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https://read.qxmd.com/read/30767742/structure-and-function-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-in-atherosclerosis
#1
Lei Zhang, Zahid Hussain, Zhuanqin Ren
BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH. OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH...
February 14, 2019: Current Drug Targets
https://read.qxmd.com/read/30767741/recent-advances-in-rational-diagnosis-and-treatment-of-normal-pressure-hydrocephalus-a-critical-appraisal-on-novel-diagnostic-therapy-monitoring-and-treatment-modalities
#2
Zahid Hussain, Lei Zhang, Zhuanqin Ren
BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH. OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH...
February 14, 2019: Current Drug Targets
https://read.qxmd.com/read/30762826/99mtc-llec-renal-dynamic-scan-in-a-patient-with-pelvic-neuroblastoma
#3
Sreenivasa Reddy Konudula, Peethamber L, Madhusudhanan Ponnusamy, Dhanapathi H, Nandini Pandit
A 5-month-old boy with ultrasonography showing bilateral hydronephrosis, referred for renal scan. On Tc-L,L,ethylenedicysteine (Tc-LLEC) renal scan, tracer blush in flow images in the region of urinary bladder was seen and tumor mass was suspected. Contrast-enhanced CT showed a soft tissue mass in sacrococcygeal region. Histopathological examination of biopsy tissue revealed malignant round cell tumor and immunohistochemistry consistent with neuroblastoma. I-MIBG scan revealed uptake in the pelvic mass with no distant metastasis...
February 8, 2019: Clinical Nuclear Medicine
https://read.qxmd.com/read/30746415/mibg-myocardial-scintigraphy-identifies-premotor-pd-dlb-during-a-negative-dat-scan-period-second-report
#4
Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba, Tsuyoshi Ogata, Masahiko Kishi, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka, Katsuyoshi Matsuoka
Objectives: Neuroimaging markers for Parkinson's disease (PD)/dementia with Lewy bodies (DLB) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is useful to identify the premotor phase PD/DLB. We reported four patients who, during a negative DAT scan period, had a positive MIBG result that suggested premotor PD/DLB. Here we report 18 additional patients. Methods: This study was a prospective cohort study...
January 2019: Movement Disorders Clinical Practice
https://read.qxmd.com/read/30741037/efficacy-of-intravesical-targeting-of-novel-quorum-sensing-inhibitor-nanoparticles-against-pseudomonas-aeruginosa-biofilm-associated-murine-pyelonephritis
#5
Anitha Vadekeetil, Sanjay Chhibber, Kusum Harjai
Pseudomonas aeruginosa biofilm-associated pyelonephritis is a severe infection that can lead to mortality. There are no strategies that can effectively manage this infection since the pathogenesis is controlled by quorum sensing (QS) regulated virulence and recalcitrant biofilms. QS inhibitors (QSIs) are emerging therapeutics against such infections but are associated with cytotoxicity or low bioactivity. Hence, we developed novel quorum sensing inhibitor loaded nanoparticles (QSINPs) using the biopolymers, chitosan (CS) and dextran sulphate (DS) and were intravesically targeted against biofilm-associated murine pyelonephritis...
February 11, 2019: Journal of Drug Targeting
https://read.qxmd.com/read/30737908/prostatic-volume-determination-by-transabdominal-ultrasonography-does-accuracy-vary-significantly-with-urinary-bladder-volumes-between-50-to-400-ml
#6
Edmund K Brakohiapa, Benard O Botwe, Benjamin D Sarkodie
INTRODUCTION: In Ghana, trans-abdominal ultrasonography is the main sonographic method of prostatic volume evaluation. The examinations are done when the patient's bladder is full. However, the delay and the discomforting experiences associated with a full bladder have been well documented. In an attempt to investigate other less discomforting options, this study was undertaken to determine if sonographic transabdominal prostatic evaluations performed at urinary bladder volumes of 50-99 mL differ significantly to evaluations done at volumes of 100-199, 200-299 and 300-399 mL...
