Andreas Wartak, Alfred K Kelada, Paola A Leon Alarcon, Ara L Bablouzian, Osman O Ahsen, Abigail L Gregg, Yuxiao Wei, Keval Bollavaram, Conor J Sheil, Edward Farewell, Schuyler VanTol, Rachel Smith, Patricia Grahmann, Aaron R Baillargeon, Joseph A Gardecki, Guillermo J Tearney
OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system...
July 1, 2021: Biomedical Optics Express