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REVIEW
Sebastiaan Dhont, Gitte van den Acker, Tim van Loon, Frederik H Verbrugge, Jan Verwerft, Sébastien Deferm, Timothy W Churchill, Wilfried Mullens, Joost Lumens, Philippe B Bertrand
Mitral regurgitation (MR) is highly prevalent among patients with heart failure and preserved ejection fraction (HFpEF). Despite this combination being closely associated with unfavourable outcomes, it remains relatively understudied. This is partly due to the inherent heterogeneity of patients with HFpEF. To address this gap, dissecting HFpEF into mechanism-based phenotypes may offer a promising avenue for advancing our comprehension of these complex intertwined conditions. This review employs the validated CircAdapt model to explore the haemodynamic implications of moderate to severe MR across a well-defined spectrum of myocardial disease, characterized by impaired relaxation and reduced myocardial compliance...
April 17, 2024: European Journal of Heart Failure
#2
JOURNAL ARTICLE
Luis F Schachner, Christopher Mullen, Wilson Phung, Joshua D Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J Agard, Matthieu Masureel, Joshua Gober, Adel M ElSohly, Rafael Melani, John E P Syka, Romain Huguet, Michael T Marty, Wendy Sandoval
The heterogeneity inherent in today's biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule's safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods are limited in their ability to analyze intact glycoproteins or other heterogeneous biotherapeutics. Here, we present an approach to the molecular assessment of biotherapeutics that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact heterogeneous and/or glycosylated proteins by mass spectrometry...
April 16, 2024: Nature Communications
#3
JOURNAL ARTICLE
Marcin Czub, Elena R Serrano-Ibáñez, Joanna Piskorz, Rosa Esteve, Helena K Lydon, Alicia E López-Martínez, Bertille Mullen, Carmen Ramírez-Maestre, Caroline Heary, Conor O'Neill, Gloria Sainero, Juan Francisco Ruiz Escalera, Line Caes, Silvia Morales Murcia, Vincent McDarby, Brian E McGuire
This international multicenter randomized controlled trial aimed to compare the effectiveness of virtual reality (VR) distraction with an identical non-VR game in reducing needle-related pain and anxiety in children undergoing venous blood draw. The study involved 304 children aged 5-9 years undergoing a blood draw procedure, randomly allocated to one of three groups: VR distraction, non-VR distraction, and control group (usual care). The distraction task was based on the Multiple Object Tracking (MOT) paradigm, and the game was identical in design and gameplay for both VR and non-VR distraction groups...
April 16, 2024: Cyberpsychology, Behavior and Social Networking
#4
JOURNAL ARTICLE
Mason Fidino, Heather A Sander, Jesse S Lewis, Elizabeth W Lehrer, Kimberly Rivera, Maureen H Murray, Henry C Adams, Anna Kase, Andrea Flores, Theodore Stankowich, Christopher J Schell, Carmen M Salsbury, Adam T Rohnke, Mark J Jordan, Austin M Green, Ashley R Gramza, Amanda J Zellmer, Jacque Williamson, Thilina D Surasinghe, Hunter Storm, Kimberly L Sparks, Travis J Ryan, Katie R Remine, Mary E Pendergast, Kayleigh Mullen, Darren E Minier, Christopher R Middaugh, Amy L Mertl, Maureen R McClung, Robert A Long, Rachel N Larson, Michel T Kohl, Lavendar R Harris, Courtney T Hall, Jeffrey D Haight, David Drake, Alyssa M Davidge, Ann O Cheek, Christopher P Bloch, Elizabeth G Biro, Whitney J B Anthonysamy, Julia L Angstmann, Maximilian L Allen, Solny A Adalsteinsson, Anne G Short Gianotti, Jalene M LaMontagne, Tiziana A Gelmi-Candusso, Seth B Magle
While there is increasing recognition that social processes in cities like gentrification have ecological consequences, we lack nuanced understanding of the ways gentrification affects urban biodiversity. We analyzed a large camera trap dataset of mammals (>500 g) to evaluate how gentrification impacts species richness and community composition across 23 US cities. After controlling for the negative effect of impervious cover, gentrified parts of cities had the highest mammal species richness. Change in community composition was associated with gentrification in a few cities, which were mostly located along the West Coast...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#5
JOURNAL ARTICLE
Satoko Goto, Tomoko Nishimura, Akemi Okumura, Taeko Harada, Mohammad Shafiur Rahman, Toshiki Iwabuchi, Motofumi Sumiya, Atsushi Senju, Kenji J Tsuchiya
OBJECTIVES: Motor planning is the cognitive process of planning necessary steps for achieving a purposeful movement and is specifically reflected through object manipulation. This study aimed to investigate whether fine motor skills, a surrogate of the motor planning ability of object manipulation, in early childhood are associated with later social skills, in a general-population birth cohort. METHODS: A total of 913 children, participating in the Hamamatsu Birth Cohort for Mothers and Children, were enrolled...