February 8, 2019: Journal of Medical Radiation Sciences
https://read.qxmd.com/read/30721772/tracheomalacia-as-a-complication-of-stenting-for-esophageal-injury-after-a-transsternal-approach-to-high-thoracic-vertebral-metastasis
#7
Kai-Chen Chung, Chih-Hung Lin, Chung-Lin Tsai, Yu-Hsuan Li, Chih-Hsiang Liao
BACKGROUND: and Importance: Esophageal injury is a severe surgical complication of a transsternal approach to the high thoracic vertebral metastasis, which can result in mediastinitis and life-threatening consequences. A covered stent can be placed in the esophagus to prevent mediastinal leakage. However, tracheomalacia is a very rare complication following esophageal stenting. CLINICAL PRESENTATION: A 56-year-old man had a pathologic fracture of the T3 vertebral body with spinal cord compression, myelopathy, and neurogenic bladder...
February 2, 2019: World Neurosurgery
https://read.qxmd.com/read/30720140/ketamine%C3%A2-induced-bladder-dysfunction-is-associated-with-extracellular-matrix-accumulation-and-impairment-of-calcium-signaling-in-a-mouse-model
#8
Cheng-Huang Shen, Shou-Tsung Wang, Shou-Chieh Wang, Shu-Mei Lin, Lei-Chen Lin, Yuan-Chang Dai, Yi-Wen Liu
Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One group was treated with ketamine (100 mg/kg/day of ketamine for 20 weeks), whereas, the control group was treated with saline solution. In each group, micturition frequency and urine volume were examined to assess urinary voiding functions...
January 29, 2019: Molecular Medicine Reports
https://read.qxmd.com/read/30712050/survival-and-metastasis-in-muscle-invasive-bladder-cancer-patients-who-present-with-indeterminate-pulmonary-nodules-before-treatment
#9
Ali Al-Daghmin, Sohaib Alhamss, Hani Al-Najjar, Ibrahim Al-Saidi, Khloud Al-Qasem, Ibrahim Abukhiran, Anas Hamad, Muna Alhusban
BACKGROUND: Indeterminate pulmonary nodules (IPNs) are common during initial evaluation of bladder cancer patients. Their significance is still unknown. OBJECTIVE: Determine the significance of indeterminate pulmonary nodules, including their size and number, in muscle-invasive bladder cancer patients before definitive local therapy by surgery or chemo-radiotherapy. DESIGN: Retrospective review, single-center descriptive study. SETTINGS: A tertiary cancer center...
January 2019: Annals of Saudi Medicine
https://read.qxmd.com/read/30707934/retentive-device-for-intravesical-drug-delivery-based-on-water-induced-shape-memory-response-of-poly-vinyl-alcohol-design-concept-and-4d-printing-feasibility
#10
A Melocchi, N Inverardi, M Uboldi, F Baldi, A Maroni, S Pandini, F Briatico-Vangosa, L Zema, A Gazzaniga
The use of shape memory polymers exhibiting water-induced shape recovery at body temperature and water solubility was proposed for the development of indwelling devices for intravesical drug delivery. These could be administered via catheter in a suitable temporary shape, retained in the bladder for a programmed period of time by recovery of the original shape and eliminated with urine following dissolution/erosion. Hot melt extrusion and fused deposition modeling 3D printing were employed as the manufacturing techniques, the latter resulting in 4D printing because of the shape modifications undergone by the printed item over time...
January 29, 2019: International Journal of Pharmaceutics
https://read.qxmd.com/read/30693883/effectiveness-of-abdominal-compression-in-reducing-internal-target-motion-during-conformal-radiotherapy-for-carcinoma-stomach-a-pilot-study
#11
Jomon C Raphael, Mathew K Varghese, Paul G Gopu, K Venkatesan, A D Jimson, Antony Febin
AIM: : To assess the effectiveness of abdominal compression in reducing internal target motion during conformal radiotherapy for stomach cancer. MATERIALS AND METHODS: A pilot study was conducted on five patients who received adjuvant radiotherapy for stomach cancer. All the patients had surgical clips and were offered radiotherapy and concurrent chemotherapy as per the institutional protocol. An abdominal compression device was developed consisting of a triangular Styrofoam's plate and an inflatable air bladder that was positioned over the patients' abdomen...
