Antonia V Seligowski, Simran S Grewal, Shady Abohashem, Hadil Zureigat, Iqra Qamar, Wesam Aldosoky, Charbel Gharios, Erin Hanlon, Omar Alani, Sandeep C Bollepalli, Antonis Armoundas, Zahi A Fayad, Lisa M Shin, Michael T Osborne, Ahmed Tawakol
While posttraumatic stress disorder (PTSD) is known to associate with an elevated risk for major adverse cardiovascular events (MACE), few studies have examined mechanisms underlying this link. Recent studies have demonstrated that neuro-immune mechanisms, (manifested by heightened stress-associated neural activity (SNA), autonomic nervous system activity, and inflammation), link common stress syndromes to MACE. However, it is unknown if neuro-immune mechanisms similarly link PTSD to MACE. The current study aimed to test the hypothesis that upregulated neuro-immune mechanisms increase MACE risk among individuals with PTSD...
January 11, 2024: Brain, Behavior, and Immunity