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Hypertriglyceridemia children

Deniz Özalp Kızılay, Semra Şen, Betül Ersoy
Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children. Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL)...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
P Xiao, D Q Hou, A Y Gao, Z X Zhu, Z C Yu, N X Lin, J T Liu, S Y Chang, J Mi
Objective: To investigate the association between blood lipid and calcaneus bone mineral density (BMD) in children and adolescents aged 6-16 years in Beijing. Methods: Children and adolescents were selected in 30 schools (8 primary schools, 21 middle schools and one 12-year education school) from Dongcheng, Tongzhou, Fangshan and Miyun districts of Beijing by using a stratified cluster sampling method from November 2017 to January 2018. A total of 14 303 students in grade 1 to 4 of primary school, grade 1 of junior and senior middle school were enrolled after excluding subjects who were not able to participate into this study due to trauma or other uncomfortable physical conditions or with missing key values or with diabetes and kidney diseases...
February 6, 2019: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Fatima Zahra Zaher, Imane Boubagura, Sana Rafi, Ghizlane Elmghari, Nawal Elansari
Diabetic ketoacidosis (DKA) is a life-threatening acute metabolic complication occurring in patients with diabetes, especially in patients with type 1 diabetes (T1D), due to an insulin deficiency. Moderate hypertriglyceridemia is commonly observed in DKA but severe hypertriglyceridemia with a triglyceride level exceeding 10g/L is very rarely reported. We report a case of a 14-year-old boy who had type 1 diabetes for 4 years treated with insulin therapy, also having adrenal insufficiency treated with hydrocortisone who presented with ketoacidosis and excruciating abdominal pain...
2019: Case Reports in Endocrinology
Yao Lin, Lin Shi, Yan-Jun Deng, Yang Liu, Hong-Wei Zhang
RATIONALE: Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology and often occurs in children under 5 years old. During the acute phase, approximately 5% of children with KD develop hypotension and shock, a severe condition termed KD shock syndrome (KDSS). Macrophage activation syndrome (MAS), another life-threatening complication, has been reported to be associated with KD, although rarely. KDSS complicated with MAS is extremely rare. In this article, we present our experience in the diagnosis and treatment of KDSS complicated with MAS...
January 2019: Medicine (Baltimore)
Fabiola Martin-Del-Campo, Carolina Batis-Ruvalcaba, Susan M Ordaz-Medina, Héctor R Martínez-Ramírez, Bárbara Vizmanos-Lamotte, Enrique Romero-Velarde, Laura Cortes-Sanabria, Alfonso M Cueto-Manzano
OBJECTIVE: Obesity is clearly associated to kidney disease in adult population; however, there is scarce evidence in children and adolescents. The aim was to compare frequency of renal damage according to the presence of overweight-obesity in children and adolescents, as well as to compare nutritional and biochemical risk factors, according to the presence of kidney alterations. METHODS: Cross-sectional study; 172 children and adolescents, 6-16 years old, without malnutrition, diabetes mellitus, hypertension and independent comorbid conditions associated to obesity or kidney disease, as well as transitory causes of microalbuminuria (MA) from a Primary Health-Care Unit were included...
January 21, 2019: Journal of Renal Nutrition
M López-Alarcón, P Inda-Icaza, M C Márquez-Maldonado, A Armenta-Álvarez, L Barbosa-Cortés, J Maldonado-Hernández, M Piña-Aguero, A Barradas-Vázquez, B A Núñez-García, M Rodríguez-Cruz, J R Fernández
BACKGROUND: Paediatric obesity and insulin resistance (IR) are potentially reversible inflammatory conditions. Long chain polyunsaturated fatty acids omega-3 (LCPUFA-ω3) show anti-inflammatory and metabolic properties, but their clinical efficacy is unclear. OBJECTIVE: The objective of this study is to evaluate whether supplementation with LCPUFA-ω3 for 3 months reduces insulin resistance and weight to adolescents with obesity. METHODS: Double-blind trial of 366 adolescents with obesity randomly assigned to 1...
December 27, 2018: Pediatric Obesity
H Cheng, F F Chen, P Y Ye, J Mi
Objective: To describe characteristics of cardiometabolic risk factors of children and adolescents aged 6-17 years in 7 cities in China from 2013 to 2015. Methods: Data was from the China Child and Adolescent Cardiovascular Health (CCACH) study. 12 590 children and adolescents were selected from 24 schools (3 kindergartens, 7 primary schools, 7 junior high schools and 7 senior high schools) in seven cities (Changchun, Yinchuan, Beijing, Jinan, Shanghai, Chongqing and Tianjin) during 2013-2015 by using a stratified cluster random sampling method...
