Sara Op de Beeck, Marijke Dieltjens, Ali Azarbarzin, Marc Willemen, Johan Verbraecken, Marc J Braem, Andrew Wellman, Scott A Sands, Olivier M Vanderveken
Rationale: Mandibular advancement device (MAD) treatment efficacy varies among patients with obstructive sleep apnea. Objectives: The current study aims to explain underlying individual differences in efficacy using obstructive sleep apnea endotypic traits calculated from baseline clinical polysomnography: collapsibility (airflow at normal ventilatory drive), loop gain (drive response to reduced airflow), arousal threshold (drive preceding arousal), compensation (increase in airflow as drive increases), and the ventilatory response to arousal (increase in drive explained by arousal)...
March 2021: Annals of the American Thoracic Society