March 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
#6
JOURNAL ARTICLE
Dylan J H A Henssen, Cynthia Pritsch, Pouyan Nazari, Wim Mulleners, Kris Vissers
BACKGROUND: Functional anatomical research proposed the existence of a bilateral trigeminal ascending system although the anatomy trajectories of the trigeminothalamic connections cranial to the pons remain largely elusive. This study therefore aimed to clarify the anatomical distributions of the trigeminothalamic connections in humans. METHODS: Advanced deterministic tractography to an averaged template of diffusion tensor imaging data from 1065 subjects from the Human Connectome Project was used...
April 2024: Cephalalgia: An International Journal of Headache
#7
JOURNAL ARTICLE
Jeroen Bijnens, Sander Trenson, Gabor Voros, Pieter Martens, Sebastian Ingelaere, Pascal Betschart, Jens-Uwe Voigt, Matthias Dupont, Alexander Breitenstein, Jan Steffel, Rik Willems, Frank Ruschitzka, Wilfried Mullens, Stephan Winnik, Bert Vandenberk
Background: Cardiac resynchronization therapy (CRT) has evolved into an established therapy for patients with chronic heart failure and a wide QRS complex. Data on long-term outcomes over time are scarce and the criteria for implantation remain a subject of investigation. Methods: An international, multicenter, retrospective registry includes 2275 patients who received CRT between 30 November 2000 and 31 December 2019, with a mean follow-up of 3.6 ± 2.7 years. Four time periods were defined, based on landmark trials and guidelines...
March 25, 2024: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Cora E Mukerji, John S Wilson, Carol L Wilkinson, Manon A Krol, Charles A Nelson, Helen Tager-Flusberg
Previous research links resting frontal gamma power to key developmental outcomes in young neurotypical (NT) children and infants at risk for language impairment. However, it remains unclear whether gamma power is specifically associated with language or with more general cognitive abilities among young children diagnosed with autism spectrum disorder (ASD). The current study evaluates differences in resting frontal gamma power between young autistic and NT children and tests whether gamma power is uniquely associated with individual differences in expressive language, receptive language and non-verbal cognitive abilities in autistic and NT children...
April 12, 2024: Journal of Autism and Developmental Disorders
#9
JOURNAL ARTICLE
Wilfried Mullens, Kevin Damman, Sebastiaan Dhont, Debasish Banerjee, Antoni Bayes-Genis, Antonio Cannata, Ovidiu Chioncel, Maja Cikes, Justin Ezekowitz, Andreas J Flammer, Pieter Martens, Alexandre Mebazaa, Robert J Mentz, Òscar Miró, Brenda Moura, Julio Nunez, Jozine M Ter Maaten, Jeffrey Testani, Roland van Kimmenade, Frederik H Verbrugge, Marco Metra, Giuseppe M C Rosano, Gerasimos Filippatos
Sodium and fluid restriction has traditionally been advocated in patients with heart failure (HF) due to their sodium and water avid state. However, most evidence regarding the altered sodium handling, fluid homeostasis and congestion-related signs and symptoms in patients with HF originates from untreated patient cohorts and physiological investigations. Recent data challenge the beneficial role of dietary sodium and fluid restriction in HF. Consequently, the European Society of Cardiology HF guidelines have gradually downgraded these recommendations over time, now advising for the limitation of salt intake to no more than 5 g/day in patients with HF, while contemplating fluid restriction of 1...
April 12, 2024: European Journal of Heart Failure
#10
JOURNAL ARTICLE
Rebecca Moreci, Rebecca S Gates, John Luckoski, Kayla Marcotte, Cody L Mullens, Chia Chye Yee, Tanvi Gupta, Daniel Kendrick, Angela Thelen, Andrew E Krumm, Brian C George
OBJECTIVE: The objective of this study is to explore the patient characteristics and practice patterns of non-certified surgeons who treat Medicare patients in the United States. SUMMARY BACKGROUND DATA: While most surgeons in the United States are board-certified, non-certified surgeons are permitted to practice in many locations. At the same time, surgical workforce shortages threaten access to surgical care for many patients. It is possible that non-certified surgeons may be able to help fill these access gaps...
