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CDX2 Colon

Shigeaki Kurihara, Kazunori Nakazawa, Hironari Miyamoto, Takuma Okada, Chihoko Nobori, En Wang, Toshiki Hirakawa, Naoki Aomatsu, Takehiko Iwauchi, Junya Morimoto, Shigehito Yamagata, Yasutake Uchima, Kazuhiro Takeuchi
A67 -year-old man was diagnosed with ascending colon cancer and multiple liver metastases and underwent laparoscopic right hemicolectomy(D3 lymphadenectomy). Pathological examination indicated tubular adenocarcinoma(tub1, pT4apN2H2M1[HEP], pStage Ⅳ). After chemotherapy, he underwent hepatectomy. One year and 9 months after the first operation, obstructive jaundice appeared. Abdominal computed tomography revealed a tumor 2 cm in size in the head of the pancreas. After several detailed examinations, he was diagnosed with pancreatic metastasis of ascending colon cancer...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Irit Ben-Aharon, Tal Goshen-Lago, Michal Sternschuss, Sara Morgenstern, Ravit Geva, Alexander Beny, Ygael Dror, Mariana Steiner, Ayala Hubert, Efraim Idelevich, Katerina Shulman, Moshe Mishaeli, Sophia Man, Nicky Liebermann, Lior Soussan-Gutman, Baruch Brenner
BACKGROUND: Anatomic location of primary tumors across the colon correlate with survival in the metastatic setting, whereas left-sided tumors may exhibit superior survival compared with right-sided tumors. The Oncotype Recurrence Score (RS) assay is a clinically validated predictor of recurrence risk in patients with stage II colorectal cancer (CRC). Previous studies had indicated that without adjuvant chemotherapy, CDX2-negative stage II CRC tumors are associated with a lower rate of disease-free survival than CDX2-positive stage II CRC tumors...
February 12, 2019: Oncologist
Gabriela M Chiocchetti, Dinoraz Vélez, Vicenta Devesa
Chronic exposure to inorganic arsenic (As)-As(III) + As(V)-is associated with type 2 diabetes, vascular diseases and various types of cancer. Although the oral route is the main way of exposure to inorganic As, the adverse gastrointestinal effects produced by chronic exposure are not well documented. The aim of the present study is to evaluate the effect of chronic exposure to As(III) on the intestinal epithelium. For this purpose, NCM460 cells, non-transformed epithelial cells from the human colon, were exposed to As(III) (0...
February 12, 2019: Journal of Applied Toxicology: JAT
Junhui Yu, Dong Liu, Xuejun Sun, Kui Yang, Jianfeng Yao, Chen Cheng, Chunbao Wang, Jianbao Zheng
Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcription factor, has been strongly implicated in the tumourigenesis of various human cancers. However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known. In this study, CDX2 knockdown in colon cancer cells promoted cell proliferation in vitro, accelerated tumor formation in vivo, and induced a cell cycle transition from G0/G1 to S phase, whereas CDX2 overexpression inhibited cell proliferation...
January 10, 2019: Cell Death & Disease
Ming Hu, Weidong Liu, Feng Yin, Dongwei Zhang, Xiuli Liu, Jinping Lai
Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. HAC originating in the colon is exceedingly rare. Here we report such a case of a 63-year-old man presented as decompensated liver failure with jaundice and weakness...
December 2018: Gastroenterology Research
Min-Shan Chen, Yuan-Hung Lo, Xi Chen, Christopher Williams, Jessica Donnelly, Zachary Criss, Shreena Patel, Joann Butkus, Julien Dubrulle, Milton Finegold, Noah Shroyer
Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the United States. Growth Factor Independent 1 (GFI1) is a zinc finger transcriptional repressor responsible for controlling secretory cell differentiation in the small intestine and colon. GFI1 plays a significant role in the development of human malignancies, including leukemia, lung cancer and prostate cancer. However, the role of GFI1 in CRC progression is largely unknown. Our results demonstrate that RNA and protein expression of GFI1 are reduced in advanced stage non-mucinous CRC...
January 3, 2019: Molecular Cancer Research: MCR
Robert R J Coebergh van den Braak, John W M Martens, Jan N M Ijzermans
New England Journal of Medicine, Volume 379, Issue 25, Page 2481-2481, December 2018.
