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CMR normal values

Philipp Heermann, H Fritsch, M Koopmann, P Sporns, M Paul, W Heindel, E Schulze-Bahr, C Schülke
OBJECTIVES: As underlying heart diseases of right ventricular tachyarrhythmias, ARVC causes wall-motion abnormalities based on fibrofatty myocardial degeneration, while RVOT-VT and BrS are thought to lack phenotypic MR characteristics. To examine whether cardiac magnetic resonance (CMR) feature tracking (FT) in addition to ARVC objectively facilitates detection of myocardial functional impairments in RVOT-VT and BrS. METHODS: Cine MR datasets of four retrospectively enrolled, age-matched study groups [n = 65; 16 ARVC, 26 RVOT-VT, 9 BrS, 14 healthy volunteers (HV)] were independently assessed by two distinctly experienced investigators regarding myocardial function using CMR-FT...
March 13, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Richard B Thompson, Paolo Raggi, Natasha Wiebe, Martin Ugander, Jannike Nickander, Scott W Klarenbach, Stephanie Thompson, Marcello Tonelli
BACKGROUND: The cardiovascular morphology and function in long-term survivors of hemodialysis are not well described. METHODS: Single-center cross-sectional study nested within a prospective cohort study of 15 long-term (> 7.5 years) and 15 matched incident (< 6 months) hemodialysis patients with 15 external matched controls. Evaluations included heart structure, function and fibrosis (myocardial longitudinal relaxation time, native T1), and aortic dimensions and elasticity, using cardiovascular magnetic resonance (CMR)...
February 18, 2019: Journal of Nephrology
Mischa de Ridder, Zeno A R Gouw, Arash Navran, Olga Hamming-Vrieze, Bas Jasperse, Michiel W M van den Brekel, Wouter V Vogel, A Al-Mamgani
PURPOSE: Early detection of residual disease (RD) after (chemo)radiation for oropharyngeal (OPC) is crucial. Surveillance of neck nodes with FDG-PET/CT has been studied extensively, whereas its value for local RD remains less clear. We aim to evaluate the diagnostic value of post-treatment FDG-PET/CT in detecting local RD and the outcome of patients with local RD. METHODS: A cohort (n = 352) of consecutively treated OPC patients at our institute between 2010 and 2017 was evaluated...
February 13, 2019: European Archives of Oto-rhino-laryngology
Michael J Zellweger
Patient tailored diagnosis and risk stratification in patients with suspected or known coronary artery disease (CAD) are pivotal. At present, cardiac imaging modalities provide the possibility to evaluate the whole ischaemic cascade noninvasively. In asymptomatic patients, the evaluation of the calcium score may be beneficial and also guide the individual preventive strategy. Furthermore, the calcium score provides complimentary information to the information as assessed by functional testing. Coronary computed tomographic angiography (CCTA) is an excellent tool to exclude CAD, having a negative predictive value of 97&ndash;99%...
February 11, 2019: Swiss Medical Weekly
John F Heitner, Raymond J Kim, Han W Kim, Igor Klem, Dipan J Shah, Dany Debs, Afshin Farzaneh-Far, Venkateshwar Polsani, Jiwon Kim, Jonathan Weinsaft, Chetan Shenoy, Andrew Hughes, Preston Cargile, Jean Ho, Robert O Bonow, Elizabeth Jenista, Michele Parker, Robert M Judd
Importance: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown. Objective: To determine whether stress CMR is associated with patient mortality. Design, Setting, and Participants: Real-world evidence from consecutive clinically ordered CMR examinations. Multicenter study of patients undergoing clinical evaluation of myocardial ischemia. Patients with known or suspected coronary artery disease (CAD) underwent clinical vasodilator stress CMR at 7 different hospitals...
