keyword
https://read.qxmd.com/read/37409311/superior-mesenteric-artery-syndrome-as-a-rare-cause-of-postoperative-intractable-vomiting-a-case-report
#21
Sanketh Edem, Aakansha Giri Goswami, Bibek Karki, Preeti Acharya, Udit Chauhan, Navin Kumar, Somprakas Basu
BACKGROUND: Superior mesenteric artery syndrome is a very rare cause of proximal intestinal obstruction. The objective of this clinical case report is to highlight that this unusual condition can occur in the early postoperative period and medical management may completely cure the condition. CLINICAL CASE: A middle-aged female who was being treated for pulmonary tuberculosis underwent exploratory laparotomy with limited ileal resection and a loop ileostomy for multiple ileal perforations...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37197582/a-new-application-of-multiplex-pcr-combined-with-membrane-biochip-assay-for-rapid-detection-of-9-common-pathogens-in-sepsis
#22
JOURNAL ARTICLE
Yun Li, LuJie Zhao, Jingye Wang, Peipei Qi, Zhongfa Yang, Xiangyu Zou, Fujun Peng, Shengguang Li
Rapid and accurate identification of specific sepsis pathogens is critical for patient treatment and disease control. This study aimed to establish a new application for the rapid identification of common pathogens in patients with suspected sepsis and evaluate its role in clinical application. A multiplex PCR assay was designed to simultaneously amplify specific conserved regions of nine common pathogenic microorganisms in sepsis, including Acinetobacter baumannii, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumonia , and Candida albicans ...
2023: PeerJ
https://read.qxmd.com/read/37183195/an-experimental-porcine-model-of-invasive-candidiasis
#23
JOURNAL ARTICLE
Anders Krifors, Anders Lignell, Miklós Lipcsey, Jan Sjölin, Markus Castegren
BACKGROUND: Invasive candidiasis (IC) is a severe and often fatal fungal infection that affects critically ill patients. The development of animal models that mimic human disease is essential for advancing our understanding of IC pathophysiology and testing experimental or novel treatments. We aimed to develop a large animal model of IC that could provide a much-needed addition to the widely used murine models. RESULTS: A total of 25 pigs (including one control), aged between 9 and 12 weeks, with a median weight of 25...
May 15, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/37107084/neonatal-brain-abscess-with-serratia-marcescens-after-intrauterine-infection-a-case-report
#24
Mihaela Bizubac, Francisca Balaci-Miroiu, Cristina Filip, Corina Maria Vasile, Carmen Herișeanu, Veronica Marcu, Sergiu Stoica, Catalin Cîrstoveanu
Brain abscesses are a possible complication of bacterial sepsis or central nervous system infection but are uncommon in the neonatal period. Gram-negative organisms often cause them, but Serratia marcescens is an unusual cause of sepsis and meningitis in this age group. This pathogen is opportunistic and frequently responsible for nosocomial infections. Despite the existing antibiotics and modern radiological tools, mortality and morbidity remain significant in this group of patients. We report an unusual unilocular brain abscess in a preterm neonate caused by Serratia marcescens ...
April 7, 2023: Antibiotics
https://read.qxmd.com/read/37067155/micafungin-pharmacodynamics-predict-clinical-outcomes-in-hospitalized-patients-with-candidemia-caused-by-certain-candida-species
#25
JOURNAL ARTICLE
Ahmed Zaki, Anne J Gonzales-Luna, Nicholas D Beyda, Todd Lasco, Kevin W Garey
STUDY OBJECTIVE: Echinocandins are guideline-preferred therapies for invasive candidiasis (IC). Fixed dosing of echinocandins is commonly used despite variations in body mass index and echinocandin susceptibility. The purpose of this study was to evaluate clinical outcomes of micafungin based on population-predicted pharmacokinetic/pharmacodynamic (PK/PD) factors and susceptibility. DESIGN AND SETTING: Candida isolate results were screened from bloodstream or intraabdominal cultures of hospitalized patients admitted to a quaternary-care teaching hospital...
June 2023: Pharmacotherapy
https://read.qxmd.com/read/37023421/microorganisms-grown-in-urine-cultures-and-antimicrobial-resistance-patterns-a-randomised-retrospective-analysis-from-a-tertiary-hospital
#26
RANDOMIZED CONTROLLED TRIAL
Canan Demir, Salih Metin
INTRODUCTION: Patients in intensive care units (ICU) are 5-7 times more susceptible to infection than other groups, which increases the prevalence of hospital-acquired infections and associated sepsis accounting for 60% of deaths. Gram-negative bacteria are the most common source of urinary tract infections that cause morbidity, mortality, and sepsis in the ICU. The aim of this study is to detect the most commonly grown microorganisms and antibiotic resistance in urine cultures in the intensive care units of our tertiary city hospital, which has more than 20% of the ICU beds in Bursa By this way, we suppose that we will contribute to surveillance studies in our province, our country...