December 20, 2018: New England Journal of Medicine
Daniel Triner, Samantha N Devenport, Sadeesh K Ramakrishnan, Xiaoya Ma, Ryan A Frieler, Joel K Greenson, Naohiro Inohara, Gabriel Nunez, Justin A Colacino, Richard M Mortensen, Yatrik M Shah
BACKGROUND & AIMS: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis. METHODS: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1fl/fl ) and wild-type littermates (LysMCre;Mcl1+/+ , control mice) by administration of azoxythmethane and/or dextran sulfate sodium...
December 11, 2018: Gastroenterology
Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Ann Christina Eriksen, Jan Lindebjerg, Lars Henrik Jensen, Flemming Brandt Sørensen, Anders Jakobsen
BACKGROUND: The aim of the present study was to validate the prognostic impact of CDX2 in patients with stage II colon cancer. METHODS: Two unbiased population-based cohorts representing all patients operated for stage II colon cancer in Denmark in 2002 and 2003. The CDX2 expression was evaluated by immunohistochemistry on whole tumour sections. Patients were classified into three groups, CDX2-positive, -moderate, and -negative, for comparison with the clinical data...
November 2018: British Journal of Cancer
Ichiro Onishi, Masato Kayahara, Ryohei Takei, Naoki Makita, Masayoshi Munemoto, Yasumichi Yagi, Atsuhiro Kawashima
BACKGROUND: Most colorectal cancer liver metastases form nodules within the hepatic parenchyma, and hepatectomy is the only radical treatment for synchronous metastases. There is concern about intrabiliary tumor growth which may affect the surgical margin, resulting in local recurrence after hepatectomy for colorectal cancer liver metastasis; however, there has been no report of the dissemination in the bile duct after hepatectomy. Here, we report an unusual case of biliary dissemination of colorectal cancer that caused recurrent intrabiliary growth after hepatectomy, and discuss the management of intrabiliary metastasis of colorectal cancer...
October 27, 2018: Journal of Medical Case Reports
Yi Chai, Huan Wang, Fang Zhou
Background: To establish one primary cell line of human liver metastasis of colon cancer. Methods: HCS1220 cell line was derived from one liver metastasis of colon cancer patient's resected tumor sample. The characterization of the cell line was defined by karyotype analysis, short tandem repeat (STR) analysis and mycoplasma contamination. Subcutaneous injection 1 × 106  cells to four BALB/c nude mice, the viable tumors were developed and diagnosed (H&E staining)...
2018: Cancer Cell International
R Parra-Medina, P Lopez-Correa, V Gutierrez, F Polo
A 43-year-old man presented with two-month history of fatigue, weakness, paleness, rectal bleeding, sweating, and weight loss of 10 kg in the past one month. A complete blood count revealed anaemia. The patient underwent a right hemicolectomy. The microscopic examination revealed an adenosquamous carcinoma associated with a mucinous adenocarcinoma in a patient with microsatellite instability due to loss of MLH1 and PMS2 expression and retention of MSH2 and MSH6 expression in both the squamous and glandular components...
August 2018: Malaysian Journal of Pathology
Eric R Fearon
Colorectal cancers (CRCs) harbor accumulated defects in key signaling pathways that regulate cell phenotypes, including proliferation, survival, metabolism, and differentiation. To study the functional contributions of the accumulated molecular defects in CRC, we have developed approaches to inactivate selected tumor suppressor and/or activate oncogenes in mouse colon epithelium. Conditional inactivation of the CDX2 tumor suppressor protein in conjunction with oncogenic activation of the BRAF protein promotes development of serrated glandular benign and malignant tumors in the mouse colon...
2018: Transactions of the American Clinical and Climatological Association
Caroline Bsirini, Pratyusha Tirumanisetty, Joseph N Dytoc, Diana Agostini-Vulaj, Christopher Steevens, Asad Ullah, Aaron R Huber
Although pancreatic and gastric heterotopias are common findings in the gastrointestinal tract, heterotopic respiratory mucosa (HRM) in the rectum is extremely rare and has only been reported twice previously. We are presenting, to our knowledge, the third case of HRM in the rectum. A 56-year-old man with a history of chronic diarrhea presented for diagnostic colonoscopy, where he was found to have a rectal subepithelial nodule. He was subsequently referred to a tertiary medical center for further evaluation with rectal endoscopic ultrasound...