February 8, 2019: JAMA Cardiology
Rocio Hinojar, Jose Luis Zamorano, MªAngeles Fernández-Méndez, Amparo Esteban, Maria Plaza-Martin, Ariana González-Gómez, Alejandra Carbonell, Luis Miguel Rincón, Jose Julio Jiménez Nácher, Covadonga Fernández-Golfín
Left atrium (LA) size has an important role in determining prognosis and risk stratification in hypertrophic cardiomyopathy (HCM). Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a novel technique for the quantification of LA function. Our aim was first to evaluate LA function by CMR-FT and volumetric analysis in patients with HCM; and secondly we sought to determine the association of LA-longitudinal strain (LA-LS) with major cardiovascular outcomes, particularly all cause mortality and heart failure...
January 31, 2019: International Journal of Cardiovascular Imaging
Felipe Kazmirczak, Prabhjot S Nijjar, Lei Zhang, Andrew Hughes, Ko-Hsuan Amy Chen, Osama Okasha, Cindy M Martin, Mehmet Akçakaya, Afshin Farzaneh-Far, Chetan Shenoy
BACKGROUND: There is a critical need for non-invasive methods to detect coronary allograft vasculopathy and to risk stratify heart transplant recipients. Vasodilator stress testing using cardiovascular magnetic resonance imaging (CMR) is a promising technique for this purpose. We aimed to evaluate the safety and the prognostic value of regadenoson stress CMR in heart transplant recipients. METHODS: To evaluate the safety, we assessed adverse effects in a retrospective matched cohort study of consecutive heart transplant recipients who underwent regadenoson stress CMR matched in a 2:1 ratio to age- and gender-matched non-heart transplant patients...
January 24, 2019: Journal of Cardiovascular Magnetic Resonance
Eric M Schrauben, Brahmdeep Singh Saini, Jack R T Darby, Jia Yin Soo, Mitchell C Lock, Elaine Stirrat, Greg Stortz, John G Sled, Janna L Morrison, Mike Seed, Christopher K Macgowan
BACKGROUND: To date it has not been possible to obtain a comprehensive 3D assessment of fetal hemodynamics because of the technical challenges inherent in imaging small cardiac structures, movement of the fetus during data acquisition, and the difficulty of fusing data from multiple cardiac cycles when a cardiac gating signal is absent. Here we propose the combination of volumetric velocity-sensitive cardiovascular magnetic resonance imaging ("4D flow" CMR) and a specialized animal preparation (catheters to monitor fetal heart rate, anesthesia to immobilize mother and fetus) to examine fetal sheep cardiac hemodynamics in utero...
January 21, 2019: Journal of Cardiovascular Magnetic Resonance
Elena Giulia Milano, Iwan B Harries, Chiara Bucciarelli-Ducci
CLINICAL INTRODUCTION: A young adult with Friedreich ataxia complaining of exertional breathlessness underwent a cardiological evaluation. On physical examination, high blood pressure and a loud systolic murmur were noted. ECG showed sinus rhythm with voltage criteria for left ventricular hypertrophy (LVH) and T-wave changes in the inferolateral leads. Transthoracic echocardiography showed biventricular hypertrophy (maximum wall thickness of the interventricular septum 26 mm and 16 mm of the posterior wall), preserved systolic function, mild left ventricular intracavity gradient and an unremarkable mitral and aortic valve...
January 15, 2019: Heart: Official Journal of the British Cardiac Society
Khodr Tello, Antonia Dalmer, Jens Axmann, Rebecca Vanderpool, Hossein A Ghofrani, Robert Naeije, Fritz Roller, Werner Seeger, Natascha Sommer, Jochen Wilhelm, Henning Gall, Manuel J Richter
BACKGROUND: Right ventricular (RV) maladaptation and failure determine outcome in pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial coupling) is defined by a ratio of end-systolic to arterial elastances (Ees/Ea). How RV-pulmonary arterial coupling relates to pulmonary hypertension severity and onset of RV failure (defined by excessive volume increase and ejection fraction [EF] decrease) is not exactly known. METHODS AND RESULTS: We performed cardiac magnetic resonance (CMR) imaging within 24 hours of a diagnostic right heart catheterization and invasive measurement of RV pressure-volume loops in 42 patients with pulmonary hypertension...
