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congenital tremors

Yanwen Yin, Kaichuang Shi, Wenchao Sun, Shenglan Mo
We report the complete genome sequence of an atypical porcine pestivirus (APPV) strain named GX01-2018 that was isolated in Guangxi Province, China, from a suckling piglet showing congenital tremor. The whole genome consisted of 11,565 bp and shared 83.4% to 98.2% nucleotide identities and 91.9% to 99.1% amino acid identities with other APPV strains from different countries.
February 2019: Microbiology resource announcements
Xin Zhang, Rui Dai, Qunhui Li, Qingfeng Zhou, Yangyang Luo, Limiao Lin, Yingzuo Bi, Feng Chen
Atypical porcine pestivirus (APPV) have been discovered in swine herds from three provinces in China, suggesting a wide distribution in China. This study reports the occurrence of three novel APPV strains in China. They were detected from newborn piglets with clinical signs of congenital tremors (CT) in Guangdong Province, China. The complete genomic sequences of three novel APPV strains exhibited only 80.5%-84.1% nucleotide sequences homology with other APPV reference sequences available in GenBank. Phylogenetic analysis showed that these novel APPV strains formed independent branch from the American, German, Netherlandish, Australian and other Chinese strains...
December 6, 2018: Infection, Genetics and Evolution
Kelei Zhou, Hua Yue, Cheng Tang, Wenqiang Ruan, Qun Zhou, Bin Zhang
Atypical porcine pestivirus (APPV) causes congenital tremor (CT) in piglets and has a wide geographical distribution. In this study, we evaluated APPV prevalence using 165 piglet sera from southwest China. Viral RNA was detectable by qRT-PCR in 43.6 % (17/39, 95 % CI 27.8-60.4 %) of piglets with CT, while viral RNA was not detected in the sera of any healthy piglets. The seven complete APPV genomes were obtained from distinct farms and were 11 269-11 459 nucleotides in length. The genomes of the seven strains shared 82...
December 5, 2018: Journal of General Virology
Daniel Schmidtke, Charlotte Lempp, Marko Dubicanac, Ute Radespiel, Elke Zimmermann, Wolfgang Baumgärtner, Sabine Kästner, Martin Meier, Anne Balkema-Buschmann, R Alan Harris, Muthuswamy Raveendran, Donna M Muzny, Kim C Worley, Jeffrey Rogers
Here we report a case of severe growth retardation and neurologic abnormalities in a female gray mouse lemur (Microcebusmurinus), a small NHP species for which the genomic sequence recently became available. The female lemur we present heredied on postnatal day 125. This lemur had impaired development of motor skills and showed severe ataxia and tremors. In addition, hearing seemed normal whereas ophthalmic examination revealed incipient bilateral cataracts, abnormal pigmentation in the lens of the left eye, and a missing optokinetic nystagmus, which indicated impaired vision...
November 28, 2018: Comparative Medicine
Huawei Zhang, Wei Wen, Genxi Hao, Huanchun Chen, Ping Qian, Xiangmin Li
An atypical porcine pestivirus (APPV) causing congenital tremor type A-II in piglets was identified in China in 2016. An increased number of cases of APPV have been reported in various countries all over the world since 2015. This study aimed to develop an effective subunit vaccine against APPV based on the E2 protein, which is the main immunogenicity protein of APPV. In this study, E2 protein was successfully expressed by the baculovirus expression system. E2 protein was confirmed by Western blot assay, which showed that E2 protein possesses N-linked glycosylation sites...
November 28, 2018: Viruses
Flávia Possatti, Thalita Evani Silva de Oliveira, Raquel Arruda Leme, Everson Zotti, Alais Maria Dall Agnol, Alice Fernandes Alfieri, Selwyn Arlington Headley, Amauri Alcindo Alfieri
Atypical porcine pestivirus (APPV) has been associated with congenital tremor (CT) type A-II in newborn piglets. Although the number of APPV-based studies is increasing, the associated pathologic findings in infected piglets are underreported. This study describes the histopathologic features of spontaneous APPV infection in CT-affected piglets and complements a previous report by our group. Four two-day-old piglets with CT were evaluated by histopathology, immunohistochemistry (IHC), and molecular assay. The main histopathologic findings at the brain and spinal cord included neuronal necrosis, gliosis, neuronophagia, satellitosis, demyelination, Wallerian degeneration, and Purkinje cell necrosis...
