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High Flow Nasal Cannula Oxygen Therapy

Martin Wallin, Patricia Tang, Rachel Yoon Kyung Chang, Mingshi Yang, Warren H Finlay, Hak-Kim Chan
BACKGROUND: Aerosol delivery through a nasal high flow (NHF) system is attractive for clinicians as it allows for simultaneous administration of oxygen and inhalable drugs. However, delivering a fine particle fraction (FPF, particle wt. fraction < 5.0 μm) of drugs into the lungs has been very challenging, with highest value of only 8%. Here, we aim to develop an efficient nose-to-lung delivery system capable of delivering improved quantities (FPF > 16%) of dry powder aerosols to the lungs via an NHF system...
February 15, 2019: BMC Pulmonary Medicine
Yun-Seong Kang, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Background: Respiratory failure requiring intubation is a risk factor for mortality in immunocompromised patients, therefore, noninvasive methods to avoid intubation are preferred in such patients. A high-flow nasal cannula (HFNC) is an alternative noninvasive technique for oxygen delivery but can be potentially harmful in cases of delayed intubation. We sought to identify the physiological predictors of outcome to assess the responsiveness to HFNC of immunocompromised patients with acute respiratory failure...
December 2018: Journal of Thoracic Disease
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2019: Chinese Journal of Tuberculosis and Respiratory Diseases
Jean-Pierre Frat, Florent Joly, Arnaud W Thille
PURPOSE OF REVIEW: High-flow nasal cannula oxygen therapy (HFOT) is becoming an alternative to noninvasive ventilation (NIV) and standard oxygen in management of patients with acute respiratory failure. RECENT FINDINGS: Patients with de novo acute respiratory failure should be managed with HFOT rather than NIV. Indeed, the vast majority of patients with de novo respiratory failure meet the criteria for ARDS, and NIV does not seem protective, as patients generate overly high tidal volume that may worsen underlying lung injury...
January 28, 2019: Current Opinion in Anaesthesiology
Ibrahim Ulas Ozturan, Elif Yaka, Selim Suner, Asim Enes Ozbek, Cansu Alyesil, Nurettin Ozgur Dogan, Serkan Yilmaz, Murat Pekdemir
BACKGROUND: Acute carbon monoxide poisoning is a common environmental emergency worldwide. Treatment options are limited to normobaric oxygen therapy with a nonrebreather face mask or endotracheal tube and hyperbaric oxygen. The aim of this study is to determine the half-life of carboxyhemoglobin (COHb) in adult patients admitted to the emergency department with acute carbon monoxide poisoning receiving high flow nasal cannula (HFNC) oxygen. Device tolerability and patient comfort with the high flow nasal cannula were also evaluated...
January 28, 2019: Clinical Toxicology
Rafael Ladeira Rosa Bocchile, Denise Carnieli Cazati, Karina Tavares Timenetsky, Ary Serpa Neto
OBJECTIVE: To evaluate the efficacy of high-flow nasal cannula in the prevention of intubation and re-intubation in critically ill patients compared to conventional oxygen therapy or noninvasive ventilation. METHODS: This systematic review was performed through an electronic database search of articles published from 1966 to April 2018. The primary outcome was the need for intubation or re-intubation. The secondary outcomes were therapy escalation, mortality at the longest follow-up, hospital mortality and the need for noninvasive ventilation...
October 2018: Revista Brasileira de Terapia Intensiva
Yasmin M Madney, Maha Fathy, Ahmed A Elberry, Hoda Rabea, Mohamed Ea Abdelrahim
BACKGROUND: There has been a growing trend toward delivering aerosolized medications using high-flow nasal cannula (HFNC). In some cases, patients who do not require high-flow oxygen to maintain adequate oxygenation may benefit from aerosol delivery while receiving low-flow oxygen via HFNC. The objective of this study was to quantify and compare the relative pulmonary and systemic delivery of salbutamol, with 2 different nebulizers, in patients with COPD receiving low-flow oxygen therapy through an HFNC...
