderocol is a novel siderophore cephalosporin antibiotic. In the present case report, a woman in her 70s presented with a 1-week history of altered mental status and progressive purulent discharge from a non-healing diabetic foot ulcer on her right heel. MRI of the right foot revealed chronic osteomyelitis of the calcaneum. Surgical debridement was performed, and the tissue cultures grew extensively drug resistant (XDR) Pseudomonas aeruginosa , XDR Acinetobacter baumannii and Enterococcus faecalis The patient received ampicillin-sulbactam and cefiderocol...
December 16, 2023: BMJ Case Reports
https://read.qxmd.com/read/38100018/effect-of-hyperbaric-oxygen-on-the-growth-and-susceptibility-of-facultatively-anaerobic-bacteria-and-bacteria-with-oxidative-metabolism-to-selected-antibiotics
#35
JOURNAL ARTICLE
Dittmar Chmelař, Miroslav Rozložník, Michal Hájek, Nikol Pospíšilová, Jozef Kuzma
Wild strains of Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis were tested in an experimental hyperbaric chamber to determine the possible effect of hyperbaric oxygen on the susceptibility of these strains to the antibiotics ampicillin, ampicillin + sulbactam, cefazolin, cefuroxime, cefoxitin, gentamicin, sulfamethoxazole + trimethoprim, colistin, oxolinic acid, ofloxacin, tetracycline, and aztreonam during their cultivation at 23 °C and 36...
December 15, 2023: Folia Microbiologica
https://read.qxmd.com/read/38099477/antimicrobial-prophylaxis-with-ampicillin-sulbactam-compared-with-cefazolin-for-esophagectomy-nationwide-inpatient-database-study-in-japan
#36
JOURNAL ARTICLE
Yuki Hirano, Takaaki Konishi, Hidehiro Kaneko, Hidetaka Itoh, Satoru Matsuda, Hirofumi Kawakubo, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hiroyuki Daiko, Osamu Itano, Hideo Yasunaga, Yuko Kitagawa
OBJECTIVE: To assess the effect of antimicrobial prophylaxis with ampicillin-sulbactam (ABPC/SBT) compared with cefazolin (CEZ) on the short-term outcomes after esophagectomy. SUMMARY BACKGROUND DATA: CEZ is widely used for antimicrobial prophylaxis in esophagectomy without procedure-specific evidence, whereas ABPC/SBT is preferred in some hospitals to target both aerobic and anaerobic oral bacteria. METHODS: Data of patients who underwent esophagectomy for cancer between July 2010 and March 2019 were extracted from a nationwide Japanese inpatient database...
December 15, 2023: Annals of Surgery
https://read.qxmd.com/read/38094676/ampicillin-sulbactam-induced-liver-injury-in-a-pediatric-patient
#37
JOURNAL ARTICLE
Corey Fowler, Katie Namtu
Drug-induced liver injury (DILI) is a rare adverse drug reaction (ADR) in pediatric patients and limited reports exist examining ampicillin-sulbactam-induced liver injury. This report summarizes a 12-year-old male who received ampicillin-sulbactam and subsequently developed liver injury characterized by elevated serum aminotransferases and bilirubin. Ampicillin-sulbactam was subsequently discontinued and the patient's liver function tests (LFTs) rapidly improved. This report describes the rare adverse reaction of ampicillin-sulbactam-induced liver injury...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38092671/-in-vivo-dose-response-and-efficacy-of-the-%C3%AE-lactamase-inhibitor-durlobactam-in-combination-with-sulbactam-against-the-acinetobacter-baumannii-calcoaceticus-complex
#38
JOURNAL ARTICLE
John O'Donnell, Angela Tanudra, April Chen, Joseph Newman, Sarah M McLeod, Rubén Tommasi
Multi-drug resistant (MDR) Acinetobacter baumannii is emerging as a pathogen of increasing prevalence and concern. Infections associated with this Gram-negative pathogen are often associated with increased morbidity and mortality and few therapeutic options. The β-lactamase inhibitor sulbactam used commonly in combination with ampicillin demonstrates intrinsic antibacterial activity against A. baumannii acting as an inhibitor of PBP1 and PBP3, which participate in cell wall biosynthesis. The production of β-lactamases, particularly class D oxacillinases, however, has limited the utility of sulbactam resorting to increased doses and the need for alternate therapies...
January 10, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38090456/pyogenic-spondylitis-caused-by-parvimonas-micra-a-case-report
#39
Saneyuki Itagaki, Tsuneaki Kenzaka
Parvimonas micra  ( P. micra ) is a gram-positive anaerobic coccus endemic to the oral cavity and intestinal tract. We report a case of pyogenic spondylitis caused by P. micra and summarize the clinical features of previous case reports. An 81-year-old man with a history of lumbar vertebral compression fracture two years previously presented to the emergency department with low back pain. He was clinically diagnosed with pyogenic spondylitis due to difficulty in moving his body, spinal tapping pain, and signs of inflammation...
November 2023: Curēus
https://read.qxmd.com/read/38071347/characterization-of-class-1-integrons-in-metallo-%C3%AE-lactamase-producing-acinetobacter-baumannii-isolates-from-hospital-environment
#40
JOURNAL ARTICLE
Farzaneh Firoozeh, Mohammad Ghorbani, Mohammad Zibaei, Farzad Badmasti, Malihe Farid, Narges Omidinia, Fatemeh Bakhshi
BACKGROUND AND OBJECTIVE: The emergence and widespread dissemination of antibiotic resistance in A. baumannii, has become a globally challenge. The increasing hospital outbreaks by multi-drug resistant (MDR) A. baumannii strains, shows the necessity of continuous monitoring to find sources of resistant strains in hospitals. This study aimed to identify the presence of class 1 integrons and metallo-β-lactamase (MBL) related genes in A. baumannii isolates from hospital environment...
December 9, 2023: BMC Research Notes
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