January 2019: Circulation. Heart Failure
Mohammad A Khan, Eric Y Yang, Yang Zhan, Robert M Judd, Wenyaw Chan, Faisal Nabi, John F Heitner, Raymond J Kim, Igor Klem, Sherif F Nagueh, Dipan J Shah
BACKGROUND: Routine cine cardiovascular magnetic resonance (CMR) allows for the measurement of left atrial (LA) volumes. Normal reference values for LA volumes have been published based on a group of European individuals without known cardiovascular disease (CVD) but not on one of similar United States (US) based volunteers. Furthermore, the association between grades of LA dilatation by CMR and outcomes has not been established. We aimed to assess the relationship between grades of LA dilatation measured on CMR based on US volunteers without known CVD and all-cause mortality in a large, multicenter cohort of patients referred for a clinically indicated CMR scan...
January 7, 2019: Journal of Cardiovascular Magnetic Resonance
Vidhya Kumar, Thura T Harfi, Xin He, Beth McCarthy, Andrea Cardona, Orlando P Simonetti, Subha V Raman
BACKGROUND: The current clinical standard for in vivo imaging of myocardial fibrosis is contrast-enhanced cardiac magnetic resonance (CMR). We sought to validate a novel non-contrast dual energy computed tomography (DECT) method to estimate myocardial fibrosis in patients undergoing CMR with contrast. METHODS: All subjects underwent non-contrast, prospectively-triggered cardiac DECT on a single source scanner with interleaved acquisition between tube voltages of 80 and 140 kVp...
December 18, 2018: Journal of Cardiovascular Computed Tomography
Mohammad Alkhalil, Alessandra Borlotti, Giovanni Luigi De Maria, Lisa Gaughran, Jeremy Langrish, Andrew Lucking, Vanessa Ferreira, Rajesh K Kharbanda, Adrian P Banning, Keith M Channon, Erica Dall'Armellina, Robin P Choudhury
BACKGROUND: It has recently been suggested that myocardial oedema follows a bimodal pattern early post ST-segment elevation myocardial infarction (STEMI). Yet, water content, quantified using tissue desiccation, did not return to normal values unlike oedema quantified by cardiovascular magnetic resonance (CMR) imaging. We studied the temporal changes in the extent and intensity of injured myocardium using T1-mapping technique within the first week after STEMI. METHODS: A first group (n = 31) underwent 3 acute 3 T CMR scans (time-point (TP) < 3 h, 24 h and 6 days), including cine, native shortened modified look-locker inversion recovery T1 mapping, T2* mapping and late gadolinium enhancement (LGE)...
December 20, 2018: Journal of Cardiovascular Magnetic Resonance
Flavio D'Ascenzi, Francesca Anselmi, Pietro Piu, Caterina Fiorentini, Salvatore Francesco Carbone, Luca Volterrani, Marta Focardi, Marco Bonifazi, Sergio Mondillo
OBJECTIVES: The aim of this meta-analysis was to derive normal reference values of biventricular size and function estimated by cardiac magnetic resonance (CMR) in competitive athletes. BACKGROUND: Exercise-induced enlargement of cardiac chambers is commonly observed in competitive athletes. However, ventricular dilatation is also a common phenotypic expression of life-threatening cardiomyopathies. The use of CMR for the exclusion of pathology is growing. However, normal reference values have not been established for athletes...
December 12, 2018: JACC. Cardiovascular Imaging
Sandra Pujadas, Maite Doñate, Chi-Hion Li, Soraya Merchan, Ana Cabanillas, Xavier Alomar, Guillem Pons-Llado, Ricard Serra-Grima, Francesc Carreras
There is still some controversy about the benignity of structural changes observed in athlete's heart, especially regarding the observation of increased biomarkers and the presence of myocardial fibrosis (MF). Aim: Our purpose was to evaluate by cardiovascular magnetic resonance (CMR) the presence of diffuse as well as focal MF in a series of high-performance veteran endurance athletes. Methods: Thirty-four veteran healthy male endurance athletes, still being in regular training, with more than 10 years of training underwent a CMR...