March 31, 2023: Journal of Infection in Developing Countries
https://read.qxmd.com/read/36970699/a-scoring-system-based-on-novel-biomarkers-and-clinical-risk-factors-to-predict-invasive-candidiasis-in-immunocompetent-critically-ill-patients
#27
JOURNAL ARTICLE
Wen Li, Gang Chen, Fengyu Lin, Hang Yang, Yanhui Cui, Rongli Lu, Chao Song, Haitao Li, Yi Li, Pinhua Pan
BACKGROUND: Delayed diagnosis further increases the mortality of invasive candidiasis (IC) in intensive care unit (ICU) patients. This study aimed to develop and validate a score based on novel serological biomarkers and clinical risk factors for predicting IC in immunocompetent ICU patients. METHODS: We retrospectively collected clinical data and novel serological markers on admission to ICU. Multivariate logistic regression was used to identify the risk factors associated with IC, which were adopted to establish a scoring system...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/36949999/a-case-of-fatal-invasive-trichosporonosis-in-the-setting-of-immunosuppression-and-post-covid-19-pneumonia
#28
Aaron Lopacinski, Christine Kim, Mahmoud Khreis
Trichosporon asahii is an opportunistic fungus that forms septate hyphae and pseudohyphae, resembling Candida albicans , and causes fungemia in susceptible individuals. Risk factors for T. asahii infection include immunosuppression, IV catheters, and malignancy. In the present case, a 67-year-old male with a history of renal transplant on immunosuppressive therapy was hospitalized for coronavirus disease 2019 (COVID-19) pneumonia. Despite treatment with steroids and broad initial antibiotic coverage with cefepime, doxycycline, and vancomycin, the patient underwent continual respiratory decline...
February 2023: Curēus
https://read.qxmd.com/read/36891692/-analysis-of-risk-factors-for-decompensated-cirrhosis-complicated-with-sepsis
#29
JOURNAL ARTICLE
H Q Ren, S Zhong, Y Lei, Z Zhou
Objective: To investigate the related risk factors in patients with decompensated cirrhosis complicated with sepsis. Methods: 1 098 cases with decompensated cirrhosis were collected from January 2018 to December 2020. A total of 492 cases with complete data meeting the inclusion criteria were included. Among them, the sepsis group (240 cases) was complicated with sepsis and the non-sepsis group (252 cases) was not complicated with sepsis. Albumin, cholinesterase, total bilirubin, prothrombin activity, urea, creatinine, international normalized ratio and other indicators of the two groups of patients were collected...
November 20, 2022: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/36881725/neonatal-invasive-candidiasis-in-low-and-middle-income-countries-data-from-the-neoobs-study
#30
JOURNAL ARTICLE
Aislinn Cook, Laura Ferreras-Antolin, Bethou Adhisivam, Daynia Ballot, James A Berkley, Paola Bernaschi, Cristina G Carvalheiro, Napaporn Chaikittisuk, Yunsheng Chen, Vindana Chibabhai, Shweta Chitkara, Sara Chiurchiu, Elisavet Chorafa, Tran Minh Dien, Angela Dramowski, Samantha Faria de Matos, Jinxing Feng, Daniel Jarovsky, Ravinder Kaur, Warunee Khamjakkaew, Premsak Laoyookhong, Edwin Machanja, Marisa M Mussi-Pinhata, Flavia Namiiro, Gita Natraj, Hakka Naziat, Hoang Thi Bich Ngoc, Claude Ondongo-Ezhet, Kanchana Preedisripipat, Hafizur Rahman, Amy Riddell, Emmanuel Roilides, Neal Russell, Apurba S Sastry, Hannington Baluku Tasimwa, Ji Tongzhen, Jeannette Wadula, Yajuan Wang, Andrew Whitelaw, Dan Wu, Varsha Yadav, Gao Yang, Wolfgang Stohr, Julia Anna Bielicki, Sally Ellis, Adilia Warris, Paul T Heath, Michael Sharland
Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC and of fluconazole-resistant Candida spp. isolates in low- and middle-income countries (LMICs) compared to high-income countries (HICs). We describe the epidemiology, Candida spp. distribution, treatment, and outcomes of neonates with NIC from LMICs enrolled in a global, prospective, longitudinal, observational cohort study (NeoOBS) of hospitalized infants <60 days postnatal age with sepsis (August 2018-February 2021)...