December 2018: Veterinary Microbiology
Shuonan Pan, Chunxiao Mou, Zhenhai Chen
Emerging porcine pestivirus diseases frequently challenge prevention and control strategies in the swine industry. Over the past decade, a few novel pestiviruses have been identified in pigs. This article focuses on the recently emerging atypical porcine pestivirus (APPV) that potentially threatens global swine herd health security. The virus was first identified in 2016, in the United States and thereafter, accumulated evidence shows that it is currently distributed in three continents. The clinical presentation of APPV-infected pigs is characterized by congenital tremor (CT) type A-II in piglets, while adult pigs may become persistent carriers and shedders...
November 9, 2018: Reviews in Medical Virology
Shuonan Pan, Yulin Yan, Kaichuang Shi, Minmin Wang, Chunxiao Mou, Zhenhai Chen
As one of emerging porcine viruses, atypical porcine pestivirus (APPV) was found in three continents since it emerged in 2015. It is now thought as the causative agent for congenital tremor type A-II in piglets. At the end of 2017, two APPV strains were identified from piglets with congenital tremor in Guangxi and Yunnan, China. The genome of APPV GX04/2017 strain was so far determined to be 11,534 nucleotides (nt) in length and contains a single open reading frame (ORF) encoding a polyprotein comprising 3,635 amino acids...
October 3, 2018: Transboundary and Emerging Diseases
Alexander Postel, Paul Becher, Ludwig Haas, Michael Wendt
Congenital tremor (CT) or "shaking piglet" syndrome of newborn piglets is a well-known disease caused by different factors and resulting in different pathological alterations. In addition to non-infectious causes (like intoxication and genetic alterations), viral infections of the sow during gestation are of utmost importance. It has long time been known that classical swine fever virus, a virus belonging to the genus Pestivirus within the family Flaviviridae , induces CT. Very recently, a novel porcine pestivirus was discovered, which is also capable to induce the disease and was designated as "atypical porcine pestivirus" (APPV)...
August 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Lilla Dénes, Imre Biksi, Mihály Albert, Levente Szeredi, Dániel G Knapp, Anna Szilasi, Ádám Bálint, Gyula Balka
Atypical porcine pestivirus (APPV) is a recently identified RNA virus within the Flaviviridae family, causing congenital tremor (CT) in the piglets of infected sows. We have investigated 25 cases of CT from 2005, 2007, 2010 and 2016-2018, originating from six different farms. RT-PCR has been performed on these samples and all of the affected piglets were positive to APPV. Our phylogenetic analysis showed that Hungarian strains show a high degree of variability and are clustered into five distinct lineages. Four strains originating from one farm have shown exceptional similarity (99...
August 13, 2018: Transboundary and Emerging Diseases
Marina Lopes Mechler, Felipe Dos Santos Gomes, Karla Alvarenga Nascimento, Andressa de Souza-Pollo, Felipe Ferreira Barbosa Pires, Samir Issa Samara, Edviges Maristela Pituco, Luís Guilherme de Oliveira
Congenital tremor in pigs involves several etiologies, including pestivirus, which may cause neurological injuries in different animal species. To evaluate whether bovine viral diarrhea virus (BVDV), an important pestivirus, is one of the etiological agents of congenital tremor in swine, gilts and the fetuses were challenged at 45 days of gestation with BVDV-2. Four pregnant gilts were inoculated oronasally, four gilts underwent fetal intrauterine inoculation, and two gilts constituted the control group. Antibody titers were determined by virus neutralization (VN), and viral RNA was detected by RT-PCR...
July 2018: Veterinary Microbiology
L Wen, A Mao, F Jiao, D Zhang, J Xie, K He
Porcine circovirus-like virus P1 is a novel unclassified circovirus that was first detected in China and may be associated with post-weaning multisystemic wasting syndrome (PMWS) and congenital tremor. In this study, we detected P1 infection in pigs in Hebei Province, China, in 2017. One hundred and forty of 500 (28.0%) serum samples from 25 pig farms with different PMWS status in seven cities were P1 positive on PCR. Twelve P1 strains were sequenced, and the complete genomes of 11 P1 strains were 648 nucleotides (nt) in length, whereas that of strain ZJK02 was 647 nt, with a G deletion at position of 183 in its genome...
