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Social interaction. Pain

Bertrand Tombal, Fred Saad, David Penson, Maha Hussain, Cora N Sternberg, Robert Morlock, Krishnan Ramaswamy, Cristina Ivanescu, Gerhardt Attard
BACKGROUND: In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here, we report the results of patient-reported outcomes of this study. METHODS: In the randomised, double-blind, placebo-controlled, phase 3 PROSPER trial, done at 254 study sites worldwide, patients aged 18 years or older with non-metastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned (2:1) via an interactive voice web recognition system to receive oral enzalutamide (160 mg per day) or placebo...
February 12, 2019: Lancet Oncology
Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Kazuto Ohata, Naoki Takada, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
Clinical evidence indicates that major depression is a common comorbidity of chronic pain, including neuropathic pain. However, the cellular basis for chronic pain-mediated major depression remains unclear. High-mobility group box 1 protein (HMGB1) has a key role in innate immune responses and appears to be have a role in mediating diverse disorders, including neuropathic pain and depression. The current study aimed to characterize neuropathic pain-induced changes in affect over time and to determine whether HMGB1 has a role in neuropathic pain-induced changes in affect...
February 11, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Marius Mbiantcha, Rauf Khalid, Amadou Dawe, Arif Mehreen, Donatien Albert Atsamo, Gilbert Ateufack, Dar Hamza, William Yousseu Nana, Francis Tatsinkou Desire Bomba, Rehman Ur Naeem, Ahmad Izhar
Painful diabetic neuropathy (PDN) is known to adversely affect psychosocial functioning by enhancing levels of anxiety and depression. This study was designed to verify the antihypernociceptive, anxiolytic, and antidepressant-like effects of Combretin A and Combretin B (two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans) in streptozotocin-induced diabetic neuropathy in mice. PDN was induced in mice by the administration of streptozotocin (STZ, 200 mg/kg, i.p.). The effect of oral administration of Combretin A (25 and 50 mg/kg) and Combretin B (25 and 50 mg/kg) on nociception (mechanical allodynia, thermal hyperalgesia, cold allodynia, and chemical hyperalgesia), anxiety (elevated plus maze, light-dark box test, social interaction), and depressant (open field test, forced swimming test, tail suspension test) was evaluated...
February 13, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
Stefanie Hardt, Caroline Fischer, Alexandra Vogel, Annett Wilken-Schmitz, Irmgard Tegeder
Inflammation or injuries of the trigeminal nerve are often associated with persistent facial pain and its sequelae. A number of models have been described to study trigeminal pain in rodents, but the long-lasting behavioral consequences are unknown. The present study characterizes the impact of a distal infraorbital nerve injury, called DIONI, which consists of ligature and transection of distal fibers of the infraorbital nerve. We assessed nociception using a conflict paradigm and optogenetics, and a set of reward, aversion, spatial, temporal and competition tasks in the IntelliCage to study multiple aspects of cognition, circadian rhythms and social interactions in groups of mice in home cage environments...
February 8, 2019: Pain
Joby Pulikkan, Agnisrota Mazumder, Tony Grace
Autism spectrum disorder (ASD) is a severe neurodevelopmental or neuropsychiatric disorder with elusive etiology and obscure pathophysiology. Cognitive inabilities, impaired communication, repetitive behavior pattern, and restricted social interaction and communication lead to a debilitating situation in autism. The pattern of co-occurrence of medical comorbidities is most intriguing in autism, compared to any other neurodevelopmental disorders. They have an elevated comorbidity burden among which most frequently are seizures, psychiatric illness, and gastrointestinal disorders...
2019: Advances in Experimental Medicine and Biology
Matthias Vogel, Christian Riediger, Martin Krippl, Jörg Frommer, Christoph Lohmann, Sebastian Illiger
Background: Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting these strains. This study is the first to investigate the influence of TDP on TKA assuming (1) negative affect (NA) to be linked to fear avoidance and to increased dissatisfaction with TKA and (2) the expression of NA and social inhibition (SI) to not be stable over time...
2019: Pain Research & Management: the Journal of the Canadian Pain Society
Daniel J Clauw, Margaret Noyes Essex, Verne Pitman, Kim D Jones
Chronic pain is a common public health problem that has a detrimental impact on patient health, quality of life (QoL), and function, and poses a substantial socioeconomic burden. Evidence supports redefinition of chronic pain as a distinct disease entity, not simply a symptom of injury or illness. Chronic pain conditions are characterized by three types of pain pathophysiology - i.e., nociceptive, neuropathic, and centralized pain/central sensitization -influenced by a cluster of coexisting psychosocial factors...