March 2, 2023: Medical Mycology
https://read.qxmd.com/read/36828515/sars-cov-2-post-infection-and-sepsis-by-saccharomyces-cerevisiae-a-fatal-case-report-focus-on-fungal-susceptibility-and-potential-virulence-attributes
#31
JOURNAL ARTICLE
Lívia S Ramos, Luca Mokus, Heloisa F Frota, Marcos V Santos, Simone S C Oliveira, Manoel M E Oliveira, Gisela L Costa, Ana Luísa Alves, Andréa R Bernardes-Engemann, Rosane Orofino-Costa, Ana Carolina Aor, Marta H Branquinha, André L S Santos
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for approximately 6.8 million deaths worldwide, threatening more than 753 million individuals. People with severe coronavirus disease-2019 (COVID-19) infection often exhibit an immunosuppression condition, resulting in greater chances of developing co-infections with bacteria and fungi, including opportunistic yeasts belonging to the Saccharomyces and Candida genera. In the present work, we have reported the case of a 75-year-old woman admitted at a Brazilian university hospital with an arterial ulcer in the left foot, which was being prepared for surgical amputation...
February 2, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/36688668/novel-intravenous-immunoglobulin-therapy-for-the-prevention-and-treatment-of-candida-auris-and-candida-albicans-disseminated-candidiasis
#32
JOURNAL ARTICLE
Hong Xin, Jonothan A Rosario-Colon, Karen Eberle
Disseminated candidiasis is a life-threatening disease and remains the most common bloodstream infection in hospitalized patients in the United States. Despite the availability of modern antifungal therapy, the crude mortality rate in the last decade has remained unacceptably high. Novel approaches are urgently needed to supplement or replace current antifungal therapies. In our study, we show that human intravenous immunoglobulin (IVIG) can provide protection against Candida auris and Candida albicans disseminated infections in A/J and C57BL/6 mouse models...
January 23, 2023: MSphere
https://read.qxmd.com/read/36676116/risk-factors-diagnosis-and-treatment-of-neonatal-fungal-liver-abscess-a-systematic-review-of-the-literature
#33
REVIEW
Paschalia Kopanou Taliaka, Andreas G Tsantes, Aikaterini Konstantinidi, Dimitra Houhoula, Konstantina A Tsante, Aristeidis G Vaiopoulos, Daniele Piovani, Georgios K Nikolopoulos, Stefanos Bonovas, Nicoletta Iacovidou, Argirios E Tsantes, Rozeta Sokou
(1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on neonatal liver abscesses due to invasive fungal infections. (2) Methods: An electronic search of the PubMed and Scopus databases was conducted, considering studies that evaluated fungal liver abscesses in the neonatal population...
January 6, 2023: Life
https://read.qxmd.com/read/36535368/maternal-origins-of-neonatal-infections-what-do-obstetrician-gynecologist-should-could-do
#34
REVIEW
Chiara Germano, Alessandro Messina, Alessio Massaro, Rossella Attini, Livio Leo, Paolo Manzoni, Bianca Masturzo
Neonatal infections are responsible for 20% of neonatal deaths yearly. In this review, we focused on the origins of the commoner neonatal infections, and we define the role of obstetricians. Regarding group B Streptococcus , a key measure for the prevention of neonatal infection is the vaginal-rectal culture screening at term pregnancy. Intravenous penicillin is the first-line prophylaxis at the start of labor, with intravenous ampicillin as an alternative. First-generation cephalosporins or clindamycin are recommended in case of penicillin allergy...
December 2022: American Journal of Perinatology
https://read.qxmd.com/read/36509311/anti-inflammatory-and-anti-biotic-drug-metronidazole-loaded-zif-90-nanoparticles-as-a-ph-responsive-drug-delivery-system-for-improved-pediatric-sepsis-management
#35
JOURNAL ARTICLE
Tingting Lin, Tao Qin, Shanshan Jiang, Chunfeng Zhang, Ling Wang
Sepsis is a life-threatening disease caused by the dis-functioning of the immune response to pathogenic infections. Despite, the discovery of modern therapeutics and treatments of sepsis are lacking due to the resistance of pathogens. Metronidazole is an antibiotic commonly used to treat bacterial infections, but usage is limited and challenging by a short half-life period. In this research work, fabricate a pH-responsive drug delivery system for controlled release of metronidazole targeted molecules. We exemplified that, the encapsulation of hydrophilic metronidazole drug within a hydrophobic ZIF-90 framework can be enhanced the pH-responsive drug release under acidic conditions...
