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Clémentine Ninive, Xavier Ferrareto, Solenne Gricourt, Marie-Astrid Llabadorde Royer, Julien Lepage, Claire Gauché-Cazalis, Sylvie Epelboin, Maëliss Peigné
With the use of antiretroviral therapy, HIV transmission from mother to fetus and between sexual partners has been significantly reduced, successively allowing pregnancy, then assisted reproductive technologies, and targeted unprotected sex among couples living with HIV. Since first french Morlat report in 2013, natural procreation is now possible under certain conditions for these couples living with HIV and the use of assisted reproductive technologies is increasingly limited to the treatment of infertility...
February 9, 2019: Gynecologie, Obstetrique, Fertilite & Senologie
Clémentine Bouchez, Emmanuelle Kempf, Christophe Tournigand
Checkpoints inhibitors are known to induce striking tumor responses in advanced MSI colorectal cancers, which used to be related to a poor clinical outcome. The incidence of the MSI phenotype is highly heterogeneous across non-colorectal cancers. The highest incidence rates are found in endometrioid forms of uterine cancers and in gastric tumors (20 to 40 % and 10 to 33 %, respectively). The association between a "MSI" tumor phenotype and other clinical or biological tumor characteristics is still under debate...
February 5, 2019: Bulletin du Cancer
Javier Terol, M José Nueda, Daniel Ventimilla, Francisco Tadeo, Manuel Talon
BACKGROUND: Harvest time is a relevant economic trait in citrus, and selection of cultivars with different fruit maturity periods has a remarkable impact in the market share. Generation of early- and late-maturing cultivars is an important target for citrus breeders, therefore, generation of knowledge regarding the genetic mechanisms controlling the ripening process and causing the early and late phenotypes is crucial. In this work we analyze the evolution of the transcriptome during fruit ripening in 3 sport mutations derived from the Fina clementine (Citrus clementina) mandarin: Clemenules (CLE), Arrufatina (ARR) and Hernandina (HER) that differ in their harvesting periods...
January 31, 2019: BMC Plant Biology
Nathanaëlle Saclier, Clémentine M François, Lara Konecny-Dupré, Nicolas Lartillot, Laurent Guéguen, Laurent Duret, Florian Malard, Christophe J Douady, Tristan Lefébure
No abstract text is available yet for this article.
January 23, 2019: Molecular Biology and Evolution
Ksenija Vucurovic, Clémentine Dupont-Gaudin, Delphine Raucher-Chéné, Arthur Kaladjian, Christine-Vanessa Cuervo-Lombard
OBJECTIVE: Self-defining memories (SDMs) are vivid, emotionally intense and well-rehearsed autobiographical memories that provide fundamental information about one's cognitive affective motivational representation of self. Exploring SDMs in fibromyalgia (FM) is of interest for understanding the psychopathology of this disorder and improving clinical interventions. Our aim was to compare patients and healthy controls (HC) on SDM characteristics. METHOD: We included 25 patients with FM and 24 HC matched for age, sex and education level...
January 7, 2019: Comprehensive Psychiatry
Maxime Garnault, Clémentine Duplaix, Pierre Leroux, Gilles Couleaud, Florence Carpentier, Olivier David, Anne-Sophie Walker
BACKGROUND: Management of pesticide resistance is a major issue in modern agricultural systems, particularly in the context of the broader challenge of reducing pesticide use. However, such management must be adapted to resistance dynamics, which remains challenging to predict due to its dependence on many biological traits of pests, interactions with the environment and pesticide use. We retrospectively studied the evolution of reported resistances to four modes of action (benzimidazoles, quinone outside inhibitors, sterol demethylation inhibitors and succinate dehydrogenase inhibitors); in French populations of the wheat pathogen Zymoseptoria tritici...
January 24, 2019: Pest Management Science
Clémentine Fritsch, Łukasz Jankowiak, Dariusz Wysocki
Although several factors have been highlighted to explain the influence of urbanization on bird fitness and survival, the role of persistent toxicants such as lead (Pb), which is typically present in urban areas worldwide, has seldom been studied despite the ecological importance of such a widespread stressor. Studying free-living European blackbirds (Turdus merula) in city parks, we tested the hypothesis that low-dose chronic exposure to Pb could shape the life-history traits of urban birds. The feather concentrations of Pb and cadmium were typical of urban areas and low-to-moderate contamination of sites...