January 31, 2019: Postgraduate Medicine
Glaukus Regiani Bueno, Lucas França Garcia, Sonia Maria Marques Gomes Bertolini, Tiago Franklin Rodrigues Lucena
BACKGROUND: Smartphones offer a variety of mobile applications for diverse purposes and access to services that contribute to an increased time of interaction with the device, influencing the users' health and behavior. INTRODUCTION: The time of interaction with smartphones is more intense with the younger generation, and physical, psychological, and social complications are reported. This research aims at identifying the factors associated with musculoskeletal symptoms due to the use of smartphones in university students in Brazil...
January 24, 2019: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Aleksi Varinen, Elise Kosunen, Kari Mattila, Sakari Suominen, Lauri Sillanmäki, Markku Sumanen
BACKGROUND: Fibromyalgia is a functional pain syndrome presenting with various psychological symptoms. Several studies have shown that adverse life events are associated with fibromyalgia. The aim of the current study is to explore the association between self-reported bullying victimization in childhood and self-reported fibromyalgia in adulthood. METHODS: The basic study setting is cross-sectional - with focused use of retrospective data - derived from a large on-going postal follow up survey (sample N = 64,797) initiated in Finland in 1998...
February 2019: Journal of Psychosomatic Research
Thais R S Paulo, Fabricio E Rossi, Juliana Viezel, Giuliano T Tosello, Sylvia C Seidinger, Regina R Simões, Ruffo de Freitas, Ismael F Freitas
BACKGROUND: This study evaluated the impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy. METHODS: Older breast cancer survivors were randomized into two groups: combined training: resistance + aerobic exercise program for nine months (n = 18) or control group (n = 18). Quality of life was assessed by the questionnaires SF36, EORTC QLQ-C30, and EORTC QLQ-BR23 at baseline, and at three, six, and nine months...
January 18, 2019: Health and Quality of Life Outcomes
Vittorio Magri, Matteo Boltri, Tommaso Cai, Roberto Colombo, Salvatore Cuzzocrea, Pieter De Visschere, Rosanna Giuberti, Clara Maria Granatieri, Maria Agnese Latino, Gaetano Larganà, Christian Leli, Giorgio Maierna, Valentina Marchese, Elisabetta Massa, Alberto Matteelli, Emanuele Montanari, Giuseppe Morgia, Kurt G Naber, Vaia Papadouli, Gianpaolo Perletti, Nektaria Rekleiti, Giorgio I Russo, Alessandra Sensini, Konstantinos Stamatiou, Alberto Trinchieri, Florian M E Wagenlehner
The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis...
January 18, 2019: Archivio Italiano di Urologia, Andrologia
Margaret A Finley, Elizabeth Euiler
OBJECTIVE: Limited evidence examines the association of psychological factors, such as fear of movement and pain catastrophizing, with musculoskeletal pain patterns in active manual wheelchair users with spinal cord injury (SCI). This study investigated the relationship among musculoskeletal pain, fear avoidance factors, quality of life (QoL), activity and duration of injury in individuals with SCI. DESIGN: Cross-sectional correlational. SETTING: Community setting...
January 11, 2019: Journal of Spinal Cord Medicine
Luna Carpinelli, Cristina Bucci, Antonella Santonicola, Fabiana Zingone, Carolina Ciacci, Paola Iovino
BACKGROUND: Anhedonia is the lowered ability to experience pleasure from rewarding or enjoyable activities and is considered a symptom of depression. Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are frequently accompanied by psychiatric disorders such as depression. However, to our knowledge, studies have yet to investigate the anhedonia in these patients. Our aim was to study the level of anhedonia in patients with IBD and IBS in comparison with healthy controls (HC), and to relate anhedonia levels with the severity of abdominal pain...
January 10, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Amy L Paine, Nina Howe, Gassiaa Karajian, Dale F Hay, Ganie DeHart
Humour is a central feature of social interactions in childhood that has received little attention. In a sample of 86 7-year-old children (M age = 7.82 years, SD = 0.80), we investigated patterns and individual differences in spontaneous humour observed during free play with their older (M age = 9.55 years, SD = 0.88) or their younger sibling (M age = 5.87 years, SD = 0.96). We coded children's instances, categories, and responses to humour. We investigated the nature of children's humour on the dyadic and individual level...
