Gabriel Herrero-Beaumont, Francisco Castro-Dominguez, Alberto Migliore, Esperanza Naredo, Raquel Largo, Jean-Yves Reginster
Osteoarthritis (OA) is a disease with systemic implications that go beyond joint problems. Its pathogenic mechanisms involve a variety of systemic conditions that contribute to joint damage. These include metabolic dysfunction, chronic low-grade inflammation, neuroplastic pain, and the influence of the central nervous system in the development of neuropathic pain. Besides, OA can negatively affect other aspects of health, such as quality of life, reduced physical activity, social isolation, depression, and anxiety...
February 20, 2024: Aging Clinical and Experimental Research