April 12, 2024: Annals of Surgery
#11
JOURNAL ARTICLE
Jordan N Williamson, Shirley A James, Sean P Mullen, Bradley P Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yang
As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer's disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex and may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity...
April 10, 2024: GeroScience
#12
JOURNAL ARTICLE
Machiko K Asaka, Tomoko Nishimura, Hitoshi Kuwabara, Hiroaki Itoh, Nagahide Takahashi, Kenji J Tsuchiya
Our previous study, which aimed to understand the early neurodevelopmental trajectories of children with and without neurodevelopmental disorders, identified five classes of early neurodevelopmental trajectories, categorized as high normal, normal, low normal, delayed, and markedly delayed. This investigation involved measurement using the Mullen Scale of Early Learning in a representative sample of Japanese infants followed up from the age of 0 to 2 years (Nishimura et al., 2016). In the present study, we investigated the potential association between cytokine concentrations in umbilical cord serum with any of the five classes of neurodevelopmental trajectories previously assigned, as follows: high normal (N = 85, 13...
2024: PloS One
#13
JOURNAL ARTICLE
Katya Remy, Merel H Hazewinkel, Connor Mullen, Robert R Hagan, William G Austen, Lisa Gfrerer
BACKGROUND: Although nerve decompression surgery is an effective treatment for refractory occipital neuralgia (ON), a proportion of patients experience recurrence of pain and undergo reoperation. This study analyzes the incidence, risk factors, and outcomes of reoperation following primary greater occipital nerve (GON) decompression. METHODS: 215 patients who underwent 399 primary GON decompressions were prospectively enrolled. Data included patient demographics, past medical and surgical history, reoperation rates, intraoperative findings, surgical technique, and postoperative outcomes in terms of pain frequency (days/month), duration (hours/day), intensity (scale 0-10), and migraine headache index (MHI)...
April 9, 2024: Plastic and Reconstructive Surgery
#14
JOURNAL ARTICLE
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jenny Shim, Hunter C Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D Kynnap, Amanda L Christie, Xiaoping Yang, Glenn S Cowley, Brittaney A Leeper, Christopher L Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M Clinton, Manoj Bhasin, Brian D Crompton, Yuen-Yi Tseng, Jesse S Boehm, Keith L Ligon, David E Root, Andrew J Murphy, David M Weinstock, Prafulla C Gokhale, Jennifer M Spangle, Miguel N Rivera, Elizabeth A Mullen, Kimberly Stegmaier, Kelly C Goldsmith, William C Hahn, Andrew L Hong
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Identifying novel targeted therapies remains challenging in part due to the lack of faithful preclinical in vitro models. Here we establish twelve patient-derived WT cell lines and demonstrate that these models faithfully recapitulate WT biology using genomic and transcriptomic techniques...
April 8, 2024: Communications Biology
#15
REVIEW
Sarah A Mullen, Emma L Myers, Rebecca L Brenner, Kim T Nguyen, Tara A Harper, Darby Welsh, Storm Keffer, Jenna Mueller, Melodi Javid Whitley
Intralesional therapies are used for recalcitrant warts, but no Food and Drug Administration-approved treatment exists nor is there consensus regarding the most efficacious therapy. Therefore, this systematic review aims to summarize efficacy and adverse events reported in 62 randomized controlled trials (RCTs) of intralesional therapies for cutaneous warts. The most studied intralesional therapies included measles, mumps, rubella (MMR) vaccine (n = 24 studies), purified protein derivative (PPD) (n = 19 studies), vitamin D3 (n = 15 studies), and Candida antigen (n = 14 studies)...