December 9, 2022: Microbial Pathogenesis
https://read.qxmd.com/read/36505995/trends-of-antimicrobial-resistance-in-patients-with-complicated-urinary-tract-infection-suggested-empirical-therapy-and-lessons-learned-from-a-retrospective-observational-study-in-oman
#36
JOURNAL ARTICLE
Yousuf Al Mamari, Hiba Sami, Khurram Siddiqui, Hashim Ba Tahir, Zaaima Al Jabri, Zakariya Al Muharrmi, Syed Gauhar A Rizvi, Meher Rizvi
BACKGROUND: Complicated urinary tract infection (cUTI) is defined as an infection associated with structural, functional, or metabolic abnormalities of the genitourinary tract. These infections are caused frequently by multidrug-resistant Gram-negative bacilli. The rapid emergence of extended-spectrum beta-lactamase (ESBL), AmpC, and carbapenemase (CR) producers has made the treatment of such infections increasingly more challenging. OBJECTIVES: The aims of the present study were threefold: to assess the clinical profile, trends in etiology, and antimicrobial susceptibility profile in cUTI over the past 10 years at a tertiary care center in Oman as an interrupted time series on the one hand and to develop guidelines for empirical management of such cases on the other...
2022: Urology Annals
https://read.qxmd.com/read/36425881/comparison-of-endogenous-endophthalmitis-in-patients-with-and-without-covid-19-infection
#37
JOURNAL ARTICLE
Ehsan Namvar, Mehdi Moallem, Mehrdad Afarid, Alireza Bolkheir
INTRODUCTION: Endogenous endophthalmitis (EE) is an ophthalmic emergency that can have severe sight-threatening complications. Prompt diagnosis and aggressive treatment are central to the successful management of EE. In recent years, a significant increase has occurred in the number of cases of EE. Some of these individuals had a COVID-19 infection. The current study compared EE in patients with and without COVID-19 infection. METHODS: All cases of EE admitted to Khalili Hospital between April 2020 and September 2021 were included in this prospective case-control study...
2022: Journal of Ophthalmology
https://read.qxmd.com/read/36364977/epidemiology-of-community-acquired-sepsis-data-from-an-e-sepsis-registry-of-a-tertiary-care-center-in-south-india
#38
JOURNAL ARTICLE
Fabia Edathadathil, Soumya Alex, Preetha Prasanna, Sangita Sudhir, Sabarish Balachandran, Merlin Moni, Vidya Menon, Dipu T Sathyapalan, Sanjeev Singh
The study aims to characterize community-acquired sepsis patients admitted to our 1300-bedded tertiary care hospital in South India from the Surviving Sepsis Campaign (SSC) guideline-compliant e-sepsis registry stratified by focus of infection. The prospective observational study recruited 1009 adult sepsis patients presenting to the emergency department at the center based on Sepsis-2 criteria for a period of three years. Of the patients, 41% were between 61 and 80 years with a mean age of 57.37 ± 13...
October 24, 2022: Pathogens
https://read.qxmd.com/read/36270215/first-case-of-neonatal-fungemia-caused-by-aureobasidium-melanogenum
#39
Arghadip Samaddar, Anuradha Sharma
Aureobasidium melanogenum is a saprophytic, dematiaceous, yeast-like fungus rarely implicated in human infections. Here, we report the first case of A. melanogenum fungemia in a 30-week-old preterm, very low birth weight neonate born to a primigravida with history of gestational diabetes, pregnancy induced hypertension and oligohydramnios. The baby developed respiratory distress, hypotension, bradycardia, coagulopathy and septic shock shortly after birth, and eventually succumbed to multiple organ dysfunction syndrome on day 9 of life...
September 25, 2022: Journal de Mycologie Médicale
https://read.qxmd.com/read/36203769/appropriate-empirical-antifungal-therapy-is-associated-with-a-reduced-mortality-rate-in-intensive-care-unit-patients-with-invasive-fungal-infection-a-real-world-retrospective-study-based-on-the-mimic-iv-database
#40
JOURNAL ARTICLE
Man-Ka Zhang, Zhi-Guo Rao, Tao Ma, Ming Tang, Tian-Qi Xu, Xiao-Xu He, Zhou-Ping Li, Yin Liu, Qing-Jie Xu, Ke-Yu Yang, Yi-Fan Gong, Jing Xue, Mei-Qing Wu, Xiao-Yan Xue
Objective: The study aimed to determine the prevalence and pathogens of invasive fungal infection (IFI) among intensive care unit (ICU) patients. The next goal was to investigate the association between empirical antifungal treatment and mortality in ICU patients. Methods: Using microbiological events, we identified all ICU patients with IFI and then retrieved electronic clinical data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The data were statistically analyzed using t -tests, chi-square tests, log-rank tests, and Cox regression...
2022: Frontiers in Medicine
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