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Interal Medicine

Angelo Silverio, Pierpaolo Cavallo, Roberta De Rosa, Gennaro Galasso
Cardiovascular disease (CVD) accounts for the majority of death and hospitalization, health care expenditures and loss of productivity in developed country. CVD research, thus, plays a key role for improving patients' outcomes as well as for the sustainability of health systems. The increasing costs and complexity of modern medicine along with the fragmentation in healthcare organizations interfere with improving quality care and represent a missed opportunity for research. The advancement in diagnosis, therapy and prognostic evaluation of patients with CVD, indeed, is frustrated by limited data access to selected small patient populations, not standardized nor computable definition of disease and lack of approved relevant patient-centered outcomes...
2019: Frontiers in Medicine
Ji Hyun Lee, Han Na Park, Ok Rim Park, Nam Sook Kim, Sung-Kwan Park, Hoil Kang
The worldwide spread of illegal sexual enhancement products is posing a threat to public health. The aim of this study was to investigate illegal products claiming to be effective in improving sexual performance through the online or offline markets between 2014 and 2017; these products include foods, dietary supplements, counterfeit drugs, and herbal medicines. These samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the presence of 80 PDE-5 inhibitors (PDE-5i) and analogues...
February 22, 2019: Forensic Science International
Nadine Ijaz, Jennifer Rioux, Charles Elder, John Weeks
OBJECTIVES: This scoping review evaluates two decades of methodological advances made by "whole systems research" (WSR) pioneers in the fields of traditional, complementary, and integrative medicine (TCIM). Rooted in critiques of the classical randomized controlled trial (RCT)'s suitability for evaluating holistic, complex TCIM interventions, WSR centralizes the principle of "model validity," representing a "fit" between research design and therapeutic paradigm...
March 2019: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Haolong Liu, Feng Qiu, Haiyu Zhao, Baolin Bian, Lei Wang
Yougui pills are a classic Chinese medicine that shows significant effects on nerve regeneration and neuroprotection in modern pharmacological studies. With a complex formula, Youngui pills have faced significant challenges in the fields of bioanalysis and pharmacokinetics in animals and human studies. In the present study, a specific and accurate high-performance liquid chromatography-tandem mass spectrometric method was developed and validated for the quantitative determination of the six bioactive components in rat plasma after oral administration of Yougui pills...
March 14, 2019: Journal of Separation Science
Toshifumi Asada, Kent Doi, Ryota Inokuchi, Naoki Hayase, Miyuki Yamamoto, Naoto Morimura
BACKGROUND: Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes. However, organ system networks remain beyond clinical application with little evidence for their importance on homeostatic mechanisms. This proof-of-concept study examined the impact of organ system networks on systemic stability in severely ill patients. METHODS: Patients admitted to the intensive care unit of the University of Tokyo Hospital with one representative variable reflecting the condition of each of the respiratory, cardiovascular, renal, hepatic, coagulation, and inflammatory systems were enrolled...
March 12, 2019: Critical Care: the Official Journal of the Critical Care Forum
Nicola Brady, Emily L O'Reilly, Christopher McComb, Alastair I Macrae, P David Eckersall
In cattle, the serum protein haptoglobin (Hp) is a major acute phase protein (APP) that rises in concentration over a thousand fold following stimulation by pro-inflammatory cytokines. As such, this APP is a valuable biomarker for infection, inflammation and trauma in cattle. The assay for bovine Hp is becoming more commonplace in clinical pathology and in experimental studies when a biomarker of innate immunity is required. The most widely used assay for Hp utilises its binding to haemoglobin (Hp-Hb binding assay), which at low pH enables the preservation of the native peroxidase activity in the haemoglobin...
2019: Comparative Clinical Pathology
Xueyan Shi, Yun Zhou, Feipeng Liu, Jianyou Mao, Yi Zhang, Tisheng Shan
Chiral 2-bromopropionates are widely used as raw materials or intermediates for synthesis of chiral pesticides and medicines with high biological activities. Enantioseparation of 2-bromopropionates is crucial for evaluating the optical purity of chiral 2-bromopropionates. In this study, the enantioseparation of 8 pairs of alkyl 2-bromopropionates and 5 pairs of cycloalkyl 2-bromopropionates were examined using 7 different cyclodextrin derivatives (CDs). For the enantiomers of methyl, ethyl, bromoethyl and prop-2-yn-1-yl 2-bromopropionates, three different kinds of enantioseparation results including baseline separation, partial separation and no separation, are obtained on the 7 different CDs...