May 2024: JID innovations
#16
JOURNAL ARTICLE
F Afzal, K Spieker, P Hurck, S Abt, P Achenbach, P Adlarson, Z Ahmed, C S Akondi, J R M Annand, H J Arends, M Bashkanov, R Beck, M Biroth, N Borisov, A Braghieri, W J Briscoe, F Cividini, C Collicott, S Costanza, A Denig, M Dieterle, E J Downie, P Drexler, S Fegan, S Gardner, D Ghosal, D I Glazier, I Gorodnov, W Gradl, D Gurevich, L Heijkenskjöld, D Hornidge, G M Huber, V L Kashevarov, S J D Kay, M Korolija, B Krusche, A Lazarev, K Livingston, S Lutterer, I J D MacGregor, R G Macrae, D M Manley, P P Martel, R Miskimen, M Mocanu, E Mornacchi, C Mullen, A Neganov, A Neiser, M Oberle, M Ostrick, P B Otte, D Paudyal, P Pedroni, A Powell, G Reicherz, T Rostomyan, C Sfienti, V Sokhoyan, O Steffen, I I Strakovsky, T Strub, I Supek, A Thiel, M Thiel, A Thomas, Yu A Usov, S Wagner, N K Walford, D P Watts, D Werthmüller, J Wettig, L Witthauer, M Wolfes, N Zachariou
We report the measurement of the helicity asymmetry E for the pπ^{0} and nπ^{+} final states using, for the first time, an elliptically polarized photon beam in combination with a longitudinally polarized target at the Crystal Ball experiment at MAMI. The results agree very well with data that were taken with a circularly polarized photon beam, showing that it is possible to simultaneously measure polarization observables that require linearly (e.g., G) and circularly polarized photons (e.g., E) and a longitudinally polarized target...
March 22, 2024: Physical Review Letters
#17
JOURNAL ARTICLE
Amanda J Goodrich, Michael J Kleeman, Daniel J Tancredi, Yunin J Ludeña, Deborah H Bennett, Irva Hertz-Picciotto, Rebecca J Schmidt
BACKGROUND: This study sought to investigate the association of prenatal and early life exposure to a mixture of air pollutants on cognitive and adaptive outcomes separately in children with or without autism spectrum disorder (ASD). METHODS: Utilizing data from the CHARGE case-control study (birth years: 2000-2016), we predicted daily air concentrations of NO2 , O3 , and particulate matter <0.1 μm (PM0.1 ), between 0.1 and 2.5 μm (PM0.1-2...
April 3, 2024: Environmental Research
#18
JOURNAL ARTICLE
Nele Mullens, Wouter Hendrycks, Jackline Bakengesa, Sija Kabota, Jenipher Tairo, Hannes Svardal, Ramadhani Majubwa, Maulid Mwatawala, Marc De Meyer, Massimiliano Virgilio
Gut microbial communities are critical in determining the evolutive success of fruit fly phytophagous pests (Diptera, Tephritidae), facilitating their adaptation to suboptimal environmental conditions and to plant allelochemical defences. An important source of variation for the microbial diversity of fruit flies is represented by the crop on which larvae are feeding. However, a "crop effect" is not always the main driver of microbial patterns, and it is often observed in combination with other and less obvious processes...
2024: PloS One
#19
JOURNAL ARTICLE
Tania M Phillips, Gavin Austin, Tait Sanders, Margaret Martin, Jacqueline Hudson, Alexandra Fort, Tarra Excell, Amy B Mullens, Annette Brömdal
ISSUES ADDRESSED: There is a paucity of data regarding depression and thoughts of self-harm or suicide among gender and sexually diverse (GSD) people living within Australian regional/rural locations. This study aims to elucidate these issues and fill a critical gap. METHODS: The sample included 91 GSD people from a regional community in South-West Queensland utilising the PHQ-9 to determine presence/severity of depression and self-harm/suicide ideation. These data were drawn from a larger health and wellbeing survey...
April 2, 2024: Health Promotion Journal of Australia
#20
JOURNAL ARTICLE
Cheng Sun, Chan Zhou, Kaveh Daneshvar, Amel Ben Saad, Arcadia J Kratkiewicz, Benjamin J Toles, Nahid Arghiani, Anja Hess, Jennifer Y Chen, Joshua V Pondick, Samuel R York, Wenyang Li, Sean Moran, Stefan Gentile, Raza Ur Rahman, Zixiu Li, Peng Zhou, Robert Sparks, Tim Habboub, Byeong-Moo Kim, Michael Y Choi, Silvia Affo, Robert F Schwabe, Yury V Popov, Alan C Mullen
BACKGROUND AND AIMS: Fibrosis is the common endpoint for all forms of chronic liver injury, and progression of fibrosis leads to the development of end-stage liver disease. Activation of hepatic stellate cells (HSCs) and their transdifferentiation into myofibroblasts results in the accumulation of extracellular matrix (ECM) proteins that form the fibrotic scar. Long noncoding (lnc) RNAs regulate the activity of HSCs and provide targets for fibrotic therapies. APPROACH AND RESULTS: We identified lncRNA TILAM located near COL1A1, expressed in HSCs, and induced with liver fibrosis in humans and mice...
April 2, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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