November 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Zeinab Hemati, Nafiseh Mozafarian, Ramin Heshmat, Zeinab Ahadi, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Mostafa Qorbani, Roya Kelishadi
Objective: This study aims to evaluate the association of sleep duration with metabolic syndrome (MetS) and its components in a pediatric population. Methods: This multi-centric cross-sectional study was conducted in 2015 in 30 provinces of Iran. Participants consisted of 4200 school students aged 7-18 years, studied in a national school-based surveillance program (CASPIAN-V). Physical examinations and laboratory tests were performed using standard protocols. The analysis was conducted based on the propensity score matching and conditional logistic regression was used to evaluate the association of short sleep (less than 8 h a day) and the onset of sleep with MetS and its components...
2018: Diabetology & Metabolic Syndrome
Vadzim Chyzhyk, Sarah Kozmic, Alan S Brown, Lisa C Hudgins, Thomas J Starc, Ashley Deleigh Davila, Thomas C Blevins, Margaret R Diffenderfer, Lihong He, Andrew S Geller, Caitlin Rush, Robert A Hegele, Ernst J Schaefer
BACKGROUND: Triglyceride (TG) concentrations >2000 mg/dL are extremely elevated and increase the risk of pancreatitis. OBJECTIVES: We characterized five cases and two kindreds and ascertained prevalence in a reference laboratory population. METHODS: Plasma lipids and DNA sequences of LPL, GPIHBP1, APOA5, APOC2, and LMF1 were determined in cases and two kindreds. Hypertriglyceridemia prevalence was assessed in 440,240 subjects. RESULTS: Case 1 (female, age 28 years) had TG concentrations >2000 mg/dL and pancreatitis since infancy...
September 18, 2018: Journal of Clinical Lipidology
Enrico Vidal, Irene Alberici, Enrico Verrina
Patients on dialysis are exposed to a series of factors that are known to be associated with risk of acute pancreatitis (AP), including medications, hyperparathyroidism, hypercalcemia, and hypertriglyceridemia; the role of the dialysis modality itself is still debated. Data regarding AP in children on chronic dialysis are scarce. Data from the Italian Registry of Pediatric Chronic Dialysis (IRPCD) confirm that children on dialysis have a significant increased relative risk (RR) for AP as compared with the general pediatric population (RR 60...
August 23, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Mohammad Esmaeil Motlagh, Mostafa Qorbani, Amir-Masood Rafiemanzelat, Majzoubeh Taheri, Tahereh Aminaee, Gita Shafiee, Zeinab Ahadi, Mahshid Hajiali, Kimia Ghaderi, Ali Safaei, Azam Goodarzi, Hasan Ziaodini, Ramin Heshmat, Roya Kelishadi
Introduction: This study presents the prevalence of cardiometabolic risk factors in a nationally representative sample of Iranian children and adolescents. Methods: This multi-centric study was conducted in 2015 among 4200 students aged 7-18 years. They were selected by multistage cluster sampling from 30 provinces of Iran. Anthropometric indices, biochemical and clinical parameters were measured. Results: The mean of weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FBG) was higher in boys than in girls ( P < 0...
2018: Journal of Cardiovascular and Thoracic Research
Azlina Daud, Siti Zuhaidah Shahadan, Muhammad Ibrahim, Muhammad Lokman Md Isa, Samsul Deraman
OBJECTIVE: Hypertriglyceridemia is an independent risk factor for cardiovascular diseases. This study aimed to determine the prevalence and association of triglyceride level and lifestyle factors among Malay obese class I and II adults. METHOD: This is a cross-sectional study of 65 Malay obese class I and class II adults aged 20-62 years (21 male, 44 female) from sub-urban areas of Malaysia. Overnight fasting venous blood samples were obtained to determine the triglyceride level (mmol/L)...
February 2018: Enfermería Clínica
Trey Richardson, Stella Aslibekyan, Ambika P Ashraf
OBJECTIVE: Severe hypertriglyceridemia (HTG) (i.e., plasma triglycerides [TGs] >1,000 mg/dL) in children is a rare but pernicious and understudied condition. Our objective was to evaluate the etiology, characteristics, and sequelae of severe pediatric HTG. METHODS: This was a retrospective electronic medical record review of pediatric patients with severe HTG at a tertiary referral Children's hospital over a 17-year period. RESULTS: There were a total of 124 patients with severe HTG...