February 27, 2019: Journal of Chromatography. A
Guangxu Xun, Kishlay Jha, Ye Yuan, Yaqing Wang, Aidong Zhang
MOTIVATION: MEDLINE is the primary bibliographic database maintained by National Library of Medicine (NLM). MEDLINE citations are indexed with Medical Subject Headings (MeSH), which is a controlled vocabulary curated by the NLM experts. This greatly facilitates the applications of biomedical research and knowledge discovery. Currently, MeSH indexing is manually performed by human experts. To reduce the time and monetary cost associated with manual annotation, many automatic MeSH indexing systems have been proposed to assist manual annotation, including Deep-MeSH and NLM's official model Medical Text Indexer (MTI)...
March 9, 2019: Bioinformatics
Yining Zhao, Zhangyao Xu, Tianming Wang, Yuanyuan Li, Li Yang, Shaoyong Liu, Rong Shi, Yueming Ma
Tanreqing capsule (TRQC) is a formulation frequently used in traditional Chinese medicine to treat pyrexia, cough, expectoration, and pharyngalgia. Since the pharmacological action of traditional Chinese medicines is closely related to their complex and diverse constituents, understanding the exact composition of TRQC is important to elucidate its clinical effectiveness and mechanism of action as well as to establish quality control methods and resolve safety issues. Herein, we employed high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry for the simultaneous quantitation of 23 bioactive compounds in five batches of TRQC; the analytes could be categorized into five types: organic acids (seven compounds), flavonoids (ten compounds), iridoids (two compounds), phenylethanoid glycosides (two compounds), and bile acids (two compounds)...
March 8, 2019: Biomedical Chromatography: BMC
T Arumugam, G Jayapriya, T Sekar
Genomic DNA of Strychnos minor (Dennst) of sixteen geographical regions were amplified using thirteen primers. The analyses of products of Radom Amplified Polymorphic DNA (RAPD) revealed polymorphism among the samples. The polymorphic information content (PIC) was maximum for the primer of OPB-04 (0.40) followed by the primer OPB-20 (0.39). Clustering analysis by Jaccard's coefficient index exhibited similarity matrix and distance matrix. The amplified products of the 13 primers collectively showed similarity index ranged from 0...
March 2019: Biotechnology Reports
Artor Niccoli Asabella, Corinna Altini, Anna G Nappi, Valentina Lavelli, Cristina Ferrari, Andrea Marzullo, Alessandra Loiodice, Giuseppe Rubini
Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of the beta-globin chain of adult hemoglobin A, resulting in hemoglobin S (HbS). The homozygous HbS disease (HbSS), an autosomal recessive disorder, is the most common form and the Mediterranean area, along with sub-Saharian African and India, have the highest prevalence (1%-15%). In particular, Sicily with a prevalence of 2%-5%, is among the most interested regions. However, migratory flows have led to a wider diffusion of the disease no longer confined to endemic areas...
March 5, 2019: Hellenic Journal of Nuclear Medicine
Kun Zhang, Yujie Liu, Yuning Wang, Jingjing Zhao, Baohong Liu
Metal nanoparticles (NPs) with decreased sizes are promising catalysts in energy and medicine. Measuring the local reactions and simultaneously acquiring molecular insights at single small NPs, however, remain an experimental challenge. Here we report on surface-enhanced Raman spectroscopic (SERS) tracking of catalytic reactions of single 13 nm gold NPs (GNPs) in situ . We designed spatially isolated (>1.5 μm of inter-dimer space) GNP dimers, each of which consisted of two GNPs with sizes of ∼200 and ∼13 nm, respectively...
February 14, 2019: Chemical Science
Natalie Taylor, Stephanie Best, Melissa Martyn, Janet C Long, Kathryn N North, Jeffrey Braithwaite, Clara Gaff
INTRODUCTION: Translating scientific advances in genomic medicine into evidence-based clinical practice is challenging. Studying the natural translation of genomics into 'early-adopting' health system sectors is essential. We will (a) examine 29 health systems (Australian and Melbourne Genomics Health Alliance flagships) integrating genomics into practice and (b) combine this learning to co-design and test an evidence-based generalisable toolkit for translating genomics into healthcare...
March 5, 2019: BMJ Open
Vibeke Sundling, Hege Anita Stene, Hilde Eide, Eirik Hugaas Ofstad
OBJECTIVE: The aim of this study was to assess the validity and reliability of the Decision Identification and Classification Taxonomy for Use in Medicine (DICTUM) applied to optometry, to compare decisions in medical and optometric consultations, and to describe decisions in optometry. METHODS: The study had a cross-sectional design. Data was collected from January to August 2016. Forty video-recorded patient-optometrist consultations were analysed. Clinical decisions were categorised according to DICTUM by two independent coders...
