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Masahiro Tahara, Kei Yamasaki, Hiroaki Ikegami, Yoko Fukuda, Keigo Uchimura, Takashi Tachiwada, Shingo Noguchi, Toshinori Kawanami, Takashi Kido, Hiroshi Mukae, Kazuhiro Yatera
An eighty-nine-year-old Japanese male was admitted to our hospital due to dry cough and dyspnea. Respiratory symptoms appeared soon after an administration of an oriental medicine, Kamikihito for tinnitus. Upon admission, chest computed tomography showed patchy consolidations and ground-glass opacities in the right upper lobe of the lungs, and ground-glass opacities in the bilateral lower lobes. Sulbactam-ampicillin combination (SBT/ABPC, 3 g × 2/day) was started in addition to the change or cessation of several other drugs, including Kamikihito, resulting in respiratory symptoms and chest radiographic exacerbations...
2019: Journal of UOEH
Jiajun Wang, Niels Fertig, Yi-Lun Ying
Multidrug-resistant bacteria are a great concern and a problem that must be addressed. Extended-spectrum β-lactamases are a common defence mechanism of bacteria to make β-lactam (BL) antibiotics ineffective. β-Lactamase inhibitors (BLIs) are consequently designed and are often clinically prescribed with a BL antibiotic to hinder degradation. Current studies focusing on how BL antibiotics or BLIs interact solely with the bacterial outer membrane nanopores (porins) on reaching the periplasmic side using a nanopore-based sensing technique...
March 2, 2019: Analytical and Bioanalytical Chemistry
Toyomitsu Sawai, Satoru Koga, Shotaro Ide, Sumako Yoshioka, Nobuko Matsuo, Hiroshi Mukae
BACKGROUND: Parvimonas micra, a Gram-positive anaerobic coccus, is a rare pathogen for psoas abscess. We describe a case of a patient with iliopsoas abscess caused by P. micra. CASE PRESENTATION: An 81-year-old Asian man presented to our department with complaints of fever since the preceding day. Abdominal computed tomography revealed the presence of a low-density mass in the right iliopsoas muscle indicative of a psoas abscess. Computed tomography-guided percutaneous drainage of the psoas abscess was performed...
March 1, 2019: Journal of Medical Case Reports
Munehiro Matsumoto, Kentaro Nagaoka, Masaru Suzuki, Satoshi Konno, Kei Takahashi, Taichi Takashina, Nobuhisa Ishiguro, Masaharu Nishimura
BACKGROUND: Until now, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MP) infection among adult patients has been low, and severe MP pneumonia due to a macrolide-resistant strain has seldom been reported. Here, we describe a rare case of severe life-threatening MP pneumonia due to a macrolide-resistant strain in an adult, which was finally treated with fluoroquinolone and tetracycline after failed treatment with macrolide and corticosteroid. CASE PRESENTATION: A 39-year-old apparently healthy woman complained of fever and productive cough...
February 28, 2019: BMC Infectious Diseases
Yuqin Huang, Quan Zhou, Wenguo Wang, Qiang Huang, Juan Liao, Junyi Li, Lei Long, Tao Ju, Quan Zhang, Hanqin Wang, Huaqiang Xu, Mingli Tu
Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against Acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth dilution methods determined the minimum inhibitory concentrations (MICs) of four antiseptic drugs singly used and combined two drugs against 36 isolates of multidrug-resistant (MDR) A. baumannii ...
2019: Frontiers in Pharmacology
Azer Özad Düzgün, Ayşegül Saral
A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing blaOXA-48 in K. pneumoniae and to use whole-genome sequencing in order to understand the genetic context of plasmid. K. pneumoniae strain was used as donor in conjugation experiments. Antibiotic susceptibility profile of selected transconjugant was determined. Plasmid was isolated from transconjugant colony and was named as pKPT...
February 26, 2019: Acta Microbiologica et Immunologica Hungarica
Seigo Okada, Yuichi Ishikawa, Maiko Shimomura, Shinpei Sunagawa, Reiji Hirano, Shinnosuke Fukunaga, Akiko Miyake, Yusuke Okada, Takashi Maki
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severe pain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which was detected in stool culture...