January 24, 2019: Scientific Reports
Alain Dutilleul, Jacques Morel, Clémentine Shilte, Odile Launay
A flagship recommendation of the citizen's steering committee on immunization, the mandatory immunization for infants extended to 11 vaccines, introduced in January 2018, is part of a set of recommendations that must be considered as a whole, each component being indispensable to the achievement of objectives: restore confidence in vaccination and increase immunization coverage. Roundtable # 6 participants identified a decade of concrete initiatives that could address, at least in part, the committee's recommendations, including: developing information systems and data generation; simplify the vaccination journey and increase vaccination opportunities; developing training of health professionals; learning vaccines at school; using motivational interviewing in educational intervention; undertaking local initiatives; improving supply and communicate on the value of vaccines...
December 20, 2018: Thérapie
Natacha Rochel, Clémentine Krucker, Laure Coutos-Thévenot, Judit Osz, Ruiyun Zhang, Elodie Guyon, Wayne Zita, Séverin Vanthong, Oscar Alba Hernandez, Maxime Bourguet, Kays Al Badawy, Florent Dufour, Carole Peluso-Iltis, Syrine Heckler-Beji, Annick Dejaegere, Aurélie Kamoun, Aurélien de Reyniès, Yann Neuzillet, Sandra Rebouissou, Claire Béraud, Hervé Lang, Thierry Massfelder, Yves Allory, Sarah Cianférani, Roland H Stote, François Radvanyi, Isabelle Bernard-Pierrot
The upregulation of PPARγ/RXRα transcriptional activity has emerged as a key event in luminal bladder tumors. It renders tumor cell growth PPARγ-dependent and modulates the tumor microenvironment to favor escape from immuno-surveillance. The activation of the pathway has been linked to PPARG gains/amplifications resulting in PPARγ overexpression and to recurrent activating point mutations of RXRα. Here, we report recurrent mutations of PPARγ that also activate the PPARγ/RXRα pathway, conferring PPARγ-dependency and supporting a crucial role of PPARγ in luminal bladder cancer...
January 16, 2019: Nature Communications
Katherine Moore, Anand Ganesan, Clementine Labrosciano, William Heddle, Andrew McGavigan, Sadia Hossain, Dennis Horton, Saranya Hariharaputhiran, Isuru Ranasinghe
Background To date, limited population-level studies have examined the impact of sex on the acute complications of cardiac implantable electronic devices ( CIED) , including permanent pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therapy devices. Methods and Results We studied all patients aged >18 years from 2010 to 2015 who were a resident of Australia or New Zealand, undergoing a new permanent pacemaker, implantable cardioverter defibrillator, or cardiac resynchronization therapy implant...
January 22, 2019: Journal of the American Heart Association
Valentin De Mazancourt, Magalie Castelin, Clementine Renneville, Musa C Mlambo, Gerard Marquet, Philippe Keith
Numerous specimens of a freshwater shrimp with small eggs belonging to the Caridina nilotica complex collected in the South Western Indian Ocean were studied and compared with recent and old collection specimens genetically (16S mitochondrial analysis for recent and type specimens) and morphologically. The results revealed that, in the Indian Ocean, what has been identified by several authors under various species names of the complex C. nilotica, was in fact C. natalensis De Man, 1908. This valid species is re-described and compared with closely related species, often confused with it in this area: C...
January 7, 2019: Zootaxa
David Brenner, Kirsten Sieverding, Clara Bruno, Patrick Lüningschrör, Eva Buck, Simon Mungwa, Lena Fischer, Sarah J Brockmann, Johannes Ulmer, Corinna Bliederhäuser, Clémentine E Philibert, Takashi Satoh, Shizuo Akira, Séverine Boillée, Benjamin Mayer, Michael Sendtner, Albert C Ludolph, Karin M Danzer, Christian S Lobsiger, Axel Freischmidt, Jochen H Weishaupt
Heterozygous loss-of-function mutations of TANK-binding kinase 1 ( TBK1 ) cause familial ALS, yet downstream mechanisms of TBK1 mutations remained elusive. TBK1 is a pleiotropic kinase involved in the regulation of selective autophagy and inflammation. We show that heterozygous Tbk1 deletion alone does not lead to signs of motoneuron degeneration or disturbed autophagy in mice during a 200-d observation period. Surprisingly, however, hemizygous deletion of Tbk1 inversely modulates early and late disease phases in mice additionally overexpressing ALS-linked SOD1G93A , which represents a "second hit" that induces both neuroinflammation and proteostatic dysregulation...