February 18, 2019: Patient Education and Counseling
Alan J Christensen
The inception, development, and rise of the Journal of Behavioral Medicine (JOBM) has paralleled that of the field of behavioral medicine. Under the leadership of founding editor, W. Doyle Gentry, published its first issue in 1978. The subsequent 40 years have seen JOBM progress to the level of a top tier journal publishing inter-disciplinary work devoted to furthering understanding of physical health and illness through the theories and methodologies of behavioral science. In recent years, JOBM has become a prominent international platform for scientific communication in the field of behavioral medicine...
February 2019: Journal of Behavioral Medicine
Clarissa J Makdessi, Carolyn Day, Betty B Chaar
BACKGROUND: Prescription opioids (POs) are well recognised for their role in pain management. However over recent years, use of POs has become an increasingly complex public health issue, with the emergence of increasing quantities of POs being misused and abused. Pharmacists represent the 'gatekeepers' of medicines, which can be a challenging role, relating in particular to POs. OBJECTIVE: This study aimed to gain insight into the challenges Australian community pharmacists experience in the dispensation of POs...
February 1, 2019: Research in Social & Administrative Pharmacy: RSAP
Shobhit Chaturvedi, Rajeev Ramanan, Sodiq Waheed, Jon Ainsley, Martin Evison, Jenny Ames, Christopher Schofield, Tatyana Karabencheva-Christova, Christo Christov
The human KDM7 subfamily histone H3 Nɛ-methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer. We describe experimentally based computational studies revealing that flexibility of the region linking the PHD finger and JmjC domains in PHF8 and KIAA1718 regulates inter-domain interactions, the nature of correlated motions, and ultimately H3 binding and demethylation site selectivity. F279S an X-linked mental retardation mutation in PHF8 is involved in correlated motions with the iron ligands and second sphere residues...
February 28, 2019: Chemistry: a European Journal
Paul S Richman, Doreen M Olvet, Sahar Ahmad, Latha Chandran
Medical educators are continually looking for ways to enhance integrated learning and help students see how the material taught in their various courses is inter-related. . At Stony Brook School of Medicine, we embarked on a school-wide new curriculum called the Learning focused, Experiential, Adaptive, Rigorous and Novel (LEARN) curriculum and developed several integrated courses that were not based in specific departments. As part of this process, the pre-clinical (Phase-1) curriculum was shortened to 17 months to accommodate an expanded set of clinical offerings...
December 2019: Medical Education Online
Rajesh Kumar, K Osahon Ogbeide, Mujeeb-Ur-Rehman, Bodunde Owolabi, Abiodun Falodun, M Iqbal Choudhary, Sammer Yousuf
The title cassane-type diterpenoid known as pulcherrimin C, C34 H36 O8 ·H2 O, systematic name 5,6-bis-(benzo-yloxy)-4a-hy-droxy-4,7,11b-trimethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodeca-hydro-phenanthro[3,2- b ]furan-4-carb-oxy-lic acid monohydrate, was isolated as a monohydrate from the medicinally important plant Caesalpinia pulcherrima , found in the tropical regions of south and south-east Asia. The mol-ecule is composed of three trans -fused six-membered rings having chair, chair and half-chair conformations, and a five-membered planar furan ring...
February 1, 2019: Acta Crystallographica. Section E, Crystallographic Communications
Rudolf A Werner, Ralph Bundschuh, Lena Bundschuh, Stefano Fanti, Mehrbod S Javadi, Takahiro Higuchi, Alexander Weich, Kenneth J Pienta, Andreas K Buck, Martin G Pomper, Michael A Gorin, Ken Herrmann, Constantin Lapa, Steven P Rowe
Standardized reporting is more and more routinely implemented in clinical practice and such structured reports have a major impact on a large variety of medical fields, e.g. laboratory medicine, pathology, and, recently, radiology. Notably, the field of nuclear medicine is constantly evolving, as novel radiotracers for numerous clinical applications are developed. Thus, framework systems for standardized reporting in this field may a) increase clinical acceptance of new radiotracers, b) allow for inter- and intra-center comparisons for quality assurance, and c) may be used in (global) multi-center studies to ensure comparable results and enable efficient data abstraction...
February 22, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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