March 2019: Yonsei Medical Journal
Omar H Ahmed, Dylan F Roden, Yasmina C Ahmed, Binhuan Wang, Cherie-Ann O Nathan, David Myssiorek
OBJECTIVES: Standards of care for total laryngectomy (TL) patients in the postoperative period have not been established. Perioperative care remains highly variable and perhaps primarily anecdotally based. The aim of this study was to survey members of the American Head and Neck Society to capture management practices in the perioperative care of TL patients. METHODS: In this survey study, an electronic survey was distributed to the international attending physician body of the American Head and Neck Society...
February 13, 2019: Annals of Otology, Rhinology, and Laryngology
Chun-Zhen Hua, Hong-Jiao Wang, Zhe Zhang, Xiao-Fen Tao, Jian-Ping Li, Yu-Mei Mi, Lan-Fang Tang, Zhi-Min Chen
BACKGROUND AND OBJECTIVE: Macrolides are the recommended antibiotics for treating pertussis and preventing transmission. The causative bacterium, Bordetella pertussis, has high macrolide resistance and has recently circulated in China. The objective of the study was to find effective alternative antibiotics in therapy by assessing the in vitro activity and clinical efficacy of antibiotics against Bordetella pertussis. METHODS: Bordetella pertussis was confirmed by agglutination with specific antisera and mass spectrometry...
January 30, 2019: Journal of Global Antimicrobial Resistance
Shanlin Mao, Zi Ge, Hui Zhao, Jun Cao, Zhijie Xia
OBJECTIVE: To investigate the distribution and drug resistance of pathogen caused community-onset bloodstream infection (COBSI) in patients of affiliated hospital of university, and to provide evidence for the clinical therapy. METHODS: The clinical data of patients with COBSI in emergency department admitted to Huashan North Hospital Affiliated to Fudan University from January 2014 to December 2017 were collected, and the distribution and drug resistance of pathogen were retrospectively analyzed...
January 2019: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Radica S Živković Zarić, Ana V Pejčić, Slobodan M Janković, Marina J Kostić, Miloš N Milosavljević, Marko J Milosavljević, Valentina D Opančina
Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. K. kristinae is a pathogen microorganism that could cause invasive infections of various tissues in patients of any age. Majority of the patients had K...
January 28, 2019: Journal of Chemotherapy
Satoko Tanaka, Keisuke Tsumura, Yukiko Nakura, Tsugumichi Tokuda, Hiroaki Nakahashi, Tomoko Yamamoto, Takeshi Ono, Itaru Yanagihara, Makoto Nomiyama
AIM: The optimal antibiotic regimen for preterm premature rupture of membrane (pPROM) is still unclear. This study aimed to determine the effects of ampicillin-sulbactam (SBT/ABPC) and azithromycin (AZM) on the incidence of bronchopulmonary dysplasia (BPD). METHODS: This retrospective study included women with singleton gestations and a diagnosis of pPROM between 22 and 27 weeks of gestation. In patients presenting with a high risk of intra-amniotic infection between January 2011 and May 2013, piperacillin or cefmetazole + clindamycin (regimen 1 group; n = 11) was administered, whereas SBT/ABPC and AZM (regimen 2 group; n = 11) were administered in patients presenting a similar risk between June 2013 and May 2016...
January 27, 2019: Journal of Obstetrics and Gynaecology Research
Asmaa A Ibrahim, Ghadir S El-Housseiny, Khaled M Aboshanab, Mahmoud A Yassien, Nadia A Hassouna
BACKGROUND: Response surface methodology (RSM) employing Box-Behnken design was used to optimize the environmental factors for the production of paromomycin, a 2 deoxystreptamine aminocyclitol aminoglycoside antibiotic, (2DOS-ACAGA) from Streptomyces (S.) rimosus NRRL 2455. Emergence of bacterial resistance caught our attention to consider the combination of antimicrobial agents. The effect of paromomycin combination with other antimicrobial agents was tested on some multiple drug resistant isolates...
January 18, 2019: BMC Microbiology
Raziyeh Kheshti, Bahman Pourabbas, Maryam Mosayebi, Afsaneh Vazin
Introduction: Acinetobacter baumannii is a gram-negative,opportunistic pathogen responsible for resistant nosocomial infections especially in the intensive care units (ICUS).One reason for the failure in the treatment of A. baumannii is its ability of develop resistance against several antimicrobials. combination of different antimicrobials can be used to overcome such a resistance. This study was done to evaluate the in vitro synergistic activity of colistin in combination with six different antimicrobials, including ciprofloxacin, levofloxacin, imipenem, meropenem, ampicillin-sulbactam, and rifampin against A...