January 22, 2019: Respiratory Care
Christophe Guitton, Stephan Ehrmann, Christelle Volteau, Gwenhael Colin, Adel Maamar, Vanessa Jean-Michel, Pierre-Joachim Mahe, Mickael Landais, Noelle Brule, Cedric Bretonnière, Olivier Zambon, Mickael Vourc'h
PURPOSE: Preoxygenation with high-flow therapy by nasal cannulae (HFNC) is now widespread in the intensive care unit (ICU). However, no large randomized study has assessed its relevance in non-severely hypoxemic patients. In a randomized controlled trial (PROTRACH study), we aimed to evaluate preoxygenation with HFNC vs. standard bag-valve mask oxygenation (SMO) in non-severely hypoxemic patients during rapid sequence intubation (RSI) in the ICU. METHODS: Randomized controlled trial including non-severely hypoxemic patients requiring intubation in the ICU...
January 21, 2019: Intensive Care Medicine
Jean-Luc Hanouz, David Lhermitte, Jean-Louis Gérard, Marc Olivier Fischer
BACKGROUND: High-flow nasal oxygen (HFNO) therapy has been proposed for pre-oxygenation before intubation, but the end-tidal fraction of oxygen (ETO2) obtained remains unknown. OBJECTIVE(S): To compare the ETO2 following a 3 min pre-oxygenation with HFNO and face mask. SETTING: Operating room in a primary university hospital. DESIGN: A prospective, randomised crossover study. PARTICIPANTS: Fifty healthy volunteers...
January 18, 2019: European Journal of Anaesthesiology
Onder Tomruk, Kıvanç Karaman, Bulent Erdur, Hamit Hakan Armagan, Nesrin Gökben Beceren, Alten Oskay, Haci Ahmet Bircan
BACKGROUND High-flow nasal cannula (HFNC) is an alternative to conventional normobaric oxygen therapy (NBO) for hypoxemic patients. Since nothing is known about its effect on carbon monoxide (CO) poisoning, we hypothesized that HFNC might be a useful device in the treatment of CO poisoning victims. MATERIAL AND METHODS We retrospectively reviewed the medical records of patients who were admitted consecutively to the emergency department with CO intoxication. Patients were divided into 2 groups: patients treated with HFNC and patients treated with conventional face mask (CFM)...
January 21, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jilei Lin, Yin Zhang, Limei Xiong, Sha Liu, Caihui Gong, Jihong Dai
OBJECTIVES: To review the effects and safety of high-flow nasal cannula (HFNC) for bronchiolitis. METHODS: Six electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, CQ VIP Database and Wanfang Data were searched from their inception to 1 June 2018. Randomised controlled trials (RCTs) which investigated the effects of HFNC versus other forms of oxygen therapies for bronchiolitis were included...
January 17, 2019: Archives of Disease in Childhood
Tania Stripoli, Savino Spadaro, Rosa Di Mussi, Carlo Alberto Volta, Paolo Trerotoli, Francesca De Carlo, Rachele Iannuzziello, Fabio Sechi, Paola Pierucci, Francesco Staffieri, Francesco Bruno, Luigi Camporota, Salvatore Grasso
PURPOSE: High-flow oxygen therapy delivered through nasal cannulae improves oxygenation and decreases work of breathing in critically ill patients. Little is known of the physiological effects of high-flow oxygen therapy applied to the tracheostomy cannula (T-HF). In this study, we compared the effects of T-HF or conventional low-flow oxygen therapy (conventional O2 ) on neuro-ventilatory drive, work of breathing, respiratory rate (RR) and gas exchange, in a mixed population of tracheostomized patients at high risk of weaning failure...
January 7, 2019: Annals of Intensive Care
Zhonghua Lu, Wei Chang, Shanshan Meng, Ming Xue, Jianfeng Xie, Jingyuan Xu, Haibo Qiu, Yi Yang, Fengmei Guo
OBJECTIVE: To evaluate the effect of high-flow nasal cannula oxygen (HFNO) therapy on hospital length of stay (LOS) and postoperative pulmonary complications (PPCs) in adult postoperative patients. DATA SOURCES: PubMed, Embase, the Cochrane Library, Web of Science of Studies, China National Knowledge Index, and Wan Fang databases were searched until July 2018. STUDY SELECTION: Randomized controlled trials (RCTs) comparing HFNO with conventional oxygen therapy or noninvasive mechanical ventilation in adult postoperative patients were included...
