Md Atique Ahmed, Pratisthita Baruah, Ahmed Saif, Jin-Hee Han, Mohammed Al-Zharani, Syeda Wasfeea Wazid, Saad Alkahtani, Saurav J Patgiri, Mohammed S Al-Eissa, Fu-Shi Quan
The cell-traversal protein for ookinetes and sporozoites (CelTOS), expressed on the surface of ookinetes and sporozoitesin Plasmodium species , is a promising malaria vaccine candidate. CelTOS is essential for parasite invasion into mosquito midgut and human hepatocytes, thereby contributing to malaria transmission and disease pathogenesis. This study explores the genetic diversity, polymorphisms, haplotypes, natural selection, phylogenetic analysis, and epitope prediction in the full-length Plasmodium knowlesi CelTOS gene in clinical samples from Sarawak, Malaysian Borneo, and long-term laboratory strains from Peninsular Malaysia and the Philippines...
July 26, 2023: Tropical Medicine and Infectious Disease