2019: Infection and Drug Resistance
I Dimitriou, U Bultmann, M Niedergethmann
BACKGROUND: Whether an immediate surgical treatment or preoperative bile drainage (PBD) should be performed in cases of obstructive jaundice caused by a pancreatic carcinoma has been a matter of controversy for decades. The aim of this study based on in-house patient data was to evaluate both the influence of PBD on septic complications and to analyze intraoperative bile samples in patients with PBD in order to formulate current recommendations for antibiotic treatment. MATERIAL AND METHODS: Relevant data from all pancreatic resections performed in this hospital from January 2013 to December 2017 were collected in a prospective database and were retrospectively analyzed...
January 11, 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Xiao Chen, Qianda Zou, Weili Zhang, Ruonan Wang, Fei Yu, Yu Chen
PURPOSE: Escherichia coli is a leading cause of bloodstream infection (BSI) in hospitals and communities. METHODOLOGY: We conducted a retrospective study in 2015 to evaluate the clinical features and microbiological characteristics of E. coli BSI acquired in the hospital and community. RESULTS: A total of 100 patients with E. coli BSI were enrolled, among whom 60 % had hospital-onset (HO) BSI while 40 % had community-onset (CO) BSI. Patients with HO BSI had higher percentages of haematological disorders, immunosuppression conditions, underwent surgery within 2 weeks and had a higher 30-day mortality...
January 9, 2019: Journal of Medical Microbiology
Wajima Safi, Mayada Elnegouly, Raphael Schellnegger, Katrin Umgelter, Fabian Geisler, Wolfgang Reindl, Bernd Saugel, Alexander Hapfelmeier, Andreas Umgelter
INTRODUCTION AND AIMS: We aimed to explore the impact of infection diagnosed upon admission and of other clinical baseline parameters on mortality of cirrhotic patients with emergency admissions. MATERIAL AND METHODS: We performed a prospective observational monocentric study in a tertiary care center. The association of clinical parameters and established scoring systems with short-term mortality up to 90 days was assessed by univariate and multivariable Cox regression analysis...
October 16, 2018: Annals of Hepatology
Shingo Nishimura, Koichiro Wada, Motoo Araki, Takuya Sadahira, Yuki Maruyama, Yosuke Mitsui, Ryuta Tanimoto, Yasuyuki Kobayashi, Toyohiko Watanabe, Yasutomo Nasu
OBJECTIVE: The aim of this study was to evaluate the efficacy of single-dose perioperative antimicrobial therapy as infection prophylaxis in recipients of living-donor renal transplants in the rituximab era. PATIENTS AND METHODS: Between 2009 and 2017, 84 recipients underwent living-donor renal transplantation (LDRT) at Okayama University Hospital; 3 with vascular/urinary complications requiring additional surgery were excluded from this analysis. Data including recipient characteristics, antimicrobial prophylaxis and administration of rituximab were retrospectively examined for an association with perioperative infections...
December 21, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Yang Tian, Yue Wang, Shanshan Wu, Zhian Sun, Bolin Gong
Surface-imprinted polymers (MIPs) microspheres with the ability to specifically recognize water-soluble molecules were prepared using self-made monodisperse porous poly(chloromethylstyrene-co-divinylbenzene) beads as the solid-phase matrix and ampicillin (AMP) as the template molecule. MIPs were synthesized using different template molecule: monomer: crosslinker ratios and the optimum preparation ratio were obtained by measuring adsorption. The maximum equilibrium amount of adsorption by the MIPs reached 115...
2018: International Journal of Analytical Chemistry
Thomas M Baker, Wesley Rogers, Kalyan D Chavda, Lars F Westblade, Stephen G Jenkins, David P Nicolau, Barry N Kreiswirth, David P Calfee, Michael J Satlin
Background: Piperacillin-tazobactam-nonsusceptible (TZP-NS) Enterobacteriaceae are typically also resistant to ceftriaxone. We recently encountered bacteremias due to Escherichia coli ( Ec ) and Klebsiella pneumoniae ( Kp ) that were TZP-NS but ceftriaxone-susceptible (CRO-S). Methods: We reviewed all Ec and Kp bacteremias from 2011 to 2015 at our center and assessed the prevalence, antimicrobial susceptibilities, genetic profiles, patient characteristics, treatments, and outcomes of TZP-NS/CRO-S infections...
December 2018: Open Forum Infectious Diseases
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