July 2018: Indian Journal of Cancer
https://read.qxmd.com/read/30692497/-a-case-of-appendiceal-cancer-wherein-the-abdominal-abscess-ruptured-into-the-urinary-bladder-owing-to-obstructive-appendicitis
#12
Gen Tsujio, Hisashi Nagahara, Masatsune Shibutani, Tatsunari Fukuoka, Shinji Matsutani, Chikako Kusunoki, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
A 73-year-old woman presented to her doctor because of lower abdominal pain and distension. A neoplastic lesion in the lower abdomen was revealed, and she was referred to our department. Enhanced CT showed wall thickening in the urinary bladder and a 6 cm mass that extended to the appendix. An appendiceal tumor invading the urinary bladder or a urinary bladder tumor invading the appendix was suspected, and we planned surgical treatment. One month later, we repeated enhanced CT scanning on admission. The mass had shrunk, but the thickening of the urinary bladder wall remained, and an enhanced appendiceal tumor was visible...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30678437/application-of-asi-kvcbct-for-volume-assessment-and-dose-estimation-an-offline-adaptive-study-for-prostate-radiotherapy
#13
Arun Gandhi, Subramani Vellaiyan, Shanmuga Subramanian, Shanmugam Thirumalai Swamy, Kala Subramanian, Anantharaman Ayyalusamy
Objective: The purpose of this study is to develop a method to estimate the dose using amorphous silicon detector panel cone beam computed tomography (aSi-kVCBCT) for the OARs and targets in prostate radiotherapy and to compare with the actual planned dose. Methods: The aSi-kVCBCT is used widely in radiotherapy to verify the patient position before treatment. The advancement in aSi-kVCBCT combined with adaptive software allows us to verify the dose distribution in daily acquired CBCT images. CBCT images from 10 patients undergoing radical prostate radiotherapy were included in this study...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/30674499/urachal-mucinous-cystadenocarcinoma
#14
Ryan Pereira, Stephen McGeorge, Marlon Perera, Ian Vela
A 57-year-old man presented with a 6-month history of pelvic fullness. He had no lower urinary tract symptoms or altered bowel habits. On examination, there was a non-tender pelvic mass which extended from the pubic symphysis to the level of the umbilicus. CT scan of the abdomen demonstrated a 22×11×11 cm cystic mass arising from the pelvis extending into the midline and superiorly to the umbilicus. Other than raised carcinoembryonic antigen of 7.6 ng/mL (<5.0), the remainder of his blood test were unremarkable...
January 22, 2019: BMJ Case Reports
https://read.qxmd.com/read/30666091/hyperprogression-after-anti-programmed-cell-death-ligand-1-therapy-in-a-patient-with-recurrent-metastatic-urothelial-bladder-carcinoma-following-first-line-cisplatin-based-chemotherapy-a-case-report
#15
Shiyu Mao, Junfeng Zhang, Yadong Guo, Ziwei Zhang, Yuan Wu, Wentao Zhang, Longsheng Wang, Jiang Geng, Yang Yan, Xudong Yao
Background: Immune checkpoint blockade targeting programmed cell death ligand-1 (PD-L1)/programmed death-1 (PD-1) signaling was approved recently for locally advanced and metastatic urothelial bladder carcinoma (UBC). Some patients experience a very rapid tumor progression, rather than clinical benefit, from anti-PD-L1/PD-1 therapy. Case presentation: A 58-year-old male diagnosed with non-muscle-invasive bladder cancer 3 years ago received transurethral resection of bladder tumor (TURBT) and intravesical chemotherapy...
2019: Drug Design, Development and Therapy
https://read.qxmd.com/read/30662477/role-of-deformable-image-registration-for-delivered-dose-accumulation-of-adaptive-external-beam-radiation-therapy-and-brachytherapy-in-cervical-cancer
#16
Laura E van Heerden, Jorrit Visser, Kees Koedooder, Coen Rn Rasch, Bradley R Pieters, Arjan Bel
Purpose: Deformable image registration (DIR) can be used to accumulate the absorbed dose distribution of daily image-guided adaptive external beam radiation treatment (EBRT) and brachytherapy (BT). Since dose-volume parameter addition assumes a uniform delivered EBRT dose around the planned BT boost, the added value of DIR over direct addition was investigated for dose accumulation in bladder and rectum. Material and methods: For 10 patients (EBRT 46/46.2 GyEQD2 , EBRT + BT: D90 85-90 GyEQD2 , in equivalent dose in 2 Gy fractions), the actually delivered dose from adaptive volumetric-modulated arc therapy (VMAT)/intensity-modulated radiotherapy (IMRT) EBRT was calculated using the daily anatomy from the cone-beam computed tomography (CBCT) scans acquired prior to irradiation...