December 26, 2018: Journal of Intensive Care Medicine
Oriol Roca, Berta Caralt, Jonathan Messika, Manuel Samper, Benjamin Sztrymf, Gonzalo Hernández, Marina García-de-Acilu, Jean-Pierre Frat, Joan R Masclans, Jean-Damien Ricard
RATIONALE: One important concern during high flow nasal cannula (HFNC) therapy in patients with acute hypoxemic respiratory failure (AHRF) is to not delay intubation. OBJECTIVES: To validate the diagnostic accuracy of an index (termed ROX and defined as the ratio of SpO2/FIO2 to respiratory rate) for determining HFNC outcome (need or not for intubation). METHODS: Two-year multicenter prospective observational cohort study including pneumonia patients treated with HFNC...
December 21, 2018: American Journal of Respiratory and Critical Care Medicine
Filippo Luca Fimognari, Massimo Rizzo, Olga Cuccurullo, Giovanna Cristiano, Roberto Ricchio, Consalvo Ricci, Claudio Iorio, Eugenio Borrelli
No abstract text is available yet for this article.
December 2018: Geriatrics & Gerontology International
Jakob Wittenstein, Lorenzo Ball, Paolo Pelosi, Marcelo Gama de Abreu
PURPOSE OF REVIEW: Patients undergoing thoracic surgery are at high risk for pulmonary and extra pulmonary complications, and may develop impairment of gas exchange during surgery and in the postoperative period. This review focuses on the potential benefits of high-flow nasal cannula (HFNC) oxygen therapy in those patients. RECENT FINDINGS: HFNC oxygen therapy can be used pre, intra and postoperatively. However, evidence for the use of HFNC oxygen therapy is still limited...
February 2019: Current Opinion in Anaesthesiology
Xiao Lu, ChunShuang Wu, YuZhi Gao, Mao Zhang
BACKGROUND: High-flow nasal cannula (HFNC) oxygen therapy has been shown to reduce the need for mechanical ventilation and decrease the duration of hospital and intensive care unit (ICU) stays for patients with a severely compromised respiratory system. This study aims to observe the evolution of lung aeration via lung ultrasound score (LUS) in a chest-injured population who had been treated with HFNC oxygen therapy, and to assess the benefit of the HFNC oxygen therapy in trauma patients...
December 4, 2018: Journal of Intensive Care Medicine
Benedict Griffiths, Shelley Riphagen, Jon Lillie
OBJECTIVE: To understand the impact of the National Institute for Health and Care Excellence (NICE) bronchiolitis guidelines on the management of children referred to paediatric intensive care unit (PICU) with bronchiolitis. DESIGN AND SETTING: Data were collected on all children referred to a regional PICU transport service with the clinical diagnosis of bronchiolitis during the winter prior to the NICE consultation period (2011-2012) and during the winter after publication (2015-2016)...
November 24, 2018: Archives of Disease in Childhood
Michael C Sklar, Alaa Mohammed, Ani Orchanian-Cheff, Lorenzo Del Sorbo, Sangeeta Mehta, Laveena Munshi
BACKGROUND: High-flow nasal-cannula (HFNC) may be an oxygen modality useful for preventing invasive mechanical ventilation and mortality; however, its role in acute hypoxemic respiratory failure is not clearly defined. We sought to evaluate the impact of HFNC on mortality across immunocompromised subjects compared to alternative noninvasive oxygen therapies, namely conventional oxygen therapy and noninvasive ventilation (NIV). METHODS: We systematically searched the major databases to identify randomized, controlled trials (RCTs) or observational studies (until May 2018)...
December 2018: Respiratory Care
Clare van Miert, Ricardo M Fernandes, Helen Eccleson, Emma Bedson, Steven Lane, Matthew Peak, Kent Thorburn, Vanessa Compton, Kerry Woolfall, David Lacy, Paula Williamson, Paul S McNamara
BACKGROUND: Bronchiolitis is an acute lower respiratory infection which predominantly affects young children. Treatment for bronchiolitis is limited to supportive therapy. Nasal oxygen therapy is part of routine care, and delivery now incorporates varying levels of non-invasive continuous positive airway pressure and/or high-flow nasal cannula oxygen therapy. Despite wide clinical use, there remains a lack of evidence on the comparative effectiveness and safety of these interventions...
November 14, 2018: Trials
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