August 16, 2018: International Journal of Surgical Pathology
Stylianos Vittorakis, Georgia Giannakopoulou, Konstantinos Konstantinides, Anna Daskalaki, Konstantinos Samitas
Colonic metastasis from lung cancer is rare, generally asymptomatic and usually develop at advanced cancer stages. Here, we report a case with a resected stage IA lung adenocarcinoma in a 51yo male patient that presented two years later with mild abdominal pain due to intestinal obstruction caused by a metastatic colon tumor. The patient underwent colonoscopy followed by surgical resection and the pathologic report was adenocarcinoma which was the same as that from a lung nodule that was excised two years earlier...
2018: Respiratory Medicine Case Reports
Weidong Liu, Dongwei Zhang, Sanda A Tan, Xiuli Liu, Jinping Lai
Lynch syndrome (LS) patients with isolated PMS2 loss in the colon cancer, while intact MMR in the prostate cancer, are exceedingly rare. Herein, we report such a case. A 71-year-old male was found to have increased serum PSA (10 ng/ml) after treatment for his urinary tract infection. Prostate biopsies showed foci of prostate cancer with Gleason score 7 (3+4) (grade grope 2) involving 10% of two cores. Through work up for treatment of the prostate cancer, he was found to have focal thickening of his sigmoid colon with adjacent lymphadenopathy in CT scans...
August 2018: Anticancer Research
Johanne Davidsen, Sylvester Larsen, Mehmet Coskun, Ismail Gögenur, Katja Dahlgaard, Eric Paul Bennett, Jesper Thorvald Troelsen
Sequencing of primary colorectal tumors has identified a gene fusion in approximately 3% of colorectal cancer patients of the VTI1A and TCF7L2 genes, encoding a VTI1A-TCF4 fusion protein containing a truncated TCF4. As dysregulation of the Wnt signaling pathway is associated with colorectal cancer development and progression, the functional properties and transcriptional regulation of the VTI1A-TCF4 fusion protein may also play a role in these processes. Functional characteristics of the VTI1A-TCF4 fusion protein in Wnt signaling were analyzed in NCI-H508 and LS174T colon cancer cell lines...
2018: PloS One
Kentaro Kikuchi, Shuichi Fukunaga, Fumio Ide, Miyako Hoshino, Harumi Inoue, Yuji Miyazaki, Tie-Jun Li, Kaoru Kusama
Intestinal-type adenocarcinoma of the primary salivary glands is extremely rare. So far, only 11 cases of primary intestinal-type adenocarcinoma of the oral cavity and major salivary glands have been reported. Two of those tumors arose in the floor of mouth, 7 in the tongue, and 2 in the major salivary glands. However, it has remained unclear whether these tumors are derived from mature salivary glands, and primary intestinal-type adenocarcinoma of the buccal mucosa has not been reported previously. Here, we present the first documented case of primary intestinal-type adenocarcinoma arising in a minor salivary gland of the buccal mucosa...
May 30, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Parag Deepak Dabir, Hans Svanholm, Jens Johannes Christiansen
CDX2 is routinely used for identifying gastrointestinal origin of metastatic adenocarcinomas; but a high percentage of other carcinomas also show positivity with this antibody. SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as 'colon-rectum'. Metastasis in 67 liver biopsies, 108 lymph nodes from resection specimens and 36 serous effusions was analyzed retrospectively...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Rui Caetano-Oliveira, Marcos António Gomes, Ana Margarida Abrantes, Edgar Tavares-Silva, Marco Carvalho Oliveira, Mafalda Laranjo, Débora Basílio Queirós, João Casalta-Lopes, Salomé Pires, Lina Carvalho, Rosa Gouveia, Paulo Rodrigues Santos, Denise Gonçalves Priolli, José Guilherme Tralhão, Maria Filomena Botelho
Colorectal cancer (CRC) is the second most frequent and fatal cancer in Western countries. Understanding its biology with different incidence along the colon and rectum, genetic profile and how these factors contribute to local/distant progression, has been hampered by the lack of a suitable CRC model. We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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