December 2018: Journal of Contemporary Brachytherapy
https://read.qxmd.com/read/30656361/underestimation-of-pelvic-organ-prolapse-in-the-supine-straining-position-based-on-magnetic-resonance-imaging-findings
#17
Anique T M Grob, Judith Olde Heuvel, Jurgen J Futterer, Diana Massop, Angelique L Veenstra van Nieuwenhoven, Frank F J Simonis, Carl H van der Vaart
OBJECTIVE: Pelvic organ prolapse (POP) is clinically diagnosed in the supine position, where the effect of gravity is simulated by having the patients put strain on their pelvic floor. The objective of this study was to determine the degree of POP underestimation in the supine position based on magnetic resonance imaging (MRI) findings. METHODS: This prospective study was conducted with symptomatic POP grade ≥ 2 patients. Fifteen female patients were examined with an MRI system that allows supine and upright imaging...
January 17, 2019: International Urogynecology Journal
https://read.qxmd.com/read/30651036/effect-of-udenafil-administration-on-postmicturition-dribbling-in-men-a-prospective-multicenter-double-blind-placebo-controlled-randomized-clinical-study
#18
Kyungtae Ko, Won Ki Lee, Sung Tae Cho, Young Gu Lee, Tae Young Shin, Min Soo Choo, Jun Hyun Han, Seong Ho Lee, Cheol Young Oh, Jin Seon Cho, Hyun Cheol Jeong, Dae Yul Yang
PURPOSE: Postmicturition dribbling (PMD) is a stressful symptom in middle-aged men characterized by urinary leakage after the completion of normal voiding. Appropriate treatments have not yet been introduced. This study assessed the efficacy of treatment of PMD with 75 mg udenafil daily. MATERIALS AND METHODS: The study included 138 men with regular sexual lifestyles. The Hallym PMD questionnaire (HPMDQ) was used to assess PMD symptoms. After all basic examinations, patients were randomly assigned to either udenafil or placebo...
January 16, 2019: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://read.qxmd.com/read/30624081/population-based-validation-of-the-national-comprehensive-cancer-network-recommendations-for-baseline-imaging-for-bladder-cancer-a-case-for-routine-baseline-bone-scan
#19
Omar Abdel-Rahman
AIM: This study aims at evaluating the performance of some of the imaging recommendations of the National Comprehensive Cancer Network (NCCN) for initial evaluation of bladder cancer. METHODS: Surveillance, epidemiology and end results program (2010-2015) was queried and patients with clinically (T1-T4) bladder cancer and complete information about clinical T/N (tumor/nodal) stage and metastatic sites were extracted. The following characteristics were evaluated in the current analysis: sensitivity, specificity, number needed to investigate (NNI), positive predictive value (PPV), negative predictive value and accuracy...
January 9, 2019: Journal of Comparative Effectiveness Research
https://read.qxmd.com/read/30618336/electrospun-nanofibrous-with-core-shell-structure-for-treatment-of-the-bladder-regeneration
#20
Chunxiang Feng, Chang Liu, Shiliang Liu, Zhixian Wang, Kai Yu, Xiaoyong Zeng
Hyaluronic acid (HA) is an important component of the extracellular matrix (ECM), and electrospun scaffolds have the 3D porous network structure characteristics similar to those of the autologous ECM. However,scaffolds fabrication of water dissolved HA without surfactant by electrospinning is difficult. This study reports the fabrication of HA-coated biomimetic nanofibrous scaffolds via coaxial electrospinning of poly(L-lactide)/poly(e-caprolactone) (PLCL) and HA to modulate proliferation and migration of smooth muscle cells (SMCs) for bladder regeneration...
January 8, 2019: Tissue Engineering. Part A
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