2018: BMJ Open Sport & Exercise Medicine
Elena Galli, Emilie Vitel, Frédéric Schnell, Virginie Le Rolle, Arnaud Hubert, Mathieu Lederlin, Erwan Donal
BACKGROUND: The estimation of myocardial work by pressure strain loops (PSLs) is a totally new non-invasive approach to assess myocardial performance, and its role in patients with hypertrophic cardiomyopathy is unknown. The aims of the present study are therefore: (a) to compare myocardial work in patients with non-obstructive hypertrophic cardiomyopathy (HCM) and in a subset of age-matched healthy controls and (b) to assess the correlation between myocardial work and left ventricular (LV) fibrosis...
November 29, 2018: Echocardiography
Gloria Tamborini, Claudia Cefalù, Fabrizio Celeste, Laura Fusini, Anna Garlaschè, Manuela Muratori, Sarah Ghulam Ali, Paola Gripari, Giovanni Berna, Mauro Pepi
Three-dimensional echocardiographic (3DE) of right ventricle (RV) has been validated in many clinical settings. However, the necessity of complicated and off-line dedicated software has reduced its diffusion. A new simplified "on board" 3DE software (OB) has been developed to obtain RV volumes and ejection fraction (EF) together with several conventional parameters automatically derived from 3DE: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), longitudinal strain (LS)...
November 15, 2018: International Journal of Cardiovascular Imaging
Sophie I Mavrogeni, Petros P Sfikakis, George Markousis-Mavrogenis, Vasiliki-Kalliopi Bournia, George Poulos, Loukia Koutsogeorgopoulou, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Kyriaki Boki, Vasiliki Vartela, Genovefa Kolovou, George Theodorakis, George D Kitas
BACKGROUND: Ventricular tachycardia/fibrillation (VT/VF) may occur in autoimmune rheumatic diseases (ARDs). We hypothesized that cardiovascular magnetic resonance (CMR) can identify arrhythmogenic substrates in ARD patients. PATIENTS - METHODS: Using a 1.5 T system, we evaluated 61 consecutive patients with various types of ARDs and normal left ventricular ejection fraction (LVEF) on echocardiography. A comparison of patients with recent VT/VF and those that never experienced VT/VF was performed...
October 25, 2018: International Journal of Cardiology
Chrysanthos Grigoratos, Giancarlo Todiere, Giovanni Donato Aquaro, Andrea Barison
Cardiac palpitations secondary to ventricular ectopic beats are a frequent clinical indication for a cardiac magnetic resonance (CMR) scan. CMR has already demonstrated its additive diagnostic value in patients with frequent arrhythmias even when echocardiogram appears normal. Hereby, we describe a case of a middle-aged male patient referred to our laboratory because of frequent ventricular ectopic beats and an inconclusive echocardiogram due to an extremely poor acoustic window. A diagnosis of pericardial agenesis (PA) was made explaining patient symptoms and arrhythmias previously detected...
July 2018: Journal of Cardiovascular Echography
Olivier Ghekiere, Jurgen Bielen, Jonathon Leipsic, Willem Dewilde, Isabelle Mancini, Dominic Hansen, Paul Dendale, Alain Nchimi
Only one-third of intermediate-grade coronary artery stenosis (i.e. 40-70% diameter narrowing) causes myocardial ischemia, requiring most often additional invasive work-up with invasive fractional flow reserve (FFR). To evaluate the correlations between FFR estimates derived from computed tomography (FFRCT ) and adenosine perfusion cardiac magnetic resonance (CMR) with invasive FFR in intermediate-grade stenosis. Thirty-seven patients (mean age 61 ± 9 years; 25 men) who underwent adenosine perfusion CMR, quantitative coronary angiography and FFR in the work-up for intermediate-grade stenoses (n = 39) diagnosed at coronary CT angiography were retrospectively evaluated...
October 3, 2018: International Journal of Cardiovascular Imaging
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