September 2018: Endocrine Practice
Mariana de Santis Filgueiras, Sarah Aparecida Vieira, Andréia Queiroz Ribeiro, Juliana Farias de Novaes
OBJECTIVE: To evaluate the association between family history and the presence of dyslipidemia in children. METHODS: A cross-sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson's chi-square test was used to identify associations, and Student's t-test was used to compare means...
July 26, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Aliye Uc, M Bridget Zimmerman, Michael Wilschanski, Steven L Werlin, David Troendle, Uzma Shah, Sarah Jane Schwarzenberg, Sue Rhee, John F Pohl, Emily R Perito, Joseph J Palermo, Chee Y Ooi, Quin Liu, Tom K Lin, Veronique D Morinville, Brian A McFerron, Sohail Z Husain, Ryan Himes, Melvin B Heyman, Tanja Gonska, Matthew J Giefer, Cheryl E Gariepy, Steven D Freedman, Douglas S Fishman, Melena D Bellin, Bradley Barth, Maisam Abu-El-Haija, Mark E Lowe
OBJECTIVE: The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). METHODS: We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations...
September 2018: Pancreas
C Salvador, A Entenmann, R Salvador, A Niederwanger, R Crazzolara, G Kropshofer
BACKGROUND: Lipemic alterations are commonly seen in pediatric patients with acute lymphoblastic leukemia (ALL) treated with corticosteroids and L-asparaginase. OBJECTIVE: In these children, hypertriglyceridemia rarely causes symptoms and mostly responds well to a low-fat diet. Only few patients demand further therapy, which is not clearly approved in the literature to date. Therefore, it may be important to compile generally accepted standard procedures for lipid-lowering therapy in the pediatric ALL population...
June 20, 2018: Journal of Clinical Lipidology
Luis E Simental-Mendía, Martha Rodríguez-Morán, Celia Aradillas-García, Fernando Guerrero-Romero
BACKGROUND: Previous studies have suggested that elevated triglyceride levels may precede the appearance of glucose metabolic disturbances in adults; nonetheless, this hypothesis has not been tested in children. Hence, we evaluated whether hypertriglyceridemia is associated with impaired fasting glucose (IFG) in normal-weight children. METHODS: Normal-weight healthy children aged 7-15 years were enrolled in a population-based cross-sectional population study and allocated into groups with and without hypertriglyceridemia...
September 2018: Pediatric Research
Yuesheng Liu, Dong Xu, Chunyan Yin, Sisi Wang, Min Wang, Yanfeng Xiao
BACKGROUND: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia. METHOD: We evaluated IL-10 and signal transducer and activator of transcription 3 (STAT3) mRNA expression in adipose tissue (AT) as well as serum IL-10 in 62 children of 3 groups and in high-fat diet (HFD) induced obese rat...
June 13, 2018: BMC Endocrine Disorders
Tom K Lin, Maisam Abu-El-Haija, Jaimie D Nathan, Joseph P Palermo, Bradley Barth, Melena Bellin, Douglas S Fishman, Steven D Freedman, Cheryl E Gariepy, Matthew J Giefer, Tanja Gonska, Melvin B Heyman, Ryan Himes, Sohail Z Husain, Quin Liu, Asim Maqbool, Maria Mascarenhas, Brian McFerron, Veronique D Morinville, Chee Y Ooi, Emily Perito, John F Pohl, Sue Rhee, Sarah Jane Schwarzenberg, Uzma Shah, David Troendle, Steven L Werlin, Michael Wilschanski, M Bridget Zimmerman, Mark E Lowe, Aliye Uc
INTRODUCTION: The significance of pancreas divisum (PD) as a risk factor for pancreatitis is controversial. We analyzed the characteristics of children with PD associated with acute recurrent or chronic pancreatitis to better understand its impact. PATIENTS AND METHODS: We compared children with or without PD in the well-phenotyped INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort. Differences were analyzed using 2-sample t test or Wilcoxon rank sum test for continuous variables, Pearson χ or Fisher exact test for categorical variables...
June 2, 2018: Journal of Clinical Gastroenterology
Silva Hovsepian, Shaghayegh Haghjooy Javanmard, Marjan Mansourian, Mohamadhasan Tajadini, Mahin Hashemipour, Roya Kelishadi
OBJECTIVE: In this study, we aimed to assess the association between four variants in three genes whose association has been reported in adults but not in children. We evaluated the relationship of the GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) polymorphisms with serum lipid levels in Iranian children. DESIGN: This cross-sectional study was conducted in a subpopulation of the CASPIAN III study. During this study, 550 frozen whole blood samples were selected randomly...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
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