January 9, 2019: British Journal of Developmental Psychology
Eri Kiyoshige, Mai Kabayama, Yasuyuki Gondo, Yukie Masui, Hirochika Ryuno, Yasuka Sawayama, Takako Inoue, Yuya Akagi, Toshiaki Sekiguchi, Kentaro Tanaka, Takeshi Nakagawa, Saori Yasumoto, Madoka Ogawa, Hiroki Inagaki, Ryousuke Oguro, Ken Sugimoto, Hiroshi Akasaka, Koichi Yamamoto, Yasushi Takeya, Yoichi Takami, Norihisa Itoh, Masao Takeda, Motonori Nagasawa, Serina Yokoyama, Satomi Maeda, Kazunori Ikebe, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi, Kei Kamide
BACKGROUND: Chronic and lifestyle-related diseases and social status were reported to be associated with long-term care (LTC). The social factors should be treated as social sub-groups of which characteristics show social profiles. However, few previous studies considered that. The present study aimed to investigate the associations between LTC and chronic and lifestyle-related diseases, and whether the associations were modified by the social sub-groups in the community-dwelling elderly...
December 24, 2018: Archives of Gerontology and Geriatrics
Alessandro Castorina, Monica Vogiatzis, James W M Kang, Kevin A Keay
Nerve injuries often result in neuropathic pain with co-morbid changes in social behaviours, motivation, sleep-wake cycles and neuroendocrine function. In an animal model of neuropathic injury (CCI) similar co-morbid changes are evoked in a subpopulation (~30%) of injured rats. In addition to anatomical evidence of altered neuronal and glial function, the periaqueductal grey (PAG) of these rats shows evidence of cell death. These changes in the PAG may play a role in the disruption of the normal emotional coping responses triggered by nerve injury...
December 15, 2018: Neuropeptides
Leticia A Deveza, Sita M A Bierma-Zeinstra, Willem Evert van Spil, Win Min Oo, Bruno T Saragiotto, Tuhina Neogi, Marienke van Middelkoop, David J Hunter
INTRODUCTION: Randomised clinical trials to date investigating the efficacy of bisphosphonates in knee osteoarthritis (OA) have found divergent results, with a recent meta-analysis finding no superiority of these drugs over placebo. Whether particular patient subgroups are more likely to benefit from this therapy than others is still unclear. We aim to investigate the effects of bisphosphonates compared with a control group (placebo, no treatment, another active treatment) on clinical and structural outcomes in specific knee OA subpopulations with possible distinct rates of subchondral bone turnover...
December 19, 2018: BMJ Open
R Klinger, J Stuhlreyer, J Schmitz, C Zöllner, C Roder, F Krug
Chronic knee and joint pain, like all chronic pain, is a complex multidimensional event that involves somatic, psychological and social factors. Patients with knee and other joint pain experience limited mobility in their daily lives, in their professional and personal activities, and in their leisure physical exercise activities. Pain increasingly prevents them from achieving their goals. Psychological factors not only interact with neurobiological and immunological processes of pain, they play an important role in the development and maintenance of pain...
December 19, 2018: Der Schmerz
Joseph W Ditre, Emily L Zale, Lisa R LaRowe
Pain and substance use are highly prevalent and co-occurring conditions that continue to garner increasing clinical and empirical interest. Although nicotine and tobacco, alcohol, and cannabis each confer acute analgesic effects, frequent or heavy use may contribute to the development and progression of chronic pain, and pain may be heightened during abstinence. Additionally, pain can be a potent motivator of substance self-administration, and it may contribute to escalating use and poorer substance-related treatment outcomes...
December 19, 2018: Annual Review of Clinical Psychology
Marco Daniel Gulewitsch, Aiste Jusyte, Katja Weimer, Michael Schönenberg
Objective: Functional abdominal pain (AP) is a prevalent issue in childhood and adolescence. The contribution of psychosocial factors in the development and maintenance of this health problem is rather unclear, and experimental studies about underlying mechanisms are lacking. This study investigates whether experimentally induced social exclusion decreases sensory and pain thresholds in children suffering from AP. Subjects: Twenty children/adolescents with AP and 22 healthy controls...
December 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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