January 11, 2019: Journal of Experimental Medicine
Charaf Eddine Watheq Malti, Clémentine Baccati, Magali Mariani, Faiçal Hassani, Brahim Babali, Fewzia Atik-Bekkara, Mathieu Paoli, Jacques Maury, Félix Tomi, Chahrazed Bekhechi
The chemical composition of 18 oil samples of Santolina africana isolated from aerial parts at full flowering, collected in three locations in eastern Algeria was determined by GC(RI), GC/MS and 13 C-NMR analysis. The major components were: germacrene D, myrcene, spathulenol, α-bisabolol, β-pinene, 1,8-cineole, cis -chrysanthenol, capillene, santolina alcohol, camphor, terpinen-4-ol and lyratol. The chemical composition appeared homogeneous and characterized by the occurrence of four derivatives which exhibited a conjugated alkene dialkyne moiety...
January 8, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Margo Ramsay, Clémentine Beutier, G Bryce McGarvey, Dennis K Hore
Polymer coatings offer a means to modulate the adsorption of molecules onto solid surfaces by offering a surface functionality, charge, roughness, and hydrophobicity that is different from the underlying substrate. One application is to provide anti-fouling functions for metal surfaces. Understanding solvent-surface interactions is an essential component to gaining mechanistic insight into the adsorption process. In this work, we study the adsorption of toluene-heptane binary mixtures onto a perflurorinated polymer surface...
January 7, 2019: Journal of Chemical Physics
Alain Dutilleul, Jacques Morel, Clémentine Shilte, Odile Launay
No abstract text is available yet for this article.
November 27, 2018: Thérapie
Maëlle Givelet, Clémentine Lapoujade, Pierre Fouchet
Mechanisms regulating maintenance of the stem cell pool in facultative niches of the mammalian testis are poorly understood. In this issue of Cell Stem Cell, Kitadate et al. (2019) propose a minimal model in which stem cells compete for limited resources of fibroblast growth factors, which predicts their density during homeostasis and regenerative conditions.
January 3, 2019: Cell Stem Cell
Anjali Silva, Sleiman Bassim, Clémentine Sarkozy, Anja Mottok, Tracy Lackraj, Vindi Jurinovic, Marianne Brodtkorb, Ole Christian Lingjaerde, Laurie H Sehn, Randy D Gascoyne, Oliver Weigert, Christian Steidl, Robert Kridel
No abstract text is available yet for this article.
January 3, 2019: Haematologica
Cynthia Simon, Jessika Moreau, Nicolas Gatimel, Clémentine Cohade, Jean Parinaud, Roger Leandri
The study aimed to assess the impacts and the targets of progesterone (P4) and estradiol (E2) levels on IVF outcomes in GnRH antagonist protocols. The study was retrospective and concerned patients for their first fresh embryo transfers, after stimulation by a recombinant FSH (rFSH)-GnRH antagonist protocol, between September 2012 and July 2017 in the Toulouse University Hospital. Multivariable analysis, taking into account female age and the ovarian stimulation index, showed that E2 levels had no impact on IVF outcomes, while high P4 levels (>1...
January 2, 2019: Gynecological Endocrinology
Shauna E Wallace Fitzsimons, Barbara Chruścicka, Clementine Druelle, Panagiota Stamou, Ken Nally, Timothy G Dinan, John F Cryan, Harriët Schellekens
Oxytocin mediates its behavioural effects via the centrally expressed oxytocin receptor (OTR). Oxytocin signalling has been implicated in multiple disorders involving centrally regulated pathways, including obesity, autism, schizophrenia and depression. The OTR has been described to have a complex downstream signalling pathway and an increased understanding of oxytocinergic signalling is needed for the development of novel and better treatments for centrally regulated disorders this neuropeptide. The ghrelin receptor (GHSR), known primarily for its role in centrally regulated energy balance and food intake, has in more recent years also been shown to play a role in mood disorders, including anxiety and depression...
December 21, 2018: Neuropharmacology
Loïc Le Guennec, Clémentine Cholet, Florent Huang, Matthieu Schmidt, Nicolas Bréchot, Guillaume Hékimian, Sébastien Besset, Guillaume Lebreton, Ania Nieszkowska, Pascal Leprince, Alain Combes, Charles-Edouard Luyt
BACKGROUND: Structural neurological complications (ischemic stroke and intracranial bleeding) and their risk factors in patients receiving venoarterial-extracorporeal membrane oxygenation (VA-ECMO) are poorly described. Our objective was to describe frequencies, outcomes and risk factors for neurological complications (ischemic stroke and intracranial bleeding) in patients receiving VA-ECMO. METHODS: Retrospective observational study conducted, from 2006 to 2014, in a tertiary referral center on patients who developed a neurological complication(s) on VA-ECMO...
December 20, 2018: Annals of Intensive Care
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