May 14, 2018: Transboundary and Emerging Diseases
Fanny G Dessureault, Martin Choinière, Chantale Provost, Carl A Gagnon
No abstract text is available yet for this article.
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
G N Cagatay, A Antos, D Meyer, C Maistrelli, O Keuling, P Becher, A Postel
The recently identified atypical porcine pestivirus (APPV) was demonstrated to be the causative agent of the neurological disorder "congenital tremor" in newborn piglets. Despite its relevance and wide distribution in domestic pigs, so far nothing is known about the situation in wild boar, representing an important wild animal reservoir for the related classical swine fever virus. In this study, 456 wild boar serum samples obtained from northern Germany were investigated for the presence of APPV genomes and virus-specific antibodies...
August 2018: Transboundary and Emerging Diseases
Ricardo A Maselli, Jessica Vázquez, Leah Schrumpf, Juan Arredondo, Marian Lara, Jonathan B Strober, Peter Pytel, Robert L Wollmann, Michael Ferns
BACKGROUND: Monogenic defects of synaptic vesicle (SV) homeostasis have been implicated in many neurologic diseases, including autism, epilepsy, and movement disorders. In addition, abnormal vesicle exocytosis has been associated with several endocrine dysfunctions. METHODS: We report an 11 year old girl with learning disabilities, tremors, ataxia, transient hyperglycemia, and muscle fatigability responsive to albuterol sulfate. Failure of neuromuscular transmission was confirmed by single fiber electromyography...
May 2018: Molecular Genetics & Genomic Medicine
I R H Gatto, K Harmon, L Bradner, P Silva, D C L Linhares, P H Arruda, L G de Oliveira, B L Arruda
Atypical porcine pestivirus (APPV) has been detected in piglets with congenital tremor (CT) from three different continents including North America, Europe and Asia. Thirteen piglets from four farms in two different states in Brazil with CT were sampled. Viral RNA was detected by quantitative real-time PCR in the cerebellum or cerebellum and spinal cord in the 100% of the piglets with CT, and APPV was not detected in any tissue sample from clinically non-affected piglets with the exception of the cerebellum of one piglet from Farm A...
April 2018: Transboundary and Emerging Diseases
Peter C Rowe, Colleen L Marden, Scott Heinlein, Charles C Edwards
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients with severe ME/CFS whose symptoms improved after recognition and surgical management of their cervical spinal stenosis. METHODS: All patients satisfied clinical criteria for ME/CFS and orthostatic intolerance, and were later found to have cervical spinal stenosis...
February 2, 2018: Journal of Translational Medicine
F Possatti, S A Headley, R A Leme, A M Dall Agnol, E Zotti, T E S de Oliveira, A F Alfieri, A A Alfieri
The recently described atypical porcine pestivirus (APPV) has been associated with congenital tremor (CT) type A-II in piglets in different countries. Another important neurological pathogen of pigs is porcine teschovirus (PTV), which has been associated with non-suppurative encephalomyelitis in pigs with severe or mild neurological disorders. There have been no reports of APPV and/or PTV coinfection associated with CT or encephalomyelitis in Brazilian pig herds. The aim of this study was to describe the pathological and molecular findings associated with simultaneous infection of APPV and PTV in piglets with clinical manifestations of CT that were derived from a herd with high rates of CT-associated lethality...
April 2018: Transboundary and Emerging Diseases
Hanqin Shen, Xiangcong Liu, Pengfei Zhang, Lei Wang, Yanling Liu, Leyi Zhang, Pengshuai Liang, Changxu Song
Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles < 26)...
May 31, 2018: Journal of Veterinary Science
L Wen, A Mao, F Jiao, D Zhang, J Xie, K He
Outbreaks of trembling and shaking were reported among pigs at two pig farms in Jiangsu Province, China. Serum and tissue samples tested positive for porcine circovirus-like virus P1 and negative for classical swine fever virus, porcine circovirus type 2, astrovirus and porcine pestivirus using PCR/RT-PCR and immunohistochemical techniques. High P1 viral genome loads were identified in sera, brain and lymph node tissue samples by qPCR. In addition, one of the most notable pathological changes was dissolution of the nucleus in Purkinje cells...
April 2018: Transboundary and Emerging Diseases
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